Combinatorial Tim‐3 and PD‐1 activity sustains antigen‐specific Th1 cell numbers during blood‐stage malaria

Recent Insights into CD4+Th Cell Differentiation in Malaria

(2018) Megan S. F. Soon et al.   JOURNAL OF IMMUNOLOGY

Early Changes in CD4+ T-Cell Activation During Blood-Stage Plasmodium falciparum Infection

(2018) Chelsea L Edwards et al.   JOURNAL OF INFECTIOUS DISEASES

Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion

(2018) Lyndsay Avery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential expression pattern of co-inhibitory molecules on CD4+ T cells in uncomplicated versus complicated malaria

(2018) Annemieke Abel et al.   Scientific Reports

The Contribution of Co-signaling Pathways to Anti-malarial T Cell Immunity

(2018) Rebecca Faleiro et al.   Frontiers in Immunology

IL-6 promotes CD4+ T-cell and B-cell activation during Plasmodium infection

(2017) I. Sebina et al.   PARASITE IMMUNOLOGY

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation

(2016) Ana C. Anderson et al.   IMMUNITY

Murine Model for Preclinical Studies of Var2CSA-Mediated Pathology Associated with Malaria in Pregnancy

(2016) Luciana V. de Moraes et al.   INFECTION AND IMMUNITY

T-Cell Immunoglobulin– and Mucin-Domain–Containing Molecule 3 Signaling Blockade Improves Cell-Mediated Immunity Against Malaria

(2016) Nan Hou et al.   JOURNAL OF INFECTIOUS DISEASES

Acute Malaria Induces PD1+CTLA4+ Effector T Cells with Cell-Extrinsic Suppressor Function

(2016) Maria Sophia Mackroth et al.   PLoS Pathogens

TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection

(2016) Pushpa Jayaraman et al.   PLoS Pathogens

Induction of Inhibitory Receptors on T Cells DuringPlasmodium vivaxMalaria Impairs Cytokine Production

(2015) Pedro A. C. Costa et al.   JOURNAL OF INFECTIOUS DISEASES

Disruption of IL-21 Signaling Affects T Cell-B Cell Interactions and Abrogates Protective Humoral Immunity to Malaria

(2015) Damián Pérez-Mazliah et al.   PLoS Pathogens

CD4 T-Cell Memory Generation and Maintenance

(2014) David J. Gasper et al.   CRITICAL REVIEWS IN IMMUNOLOGY

The Subcellular Location of Ovalbumin in Plasmodium berghei Blood Stages Influences the Magnitude of T-Cell Responses

(2014) Jing-Wen Lin et al.   INFECTION AND IMMUNITY

Tim-3 Directly Enhances CD8 T Cell Responses to Acute Listeria monocytogenes Infection

(2014) J. V. Gorman et al.   JOURNAL OF IMMUNOLOGY

Expression of Tim-1 and Tim-3 in Plasmodium berghei ANKA infection

(2013) Bo Huang et al.   PARASITOLOGY RESEARCH

IL-27 Receptor Signalling Restricts the Formation of Pathogenic, Terminally Differentiated Th1 Cells during Malaria Infection by Repressing IL-12 Dependent Signals

(2013) Ana Villegas-Mendez et al.   PLoS Pathogens

IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma

(2012) Zhi-Zhang Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic Exposure to Plasmodium falciparum Is Associated with Phenotypic Evidence of B and T Cell Exhaustion

(2012) J. Illingworth et al.   JOURNAL OF IMMUNOLOGY

Expansion of experimental genetics approaches for Plasmodium berghei with versatile transfection vectors

(2012) Taco W.A. Kooij et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A new therapeutic strategy for malaria: targeting T cell exhaustion

(2012) Gordon J Freeman et al.   NATURE IMMUNOLOGY

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion

(2012) Manu Rangachari et al.   NATURE MEDICINE

TIM-3 Expression Characterizes Regulatory T Cells in Tumor Tissues and Is Associated with Lung Cancer Progression

(2012) Xin Gao et al.   PLoS One

Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells

(2011) Marion Pepper et al.   IMMUNITY

Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection

(2011) Noah S Butler et al.   NATURE IMMUNOLOGY

A Novel ‘Gene Insertion/Marker Out’ (GIMO) Method for Transgene Expression and Gene Complementation in Rodent Malaria Parasites

(2011) Jing-wen Lin et al.   PLoS One

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

(2010) Rachel H. McMahan et al.   JOURNAL OF CLINICAL INVESTIGATION

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

(2009) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

Effective induction of high-titer antibodies by viral vector vaccines

(2008) Simon J Draper et al.   NATURE MEDICINE

IL-10 from CD4+CD25−Foxp3−CD127− Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection

(2008) Kevin N. Couper et al.   PLoS Pathogens