Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Validation of NRG oncology/RTOG‐0129 risk groups for HPV‐positive and HPV‐negative oropharyngeal squamous cell cancer: Implications for risk‐based therapeutic intensity trials

(2019) Carole Fakhry et al.   CANCER

The DNA-PK Inhibitor VX-984 Enhances the Radiosensitivity of Glioblastoma Cells GrownIn Vitroand as Orthotopic Xenografts

(2018) Cindy R. Timme et al.   MOLECULAR CANCER THERAPEUTICS

Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial

(2018) Hisham Mehanna et al.   LANCET

Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial

(2018) Maura L Gillison et al.   LANCET

Consider the workhorse: Nonhomologous end-joining in budding yeast

(2016) Charlene H. Emerson et al.   Biochemistry and Cell Biology

Clinical Outcomes and Patterns of Disease Recurrence After Intensity Modulated Proton Therapy for Oropharyngeal Squamous Carcinoma

(2016) G. Brandon Gunn et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

TP53Mutations in Head and Neck Squamous Cell Carcinoma and Their Impact on Disease Progression and Treatment Response

(2016) Ge Zhou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HPV Associated Head and Neck Cancer

(2016) Tara Spence et al.   Cancers

Analysis of loco-regional failures in head and neck cancer after radical radiation therapy

(2015) Francesca De Felice et al.   ORAL ONCOLOGY

p16 Protein Expression and Human Papillomavirus Status As Prognostic Biomarkers of Nonoropharyngeal Head and Neck Squamous Cell Carcinoma

(2014) Christine H. Chung et al.   JOURNAL OF CLINICAL ONCOLOGY

Randomized Phase III Trial of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Stage III to IV Head and Neck Carcinoma: RTOG 0522

(2014) K. Kian Ang et al.   JOURNAL OF CLINICAL ONCOLOGY

Charged particle therapy versus photon therapy for paranasal sinus and nasal cavity malignant diseases: a systematic review and meta-analysis

(2014) Samir H Patel et al.   LANCET ONCOLOGY

TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer

(2014) Rajat Banerjee et al.   Nature Communications

Biological Consequences of Radiation-induced DNA Damage: Relevance to Radiotherapy

(2013) M.E. Lomax et al.   CLINICAL ONCOLOGY

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

(2013) Liz J. Valente et al.   Cell Reports

Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond

(2013) David Davidson et al.   Frontiers in Pharmacology

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

(2012) Mrinal Srivastava et al.   CELL

APLF promotes the assembly and activity of non-homologous end joining protein complexes

(2012) Gabrielle J Grundy et al.   EMBO JOURNAL

The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage

(2012) Pamela Reynolds et al.   NUCLEIC ACIDS RESEARCH

Inhibition of Non-Homologous End Joining Repair Impairs Pancreatic Cancer Growth and Enhances Radiation Response

(2012) Ying-Hua Li et al.   PLoS One

Ionizing Radiation Induces Stemness in Cancer Cells

(2012) Laura Ghisolfi et al.   PLoS One

Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma

(2012) Wael Y. Mansour et al.   RADIOTHERAPY AND ONCOLOGY

EGFR Nuclear Translocation Modulates DNA Repair following Cisplatin and Ionizing Radiation Treatment

(2011) G. Liccardi et al.   CANCER RESEARCH

DNA Repair Biomarker Profiling of Head and Neck Cancer: Ku80 Expression Predicts Locoregional Failure and Death following Radiotherapy

(2011) B. J. Moeller et al.   CLINICAL CANCER RESEARCH

TP53 Disruptive Mutations Lead to Head and Neck Cancer Treatment Failure through Inhibition of Radiation-Induced Senescence

(2011) H. D. Skinner et al.   CLINICAL CANCER RESEARCH

Recurrence patterns of locally advanced head and neck squamous cell carcinoma after 3D conformal (chemo)-radiotherapy

(2011) Didem C Oksuz et al.   Radiation Oncology

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

Genomic instability and cancer: Lessons learned from human papillomaviruses

(2010) Nina Korzeniewski et al.   CANCER LETTERS

The Limitations of the G1-S Checkpoint

(2010) Dorothee Deckbar et al.   CANCER RESEARCH

Some unsolved problems and unresolved issues in radiation cytogenetics: A review and new data on roles of homologous recombination and non-homologous end joining

(2010) Hatsumi Nagasawa et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer

(2010) K. Kian Ang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Radiation-induced cell death mechanisms

(2010) David Eriksson et al.   TUMOR BIOLOGY

Identification of a Small Molecule Inhibitor of the Human DNA Repair Enzyme Polynucleotide Kinase/Phosphatase

(2009) G. K. Freschauf et al.   CANCER RESEARCH

Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex

(2009) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p38 Mitogen-Activated Protein Kinase- and HuR-Dependent Stabilization of p21Cip1 mRNA Mediates the G1/S Checkpoint

(2009) V. Lafarga et al.   MOLECULAR AND CELLULAR BIOLOGY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Oxidatively Generated Damage to the Guanine Moiety of DNA: Mechanistic Aspects and Formation in Cells

(2008) Jean Cadet et al.   ACCOUNTS OF CHEMICAL RESEARCH

Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair

(2008) X. Chen et al.   CANCER RESEARCH

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

(2008) E M Michalak et al.   CELL DEATH AND DIFFERENTIATION

Ku80 removal from DNA through double strand break–induced ubiquitylation

(2008) Lisa Postow et al.   JOURNAL OF CELL BIOLOGY

Randomized Trial of Postoperative Reirradiation Combined With Chemotherapy After Salvage Surgery Compared With Salvage Surgery Alone in Head and Neck Carcinoma

(2008) François Janot et al.   JOURNAL OF CLINICAL ONCOLOGY

Understanding and re-engineering nucleoprotein machines to cure human disease

(2008) William Dynan et al.   Nanomedicine

Molecular Target Approaches in Head and Neck Cancer: Epidermal Growth Factor Receptor and Beyond

(2008) Paul M. Harari et al.   SEMINARS IN RADIATION ONCOLOGY