Machine learning predicts new anti-CRISPR proteins

Potent CRISPR-Cas9 inhibitors fromStaphylococcusgenomes

(2020) Kyle E. Watters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery and Characterization of Cas9 Inhibitors Disseminated across Seven Bacterial Phyla

(2019) Ruben V. Uribe et al.   Cell Host & Microbe

Broad-spectrum enzymatic inhibition of CRISPR-Cas12a

(2019) Gavin J. Knott et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An anti-CRISPR protein disables type V Cas12a by acetylation

(2019) Liyong Dong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins

(2019) Heng Zhang et al.   Cell Host & Microbe

Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a

(2019) Gavin J Knott et al.   eLife

Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome

(2019) Kevin J Forsberg et al.   eLife

Inhibition of Type III CRISPR-Cas Immunity by an Archaeal Virus-Encoded Anti-CRISPR Protein

(2019) Yuvaraj Bhoobalan-Chitty et al.   CELL

Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome Editing

(2019) Bianca Garcia et al.   Cell Reports

Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins

(2018) Yuwei Zhu et al.   BMC BIOLOGY

Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins

(2018) Alexander P. Hynes et al.   Nature Communications

Anti-CRISPR proteins encoded by archaeal lytic viruses inhibit subtype I-D immunity

(2018) Fei He et al.   Nature Microbiology

A flavin-based extracellular electron transfer mechanism in diverse Gram-positive bacteria

(2018) Samuel H. Light et al.   NATURE

Discovery of widespread Type I and Type V CRISPR-Cas inhibitors

(2018) Nicole D. Marino et al.   SCIENCE

Systematic discovery of natural CRISPR-Cas12a inhibitors

(2018) Kyle E. Watters et al.   SCIENCE

CRISPR-Cas guides the future of genetic engineering

(2018) Gavin J. Knott et al.   SCIENCE

Temperature-Responsive Competitive Inhibition of CRISPR-Cas9

(2018) Fuguo Jiang et al.   MOLECULAR CELL

Staphylococcus aureus Cas9 is a multiple-turnover enzyme

(2018) Paul Yourik et al.   RNA

Anti-CRISPRs on the march

(2018) Eugene V. Koonin et al.   SCIENCE

Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins

(2018) Jooyoung Lee et al.   mBio

The Anti-CRISPR Story: A Battle for Survival

(2017) Karen L. Maxwell   MOLECULAR CELL

Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9

(2017) Hui Yang et al.   MOLECULAR CELL

Anti-CRISPR: discovery, mechanism and function

(2017) April Pawluk et al.   NATURE REVIEWS MICROBIOLOGY

Anti-CRISPRdb: a comprehensive online resource for anti-CRISPR proteins

(2017) Chuan Dong et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of an anti-CRISPR protein, AcrIIA1

(2017) Donghyun Ka et al.   NUCLEIC ACIDS RESEARCH

Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein

(2017) April Pawluk et al.   mBio

The Discovery, Mechanisms, and Evolutionary Impact of Anti-CRISPRs

(2017) Adair L. Borges et al.   Annual Review of Virology

An anti-CRISPR from a virulent streptococcal phage inhibits Streptococcus pyogenes Cas9

(2017) Alexander P. Hynes et al.   Nature Microbiology

Disabling Cas9 by an anti-CRISPR DNA mimic

(2017) Jiyung Shin et al.   Science Advances

Friendly Fire: Biological Functions and Consequences of Chromosomal Targeting by CRISPR-Cas Systems

(2016) Gary E. Heussler et al.   JOURNAL OF BACTERIOLOGY

CRISPR: gene editing is just the beginning

(2016) Heidi Ledford   NATURE

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

(2016) Alexandra East-Seletsky et al.   NATURE

PHASTER: a better, faster version of the PHAST phage search tool

(2016) David Arndt et al.   NUCLEIC ACIDS RESEARCH

Phages Fight Back: Inactivation of the CRISPR-Cas Bacterial Immune System by Anti-CRISPR Proteins

(2016) Karen L. Maxwell   PLoS Pathogens

CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections

(2016) Ferdy R. van Diemen et al.   PLoS Pathogens

Inactivation of CRISPR-Cas systems by anti-CRISPR proteins in diverse bacterial species

(2016) April Pawluk et al.   Nature Microbiology

Correct machine learning on protein sequences: a peer-reviewing perspective

(2015) Ian Walsh et al.   BRIEFINGS IN BIOINFORMATICS

The roles of CRISPR–Cas systems in adaptive immunity and beyond

(2015) Rodolphe Barrangou   CURRENT OPINION IN IMMUNOLOGY

Multiple mechanisms for CRISPR–Cas inhibition by anti-CRISPR proteins

(2015) Joseph Bondy-Denomy et al.   NATURE

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

CRISPR/Cas9 for genome editing: progress, implications and challenges

(2014) F. Zhang et al.   HUMAN MOLECULAR GENETICS

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

A New Group of Phage Anti-CRISPR Genes Inhibits the Type I-E CRISPR-Cas System of Pseudomonas aeruginosa

(2014) A. Pawluk et al.   mBio

Multiple instance learning of Calmodulin binding sites

(2012) F. u. A. A. Minhas et al.   BIOINFORMATICS

Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system

(2012) Joe Bondy-Denomy et al.   NATURE

CD-HIT Suite: a web server for clustering and comparing biological sequences

(2010) Ying Huang et al.   BIOINFORMATICS

Protein sequences classification by means of feature extraction with substitution matrices

(2010) Rabie Saidi et al.   BMC BIOINFORMATICS

CRISPR/Cas, the Immune System of Bacteria and Archaea

(2010) P. Horvath et al.   SCIENCE