Article
Neurosciences
Wim Hendricus Quint, Irena Matecko-Burmann, Irene Schilcher, Tina Loeffler, Michael Scholl, Bjorn Marcus Burmann, Thomas Vogels
Summary: The study developed three bispecific antibodies targeting tau and either alpha-synuclein or C1q, with varying affinities compared to monospecific counterparts. These bispecific antibodies retained binding to aggregated protein in patient-derived brain sections and showed potential as a promising approach to treat tauopathies and other neurodegenerative disorders.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Cell Biology
Katelyn Mroczek, Sanjanie Fernando, Paul R. Fisher, Sarah J. Annesley
Summary: Tau and alpha-synuclein exhibit different but overlapping patterns of intracellular localization, exerting distinct but overlapping patterns of cytotoxic effects. They may interact physically in the cell cortex, affecting some phenotypes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Clinical Neurology
Kyu Hwan Shim, Min Ju Kang, Young Chul Youn, Seong Soo A. An, SangYun Kim
Summary: The study reviews and summarizes the physiological and pathophysiological functions, structures, and genetics of alpha-syn in Alzheimer's disease (AD). Numerous associations of alpha-syn with A beta and tau suggest its significance as a partner in the pathological roles of AD. Understanding the involvement of alpha-syn in the pathology of A beta and tau could help address unresolved issues of AD. Specifically, the current status of CSF alpha-syn in AD recommends it as an additional biomarker in AD diagnosis.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Michael Wolgin, Magdalena Zobernig, Valentyn Dvornyk, Ralf J. Braun, Andrej M. Kielbassa
Summary: Salivary samples of AD patients show significant increases in levels of amyloid-beta Aβ42 and elevated p-tau to t-tau ratios compared to healthy controls. In PD patients, levels of alpha-synuclein in salivary samples decrease significantly, while oligomeric alpha-synuclein and the ratio of oligomeric alpha-synuclein to total alpha-synuclein increase markedly.
Review
Biochemistry & Molecular Biology
Chun-Ling Dai, Fei Liu, Khalid Iqbal, Cheng-Xin Gong
Summary: The article discusses the interaction between gut microbiota, the immune system, and AD immunotherapy, emphasizing the crucial role of gut microbiota in the pathogenesis and treatment of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Jacqui Taryn Nimmo, Louise Kelly, Ajay Verma, Roxana O. Carare, James A. R. Nicoll, Jean-Cosme Dodart
Summary: This article discusses the application of immunotherapy in neurodegenerative diseases, specifically Alzheimer's disease and Lewy body diseases. While immunotherapies have shown promising results in animal models, they have faced challenges in clinical trials, indicating a disconnect between experimental and clinical outcomes.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Cecilia Tremblay, Geidy E. Serrano, Anthony J. Intorcia, Lucia Sue, Jeffrey R. Wilson, Charles H. Adler, Holly A. Shill, Erika Driver-Dunckley, Shyamal H. Mehta, Thomas G. Beach
Summary: The decline of olfactory function is frequently observed in aging. This study found that tau pathology is commonly observed in the olfactory bulb of normally aging individuals, but it does not independently contribute to age-related olfactory decline. Further involvement of the brain seems to be necessary for age-related olfactory impairment.
Review
Biochemistry & Molecular Biology
Abbie T. Rodger, Maryam A. L. Nasser, Wayne G. Carter
Summary: Currently, there are no pharmacological treatments that can completely stop or reverse the progression of Parkinson's Disease (PD). Therefore, there is a need for neuroprotective therapies. This systematic review examines the effectiveness of anti-a-synuclein (a-syn) therapies in preventing PD progression in preclinical models and human clinical trials. The review found that novel preclinical anti-a-syn therapeutics reduced a-syn aggregations and protected against dopaminergic neuronal loss. Completed clinical trials showed significant tolerability and efficacy in reducing a-syn and minimal adverse effects. Overall, this review highlights the potential of anti-a-syn therapies in both preclinical and clinical settings to reduce a-syn accumulation and potentially slow down PD progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Tanzeel Khan, Rashid Waseem, Mohammad Shahid, Jaoud Ansari, Ishfaq Ahmad Ahanger, Imtaiyaz Hassan, Asimul Islam
Summary: Alzheimer's disease is the most prevalent form of dementia, and there is currently no permanent cure. Stem cell therapy has shown promising results in preclinical studies and is being explored as a potential treatment. This article reviews research from the past decade, discusses hypotheses related to the pathology of Alzheimer's disease, and provides an overview of ongoing clinical trials for immunotherapy and stem cell therapy.
AGEING RESEARCH REVIEWS
(2023)
Article
Clinical Neurology
Fardin Nabizadeh, Kasra Pirahesh, Parya Valizadeh
Summary: The study found that the changes in CSF alpha-syn, t-tau, and p-tau were not significant enough to distinguish PD patients with and without RBD. However, CSF A beta 1-42 decreased in the short term and showed a significant difference after a while in PD patients with and without RBD.
JOURNAL OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanfei Xie, Jiani Lu, Tiantian Yang, Chao Chen, Yongjie Bao, Luying Jiang, Hua Wei, Xiang Wu, Li Zhao, Shan He, Dongdong Lin, Fufeng Liu, Hao Liu, Xiaojun Yan, Wei Cui
Summary: Phloroglucinol has the ability to degrade pre-formed amyloid aggregates, inhibit seeding during amyloid aggregation, and reduce neurotoxicity, indicating its potential as a novel drug for treating neurodegenerative disorders.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Neurosciences
Urmi Sengupta, Rakez Kayed
Summary: This review summarizes the histopathological features of specific protein aggregation in several neurodegenerative diseases and discusses their overlap. It also highlights the synergistic interplay among Aβ, tau, and alpha-Syn in these diseases, suggesting a protein triumvirate.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Corinne Quadalti, Sebastian Palmqvist, Sara Hall, Marcello Rossi, Angela Mammana, Shorena Janelidze, Sofia Dellavalle, Niklas Mattsson-Carlgren, Simone Baiardi, Erik Stomrud, Oskar Hansson, Piero Parchi
Summary: Prospective and longitudinal analyses of patients with cognitive impairment revealed that the in vivo detection of Lewy body pathology is independently associated with hallucinations, worse attention/executive, visuospatial and motor function, and predicted future cognitive decline. LB pathology has clinical effects in patients with cognitive impairment, especially in those coexisting with AD pathology. LB pathology is associated with faster cognitive decline, regardless of AD pathology and cognitive stage, which suggests that LB status is a better predictor for clinical trajectories than AD biomarkers and clinical diagnosis.
Article
Multidisciplinary Sciences
Kevin A. Murray, Carolyn J. Hu, Sarah L. Griner, Hope Pan, Jeannette T. Bowler, Romany Abskharon, Gregory M. Rosenberg, Xinyi Cheng, Paul M. Seidler, David S. Eisenberg
Summary: Neurodegenerative diseases are characterized by the accumulation of aggregated proteins, and inhibiting the formation of these aggregates is a potential therapeutic strategy. Using de novo protein design, researchers have developed a library of mini-protein inhibitors that specifically target the amyloid structures of tau, Aβ, and α Syn. These inhibitors show promising results in preventing aggregation and rescuing motor deficits in animal models of PD and AD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Medicine, General & Internal
Patrycja Pawlik, Katarzyna Blochowiak
Summary: Neurodegenerative diseases result in progressive neuronal degeneration, emphasizing the need for early screening and diagnosis. Biomarkers show promise for early detection, with saliva being explored as a potential non-invasive diagnostic tool. Research on salivary biomarkers for Alzheimer's and Parkinson's diseases continues, aiming to identify correlations between specific biomarkers and early clinical symptoms for improved treatment strategies.
Article
Neurosciences
Michiyo Iba, Changyoun Kim, Jazmin Florio, Michael Mante, Anthony Adame, Edward Rockenstein, Somin Kwon, Robert Rissman, Eliezer Masliah
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Immunology
Michiyo Iba, Changyoun Kim, Michelle Sallin, Somin Kwon, Anjali Verma, Cassia Overk, Robert A. Rissman, Ranjan Sen, Jyoti Misra Sen, Eliezer Masliah
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Cell Biology
Changyoun Kim, Alexandria Beilina, Nathan Smith, Yan Li, Minhyung Kim, Ravindran Kumaran, Alice Kaganovich, Adamantios Mamais, Anthony Adame, Michiyo Iba, Somin Kwon, Won-Jae Lee, Soo-Jean Shin, Robert A. Rissman, Sungyong You, Seung-Jae Lee, Andrew B. Singleton, Mark R. Cookson, Eliezer Masliah
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Changyoun Kim, Somin Kwon, Michiyo Iba, Brian Spencer, Edward Rockenstein, Michael Mante, Anthony Adame, Soo Jean Shin, Jerel A. Fields, Robert A. Rissman, Seung-Jae Lee, Eliezer Masliah
Summary: This study revealed that stimulation of TLR2 accelerated the uptake of alpha-syn fibrils in neurons and glia while delaying their degradation, exacerbating alpha-syn pathology in mouse brains. Indirect modulation of alpha-syn spreading via innate immune receptors, such as TLR2, could be a potential therapeutic strategy for synucleinopathies.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Eunbyeol Go, Su-Jin Yoo, Suyoung Choi, Pureum Sun, Min Kyung Jung, Somin Kwon, Bu Yeon Heo, Yeeun Kim, Ju-Gyeong Kang, Jinhyun Kim, Eui-Cheol Shin, Seong Wook Kang, Jaeyul Kwon
Summary: In patients with Rheumatoid arthritis (RA), there is a significant decrease in the frequency of effector T-reg cells and a reduction in overall CD25 expression in T-reg cells in peripheral blood. These findings suggest altered T-reg homeostasis associated with RA pathogenesis.
Article
Biochemistry & Molecular Biology
Adamantios. Mamais, Jillian Kluss, Luis C. Bonet-Ponce, Natalie Landeck, Rebekah Langston, Nathan Smith, Alexandra R. Beilina, Alice Kaganovich, Manik C. Ghosh, Laura Pellegrini, Ravindran J. Kumaran, Ioannis C. Papazoglou, George R. Heaton, Rina Bandopadhyay, Nunziata Maio, Changyoun Kim, Matthew LaVoie, David Gershlick, Mark Cookson
Summary: Mutations in LRRK2 affect the function of Rab8a and may lead to mislocalization of transferrin, potentially exacerbating iron load in microglia. This suggests a crucial role of LRRK2 in modulating iron uptake and storage in response to inflammatory stimuli.
Article
Immunology
Changyoun Kim, Armine Hovakimyan, Karen Zagorski, Tatevik Antonyan, Irina Petrushina, Hayk Davtyan, Gor Chailyan, Jonathan Hasselmann, Michiyo Iba, Anthony Adame, Edward Rockenstein, Marcell Szabo, Mathew Blurton-Jones, David H. Cribbs, Anahit Ghochikyan, Eliezer Masliah, Michael G. Agadjanyan
Summary: The use of specific DNA vaccines targeting alpha-synuclein can effectively reduce neurodegenerative pathology associated with PD/DLB, particularly in specific brain regions, and is sex-dependent.
Article
Neurosciences
Michiyo Iba, Ross A. McDevitt, Changyoun Kim, Roshni Roy, Dimitra Sarantopoulou, Ella Tommer, Byron Siegars, Michelle Sallin, Somin Kwon, Jyoti Misra Sen, Ranjan Sen, Eliezer Masliah
Summary: This study investigates the role of aging and inflammation in the manifestation of neurodegenerative diseases such as Parkinson's disease and dementia with Lewy bodies. The results show that aged mice have more extensive accumulation of alpha-synuclein and behavioral deficits compared to young mice. The study suggests that enhanced age-associated pathologies may result from inflammatory synergy between aging and the effects of alpha-synuclein aggregation.
MOLECULAR NEURODEGENERATION
(2022)
Article
Cell Biology
Michiyo Iba, Changyoun Kim, Somin Kwon, Marcell Szabo, Liam Horan-Portelance, Cody J. Peer, William D. Figg, Xylena Reed, Jinhui Ding, Seung-Jae Lee, Robert A. Rissman, Mark R. Cookson, Cassia Overk, Wolf Wrasidlo, Eliezer Masliah
Summary: Alterations in p38 mitogen-activated protein kinases (MAPKs) are involved in the pathogenesis of dementia with Lewy bodies (DLB) and Parkinson's disease (PD). Inhibition of p38α reduces neuroinflammation and improves synaptic, neurodegenerative, and motor behavioral deficits. Treatment with SKF-86002 promotes the redistribution of p38γ to synapses and reduces accumulation of alpha-synuclein. These findings provide a mechanistic connection between p38α and p38γ and support targeting this pathway in DLB/PD.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Andrew J. Lee, Changyoun Kim, Seongwan Park, Jaegeon Joo, Baekgyu Choi, Dongchan Yang, Kyoungho Jun, Junghyun Eom, Seung-Jae Lee, Sun Ju Chung, Robert A. Rissman, Jongkyeong Chung, Eliezer Masliah, Inkyung Jung
Summary: This study establishes genomic and epigenomic landscapes of the substantia nigra and identifies cell type-specific dysregulations in regulatory elements related to Parkinson's disease (PD). High-resolution three-dimensional chromatin contact maps uncover target genes of dysregulated regulatory elements and genetic risk loci, revealing altered molecular mechanisms in dopaminergic neurons and glial cells. Overall, this research reveals cell type-specific disruption in transcriptional regulations related to PD.
Article
Hematology
Somin Kwon, Brian G. Casleton, Glorimar Z. Rivera, Melita M. Gella, Erin L. Winkler, John W. Kieffer, Angela B. Osuna, Theresa M. Casey, Heather C. Yun, Joseph E. Marcus
Summary: This study evaluated the infectious etiologies of deferred blood donors at a military blood donation center. The findings suggest that the risk of transfusion-transmissible infections is low in this military cohort, and HBV, HCV, and syphilis are the most common pathogens.
Review
Biochemistry & Molecular Biology
Marcell P. Szabo, Michiyo Iba, Avindra Nath, Eliezer Masliah, Changyoun Kim
Summary: The interaction between the SARS-CoV-2 virus and the immune receptor TLR2 in the central nervous system (CNS) is implicated in the neurological symptoms of COVID-19. TLR2 plays a critical role in the response to SARS-CoV-2 infiltration into the CNS and may contribute to the development of neurodegenerative diseases. Understanding this link could help in developing new treatments for the neurological symptoms of COVID-19.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
