Article
Optics
Adrian A. Budini
Summary: Quantum memory effects can result from bidirectional information exchange between a system and its environment, or from environments whose dynamics remain unaffected during system evolution. An operational scheme has been proposed to distinguish between these two types of memory effects based on successive measurement processes. This method accurately detects bidirectional information flows in various non-Markovian open system dynamics.
Article
Computer Science, Artificial Intelligence
B. J. D. Kalyani, U. Hemavathi, K. Meena, B. S. Deepapriya, Shareefunnisa Syed
Summary: Traditional IT, combined with convolution neural networks and deep learning, is transforming the healthcare sector by enabling disease identification and prediction. The virtualization of hospital policies and care models during the pandemic has allowed for disease detection without the need for doctor consultation, enhancing patient care and performance.
Article
Engineering, Electrical & Electronic
Yuanbin Cheng, Nanpeng Yu, Brandon Foggo, Koji Yamashita
Summary: This paper develops a bidirectional anomaly generative adversarial network (GAN)-based algorithm to detect power system events using streaming PMU data. By introducing conditional entropy constraint and graph signal processing-based PMU sorting technique, the proposed algorithm significantly outperforms existing algorithms in terms of accuracy. An online platform is also developed for real-time event detection.
IEEE TRANSACTIONS ON POWER SYSTEMS
(2022)
Article
Robotics
Bo-Yeon Lee, Seonggi Kim, Sunjong Oh, Youngoh Lee, Jonghwa Park, Hyunhyub Ko, Ja Choon Koo, Youngdo Jung, Hyuneui Lim
Summary: In this study, a real-time and multimodal tactile system was developed to mimic the function of human skin. The system is capable of acquiring different types of tactile information simultaneously and differentiating between various tactile stimuli, texture characteristics, and consecutive complex motions.
Article
Engineering, Electrical & Electronic
Dongbo Zhang, Min Chen, Bodong Li, Xiaoqing Wang, Xinnan Sun, Feng Jiang
Summary: Bidirectional wireless power transfer improves power supply reliability, but wireless communication for load information transmission has issues with time delay and electromagnetic interference. This article proposes a constant current control strategy without communication, which achieves stable operation through synchronized operation of the secondary side bridge.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2022)
Article
Cell Biology
Mihwa Choi, Marc Schneeberger, Wei Fan, Abhijit Bugde, Laurent Gautron, Kevin Vale, Robert E. Hammer, Yuan Zhang, Jeffrey M. Friedman, David J. Mangelsdorf, Steven A. Kliewer
Summary: Animals that consume fermenting fruit and nectar are at risk of exposure to ethanol and the detrimental effects of inebriation. This report demonstrates that the hormone FGF21 plays a role in stimulating arousal from intoxication without affecting ethanol metabolism. FGF21 activates noradrenergic neurons in the locus coeruleus region, suggesting that it could be targeted pharmacologically for treating acute alcohol poisoning.
Article
Neurosciences
Florence P. Varodayan, Reesha R. Patel, Alessandra Matzeu, Sarah A. Wolfe, Dallece E. Curley, Sophia Khom, Pauravi J. Gandhi, Larry Rodriguez, Michal Bajo, Shannon D'Ambrosio, Hui Sun, Tony M. Kerr, Rueben A. Gonzales, Lorenzo Leggio, Luis A. Natividad, Carolina L. Haass-Koffler, Remi Martin-Fardon, Marisa Roberto
Summary: This study sheds light on the crucial role of adrenergic receptors in the central amygdala (CeA) in alcohol use disorder (AUD) and uncovers the mechanisms underlying the association between specific adrenergic receptors and AUD. These findings are significant for the development of novel medications for the treatment of AUD.
BIOLOGICAL PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Jacopo Pruccoli, Antonia Parmeggiani, Duccio Maria Cordelli, Marcello Lanari
Summary: Noradrenaline plays a role in modulating feeding behavior and satiety, with conflicting evidence in its relationship with Eating Disorders (EDs). Preclinical studies suggest involvement of noradrenergic pathways in binge-like behaviors, while genetic and clinical studies show inconsistent findings on the absolute alterations in plasma NE values in patients with EDs. Pharmacological studies support the efficacy of noradrenaline-modulating therapies in treating EDs, but further research is needed to understand the potential of the noradrenergic system as a target for treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Ludovica Arpinati, Naomi Kaisar-Iluz, Merav E. Shaul, Christopher Groth, Viktor Umansky, Zvi G. Fridlender
Summary: Neutrophils, an abundant type of circulating leukocytes, play crucial roles in cancer biology. This study reveals that tumor-associated neutrophils can originate from different subpopulations and exhibit plasticity under the influence of chemokines and tumor-derived factors, potentially transitioning through phenotypical changes.
Review
Biochemistry & Molecular Biology
Alessandro Galgani, Emanuele Bartolini, Marta D'Amora, Ugo Faraguna, Filippo Sean Giorgi
Summary: The article highlights the potential role of the locus-coeruleus-noradrenergic (LC-NA) system in neurodevelopmental disorders (NdDs). Clinical data suggests the involvement of the LC-NA system in the development of NdDs. A new neuroimaging tool, LC Magnetic Resonance Imaging (MRI), has been developed to visualize the LC in vivo, allowing for the exploration of morphological alterations in NdDs. Further research is needed to fully understand the interplay between the LC-NA system and NdDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Computer Science, Cybernetics
Oliver Beren Kaul, Michael Rohs, Marc Mogalle, Benjamin Simon
Summary: This article presents a concept of providing precise micro-navigation instructions through tactile patterns and validates the effectiveness of the system through experiments. Compared to previous tactile navigation systems, the system provides more precise guidance and is suitable for individuals with visual impairments.
ACM TRANSACTIONS ON COMPUTER-HUMAN INTERACTION
(2021)
Article
Obstetrics & Gynecology
Giovanni Coticchio, Kenji Ezoe, Cristina Lagalla, Kiyoe Shimazaki, Kazuki Ohata, Maya Ninomiya, Natsuki Wakabayashi, Tadashi Okimura, Kazuo Uchiyama, Keiichi Kato, Andrea Borini
Summary: The study showed that the exclusion and extrusion of cells during blastocyst formation have a significant impact on the embryo development and clinical outcomes, especially with negative effects on pregnancy and live birth rates.
HUMAN REPRODUCTION
(2021)
Article
Chemistry, Multidisciplinary
Haiqing Wang, Yongtao Xu, Zhenda Liang, Zhiquan Chen, Li Zhou, Bing Yan
Summary: This study investigated the impact of nanoplastics (NPs) on the spread of antibiotic resistance genes (ARGs) and found that negatively charged polystyrene (PS) and PS-COOH enhanced ARG transfer at low concentrations, while transfer declined at higher concentrations. Conversely, PS-NH2 increased ARG transfer at all tested concentrations, with the highest promotion effect at 500 mg L-1. The effects on ARG transfer were a combination of ROS production-induced promotion and NP agglomeration-caused inhibition at high concentrations.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Article
Automation & Control Systems
Shuran Jia, Shanxu Duan, Changsong Chen
Summary: This article proposes a phase synchronization method for bidirectional wireless power transfer (BWPT) systems, which is insensitive to harmonics and does not require complicated signal processing circuit or digital signal processing technique. Experimental results show that the proposed method has small phase-lock error under various conditions and has a fast transient response.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2023)
Article
Cell Biology
Anthony H. Taylor, Panos Bachkangi, Justin C. Konje
Summary: Plasma concentrations of N-arachidonyletholamine (AEA), N-oleoylethanolamide (OEA) and N-palmitoylethanolamide (PEA) increase at term and can predict labor. The study examined the expression of cannabinoid receptors (CB1 and CB2) and enzymes involved in the modulation of endocannabinoids in the placenta during preterm and term labor. The results suggest that perturbations in the endocannabinoid system in the placenta may contribute to preterm labor.
HISTOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marilda da Cruz Fernandes, Antonio Generoso Severino, Adriana Maria Zago, Lucas Tortorelli, Fabiano B. Carvalho, Felipe Luis Schneider
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Donal T. Skelly, Eadaoin W. Griffin, Carol L. Murray, Sarah Harney, Conor O'Boyle, Edel Hennessy, Marc-Andre Dansereau, Arshed Nazmi, Lucas Tortorelli, J. Nicholas Rawlins, David M. Bannerman, Colm Cunningham
MOLECULAR PSYCHIATRY
(2019)
Article
Neurosciences
Marilia M. Wallauer, Fernanda Huf, Lucas S. Tortorelli, Francine L. Rahmeier, Fabiano B. Carvalho, Rosalva T. Meurer, Marilda da Cruz Fernandes
NEUROSCIENCE LETTERS
(2018)
Article
Substance Abuse
Fernanda Huf, Solange Bandiera, Carolina B. Mueller, Luiza Gea, Fabiano B. Carvalho, Francine L. Rahmeier, Keli C. Reiter, Lucas S. Tortorelli, Rosane Gomez, Marilda da Cruz Fernandes
Article
Neurosciences
Arshed Nazmi, Robert H. Field, Eadaoin W. Griffin, Orla Haugh, Edel Hennessy, Donal Cox, Renata Reis, Lucas Tortorelli, Carol L. Murray, Ana Belen Lopez-Rodriguez, Lei Jin, Ed C. Lavelle, Aisling Dunne, Colm Cunningham
Review
Behavioral Sciences
Jim McBurney-Lin, Ju Lu, Yi Zuo, Hongdian Yang
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2019)
Article
Neurosciences
John Kealy, Carol Murray, Eadaoin W. Griffin, Ana Belen Lopez-Rodriguez, Daire Healy, Lucas Silva Tortorelli, John P. Lowry, Leiv Otto Watne, Colm Cunningham
JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Quynh Anh Thi Nguyen, David Hillis, Sayako Katada, Timothy Harris, Crystal Pontrello, Theodore Garland, Sachiko Haga-Yamanaka
Article
Immunology
Niamh McGarry, Carol L. Murray, Sean Garvey, Abigail Wilkinson, Lucas Tortorelli, Lucy Ryan, Lorna Hayden, Daire Healy, Eadaoin W. Griffin, Edel Hennessy, Malathy Arumugam, Donal T. Skelly, Kevin J. Mitchell, Colm Cunningham
Summary: Research demonstrates that the length of double stranded RNA, IFNAR1, and age have effects on anti-viral inflammation and cognitive function. In aged animals, the use of poly I:C induces exaggerated inflammatory responses and acute memory deficits.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Multidisciplinary Sciences
Takuya Osakada, Takayuki Abe, Takumi Itakura, Hiromi Mori, Kentaro K. Ishii, Ryo Eguchi, Ken Murata, Kosuke Saito, Sachiko Haga-Yamanaka, Hiroko Kimoto, Yoshihiro Yoshihara, Kazunari Miyamichi, Kazushige Touhara
Summary: Hemoglobin serves as a chemosensory signal that activates specific vomeronasal sensory neurons and enhances behavioral responses in lactating female mice.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Marine Megemont, Jim McBurney-Lin, Hongdian Yang
Summary: Pupil diameter is often used as a noninvasive measure of locus coeruleus (LC) activity. However, there is substantial variability in the relationship between pupil diameter and LC activity, limiting its accuracy in predicting LC activity. Additionally, pupil responses to optical stimulation in the LC show session-to-session fluctuations, and these variations are correlated with decision bias-related behavioral variables.
Correction
Biochemistry & Molecular Biology
Donal T. Skelly, Eadaoin W. Griffin, Carol L. Murray, Sarah Harney, Conor O'Boyle, Edel Hennessy, Marc-Andre Dansereau, Arshed Nazmi, Lucas Tortorelli, J. Nicholas Rawlins, David M. Bannerman, Colm Cunningham
MOLECULAR PSYCHIATRY
(2019)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.