Intestinal resident macrophages: Multitaskers of the gut

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD

(2019) Yi Rang Na et al.   Nature Reviews Gastroenterology & Hepatology

Some news from the unknown soldier, the Peyer’s patch macrophage

(2018) Camille Wagner et al.   CELLULAR IMMUNOLOGY

Critical Role for the Microbiota in CX 3 CR1 + Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses

(2018) Myunghoo Kim et al.   IMMUNITY

TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells

(2018) Jialie Luo et al.   IMMUNITY

Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression

(2018) Tovah N. Shaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human intestinal pro-inflammatory CD11chighCCR2+CX3CR1+ macrophages, but not their tolerogenic CD11c−CCR2−CX3CR1− counterparts, are expanded in inflammatory bowel disease

(2018) D. Bernardo et al.   Mucosal Immunology

Muscularis macrophage development in the absence of an enteric nervous system

(2018) Marina Avetisyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche

(2018) Anuj Sehgal et al.   Nature Communications

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis

(2018) Sebastiaan De Schepper et al.   CELL

Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen

(2018) Hwee Ying Lim et al.   IMMUNITY

Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles

(2018) Hisako Kayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons

(2018) Nathalie Stakenborg et al.   GUT

Irf4-dependent CD103+CD11b+dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus

(2017) Judith-Mira Pohl et al.   GUT

T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node

(2017) Myriam Baratin et al.   IMMUNITY

Transcriptional and functional profiling defines human small intestinal macrophage subsets

(2017) Anna Bujko et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling

(2017) A Schridde et al.   Mucosal Immunology

Diabetic and idiopathic gastroparesis is associated with loss of CD206-positive macrophages in the gastric antrum

(2017) M. Grover et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Macrophages in gastrointestinal homeostasis and inflammation

(2017) John R. Grainger et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis

(2017) Subhash Kulkarni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Peyer’s Patch Mononuclear Phagocyte System at Steady State and during Infection

(2017) Clément Da Silva et al.   Frontiers in Immunology

Muscularis macrophages: Key players in intestinal homeostasis and disease

(2017) Sebastiaan De Schepper et al.   CELLULAR IMMUNOLOGY

Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

(2016) Ilana Gabanyi et al.   CELL

Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs

(2016) Ryan J. Cummings et al.   NATURE

Smooth muscle and neural dysfunction contribute to different phases of murine postoperative ileus

(2016) G. Farro et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

(2016) Calum C. Bain et al.   Nature Communications

Intestinal CD169+ macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes

(2015) Kenichi Asano et al.   Nature Communications

IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis

(2015) Petra Krause et al.   Nature Communications

Innate and Adaptive Immune Functions of Peyer’s Patch Monocyte-Derived Cells

(2015) Johnny Bonnardel et al.   Cell Reports

Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses

(2015) Casandra Panea et al.   Cell Reports

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

(2014) Paul Andrew Muller et al.   CELL

Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction

(2014) Timo Heidt et al.   CIRCULATION RESEARCH

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

(2014) Ehud Zigmond et al.   IMMUNITY

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Oral Tolerance Can Be Established via Gap Junction Transfer of Fed Antigens from CX3CR1+ Macrophages to CD103+ Dendritic Cells

(2014) Elisa Mazzini et al.   IMMUNITY

The identification and developmental requirements of colonic CD169+macrophages

(2014) Ida H. Hiemstra et al.   IMMUNOLOGY

Progressive replacement of embryo-derived cardiac macrophages with age

(2014) Kaaweh Molawi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dynamic Changes in Macrophage Activation and Proliferation during the Development and Resolution of Intestinal Inflammation

(2014) Matthew C. Little et al.   JOURNAL OF IMMUNOLOGY

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice

(2014) K. A. Sauter et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen

(2013) Gianluca Matteoli et al.   GUT

Origins and Functional Specialization of Macrophages and of Conventional and Monocyte-Derived Dendritic Cells in Mouse Skin

(2013) Samira Tamoutounour et al.   IMMUNITY

Identification of a Tissue-Specific, C/EBP -Dependent Pathway of Differentiation for Murine Peritoneal Macrophages

(2013) D. W. Cain et al.   JOURNAL OF IMMUNOLOGY

CD14+ CD33+ myeloid cell-CCL11-eosinophil signature in ulcerative colitis

(2013) Maria Lampinen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD14hi HLA-DRdim macrophages, with a resemblance to classical blood monocytes, dominate inflamed mucosa in Crohnˈs disease

(2013) Susanne Thiesen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection

(2013) John R Grainger et al.   NATURE MEDICINE

CSF-1 Receptor-Dependent Colon Development, Homeostasis and Inflammatory Stress Response

(2013) Duy Huynh et al.   PLoS One

Nicotine Attenuates Activation of Tissue Resident Macrophages in the Mouse Stomach through the β2 Nicotinic Acetylcholine Receptor

(2013) Andrea Nemethova et al.   PLoS One

Intestinal macrophages: well educated exceptions from the rule

(2013) Ehud Zigmond et al.   TRENDS IN IMMUNOLOGY

Dectin-1 Is Essential for Reverse Transcytosis of Glycosylated SIgA-Antigen Complexes by Intestinal M Cells

(2013) Nicolas Rochereau et al.   PLOS BIOLOGY

CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis

(2012) Samira Tamoutounour et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ly6Chi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells

(2012) Ehud Zigmond et al.   IMMUNITY

Inflammation switches the differentiation program of Ly6Chimonocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

(2012) Aymeric Rivollier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

(2012) C C Bain et al.   Mucosal Immunology

Intestinal CD103− dendritic cells migrate in lymph and prime effector T cells

(2012) V Cerovic et al.   Mucosal Immunology

Colonic epithelial response to injury requires Myd88 signaling in myeloid cells

(2012) N P Malvin et al.   Mucosal Immunology

Regulation of gastrointestinal motility—insights from smooth muscle biology

(2012) Kenton M. Sanders et al.   Nature Reviews Gastroenterology & Hepatology

Prevalence of Hidden Gastroparesis in the Community: The Gastroparesis "Iceberg"

(2012) Enrique Rey et al.   Journal of Neurogastroenterology and Motility

Th17 Responses Are Not Induced in Dextran Sodium Sulfate Model of Acute Colitis

(2012) Yoon Suk Kim et al.   Immune Network

TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function

(2011) Reena Rani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CX3CR1 defines functionally distinct intestinal mononuclear phagocyte subsets which maintain their respective functions during homeostatic and inflammatory conditions

(2011) Benjamin Weber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

(2011) Usriansyah Hadis et al.   IMMUNITY

Functional Specializations of Intestinal Dendritic Cell and Macrophage Subsets That Control Th17 and Regulatory T Cell Responses Are Dependent on the T Cell/APC Ratio, Source of Mouse Strain, and Regional Localization

(2011) T. L. Denning et al.   JOURNAL OF IMMUNOLOGY

An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation

(2010) K. P. A. MacDonald et al.   BLOOD

CD206-Positive M2 Macrophages That Express Heme Oxygenase-1 Protect Against Diabetic Gastroparesis in Mice

(2010) Kyoung Moo Choi et al.   GASTROENTEROLOGY

Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages

(2010) Camila Marques-da-Silva et al.   IMMUNOBIOLOGY

Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10

(2010) Yoshiyasu Ueda et al.   INTERNATIONAL IMMUNOLOGY

Inflammation Anergy in Human Intestinal Macrophages Is Due to Smad-induced IκBα Expression and NF-κB Inactivation

(2010) Lesley E. Smythies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interstitial cells of Cajal, macrophages and mast cells in the gut musculature: morphology, distribution, spatial and possible functional interactions

(2010) Hanne B. Mikkelsen   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Monocyte Chemoattractant Protein-1 Contributes to Gut Homeostasis and Intestinal Inflammation by Composition of IL-10–Producing Regulatory Macrophage Subset

(2010) Yasuhiro Takada et al.   JOURNAL OF IMMUNOLOGY

Intestinal macrophages and response to microbial encroachment

(2010) P D Smith et al.   Mucosal Immunology

T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract

(2010) Daniel R Engel et al.   NATURE MEDICINE

Anti-inflammatory role of glycine in reducing rodent postoperative inflammatory ileus

(2010) B. Stoffels et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Transient perioperative pharmacologic inhibition of muscularis macrophages as a target for prophylaxis of postoperative ileus does not affect anastomotic healing in mice

(2010) Dimitrios Pantelis et al.   SURGERY

Pathogenic Bacteria and Dead Cells Are Internalized by a Unique Subset of Peyer's Patch Dendritic Cells That Express Lysozyme

(2009) Hugues Lelouard et al.   GASTROENTEROLOGY

Neuroimmune mechanisms in postoperative ileus

(2009) G E Boeckxstaens et al.   GUT

Origin of the Lamina Propria Dendritic Cell Network

(2009) Milena Bogunovic et al.   IMMUNITY

Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions

(2009) Olga Schulz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Heme Oxygenase-1 Protects Interstitial Cells of Cajal From Oxidative Stress and Reverses Diabetic Gastroparesis

(2008) Kyoung Moo Choi et al.   GASTROENTEROLOGY

TGF-β1 and Smad7 in the regulation of IBD

(2008) G Monteleone et al.   Mucosal Immunology

Mentation on the immunological modulation of gastrointestinal motility

(2008) a. j. bauer   NEUROGASTROENTEROLOGY AND MOTILITY

MCP-1 targeting inhibits muscularis macrophage recruitment and intestinal smooth muscle dysfunction in colonic inflammation

(2007) Masatoshi Hori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY