Article
Spectroscopy
Fang Zhang, Jiaman Liang, Yang Liu, Qiuju Zhou, Yushuang Hong, Xianping Chen, Kejun Tan
Summary: A dual-readout strategy using water-soluble CdTe quantum dots is proposed for the detection of PFOA and PFOS. The method is simple, sensitive, and cost-effective.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Hongyu Chen, Qingfeng Li, Bin Hu, Wenping Zhu, Hongjun Xia, Weijie Yang
Summary: A novel and highly sensitive upconversion fluorescence and colorimetric dual readout nanosensor system was developed for iodate (IO3-) detection. The system utilized NaYF4:Yb, Tm upconversion nanoparticles (UCNPs) and analyte-triggered cascade signal amplification (CSA) technique. The system demonstrated good selectivity and sensitivity for IO3- measurement with a linear range of 0.06-100 μM and a detection limit of 0.026 μM. The method was successfully applied for IO3- detection in table salt samples with satisfactory results.
Article
Chemistry, Physical
Marie Barale, Muriel Escadeillas, Gregory Taupier, Yann Molard, Clement Orione, Elsa Caytan, Remi Metivier, Julien Boixel
Summary: In this study, the first intramolecular excimer photoswitching induced by molecular motion within a dithienylethene (DTE) molecule without destructive readout was reported. The DTE-based pyrene compound displayed intense pyrene excimer luminescence upon both one-and two-photon excitation. The stability of the DTE-based pyrene under TPE irradiation and high photocyclization quantum yield allowed for nondestructive readout fluorescence.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Physical
Benedikt Ames, Andreas Buchleitner, Edoardo G. Carnio, Vyacheslav N. Shatokhin
Summary: The research shows that 1QC and 2QC signals are periodic functions of the pulse area, reflecting the interactions between particles via photon exchange, the polarizations of laser pulses, and the observation direction.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Materials Science, Biomaterials
Anna Luongo, Alexander Ritter von Stockert, Frank D. Scherag, Thomas Brandstetter, Markus Biesalski, Juergen Ruehe
Summary: Paper is a suitable material for developing disposable diagnostic devices due to its low cost, capillary action for liquid transport, and eco-friendliness. This study explores the use of fluorescence as a readout tool for paper-based diagnostics, which shows better optical readout compared to the current choice of colorimetric assays using nitrocellulose. Additionally, coating the paper fibers with a protein-repellent hydrogel enhances the sensitivity of paper-based analysis.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Astronomy & Astrophysics
Adrian Kent
Summary: Theories involving localized collapse explore the possibility of obtaining classical information about quantum states through mechanisms beyond standard quantum dynamics, without allowing superluminal signaling. This can be modeled by extending quantum theory to include hypothetical devices that read information about local quantum states, potentially surpassing traditional quantum theory applications.
Article
Computer Science, Information Systems
Taeju Lee, Jee-Ho Park, Namsun Chou, Il-Joo Cho, Seong-Jin Kim, Minkyu Je
Summary: This paper introduces a multimodal multichannel neural activity readout integrated circuit for cell-type-specific study, capable of recording electrical neural signals and fluorescence recording of neural activity. The circuit is able to monitor calcium ions and record electrical neural signals, while consuming low power and achieving high recording range and low input-referred noise.
Article
Engineering, Biomedical
Da-Hyun Kim, Jungho Ahn, Hyun Kyoung Kang, Min-Soo Kim, Nam-Gyo Kim, Myung Geun Kook, Soon Won Choi, Noo Li Jeon, Heung-Myong Woo, Kyung-Sun Kang
Summary: Liver tissue engineering with vascular reconstruction using decellularized liver scaffolds showed enhanced liver-specific functions and perfusable vessel networks, providing a promising strategy for liver failure treatment.
Article
Optics
Daniel C. Luenemann, Anitta R. Thomas, Jingjing Xu, Rabea Bartoelke, Henrik Mouritsen, Antonietta De Sio, Christoph Lienau
Summary: The study demonstrates that the separation of incoherent emission signals from coherent light scattering can be easily achieved using highly stable common-path interferometers for both excitation and detection. This approach has been successfully applied to suppress scattering from FAD and Cry4, showing potential benefits for fluorescence lifetime or Raman-based imaging and spectroscopy.
Article
Optics
Shijie Tu, Qiannan Lei, Yangjian Cai, Qian Zhao
Summary: This study explores the construction of Lommel beams through highly scattering media using a transmission matrix-based method, and successfully generates various Lommel beams with different parameters experimentally.
CHINESE OPTICS LETTERS
(2022)
Article
Optics
Mahmoud E. Khani, Zachery B. Harris, Mengkun Liu, M. Hassan Arbab
Summary: This work presents a novel computational technique for creating spatially- and spectrally-resolved chemical maps through a diffusive cloak using terahertz time-domain spectroscopy. The technique utilizes the maximal overlap discrete wavelet transform to obtain a multiresolution spectral decomposition of THz extinction coefficients and introduces a new spectroscopic concept called the bimodality coefficient spectrum.
Article
Medicine, General & Internal
Omnia Hamdy, Zienab Abdel-Salam, Mohamed Abdel-Harith
Summary: Optical diagnostics methods are important in biological applications for their non-destructive, safe, and minimally invasive nature. This study successfully distinguished tissues under different conditions using a combination of laser-induced fluorescence and diffuse optics techniques, and evaluated the accuracy of the measurements through mathematical modeling and statistical analysis.
Article
Chemistry, Analytical
Lili Zhang, Xiang Zou, Jing Huang, Jie Fan, Xiangjie Sun, Bohan Zhang, Bin Zheng, Chongyuan Guo, Deliang Fu, Lie Yao, Minbiao Ji
Summary: The study shows that label-free coherent nonlinear optical microscopy with combined SRS and SHG can reveal key diagnostic features of both normal and cancerous pancreatic tissues, providing potential for rapid intraoperative diagnosis of pancreatic cancer and predictive value for postoperative pancreatic fistula.
ANALYTICAL CHEMISTRY
(2021)
Article
Biology
Jessica Royles, Sophie Young, Howard Griffiths
Summary: Living moss biomass and archival peat deposits are important indicators of present and past climatic conditions. This study investigates stable isotope signals in high latitude moss deposits as potential climatic proxies. The study compares seasonal changes in delta C-13 and delta O-18 of organic material in different functional groups of moss, and their photosynthetic activity, as a function of tissue water content.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biochemical Research Methods
Tengfei Sun, Caigang Zhu
Summary: The study introduced an empirical ratio-metric method for rapid attenuation correction of fluorescence spectra, allowing real-time quantification of metabolic parameters in vivo, with successful implementation in tissue-mimicking phantom studies.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Article
Multidisciplinary Sciences
Lei Zhu, Fernando Soldevila, Claudio Moretti, Alexandra d'Arco, Antoine Boniface, Xiaopeng Shao, Hilton B. de Aguiar, Sylvain Gigan
Summary: The authors demonstrate a method for non-invasive fluorescence imaging behind scattering layers that extends beyond the optical memory effect. By demixing speckle patterns emitted by a fluorescent object using matrix factorization and fingerprint-based reconstruction, they achieve imaging with a larger field of view. Experimental validation confirms the efficiency and robustness of the method across various fluorescent samples.
NATURE COMMUNICATIONS
(2022)
Article
Optics
A. Cavailles, P. Boucher, L. Daudet, I Carron, S. Gigan, K. Muller
Summary: This article reports the implementation of a reconfigurable linear optical network device based on an innovative design, which utilizes multimode fiber and programmable wavefront shaping to achieve high fidelity and low loss transmission capabilities, and demonstrates stable performance in practical use.
Article
Optics
Alexandra D'Arco, Fei Xia, Antoine Boniface, Jonathan Dong, Sylvain Gigan
Summary: Optical imaging through complex media is challenging due to light scattering. In this study, a non-invasive method using a physics-based neural network was proposed to characterize and control light scattering in the medium and retrieve information of hidden objects. The neural network architecture was designed to mimic the propagation of light and trained with experimental data. The method was demonstrated on a fluorescence microscope and showed promising performance in simulations and experiments, suggesting its potential for other systems.
Article
Optics
Sylvain Gigan, Ori Katz, Hilton B. de Aguiar, Esben Ravn Andresen, Alexandre Aubry, Jacopo Bertolotti, Emmanuel Bossy, Dorian Bouchet, Joshua Brake, Sophie Brasselet, Yaron Bromberg, Hui Cao, Thomas Chaigne, Zhongtao Cheng, Wonshik Choi, Tomas Cizmar, Meng Cui, Vincent R. Curtis, Hugo Defienne, Matthias Hofer, Ryoichi Horisaki, Roarke Horstmeyer, Na Ji, Aaron K. LaViolette, Jerome Mertz, Christophe Moser, Allard P. Mosk, Nicolas C. Pegard, Rafael Piestun, Sebastien Popoff, David B. Phillips, Demetri Psaltis, Babak Rahmani, Herve Rigneault, Stefan Rotter, Lei Tian, Ivo M. Vellekoop, Laura Waller, Lihong Wang, Timothy Weber, Sheng Xiao, Chris Xu, Alexey Yamilov, Changhuei Yang, Hasan Yilmaz
Summary: In the last decade, various tools such as wavefront shaping and computational methods have been developed to understand and control the propagation of light in complex mediums. This field has revolutionized the possibility of diffraction-limited imaging at depth in tissues, and a vibrant community is actively working on it.
JOURNAL OF PHYSICS-PHOTONICS
(2022)
Article
Physics, Multidisciplinary
Sylvain Gigan
Summary: Multiple scattering in complex and disordered media can be utilized to extract and process information, despite its seemingly detrimental effects. Complex and inhomogeneous media are common in our surroundings, and although scattering appears to destroy all information, it can be exploited for imaging and computing purposes.
Article
Optics
Bernhard Rauer, Hilton B. de Aguiar, Laurent Bourdieu, Sylvain Gigan
Summary: This study demonstrates scattering correcting wavefront shaping using a simple continuous optimization algorithm to improve the performance of three-photon microscopy in deep tissue imaging. The research shows the ability to focus and image behind scattering layers and explores convergence trajectories for different sample geometries and feedback non-linearities. Additionally, a novel fast phase estimation scheme is presented for imaging through a mouse skull.
Article
Engineering, Electrical & Electronic
Jonathan Dong, Lorenzo Valzania, Antoine Maillard, Thanh-an Pham, Sylvain Gigan, Michael Unser
Summary: Phase retrieval is the process of recovering a complex-valued signal from intensity-only measurements. Recent advances in machine learning have brought new vitality to the field of phase retrieval, with significant theoretical and practical breakthroughs. This tutorial provides a unifying framework that reviews classical and machine learning methods in phase retrieval, focusing on applications, recent reconstruction algorithms, and the latest theoretical results.
IEEE SIGNAL PROCESSING MAGAZINE
(2023)
Article
Optics
F. Soldevila, C. Moretti, T. Nobauer, H. Sarafraz, A. Vaziri, S. Gigan
Summary: Recently, fluorescence-based optical techniques have been used to probe information in the mammalian brain, but light scattering from tissue heterogeneities hinders clear imaging of deep neuron bodies. While some approaches allow shallow-depth retrieval of information, non-invasive localization and functional imaging at depth remains challenging. A matrix factorization algorithm has been shown to retrieve functional signals from fluorescent emitters behind scattering samples, and in this study, it is demonstrated that low-contrast fluorescent speckle patterns recovered by the algorithm can be used to locate individual emitters, even in the presence of background fluorescence. The approach is tested on different scattering phantoms and a brain slice.
Article
Optics
Baptiste Courme, Chloe Verniere, Peter Svihra, Sylvain Gigan, Andrei Nomerotski, Hugo Defienne
Summary: Using a single-photon-sensitive time-stamping camera, researchers have successfully quantified high-dimensional spatial entanglement without needing background subtraction. They showed position-momentum Einstein-Podolsky-Rosen (EPR) correlations and quantified the entanglement of formation of their source to be larger than 2.8, indicating a dimension higher than 14. This work overcomes important challenges in photonic entanglement quantification and paves the way for practical quantum information processing protocols based on high-dimensional entanglement.
Article
Multidisciplinary Sciences
Damien Degoulange, Raj Pandya, Michael Deschamps, Dhyllan A. Skiba, Betar M. Gallant, Sylvain Gigan, Hilton B. de Aguiar, Alexis Grimaud
Summary: High-resolution Raman imaging is used to investigate the interface of salt-salt aqueous biphasic systems (ABSs) at a molecular level, revealing a gradual change of environment instead of a sharp molecular interface. This knowledge is of great importance in understanding aqueous interfaces and has significant implications in various biological and technological settings, including novel battery technologies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Optics
Lorenzo Valzania, Sylvain Gigan
Summary: Following recent advancements in wavefront shaping, optical methods have proven crucial for imaging and light control in multiply scattering media, such as biological tissues. However, the stability times of living biological specimens often prevent such methods from providing insights into relevant functioning mechanisms in cellular and organ systems. Here, we present a recursive and online optimization routine, borrowed from time series analysis, to optimally track the transmission matrices of dynamic scattering media over arbitrarily long time scales. It operates in a memory-efficient manner while preserving the advantages of both optimization-based routines and transmission-matrix measurements. Because it can be readily implemented in existing wavefront shaping setups featuring amplitude and/or phase modulation and phase-resolved or intensity-only acquisition, it could enable efficient optical investigations of living biological specimens.
Article
Optics
YoonSeok Baek, Hilton B. de Aguiar, Sylvain Gigan
Summary: Shaping light deep inside complex media is crucial for various research fields, and controlling light without physical access to the inside of a medium has been a challenge. In this study, a phase conjugation method for spatially incoherent light is presented, enabling non-invasive light control based on incoherent emission from multiple target positions. The method retrieves mutually incoherent scattered fields from speckle patterns and time-reverses scattered fluorescence with digital phase conjugation. Various experimental demonstrations, including focusing light on individual and multiple targets, as well as delivering maximum energy to an extended target through a scattering medium, highlight the potential for controlling light propagation in complex media using incoherent contrasts mechanisms.
Article
Optics
Ruben Ohana, Daniel Hesslow, Daniel Brunner, Sylvain Gigan, Kilian Mueller
Summary: We propose a novel method for linear optical random projections without holography. By combining multiple intensity measurements, our method mitigates the information loss caused by non-linearity in optical intensity measurements. Experimental and numerical results show that the resulting matrix consists of real-valued, independent, and identically distributed Gaussian random entries. Our simple and robust optical setup does not require interference between two beams. We demonstrate the practical applicability of our method by performing dimensionality reduction on high-dimensional data, a common task in randomized numerical linear algebra with relevant applications in machine learning.
Article
Quantum Science & Technology
Baptiste Courme, Patrick Cameron, Daniele Faccio, Sylvain Gigan, Hugo Defienne
Summary: High-dimensional entangled quantum states improve the performance of quantum technologies, allowing for higher information capacities and enhanced imaging protocols in quantum communication. However, the presence of optical disorder hinders practical use. This study demonstrates a wavefront shaping approach to transmit high-dimensional spatially entangled photon pairs through scattering media using a transmission matrix approach and wavefront correction with an intense classical beam. By violating the Einstein-Podolski-Rosen criterion by 988 sigma, entanglement is shown to exist after the medium, with a dimensionality of 17. This work opens the door for manipulating and transporting entanglement through scattering media, with potential applications in quantum microscopy and quantum key distribution.