期刊
NATURE PHOTONICS
卷 14, 期 6, 页码 361-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41566-020-0612-2
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资金
- European Research Council (ERC) [SMARTIES-724473]
Fluorescence is a powerful means to probe information processing in the mammalian brain(1). However, neuronal tissues are highly heterogeneous and thus opaque to light. A wide set of non-invasive or invasive techniques for scattered light rejection, optical sectioning or localized excitation have been developed, but non-invasive optical recording of activity through a highly scattering layer beyond the ballistic regime is impossible as yet. Here, we show that functional signals from fluorescent time-varying sources located below a highly scattering bone tissue can be retrieved efficiently by exploiting matrix factorization algorithms to demix this information from temporal sequences of low-contrast fluorescence speckle patterns. By exploiting low-contrast fluctuating speckle patterns from extended fluorescence sources using an advanced signal-processing algorithm, functional signals through highly scattering tissues can be extracted.
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