A randomized proof-of-mechanism trial applying the ‘fast-fail’ approach to evaluating κ-opioid antagonism as a treatment for anhedonia

Anhedonia modulates the effects of positive mood induction on reward-related brain activation

(2019) Isobel W. Green et al.   NEUROIMAGE

The anticipation and outcome phases of reward and loss processing: A neuroimaging meta-analysis of the monetary incentive delay task

(2018) Stuart Oldham et al.   HUMAN BRAIN MAPPING

Improving motivation through real-time fMRI-based self-regulation of the nucleus accumbens.

(2018) Zhi Li et al.   NEUROPSYCHOLOGY

The Neural Substrate of Reward Anticipation in Health: A Meta-Analysis of fMRI Findings in the Monetary Incentive Delay Task

(2018) Robin Paul Wilson et al.   NEUROPSYCHOLOGY REVIEW

The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development

(2018) Andrew D. Krystal et al.   NATURE REVIEWS DRUG DISCOVERY

Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials

(2016) William A. Carlezon et al.   DEPRESSION AND ANXIETY

Reward processing dysfunction in major depression, bipolar disorder and schizophrenia

(2015) Alexis E. Whitton et al.   CURRENT OPINION IN PSYCHIATRY

REWARD LEARNING IN PEDIATRIC DEPRESSION AND ANXIETY: PRELIMINARY FINDINGS IN A HIGH-RISK SAMPLE

(2015) Bethany H. Morris et al.   DEPRESSION AND ANXIETY

Anhedonia in melancholic and non-melancholic depressive disorders

(2015) Kathryn Fletcher et al.   JOURNAL OF AFFECTIVE DISORDERS

Evaluation of anhedonia with the Snaith–Hamilton Pleasure Scale (SHAPS) in adult outpatients with major depressive disorder

(2015) Paul A. Nakonezny et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Two decades of new drug development for central nervous system disorders

(2015) Aaron S. Kesselheim et al.   NATURE REVIEWS DRUG DISCOVERY

Neural Correlates of Three Promising Endophenotypes of Depression: Evidence from the EMBARC Study

(2015) Christian A Webb et al.   NEUROPSYCHOPHARMACOLOGY

Safety, tolerability, and pharmacokinetic evaluation of single- and multiple-ascending doses of a novel kappa opioid receptor antagonist LY2456302 and drug interaction with ethanol in healthy subjects

(2014) Stephen L. Lowe et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The STAR*D Trial: Revealing the Need for Better Treatments

(2014) Thomas R. Insel et al.   PSYCHIATRIC SERVICES

Synthesis and Evaluation of 11C-LY2795050 as a  -Opioid Receptor Antagonist Radiotracer for PET Imaging

(2013) M.-Q. Zheng et al.   JOURNAL OF NUCLEAR MEDICINE

Trait anhedonia is associated with reduced reactivity and connectivity of mesolimbic and paralimbic reward pathways

(2013) Jennifer Keller et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Reduced Reward Learning Predicts Outcome in Major Depressive Disorder

(2012) Elske Vrieze et al.   BIOLOGICAL PSYCHIATRY

Anhedonia and major depression: The role of agomelatine

(2012) Massimo Di Giannantonio et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Multiple imputation by chained equations: what is it and how does it work?

(2011) Melissa J. Azur et al.   INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH

Activation of CREB in the Nucleus Accumbens Shell Produces Anhedonia and Resistance to Extinction of Fear in Rats

(2011) J. W. Muschamp et al.   JOURNAL OF NEUROSCIENCE

Hyporeactivity of ventral striatum towards incentive stimuli in unmedicated depressed patients normalizes after treatment with escitalopram

(2011) Meline Stoy et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Ventral striatal and medial prefrontal BOLD activation is correlated with reward-related electrocortical activity: A combined ERP and fMRI study

(2011) Joshua M. Carlson et al.   NEUROIMAGE

Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats

(2011) Elena Chartoff et al.   NEUROPHARMACOLOGY

Translating Discoveries into Medicine: Psychiatric Drug Development in 2011

(2011) Linda S Brady et al.   NEUROPSYCHOPHARMACOLOGY

Deficits in sustaining reward responses in subsyndromal and syndromal major depression

(2011) Wen-hua Liu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Acetyl-l-Carnitine in the treatment of anhedonia, melancholic and negative symptoms in alcohol dependent subjects

(2011) Giovanni Martinotti et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Research Domain Criteria (RDoC): Toward a New Classification Framework for Research on Mental Disorders

(2010) Thomas Insel et al.   AMERICAN JOURNAL OF PSYCHIATRY

Psychometric evaluation of the Snaith–Hamilton pleasure scale in adult outpatients with major depressive disorder

(2010) Paul A. Nakonezny et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse

(2010) Sunmee Wee et al.   PSYCHOPHARMACOLOGY

Depressive-like effects of the kappa opioid receptor agonist salvinorin A are associated with decreased phasic dopamine release in the nucleus accumbens

(2010) Stephanie R. Ebner et al.   PSYCHOPHARMACOLOGY

kappa-Opioid receptor signaling and brain reward function

(2009) Adrie W. Bruijnzeel   BRAIN RESEARCH REVIEWS

The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques

(2009) Jan Wacker et al.   NEUROIMAGE

Nucleus accumbens activation mediates the influence of reward cues on financial risk taking

(2009) Brian Knutson et al.   NEUROREPORT

Kappa-opioid ligands in the study and treatment of mood disorders

(2009) William A. Carlezon et al.   PHARMACOLOGY & THERAPEUTICS

Worth the ‘EEfRT’? The Effort Expenditure for Rewards Task as an Objective Measure of Motivation and Anhedonia

(2009) Michael T. Treadway et al.   PLoS One

Reliability and Validity of the Massachusetts General Hospital Cognitive and Physical Functioning Questionnaire

(2009) Maurizio Fava et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Activation in the VTA and nucleus accumbens increases in anticipation of both gains and losses

(2009) R. McKell Carter   Frontiers in Behavioral Neuroscience

The Kappa-Opioid Agonist U69,593 Blocks Cocaine-Induced Enhancement of Brain Stimulation Reward

(2008) Hilarie C. Tomasiewicz et al.   BIOLOGICAL PSYCHIATRY

Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release

(2008) B. H. Schott et al.   JOURNAL OF NEUROSCIENCE

Reduced hedonic capacity in major depressive disorder: Evidence from a probabilistic reward task

(2008) Diego A. Pizzagalli et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Individual differences in reinforcement learning: Behavioral, electrophysiological, and neuroimaging correlates

(2008) Diane L. Santesso et al.   NEUROIMAGE

Bayesian analysis of neuroimaging data in FSL

(2008) Mark W. Woolrich et al.   NEUROIMAGE

Neural Responses to Monetary Incentives in Major Depression

(2007) Brian Knutson et al.   BIOLOGICAL PSYCHIATRY