Materials science approaches in the development of broad-spectrum antiviral therapies

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020

(2020) Gianfranco Spiteri et al.   Eurosurveillance

Coronavirus Infections—More Than Just the Common Cold

(2020) Catharine I. Paules et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Is COVID-19 receiving ADE from other coronaviruses?

(2020) Jason A. Tetro   MICROBES AND INFECTION

Four ways researchers are responding to the COVID-19 outbreak

(2020) Amanda B. Keener   NATURE MEDICINE

Evidence of SARS-CoV-2 Infection in Returning Travelers from Wuhan, China

(2020) Sebastian Hoehl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evolutionary Perspectives on Novel Coronaviruses Identified in Pneumonia Cases in China

(2020) Xiaoman Wei et al.   National Science Review

On the origin and continuing evolution of SARS-CoV-2

(2020) Xiaolu Tang et al.   National Science Review

Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion

(2019) Achille Broggi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics

(2019) Sabue Mulangu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antivirals acting on viral envelopes via biophysical mechanisms of action

(2018) Sietske Speerstra et al.   ANTIVIRAL RESEARCH

Repurposing of Kinase Inhibitors as Broad-Spectrum Antiviral Drugs

(2018) Stanford Schor et al.   DNA AND CELL BIOLOGY

Optimizing lonafarnib treatment for the management of chronic delta hepatitis: The LOWR HDV-1 study

(2018) Cihan Yurdaydin et al.   HEPATOLOGY

Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide

(2018) Joshua A. Jackman et al.   NATURE MATERIALS

Targeting the Achilles Heel of Mosquito-Borne Viruses for Antiviral Therapy

(2018) Joshua A. Jackman et al.   ACS Infectious Diseases

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

(2017) Elena Bekerman et al.   JOURNAL OF CLINICAL INVESTIGATION

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

(2017) Valeria Cagno et al.   NATURE MATERIALS

The Ebola outbreak, 2013–2016: old lessons for new epidemics

(2017) Cordelia E. M. Coltart et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Zika Virus in the Americas — Yet Another Arbovirus Threat

(2016) Anthony S. Fauci et al.   NEW ENGLAND JOURNAL OF MEDICINE

Countering the Zika epidemic in Latin America

(2016) N. M. Ferguson et al.   SCIENCE

Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome

(2015) Nam-Joon Cho et al.   GASTROENTEROLOGY

Interferon-λ: Immune Functions at Barrier Surfaces and Beyond

(2015) Helen M. Lazear et al.   IMMUNITY

Oral prenylation inhibition with lonafarnib in chronic hepatitis D infection: a proof-of-concept randomised, double-blind, placebo-controlled phase 2A trial

(2015) Christopher Koh et al.   LANCET INFECTIOUS DISEASES

Broad-spectrum antivirals against viral fusion

(2015) Frederic Vigant et al.   NATURE REVIEWS MICROBIOLOGY

Combating emerging viral threats

(2015) E. Bekerman et al.   SCIENCE

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

(2014) Travis K. Warren et al.   NATURE

Favipiravir (T-705), a novel viral RNA polymerase inhibitor

(2013) Yousuke Furuta et al.   ANTIVIRAL RESEARCH

Type I and Type III Interferons Drive Redundant Amplification Loops to Induce a Transcriptional Signature in Influenza-Infected Airway Epithelia

(2013) Stefania Crotta et al.   PLoS Pathogens

The Age-Specific Cumulative Incidence of Infection with Pandemic Influenza H1N1 2009 Was Similar in Various Countries Prior to Vaccination

(2011) Heath Kelly et al.   PLoS One

A broad-spectrum antiviral targeting entry of enveloped viruses

(2010) M. C. Wolf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses

(2010) M. R. St.Vincent et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA