Paradoxical mitotic exit induced by a small molecule inhibitor of APC/CCdc20

A novel strategy to block mitotic progression for targeted therapy

(2019) Junlong (Jack) Chi et al.   EBioMedicine

Streamlined Tandem Mass Tag (SL-TMT) Protocol: An Efficient Strategy for Quantitative (Phospho)proteome Profiling Using Tandem Mass Tag-Synchronous Precursor Selection-MS3

(2018) José Navarrete-Perea et al.   JOURNAL OF PROTEOME RESEARCH

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division

(2018) Edmond R. Watson et al.   TRENDS IN CELL BIOLOGY

Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)

(2017) Claudio Alfieri et al.   Open Biology

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C

(2016) Nicholas G. Brown et al.   CELL

The ubiquitin ligase CRL2 ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage

(2016) Riju S. Balachandran et al.   JOURNAL OF CELL BIOLOGY

A Triple Knockout (TKO) Proteomics Standard for Diagnosing Ion Interference in Isobaric Labeling Experiments

(2016) Joao A. Paulo et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C

(2016) Barbara Di Fiore et al.   MOLECULAR CELL

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation

(2016) Masaya Yamaguchi et al.   MOLECULAR CELL

Molecular mechanism of APC/C activation by mitotic phosphorylation

(2016) Suyang Zhang et al.   NATURE

Molecular basis of APC/C regulation by the spindle assembly checkpoint

(2016) Claudio Alfieri et al.   NATURE

biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes

(2016) Florian Weissmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of APC/CCDC20activation by mitotic phosphorylation

(2016) Renping Qiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the APC/C co-factor FZR1 as a novel therapeutic target for multiple myeloma

(2016) Lisa J. Crawford et al.   Oncotarget

MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes

(2014) Graeme C. McAlister et al.   ANALYTICAL CHEMISTRY

Genome‐wide siRNA screen reveals coupling between mitotic apoptosis and adaptation

(2014) Laura A Díaz‐Martínez et al.   EMBO JOURNAL

The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C

(2014) Daisuke Izawa et al.   NATURE

Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

(2014) Katharine L. Sackton et al.   NATURE

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

Targeting mitotic exit with hyperthermia or APC/C inhibition to increase paclitaxel efficacy

(2013) Serena Giovinazzi et al.   CELL CYCLE

Depletion of p31cometProtein Promotes Sensitivity to Antimitotic Drugs

(2012) Hoi Tang Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination

(2012) Xing Zeng et al.   Nature Chemical Biology

p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit

(2011) F. G. Westhorpe et al.   JOURNAL OF CELL SCIENCE

Homeostatic Control of Mitotic Arrest

(2011) Gianluca Varetti et al.   MOLECULAR CELL

APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment

(2011) Jörg Mansfeld et al.   NATURE CELL BIOLOGY

MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics

(2011) Lily Ting et al.   NATURE METHODS

A Time-Series Method for Automated Measurement of Changes in Mitotic and Interphase Duration from Time-Lapse Movies

(2011) Frederic D. Sigoillot et al.   PLoS One

Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage

(2010) Xing Zeng et al.   CANCER CELL

Targeting Mitotic Exit Leads to Tumor Regression In Vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ Phosphatase

(2010) Eusebio Manchado et al.   CANCER CELL

Strong inducible knockdown of APC/CCdc20does not cause mitotic arrest in human somatic cells

(2010) Axel J. Baumgarten et al.   CELL CYCLE

The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer

(2010) Donald P McDonnell et al.   CURRENT OPINION IN PHARMACOLOGY

The APC/C recruits cyclin B1–Cdk1–Cks in prometaphase before D box recognition to control mitotic exit

(2010) Wouter van Zon et al.   JOURNAL OF CELL BIOLOGY

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

(2010) Laura Hewitt et al.   JOURNAL OF CELL BIOLOGY

Evidence that Mitotic Exit Is a Better Cancer Therapeutic Target Than Spindle Assembly

(2009) Hsiao-Chun Huang et al.   CANCER CELL

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

Cdc20 and Cks Direct the Spindle Checkpoint-Independent Destruction of Cyclin A

(2008) Rob Wolthuis et al.   MOLECULAR CELL