Review
Materials Science, Multidisciplinary
Xiangyi Kong, Yihang Qi, Xiangyu Wang, Rui Jiang, Jing Wang, Yi Fang, Jidong Gao, Kuo Chu Hwang
Summary: The therapeutic effect of highly malignant triple negative breast cancer (TNBC) is negatively affected by resistant clone formation and severe toxicity. Nano delivery system effectively suppresses and kills tumor cells by targeted delivery of chemotherapeutic drugs, gene fragments, and immune enhancing factors. Combined with photothermal ablation therapy, it achieves synergism, toxicity reduction, gene inhibition, and immune system activation. These nanoparticle delivery systems revolutionize drug design and usage, reducing adverse effects of toxic chemodrugs.
PROGRESS IN MATERIALS SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Moon Jung Choi, Yeon Kyung Lee, Kang Chan Choi, Do Hyun Lee, Hwa Yeon Jeong, Seong Jae Kang, Min Woo Kim, Young Myoung You, Chan Su Im, Tae Sup Lee, Yong Serk Park
Summary: Biocompatible theranostic erythrocyte-derived nanoparticles (EDNs) were developed for effective early diagnosis and treatment of triple-negative breast cancer (TNBC). The EDNs encapsulated the anti-cancer drug doxorubicin (DOX) and incorporated diagnostic quantum dots (QDs) for tumor bio-imaging. The surface of the EDNs was conjugated with anti-epidermal growth factor receptor (EGFR) antibody molecules to achieve TNBC targeting. This study demonstrated that the resulting antibody-conjugated EDNs exhibited strong biocompatibility, prolonged blood circulation, and efficient targeting of TNBC, making them potential co-delivery systems for therapeutics and diagnostics.
Article
Pharmacology & Pharmacy
Zimiao Luo, Sunyi Wu, Jianfen Zhou, Weixia Xu, Qianzhu Xu, Linwei Lu, Cao Xie, Yu Liu, Weiyue Lu
Summary: Brain metastasis is a common and serious complication of breast cancer, especially in triple-negative breast cancer (TNBC). This study develops a Y-shaped peptide pVAP-decorated platelet-hybrid liposome drug delivery system to achieve targeted drug delivery for the treatment of brain metastasis from TNBC. The results show that this delivery platform significantly improves drug accumulation and exhibits superior inhibition of brain metastasis compared to the free drug. This work provides a promising prospect for the comprehensive treatment of brain metastasis in TNBC.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Nanoscience & Nanotechnology
Siyan Liu, Jing Li, Lin Gu, Kunzhe Wu, Hua Xing
Summary: Chemoimmunotherapy shows promise for treating TNBC, but challenges remain in improving efficacy and reducing side effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Pharmacology & Pharmacy
Yifeng Cao, Chuyang Chen, Yi Tao, Weifeng Lin, Ping Wang
Summary: Triple-negative breast cancer (TNBC) is characterized by extensive tumor heterogeneity at both the pathologic and molecular levels, leading to increased mortality of patients due to accelerated aggressiveness and terrible metastasis. Hindered by the negative expression of certain receptors, targeted therapy has been challenging, but the higher immune response in TNBC compared to other breast cancer types makes it suitable for immunotherapy.
Article
Biochemistry & Molecular Biology
Elizabeth A. Bowling, Jarey H. Wang, Fade Gong, William Wu, Nicholas J. Neill, Ik Sun Kim, Siddhartha Tyagi, Mayra Orellana, Sarah J. Kurley, Rocio Dominguez-Vidana, Hsiang-Ching Chung, Tiffany Y-T Hsu, Julien Dubrulle, Alexander B. Saltzman, Heyuan Li, Jitendra K. Meena, Gino M. Canlas, Srinivas Chamakuri, Swarnima Singh, Lukas M. Simon, Calla M. Olson, Lacey E. Dobrolecki, Michael T. Lewis, Bing Zhang, Ido Golding, Jeffrey M. Rosen, Damian W. Young, Anna Malovannaya, Fabio Stossi, George Miles, Matthew J. Ellis, Lihua Yu, Silvia Buonamici, Charles Y. Lin, Kristen L. Karlin, Xiang H-F Zhang, Thomas F. Westbrook
Summary: This study reveals that mis-spliced RNA can trigger tumor cell death through viral mimicry, where dsRNA-binding proteins recognize mis-spliced RNA and induce antiviral signaling and apoptosis. Additionally, the findings suggest that STTs may activate anti-tumor immune pathways by responding to global aberrations of RNA splicing in cancer.
Article
Biochemistry & Molecular Biology
Longkun Wang, Chunqian Zhao, Lu Lu, Honglei Jiang, Fengshan Wang, Xinke Zhang
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis, and the current treatment mainly relies on surgery and chemotherapy. However, the application of paclitaxel (PTX) is limited due to its hydrophobicity and side effects. To overcome these problems, a novel PTX conjugate called PTX-SM-TAR was constructed, which improved the specificity and penetrability of PTX at the tumor site. PTX-SM-TAR exhibited receptor-targeting and endocytosis-mediated cell uptake, as well as great transvascular transport and tumor penetration ability. In vivo experiments showed that PTX-SM-TAR had higher antitumor effects compared to PTX, suggesting its potential as a targeted delivery system for TNBC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Mahak Fatima, Afsana Sheikh, Mohammed A. S. Abourehab, Prashant Kesharwani
Summary: Triple-negative breast cancer is a destructive disease with poor prognosis and low survival rate. Current therapies have limitations, and thus, new approaches using polymeric nanocarriers are important for effective treatment of TNBC.
Review
Biochemistry & Molecular Biology
Abygail G. Chapdelaine, Gongqin Sun
Summary: Triple negative breast cancer (TNBC) is a heterogeneous group of breast cancers characterized by their lack of estrogen receptors, progesterone receptors, and the HER2 receptor. Developing targeted therapies for TNBC has been a major challenge due to its heterogeneity, and its treatment still largely relies on surgery, radiation therapy, and chemotherapy. Accumulating evidence supports TNBCs as multi-driver cancers, and a strategy designed to generate mechanism-based combination targeted therapies for TNBC is discussed.
Article
Chemistry, Multidisciplinary
Zitong Zhao, Lei Fang, Ping Xiao, Xiangshi Sun, Lei Zhou, Xiaochen Liu, Jue Wang, Guanru Wang, Haiqiang Cao, Pengcheng Zhang, Yanyan Jiang, Dangge Wang, Yaping Li
Summary: In this study, walking dead TNBC cells were developed by conjugating anti-PD-1 and doxorubicin-loaded liposomes onto cell corpses for temporal chemo-immunotherapy against lung metastasis. The walking dead TNBC cells improved drug accumulation and local retention in the lungs, reprogrammed the lung microenvironment, and prolonged overall survival in mice with lung metastasis.
ADVANCED MATERIALS
(2022)
Article
Oncology
Ghazal Nabil, Rami Alzhrani, Hashem O. Alsaab, Mohammed Atef, Samaresh Sau, Arun K. Iyer, Hossny El Banna
Summary: Triple-negative breast cancer (TNBC) is a challenging and aggressive tumor with limited therapeutic options. Combination therapies, such as using apoptosis inducers and JAK/STAT3 inhibitors, have shown improvement in TNBC cell killing activity. CD44 targeted polymeric nanoparticles and Hyaluronic acid-tagged nanoparticles have enhanced drug activity and tumor accumulation, leading to improved therapeutic efficacy for TNBC treatment.
Review
Oncology
Kai Hou, Zeng Ning, Hongbo Chen, Yiping Wu
Summary: This review discusses the mechanisms and prospects of nanotechnology in the treatment of TNBC, providing potential new strategies for the diagnosis and treatment of TNBC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Suchetan Pal, Tatini Rakshit
Summary: Researchers have developed folate-functionalized DNA origami structures that can effectively target and kill cells overexpressing FOLR1, with better efficacy than non-targeted structures. This study is expected to enable target-specific delivery of anticancer drug combinations to drug-resistant cancer cells using versatile DNA origami nanostructures.
FRONTIERS IN CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Maryam Nakhjavani, Rasika M. Samarasinghe, Sarah Shigdar
Summary: The key challenges in treating triple-negative breast cancer brain metastasis (TNBC-BM) lie in the absence of targeted therapy and difficulties in delivering drugs to the brain. This review introduces current drugs based on their molecular targets and seeks to improve drug delivery to the brain using more efficient and promising drug delivery systems. Ongoing clinical trials on druggable targets in TNBC-BM are described to achieve more targeted treatment, along with an introduction to the obstacles hindering drug delivery to the brain and strategies for future advancements in TNBC-BM patient treatment.
DRUG DISCOVERY TODAY
(2022)
Article
Chemistry, Multidisciplinary
Lan Yang, Yongshun Zhang, Yu Zhang, Yani Xu, Yuai Li, Zhigiang Xie, Hairui Wang, Yunzhu Lin, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang
Summary: This study demonstrates a system for treating triple-negative breast cancer by utilizing the tumor-targeting capabilities of macrophages. By loading doxorubicin-carrying liposomes on the surfaces of macrophages, the system significantly enhances drug accumulation at tumor sites, penetrates deeper into tumor tissue, and enhances the anti-tumor immune response, leading to improved survival rates in mice.
Article
Chemistry, Physical
Kimberly R. Dean, Brian Novak, Mahsa Moradipour, Xinjie Tong, Dorel Moldovan, Barbara L. Knutson, Stephen E. Rankin, Bert C. Lynn
Summary: This study revealed the inclusion interactions between cyclodextrins and lignin model compounds derived from lignocellulosic biomass degradation products through experiments and simulations, showing substantial differences in binding stability among different linkage types, providing valuable information for environmentally sustainable separation of lignin compounds.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Nanoscience & Nanotechnology
Timea Kacso, Eban A. Hanna, Fallon Salinas, Carlos E. Astete, Ede Bodoki, Radu Oprean, Paul P. Price, Vinson P. Doyle, Colin A. R. Bonser, Jeffrey A. Davis, Cristina M. Sabliov
Summary: This study synthesized zein nanoparticles and lignin-graft-poly(lactic-co-glycolic) acid nanoparticles using surfactants and applied them as antifungal seed treatments on soybeans. The results showed that the treated seeds had similar germination rates and plant health compared to the control group, indicating that these nanoparticles are safe and effective delivery systems for active compounds in seed treatments.
APPLIED NANOSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Victoria Dupuis, Constantin Cerbu, Lucjan Witkowski, Adrian-Valentin Potarniche, Maria Cristina Timar, Monika Zychska, Cristina M. Sabliov
Summary: This review provides a synthesis of the last ten years of research on nanodelivery systems for essential oils (EOs) and their potential as an alternative to antibiotics in human and veterinary therapy. Nanodelivery systems seem to be able to overcome the limitations of using essential oils alone. The choice of essential oil and nanodelivery system influences therapeutic efficacy. The review assesses the characteristics of nanomaterials used for essential oil delivery and their impact on functionality, as well as successful applications. More quantitative and in vivo studies are needed before the adoption of EOs loaded NPs as an alternative to antibiotics.
Article
Entomology
Colin A. R. Bonser, Carlos E. Astete, Cristina M. Sabliov, Jeffrey A. Davis
Summary: Research shows that nanoparticles can be an effective tool for managing agricultural pests, but their unintended effects on insects should be evaluated before using them in agroecosystems. In this study, chronic parental and generational exposure to positively charged zein nanoparticles and methoxyfenozide-loaded zein nanoparticles were evaluated on Chrysodeixis includens. The study found that the nanoparticles had different effects on the insect's population dynamics, with the methoxyfenozide-loaded nanoparticles being more deleterious than the positively charged nanoparticles.
ENVIRONMENTAL ENTOMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tomas Komprda, Zbysek Sladek, Monika Vicenova, Jana Simonova, Gabriela Franke, Katarina Kacvinska, Cristina Sabliov, Carlos E. Astete, Lenka Leva, Vendula Popelkova, Andrej Batik, Lucy Vojtova, Bretislav Lipovy, Milena Matejovicova
Summary: The utilization of PLGA nanoparticles with entrapped fish oil in collagen-based scaffolds for cutaneous wound healing showed promising results in a porcine model. The NP/FO treatment had advantages compared to FO alone and tended to have similar effects to NP/MUP treatment, suggesting it as a suitable alternative for wound treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ioana Craciun, Carlos E. Astete, Dorin Boldor, Merilyn H. Jennings, Jake D. Gorman, Cristina M. Sabliov, Tammy R. Dugas
Summary: This study aimed to design a novel drug-coated balloon using a polymeric nanodelivery system for sustained release of polyphenols to reduce restenosis in patients with peripheral artery disease (PAD) after balloon angioplasty. The results showed that the nanoparticle system with quercetin covalently attached had the highest sustained release and anti-proliferative effect, while maintaining adhesion even under calcification conditions. Additionally, the ultrasound coating method produced a uniform balloon coating.
Article
Chemistry, Multidisciplinary
Sheyda Shakiba, Saba Shariati, Haoran Wu, Carlos E. Astete, Rafael Cueto, Elham H. Fini, Debora F. Rodrigues, Cristina M. Sabliov, Stacey M. Louie
Summary: This research presents the development and application of a multi-detector AF4 method to study drug loading and release from polymeric nanoparticles. By using multiple online detectors, the researchers were able to determine the release mechanism and draw important conclusions.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Entomology
Colin A. R. Bonser, Carlos E. Astete, Cristina M. Sabliov, Jeffrey A. Davis
Summary: Previous research found that positively charged zein nanoparticles were toxic to neonates of Anticarsia gemmatalis Hubner and other noctuid pests, but the specific mechanisms were unknown. This study ruled out the hypotheses that toxic effects were caused by surfactant charges and antifeedant capabilities. It also found that both (+)ZNP and its cationic surfactant DDAB decreased antioxidant levels in A. gemmatalis neonates, suggesting inhibition of antioxidant levels. These findings contribute to the understanding of potential modes of action of biopolymeric nanoparticles.
JOURNAL OF ECONOMIC ENTOMOLOGY
(2023)
Article
Entomology
C. A. R. Bonser, C. Tamez, J. C. White, C. E. Astete, C. M. Sabliov, J. A. Davis
Summary: Biopolymeric nanoparticles have the potential to improve insecticide efficacy through improved absorption, coverage, and permeability, while protecting the active ingredient and extending efficacy. The experiments showed that positively charged zein nanoparticles loaded with methoxyfenozide had comparable efficacy to a commercial product.
JOURNAL OF INSECT SCIENCE
(2023)
Article
Agronomy
Colin A. R. Bonser, Jaya Borgatta, Jason C. White, Carlos E. Astete, Cristina M. Sabliov, Jeffrey A. Davis
Summary: Biopolymer nanoparticles, designed to be biocompatible and degradable, have been found to have no negative effects on plant growth, yield, and herbivore susceptibility, making them suitable for use in agriculture.
AGROSYSTEMS GEOSCIENCES & ENVIRONMENT
(2023)
Article
Agriculture, Multidisciplinary
Omar E. Mendez, Carlos E. Astete, Rafael Cueto, Brian Eitzer, Eban A. Hanna, Fallon Salinas, Carlos Tamez, Yi Wang, Jason C. White, Cristina M. Sabliov
Summary: This study explores the use of lignin nanoparticles (LNPs) to enhance the translocation of the non-systemic pesticide methoxyfenozide (MFZ) in soybean plants. The results show that LNPs effectively transfer MFZ from the hydroponic suspension to the roots, and then from the roots to the leaves within 24 hours. The concentration and total amount of MFZ translocated by LNPs are higher than those of free MFZ, although the translocation efficiency is higher for free MFZ.
JOURNAL OF AGRICULTURE AND FOOD RESEARCH
(2022)
