Synthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory Viruses

Synthesis and anti‐coronavirus activity of a series of 1‐thia‐4‐azaspiro[4.5]decan‐3‐one derivatives

(2019) Çağla Begüm Apaydın et al.   ARCHIV DER PHARMAZIE

New Quinolone-Based Thiosemicarbazones Showing Activity Against Plasmodium falciparum and Mycobacterium tuberculosis

(2019) Richard M. Beteck et al.   MOLECULES

Advances in respiratory virus therapeutics – A meeting report from the 6th isirv Antiviral Group conference

(2019) John H. Beigel et al.   ANTIVIRAL RESEARCH

Overview of Current Therapeutics and Novel Candidates Against Influenza, Respiratory Syncytial Virus, and Middle East Respiratory Syndrome Coronavirus Infections

(2019) Mohammad Amin Behzadi et al.   Frontiers in Microbiology

Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR)

(2018) Valeria Francesconi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nucleosides of Benzimidazole: Antiviral and Antitumor Activity, Methods of Preparation

(2018) Maria I Kharitonova et al.   RUSSIAN CHEMICAL REVIEWS

Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria

(2018) Cauê Benito Scarim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic evolution of benzimidazole derivatives in the last quinquennial period

(2017) Wasim Akhtar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus

(2017) Michele Tonelli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel biguanide-based derivatives scouted as TAAR1 agonists: Synthesis, biological evaluation, ADME prediction and molecular docking studies

(2017) Michele Tonelli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles

(2017) Elena Cichero et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor

(2017) Dirk Roymans et al.   Nature Communications

Functionalized Benzimidazole Scaffolds: Privileged Heterocycle for Drug Design in Therapeutic Medicine

(2016) Olayinka O. Ajani et al.   ARCHIV DER PHARMAZIE

Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB 2 receptor ligands with antagonist/inverse agonist properties

(2016) Valeria Deiana et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of a New Benzimidazole Derivative as an Antiviral against Hepatitis C Virus

(2016) Thibaut Vausselin et al.   JOURNAL OF VIROLOGY

In silico evaluation of human small heat shock protein HSP27: Homology modeling, mutation analyses and docking studies

(2015) Paola Fossa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chemotherapy of respiratory syncytial virus infections: the final breakthrough

(2015) Erik De Clercq   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Investigation of the salicylaldehyde thiosemicarbazone scaffold for inhibition of influenza virus PA endonuclease

(2015) Dominga Rogolino et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Molecular mechanism of respiratory syncytial virus fusion inhibitors

(2015) Michael B Battles et al.   Nature Chemical Biology

Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry

(2014) Rangappa S. Keri et al.   Chemical Biology & Drug Design

Docking assay of small molecule antivirals to p7 of HCV

(2014) Leon Bichmann et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Synthesis, NMR structural characterization and molecular modeling of substituted thiosemicarbazones and semicarbazones using DFT calculations to prove the syn/anti isomer formation

(2014) T. K. Venkatachalam et al.   MAGNETIC RESONANCE IN CHEMISTRY

Primary anti-proliferative activity evaluation of 1-(quinolizidin-1’-yl)methyl- and 1-( $$\omega $$ -tert-amino)alkyl-substituted 2-phenyl-, 2-benzyl- and 2-[(benzotriazol-1/2-yl)methyl]benzimidazoles on human cancer cell lines

(2013) Michele Tonelli et al.   MOLECULAR DIVERSITY

5-Acetyl-2-arylbenzimidazoles as antiviral agents. Part 4

(2012) Gabriella Vitale et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Organoplatinum(II) Complexes with 2-Acetylthiophene Thiosemicarbazone: Synthesis, Characterization, Crystal Structures, and in Vitro Antitumor Activity

(2012) Awadelkareem A. Ali et al.   ORGANOMETALLICS

Substantial improvements in large-scale redocking and screening using the novel HYDE scoring function

(2011) Nadine Schneider et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Antiviral activity of benzimidazole derivatives. II. Antiviral activity of 2-phenylbenzimidazole derivatives

(2010) Michele Tonelli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

LowModeMD—Implicit Low-Mode Velocity Filtering Applied to Conformational Search of Macrocycles and Protein Loops

(2010) Paul Labute   Journal of Chemical Information and Modeling

Novel Inhibitors of Influenza Virus Fusion: Structure-Activity Relationship and Interaction with the Viral Hemagglutinin

(2010) E. Vanderlinden et al.   JOURNAL OF VIROLOGY

Antiviral Activity of Benzimidazole Derivatives. I. Antiviral Activity of 1-Substituted-2-[(Benzotriazol-1/2-yl)methyl]benzimidazoles

(2008) Michele Tonelli et al.   CHEMISTRY & BIODIVERSITY

Towards an Integrated Description of Hydrogen Bonding and Dehydration: Decreasing False Positives in Virtual Screening with the HYDE Scoring Function

(2008) Ingo Reulecke et al.   ChemMedChem

A molecular mechanism of P-loop pliability of Rho-kinase investigated by molecular dynamic simulation

(2008) Keigo Gohda et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN