Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases

Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism

(2019) Gianni Colotti et al.   AMINO ACIDS

In silico identification and evaluation of new Trypanosoma cruzi trypanothione reductase (TcTR) inhibitors obtained from natural products database of the Bahia semi-arid region (NatProDB)

(2019) Vinícius Guimarães da Paixão et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase

(2019) Alejandro Revuelto et al.   ACS Infectious Diseases

Targeting a Large Active Site: Structure‐Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase

(2019) Raoul De Gasparo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma

(2018) Raoul De Gasparo et al.   ChemMedChem

Identification of chalcone-based antileishmanial agents targeting trypanothione reductase

(2018) Margherita Ortalli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antikinetoplastid evaluation of bis(benzyl)spermidine derivatives

(2018) Elodie Jagu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Metal- and metalloid-containing drugs for the treatment of trypanosomatid diseases

(2018) Andrea Ilari   Frontiers in Bioscience-Landmark

Toward a Drug Against All Kinetoplastids: From LeishBox to Specific and Potent Trypanothione Reductase Inhibitors

(2018) Andrea Ilari et al.   MOLECULAR PHARMACEUTICS

Synthesis and SAR of new isoxazole-triazole bis-heterocyclic compounds as analogues of natural lignans with antiparasitic activity

(2018) Lara A. Zimmermann et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening

(2018) Lorenzo Turcano et al.   PLoS Neglected Tropical Diseases

Polyamine-trypanothione pathway: an update

(2017) Andrea Ilari et al.   Future Medicinal Chemistry

Catalase in Leishmaniinae: With me or against me?

(2017) Natalya Kraeva et al.   INFECTION GENETICS AND EVOLUTION

Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives

(2017) Francesco Saccoliti et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Trypanocidal Activity of Quinoxaline 1,4 Di-N-oxide Derivatives as Trypanothione Reductase Inhibitors

(2017) Karla Chacón-Vargas et al.   MOLECULES

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

(2017) Mark C. Field et al.   NATURE REVIEWS MICROBIOLOGY

Synthesis and evaluation against Leishmania amazonensis of novel pyrazolo[3,4- d ]pyridazinone- N -acylhydrazone-(bi)thiophene hybrids

(2016) Andrey P. Jacomini et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Febrifugine analogues as Leishmania donovani trypanothione reductase inhibitors: binding energy analysis assisted by molecular docking, ADMET and molecular dynamics simulation

(2016) Rajan Kumar Pandey et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Trypanothione Reductase: A Target Protein for a Combined In Vitro and In Silico Screening Approach

(2015) Mathias Beig et al.   PLoS Neglected Tropical Diseases

Binding to Large Enzyme Pockets: Small-Molecule Inhibitors of Trypanothione Reductase

(2014) Elke Persch et al.   ChemMedChem

Probing the Dimerization Interface ofLeishmania infantumTrypanothione Reductase with Site-Directed Mutagenesis and Short Peptides

(2013) Miguel A. Toro et al.   CHEMBIOCHEM

Metal-Based Compounds as Prospective Antileishmanial Agents: Inhibition of Trypanothione Reductase by Selected Gold Complexes

(2013) Gianni Colotti et al.   ChemMedChem

Inhibition ofLeishmania infantumTrypanothione Reductase by Azole-Based Compounds: a Comparative Analysis with Its Physiological Substrate by X-ray Crystallography

(2013) Paola Baiocco et al.   ChemMedChem

A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition

(2011) Andrea Ilari et al.   AMINO ACIDS

A fast virtual screening approach to identify structurally diverse inhibitors of trypanothione reductase

(2011) Giorgio Maccari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

(2011) Stephen Patterson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Improved Inhibitors of Trypanothione Reductase by Combination of Motifs: Synthesis, Inhibitory Potency, Binding Mode, and Antiprotozoal Activities

(2010) Christian Eberle et al.   ChemMedChem

Inhibitory Effect of Silver Nanoparticles on Trypanothione Reductase Activity and Leishmania infantum Proliferation

(2010) Paola Baiocco et al.   ACS Medicinal Chemistry Letters

Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity

(2009) G. A. Holloway et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

(2009) Stephen Patterson et al.   ChemMedChem

Synthesis, Inhibition Potency, Binding Mode, and Antiprotozoal Activities of Fluorescent Inhibitors of Trypanothione Reductase Based on Mepacrine-Conjugated Diaryl Sulfide Scaffolds

(2009) Christian Eberle et al.   ChemMedChem

Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis

(2009) John L. Richardson et al.   ChemMedChem

Molecular Basis of Antimony Treatment in Leishmaniasis†

(2009) Paola Baiocco et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a Novel Virtual Screening Cascade Protocol to Identify Potential Trypanothione Reductase Inhibitors

(2009) Rolando Perez-Pineiro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi

(2009) Deuan C. Jones et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities

(2008) Bernhard Stump et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Inflammation and oxidative stress in vertebrate host-parasite systems

(2008) G. Sorci et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES