Organosilicon Compounds, SILA-409 and SILA-421, as Doxorubicin Resistance-Reversing Agents in Human Colon Cancer Cells

Cytotoxic and multidrug resistance reversal activity of phenothiazine derivative is strongly enhanced by theobromine, a phytochemical from cocoa

(2019) Kamila Środa-Pomianek et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Amyloid-beta Interactions with ABC Transporters and Resistance Modifiers

(2018) JOSEPH MOLNAR et al.   ANTICANCER RESEARCH

Increased lipid peroxidation, apoptosis and selective cytotoxicity in colon cancer cell line LoVo and its doxorubicin-resistant subline LoVo/Dx in the presence of newly synthesized phenothiazine derivatives

(2018) Kamila Środa-Pomianek et al.   BIOMEDICINE & PHARMACOTHERAPY

Targeting the multidrug transporter Patched potentiates chemotherapy efficiency on adrenocortical carcinoma in vitro and in vivo

(2018) Anida Hasanovic et al.   INTERNATIONAL JOURNAL OF CANCER

Evaluating the biological properties of synthetic 4-nitrophenyl functionalized benzofuran derivatives with telomeric DNA binding and antiproliferative activities

(2018) Antonio Carella et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies

(2016) Wen Li et al.   DRUG RESISTANCE UPDATES

SILA-421 activity in vitro against rifampicin-susceptible and rifampicin-resistant Mycobacterium tuberculosis, and in vivo in a murine tuberculosis model

(2015) Gerjo J. de Knegt et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development

(2014) Young Choi et al.   CURRENT PHARMACEUTICAL DESIGN

Activity of the efflux pump inhibitor SILA 421 against drug-resistant tuberculosis

(2013) Sami O. Simons et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Anticancer Effects of the Organosilicon Multidrug Resistance Modulator SILA 421

(2012) Ulrike Olszewski et al.   Anti-Cancer Agents in Medicinal Chemistry

The Hedgehog Receptor Patched Functions in Multidrug Transport and Chemotherapy Resistance

(2012) M. Bidet et al.   MOLECULAR CANCER RESEARCH

Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999

(2010) L. D. Cripe et al.   BLOOD

A Pharmacodynamic Study of Docetaxel in Combination with the P-glycoprotein Antagonist Tariquidar (XR9576) in Patients with Lung, Ovarian, and Cervical Cancer

(2010) R. J. Kelly et al.   CLINICAL CANCER RESEARCH

8-Prenylnaringenin is an inhibitor of multidrug resistance-associated transporters, P-glycoprotein and MRP1

(2010) Olga Wesołowska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SILA 421, an inhibitor of efflux pumps of cancer cells, enhances the killing of intracellular extensively drug-resistant tuberculosis (XDR-TB)

(2009) Marta Martins et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Development of inhibitors of ATP-binding cassette drug transporters – present status and challenges

(2008) Suneet Shukla et al.   Expert Opinion on Drug Metabolism & Toxicology

ABC multidrug transporters: structure, function and role in chemoresistance

(2007) Frances J Sharom   PHARMACOGENOMICS