Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine

Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects

(2019) Brendan D. Hare et al.   Nature Communications

Ketamine: A Paradigm Shift for Depression Research and Treatment

(2019) John H. Krystal et al.   NEURON

MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients

(2019) Daniella Dwir et al.   MOLECULAR PSYCHIATRY

SEP-363856, A NOVEL PSYCHOTROPIC AGENT WITH A UNIQUE, NON-D2 RECEPTOR MECHANISM OF ACTION

(2019) Nina Dedic et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Stress-sensitive antidepressant-like effects of ketamine in the mouse forced swim test

(2019) Paul J. Fitzgerald et al.   PLoS One

Pre-frontal parvalbumin interneurons in schizophrenia: a meta-analysis of post-mortem studies

(2019) Stephen J. Kaar et al.   JOURNAL OF NEURAL TRANSMISSION

Mechanisms of ketamine action as an antidepressant

(2018) P Zanos et al.   MOLECULAR PSYCHIATRY

Deletion of dopamine D2receptors from parvalbumin interneurons in mouse causes schizophrenia-like phenotypes

(2018) Eugenia Tomasella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TrkB Regulates N-Methyl-D-Aspartate Receptor Signaling by Uncoupling and Recruiting the Brain-Specific Guanine Nucleotide Exchange Factor, RasGrf1

(2018) Asghar Talebian et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)

(2018) Maurizio Fava et al.   MOLECULAR PSYCHIATRY

Single cocaine exposure does not alter striatal pre-synaptic dopamine function in mice: an [18 F]-FDOPA PET study

(2017) David R Bonsall et al.   JOURNAL OF NEUROCHEMISTRY

The effects of ketamine on dopaminergic function: meta-analysis and review of the implications for neuropsychiatric disorders

(2017) M Kokkinou et al.   MOLECULAR PSYCHIATRY

Beyond the Classic VTA: Extended Amygdala Projections to DA-Striatal Paths in the Primate

(2017) Julie L Fudge et al.   NEUROPSYCHOPHARMACOLOGY

Chemogenetics revealed: DREADD occupancy and activation via converted clozapine

(2017) Juan L. Gomez et al.   SCIENCE

A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia

(2017) Sameer Jauhar et al.   JAMA Psychiatry

Pathological Basis for Deficient Excitatory Drive to Cortical Parvalbumin Interneurons in Schizophrenia

(2016) Daniel W. Chung et al.   AMERICAN JOURNAL OF PSYCHIATRY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression

(2016) Anthony A. Grace   NATURE REVIEWS NEUROSCIENCE

Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia

(2016) John F Enwright et al.   NEUROPSYCHOPHARMACOLOGY

Evaluating the dopamine hypothesis of schizophrenia in a large-scale genome-wide association study

(2016) Alexis C. Edwards et al.   SCHIZOPHRENIA RESEARCH

Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics

(2015) Chadi G. Abdallah et al.   Annual Review of Medicine

Impact of subanesthetic doses of ketamine on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons

(2015) Kareem S El Iskandrani et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Glutamate and dopamine in schizophrenia: An update for the 21st century

(2015) Oliver Howes et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Closing the translational gap between mutant mouse models and the clinical reality of psychotic illness

(2015) Colm M. O’Tuathaigh et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Role of Dopaminergic VTA Neurons in General Anesthesia

(2015) Xuelong Zhou et al.   PLoS One

Restoring Mood Balance in Depression: Ketamine Reverses Deficit in Dopamine-Dependent Synaptic Plasticity

(2014) Pauline Belujon et al.   BIOLOGICAL PSYCHIATRY

Downregulation of Neuregulin 1-ErbB4 Signaling in Parvalbumin Interneurons in the Rat Brain May Contribute to the Antidepressant Properties of Ketamine

(2014) Nan Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

MAPK signaling correlates with the antidepressant effects of ketamine

(2014) Gislaine Z. Réus et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Loss of Phenotype of Parvalbumin Interneurons in Rat Prefrontal Cortex Is Involved in Antidepressant- and Propsychotic-Like Behaviors Following Acute and Repeated Ketamine Administration

(2014) ZhiQiang Zhou et al.   MOLECULAR NEUROBIOLOGY

Taar1-mediated modulation of presynaptic dopaminergic neurotransmission: Role of D2 dopamine autoreceptors

(2014) D. Leo et al.   NEUROPHARMACOLOGY

Mice Lacking NMDA Receptors in Parvalbumin Neurons Display Normal Depression-Related Behavior and Response to Antidepressant Action of NMDAR Antagonists

(2014) Laura Pozzi et al.   PLoS One

Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses

(2014) E. S. Gideons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast-spiking, parvalbumin+ GABAergic interneurons: From cellular design to microcircuit function

(2014) H. Hu et al.   SCIENCE

Ketamine increases striatal dopamine release and hyperlocomotion in adult rats after postnatal functional blockade of the prefrontal cortex

(2013) Y. Usun et al.   BEHAVIOURAL BRAIN RESEARCH

Presynaptic Striatal Dopamine Dysfunction in People at Ultra-high Risk for Psychosis: Findings in a Second Cohort

(2013) Alice Egerton et al.   BIOLOGICAL PSYCHIATRY

Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010

(2013) Harvey A Whiteford et al.   LANCET

Diverging neural pathways assemble a behavioural state from separable features in anxiety

(2013) Sung-Yon Kim et al.   NATURE

Parvalbumin-expressing basket-cell network plasticity induced by experience regulates adult learning

(2013) Flavio Donato et al.   NATURE

Combinational effects of ketamine and amphetamine on behaviors and neurotransmitter systems of mice

(2013) Chuan-Ching Lai et al.   NEUROTOXICOLOGY

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants

(2013) Caroline A. Browne et al.   Frontiers in Pharmacology

Chronic Ketamine Reduces the Peak Frequency of Gamma Oscillations in Mouse Prefrontal Cortex Ex vivo

(2013) James M. McNally et al.   Frontiers in Psychiatry

The Nature of Dopamine Dysfunction in Schizophrenia and What This Means for Treatment

(2012) Oliver D. Howes et al.   ARCHIVES OF GENERAL PSYCHIATRY

Topography of descending projections from anterior insular and medial prefrontal regions to the lateral habenula of the epithalamus in the rat

(2012) Uhnoh Kim et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

In-vivo Measurement of LDOPA Uptake, Dopamine Reserve and Turnover in the Rat Brain Using [18F]FDOPA PET

(2012) Matthew D Walker et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology

(2012) J M Stone et al.   MOLECULAR PSYCHIATRY

Has an Angel Shown the Way? Etiological and Therapeutic Implications of the PCP/NMDA Model of Schizophrenia

(2012) D. C. Javitt et al.   SCHIZOPHRENIA BULLETIN

NMDA Receptor and Schizophrenia: A Brief History

(2012) J. T. Coyle   SCHIZOPHRENIA BULLETIN

Dopamine Synthesis Capacity Before Onset of Psychosis: A Prospective [18F]-DOPA PET Imaging Study

(2011) Oliver D. Howes et al.   AMERICAN JOURNAL OF PSYCHIATRY

Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression

(2011) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

Dopamine D2 Receptor Occupancy and Clinical Effects

(2011) Hiroyuki Uchida et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study

(2011) O Howes et al.   MOLECULAR PSYCHIATRY

How the 'slow' Ca2+ buffer parvalbumin affects transmitter release in nanodomain-coupling regimes

(2011) Emmanuel Eggermann et al.   NATURE NEUROSCIENCE

Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists

(2011) Hiroyuki Koike et al.   NEUROPHARMACOLOGY

The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf+/− heterozygous null mice

(2011) Jesse S.O. Lindholm et al.   NEUROPHARMACOLOGY

In vivoandex vivoevidence for ketamine-induced hyperglutamatergic activity in the cerebral cortex of the rat: Potential relevance to schizophrenia

(2011) Sang-Young Kim et al.   NMR IN BIOMEDICINE

TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity

(2011) F. G. Revel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophrenia

(2011) Daniel J. Lodge et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Trace amine-associated receptor 1 as a monoaminergic modulator in brain

(2009) Zhihua Xie et al.   BIOCHEMICAL PHARMACOLOGY

A Loss of Parvalbumin-Containing Interneurons Is Associated with Diminished Oscillatory Activity in an Animal Model of Schizophrenia

(2009) D. J. Lodge et al.   JOURNAL OF NEUROSCIENCE

The test–retest reliability of 18F-DOPA PET in assessing striatal and extrastriatal presynaptic dopaminergic function

(2009) Alice Egerton et al.   NEUROIMAGE

The Rostromedial Tegmental Nucleus (RMTg), a GABAergic Afferent to Midbrain Dopamine Neurons, Encodes Aversive Stimuli and Inhibits Motor Responses

(2009) Thomas C. Jhou et al.   NEURON

Toluene has antidepressant-like actions in two animal models used for the screening of antidepressant drugs

(2009) Silvia L. Cruz et al.   PSYCHOPHARMACOLOGY

Alterations in Somatostatin mRNA Expression in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia or Schizoaffective Disorder

(2008) Harvey M. Morris et al.   CEREBRAL CORTEX

Prolonged Exposure to NMDAR Antagonist Suppresses Inhibitory Synaptic Transmission in Prefrontal Cortex

(2008) Yuchun Zhang et al.   JOURNAL OF NEUROPHYSIOLOGY

Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia

(2008) John E. Lisman et al.   TRENDS IN NEUROSCIENCES