Editorial Material
Biochemistry & Molecular Biology
Pu Zhang, Omar Abdel-Wahab
Summary: In this issue of Molecular Cell, Yu et al. identify RBM33 as a previously unrecognized m(6)A RNA binding protein that plays a critical role in ALKBH5-mediated m(6)A demethylation of a subset of mRNA transcripts by forming a complex with ALKBH5.
Article
Cell Biology
Yuan He, HongQin Yue, Ying Cheng, Zhilong Ding, Zhen Xu, Chunyang Lv, Zheng Wang, Jing Wang, Chenglong Yin, Huihui Hao, Chuang Chen
Summary: Long noncoding RNA KCNK15-AS1 is down-regulated in pancreatic cancer cells, and its overexpression inhibits cell proliferation, migration, and induces apoptosis. Mechanistically, ALKBH5 induces m(6)A demethylation of KCNK15-AS1, leading to up-regulation and subsequent inhibition of AKT pathway through regulating KCNK15 and PTEN.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Yiyang Hu, Chunli Gong, Zhibin Li, Jiao Liu, Yang Chen, Yu Huang, Qiang Luo, Sumin Wang, Yu Hou, Shiming Yang, Yufeng Xiao
Summary: This study established an ALKBH5-PKMYT1-IGF2BP3 regulation system in metastasis, providing a new therapeutic target for gastric cancer metastasis.
Editorial Material
Hematology
Andrew Volk
Summary: YTHDC1 protein promotes leukemic cell proliferation by stabilizing the transcription of MCM4.
Article
Biochemistry & Molecular Biology
Yi Zhang, Xiaomeng Liu, Yan Wang, Shihui Lai, Zhiqian Wang, Yudie Yang, Wenhui Liu, Hongquan Wang, Bo Tang
Summary: The study revealed that ALKBH5-mediated m(6)A modification leads to overexpression of DDIT4-AS1 in PDAC, increasing cancer stemness and reducing chemosensitivity to Gemcitabine (GEM).
Article
Multidisciplinary Sciences
Yuting Tang, Yang Liu, Xiaoshu Zhu, Yanlin Chen, Xinluan Jiang, Siyang Ding, Que Zheng, Ming Zhang, Jiashu Yang, Yunfei Ma, Mengying Xing, Zongyu Zhang, Huimin Ding, Yucui Jin, Changyan Ma
Summary: The downregulated long noncoding RNA HS3ST3B1-IT1 has been found to be associated with osteoarthritis. Its overexpression promotes chondrocyte viability and extracellular matrix synthesis, inhibiting the progression of osteoarthritis. It exerts its effects by upregulating its maternal gene HS3ST3B1.
Article
Pharmacology & Pharmacy
Fu-Chun Huo, Zhi-Man Zhu, Wen-Qi Du, Yao-Jie Pan, Xin Jiang, Meng-Jie Kang, Bo-Wen Liu, Jie Mou, Dong-Sheng Pei
Summary: Human papillomavirus (HPV) infection is a causative agent of cervical cancer (CC) and m6A modification plays a role in this process. HPV E6/7 oncoproteins affect global m6A modification and E7 specifically promotes the expression of ALKBH5. ALKBH5 is upregulated in CC and may serve as a prognostic marker. ALKBH5 enhances malignant phenotypes of CC cells and promotes tumorigenesis and metastasis through regulation of PAK5.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Oncology
Sipei Nie, Lin Zhang, Jinhui Liu, Yicong Wan, Yi Jiang, Jing Yang, Rui Sun, Xiaolling Ma, Guodong Sun, Huangyang Meng, Mengting Xu, Wenjun Cheng
Summary: In this study, it was found that ALKBH5 is upregulated in cisplatin-resistant EOC and promotes cancer cell resistance to cisplatin. The ALKBH5-HOXA10 loop activates the JAK2/STAT3 signaling pathway, leading to EOC chemoresistance. Inhibition of the expression of the ALKBH5-HOXA10 loop may be a potential strategy to overcome cisplatin resistance in EOC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Yingjie Shao, Zhenhua Liu, Xing Song, Rui Sun, You Zhou, Dachuan Zhang, Huihui Sun, Junchao Huang, Chenxi Wu, Wendong Gu, Xiao Zheng, Jingting Jiang
Summary: In this study, researchers identified and characterized circAFF2 as a novel m6A-modified circRNA that is closely related to radiosensitivity and prognosis in colorectal cancer (CRC) patients. They found that circAFF2 could enhance the radiosensitivity of CRC cells both in vitro and in vivo. Mechanistically, circAFF2 regulated the radiosensitivity of CRC through the ALKBH5/YTHDF2/Cullin-NEDD8 axis. These findings suggest that circAFF2 could be a potential target for radiotherapy in CRC.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Omprakash Shriwas, Pallavi Mohapatra, Sibasish Mohanty, Rupesh Dash
Summary: m6A RNA methylation plays a critical role in regulating oncogene expression and tumor progression. While its potential role in cancer cell proliferation has been well documented, further research is needed to understand its involvement in the development of therapy resistance in cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Deliang Fang, Xinde Ou, Kaiyu Sun, Xingyu Zhou, Youpei Li, Peng Shi, Zirui Zhao, Yulong He, Jianjun Peng, Jianbo Xu
Summary: The long noncoding RNA TP53TG1 is downregulated in gastric cancer and acts as a tumor suppressor, playing an important role in inhibiting the progression of gastric cancer. Low TP53TG1 expression is significantly associated with poor survival in gastric cancer patients. TP53TG1 interacts with the cancerous inhibitor of protein phosphatase 2A and triggers its degradation, thereby inhibiting the proliferation, metastasis, and cell cycle progression of gastric cancer cells and promoting apoptosis.
Article
Oncology
Tiannan Ji, Xiaohui Gao, Dan Li, Siyuan Huai, Yajing Chi, Xian An, Wenyu Ji, Siming Yang, Jianxiong Li
Summary: This study found that ALKBH5 may be a suppressor of gastric cancer, and ALKBH5 and its related genes could be potential biomarkers and immunotherapy targets.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Rui Sun, Lin Yuan, Yi Jiang, Yicong Wan, Xiaolling Ma, Jing Yang, Guodong Sun, Shulin Zhou, Hui Wang, Jiangnan Qiu, Lin Zhang, Wenjun Cheng
Summary: The study found that the m6A modification was reduced in ovarian cancers with LN metastases. Overexpression of ALKBH5 increased tumor-associated lymphangiogenesis and LN metastasis. Blocking ITGB1 and FAK kinase-inhibitors shows promise as anti-metastatic agents.
Article
Medicine, Research & Experimental
Hao Yu, Xiao Yang, Jinyuan Tang, Shuhui Si, Zijian Zhou, Jiancheng Lu, Jie Han, Baorui Yuan, Qikai Wu, Qiang Lu, Haiwei Yang
Summary: In bladder cancer, downregulation of ALKBH5 is associated with worse prognosis, and knockdown of ALKBH5 promotes cell proliferation, migration, and invasion while decreasing sensitivity to cisplatin chemotherapy. ALKBH5 inhibits bladder cancer progression and sensitizes cells to cisplatin through regulation of the m6A-dependent casein kinase 2 (CK2)α-mediated glycolysis pathway.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Immunology
Tingting Chen, Wenhui Zhu, Congyao Wang, Xia Dong, Fenfen Yu, Yihua Su, Jingwen Huang, Lijun Huo, Pengxia Wan
Summary: This study investigated the role of microglia polarization in the pathogenesis of diabetic retinopathy, as well as the mechanism of ALKBH5-mediated m(6)A modification of A20 in retinal microglia polarization. The results showed that diabetic rats had a higher M1 polarization rate and a lower M2 polarization rate of retinal microglia. With increasing glucose concentration, microglia tended to polarize into the M1 inflammatory type rather than the M2 anti-inflammatory type. Moreover, lower expression of A20 resulted in enhanced M1 polarization of retinal microglia in diabetic retinopathy, which was caused by ALKBH5-mediated m(6)A modification. This study may provide new perspectives on the pathogenesis, diagnosis, and treatment of diabetic retinopathy.
FRONTIERS IN IMMUNOLOGY
(2022)