Article
Multidisciplinary Sciences
Qing Guo, Shuai Shen, Gefei Guan, Chen Zhu, Cunyi Zou, Jingyuan Cao, Wen Cheng, Xiaoyan Xu, Juanhan Yu, Zhiguo Lin, Guoli Wang, Ling Chen, Peng Cheng, Anhua Wu
Summary: Glioblastoma (GBM) shares common signaling pathways involving TIM-3, an immune checkpoint, between tumor and non-tumor cells. The study reveals that TIM-3 in glioma cells not only regulates the malignant behaviors of glioma cells but also induces macrophage migration and transition to an anti-inflammatory/protumorigenic phenotype through the TIM-3/IL6 signal. Blocking this feedback loop may provide a novel therapeutic strategy for GBM.
Review
Cell Biology
Morgan Brisset, Patrick Mehlen, Olivier Meurette, Frederic Hollande
Summary: The heterogeneity of cancer cells plays a significant role in therapeutic failure and post-treatment recurrence. Targeting specific subpopulations responsible for chemoresistance and recurrence may improve treatment outcomes in cancer patients. However, the complexity and incomplete understanding of tumor cell subpopulations make it challenging to achieve this.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Sheng Li, Leilei Zhang, Guoan Zhang, Guoqiang Shangguan, Xitan Hou, Wanglin Duan, Yan Xi, Nan Xu, Bowen Zhang, Junli Dong, Yequan Wang, Wen Cui, Su Chen
Summary: Autophagy is a crucial biological process for maintaining cell homeostasis, with levels usually lower under normal conditions but still with important regulatory factors present. A study revealed that the autophagy-related protein ATG5 regulates c-Myc protein degradation through the ubiquitin-proteasome pathway in normal conditions, limiting cell growth and playing a key role in embryonic stem cell differentiation.
Review
Plant Sciences
Antoine Nicolas, Patrick Laufs
Summary: Plant aerial development relies on meristem activity, with shoot apical meristem (SAM) formed in the embryo contributing to the main stem and axillary meristems (AMs) formed post-embryonically contributing to the branched structure. This review discusses recent findings on the de novo establishment of AMs and emphasizes the progressive process of stem cell formation, different from functional meristems.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Cell & Tissue Engineering
Zhiran Li, Yunhao Wu, Yangbo Fu, Xia Chen, Xi Zhao, Xiaolong Wu, Yajuan Lu, Hui He, Cong Shen, Bo Zheng, Jun Yu, Fei Sun
Summary: This study investigates the communication mechanism between CySC lineage cells and germ cells in Drosophila testes, and reveals the involvement of translation initiation factor eIF5, along with eIF1A or eIF2 gamma, in maintaining the homeostasis of the stem cell population and preventing the formation of TGCTs.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Wenzhe Luo, Yueyuan Xu, Ruige Liu, Yinlong Liao, Sheng Wang, Haoyuan Zhang, Xinyun Li, Heng Wang
Summary: This study reveals the importance of retinoic acid signaling in the maintenance of the quiescent state of satellite cells, achieved through regulation of protein translation initiation.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Joachim Hanna, Flavio Beke, Louise M. O'Brien, Chrysa Kapeni, Hung-Chang Chen, Valentina Carbonaro, Alexander B. Kim, Kamal Kishore, Timon E. Adolph, Mikkel-Ole Skjoedt, Karsten Skjoedt, Marc de la Roche, Maike de la Roche
Summary: The study implicates Hedgehog signaling in Th17 polarization and intestinal immunopathology, suggesting the potential therapeutic use of Hedgehog inhibitors in the treatment of inflammatory bowel disease.
NATURE COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
Peter Uhl, John Lowengrub, Natalia Komarova, Dominik Wodarz
Summary: This study demonstrates that the negative feedback loop from differentiated cells onto stem cell division patterns loses the ability to maintain tissue homeostasis in spatially explicit computational models. However, negative feedback on stem cell division can lead to the spatial organization of stem and differentiated cells into distinct islands. Further research shows that tissue homeostasis can be achieved by combining spatially restricted negative feedback on self-renewal with other experimentally documented spatial control mechanisms.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Ying Ding, Juanjuan Zhao, Xianshuai Xu, Qisheng Zuo, Yani Zhang, Kai Jin, Wei Han, Bichun Li
Summary: Autophagy plays a crucial role in the pluripotency and differentiation of stem cells. It is indispensable for the formation of chicken primordial germ cells (PGCs) and provides a foundation for studying the mechanism of autophagy in chicken PGCs, as well as bird gene editing and the rescue of endangered birds.
STEM CELLS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Hee Yeon Kim, Sung Jin Bae, Ji-Woong Choi, Suji Han, Seung-Hyun Bae, Jae-Ho Cheong, Hyonchol Jang
Summary: The cholesterol synthesis pathway plays an important role in the distant metastasis of breast cancer cells by augmenting tumor sphere formation and invasion capacity.
Article
Cell Biology
Idil Orhon, Cecilia Rocchi, Beatriz Villarejo-Zori, Paola Serrano Martinez, Mirjam Baanstra, Uilke Brouwer, Patricia Boya, Rob Coppes, Fulvio Reggiori
Summary: In dormant salivary gland stem cells, autophagy has a slower flux compared to self-renewing cells; however, enhancement of autophagy upon activation promotes self-renewal and tissue regeneration. Autophagy is a key pathway in activating self-renewal in low proliferative adult tissues, with potential for promoting tissue regeneration through pharmacological manipulation.
Editorial Material
Cell Biology
Kaosheng Lv, Wei Tong
Summary: The novel role of Bmi1 in regulating ribosome biogenesis and protein synthesis in hematopoietic stem cells has been discovered. Bmi1 is essential for maintaining HSCs, and its deficiency leads to reduced transplantability and protein stress.
GENES & DEVELOPMENT
(2022)
Review
Oncology
Wenjun Ren, Yixiao Yuan, Yongwu Li, Luciano Mutti, Jun Peng, Xiulin Jiang
Summary: YTHDF1 is an m6A reader protein that plays a vital role in protein translation, stem cell self-renewal, and embryonic development. It regulates target gene expression through various mechanisms, including promoting protein translation and modulating mRNA stability. The cellular levels of YTHDF1 are tightly controlled by transcriptional, post-transcriptional, and post-translational mechanisms.
BIOMARKER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiaofeng Li, Peng Chen, Junxiang Ji, Quanchao Duan, Jianjian Cao, Ru Huang, Shou-Dong Ye
Summary: In this study, the researchers found that overexpression of Rhox6 promotes the formation of primordial germ cell-like cells (PGCLCs), while depletion of Rhox6 inhibits the generation of PGCLCs. Mechanistically, Rhox6 directly induces the expression of Nanos3 during PGCLC specification. In addition, depletion of Rhox6 facilitates the self-renewal of mouse embryonic stem cells (mESCs) through upregulation of pluripotency genes and downregulation of Tbx3 expression.
CELL AND BIOSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Victor Schweiger, Ena Hasimbegovic, Nina Kastner, Andreas Spannbauer, Denise Traxler, Mariann Gyoengyoesi, Julia Mester-Tonczar
Summary: This article discusses the challenges of myocardial infarction-induced cardiomyocyte loss and impaired ventricular function, as well as the potential of stem cell therapy in cardiac regeneration. The focus of the research is on the role of ncRNAs in regulating stem cells, particularly circRNAs and miRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Environmental Sciences
Francisco Alejandro Lagunas-Rangel, Blazej Kudlak, Wen Liu, Michael J. Williams, Helgi B. Schioth
Summary: Tumor suppressor genes, including circadian clock genes, play a crucial role in the development of leukemia. Environmental pollutants, such as benzene and tobacco smoke, may disrupt circadian rhythms and potentially contribute to the development of leukemia. Interdisciplinary research and advanced methodologies are needed to further explore the relationship between environmental pollution and leukemia.
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2022)
Article
Environmental Sciences
Francisco Alejandro Lagunas-Rangel, Wen Liu, Helgi B. Schioth
Summary: Environmental pollutants can have harmful effects on health and be linked to the development of diseases, including cancer. Exposure to certain pollutants may increase the risk of developing cancer and reduce the efficacy of chemotherapy drugs. Molecular mechanisms such as apoptosis evasion, DNA damage repair, activation of pro-cancer signaling pathways, drug efflux, and action of antioxidant enzymes may contribute to the chemoresistance caused by environmental pollutants.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Francisco Alejandro Lagunas-Rangel
Summary: Aging is caused by the accumulation of molecular and cellular damage over time. SIRT7, an enzyme with important functions in aging and life extension, has been found to be closely related to age-related processes and may be associated with certain age-related diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Michael J. Williams, Ahmed M. Alsehli, Sarah N. Gartner, Laura E. Clemensson, Sifang Liao, Anders Eriksson, Kiriana Isgrove, Lina Thelander, Zaid Khan, Pavel M. Itskov, Thiago C. Moulin, Valerie Ambrosi, Mohamed H. Al-Sabri, Francisco Alejandro Lagunas-Rangel, Pawel K. Olszewski, Helgi B. Schioth
Summary: This study reveals the significant role of central Hmgcr in regulating metabolism, feeding behavior, and insulin signaling, which in turn affects body size, lipid storage, and blood glucose levels, potentially influencing BMI.
Review
Environmental Sciences
Francisco Alejandro Lagunas-Rangel, Jenni Viivi Linnea-Niemi, Blazej Kudlak, Michael J. Williams, Jorgen Jonsson, Helgi B. Schioth
Summary: There is an increasing awareness of the adverse health effects caused by the large number of environmental pollutants we are exposed to on a daily basis. However, compared to individual pollutants, there are relatively few studies on how pollutant mixtures interact and contribute to these health problems, especially in relation to cancer development. This paper discusses recent reports on possible synergistic interactions between different types of environmental pollutants and their impact on cancer development. The need for a better understanding of the physiological effects of pollutant mixtures, as well as improvements in research methodologies and tools, is emphasized.
Review
Oncology
Francisco Alejandro Lagunas-Rangel
Summary: This article discusses the molecular mechanisms of FLT3-ITD in acute myeloid leukemia, including its impact on cell survival and proliferation, on reactive oxygen species and DNA damage repair, and how it facilitates clonal evolution. The feasibility of combined therapies with FLT3 inhibitors and inhibitors of DNA repair pathways is also explored.
HEMATOLOGICAL ONCOLOGY
(2023)
Article
Toxicology
Francisco Alejandro Lagunas-Rangel, Wen Liu, Helgi B. Schioth
Summary: Every day, exposure to environmental pollutants poses a significant risk to our health, and studies show that these pollutants contribute to millions of deaths annually. This research focuses on the impact of specific pollutants on the efficacy of vincristine treatment for acute lymphoblastic leukemia (ALL) in pediatric patients. The study reveals that low concentrations of bisphenol A (BPA), bisphenol A diglycidyl ether (BADGE), and perfluorooctanoic acid (PFOA) can reduce the cytotoxic effects of vincristine on ALL cells, highlighting the importance of considering pollutant exposure during chemotherapy treatment.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Francisco Alejandro Lagunas-Rangel
Summary: Sirtuins, including SIRT7, are highly conserved proteins that play important roles in various cellular processes. This study analyzed the sequence and structure of SIRT7 orthologs in different organisms, revealing key residues and a conserved catalytic domain. A phylogenetic tree showed distinct clustering of SIRT7 orthologs from various animal groups. Predicted three-dimensional structures displayed the classic catalytic region structure of most sirtuins, with unique N- and C-terminal regions for each phylogenetic group. This research contributes to our understanding of SIRT7 function and provides insights for the development of small molecules for human and animal health.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Francisco Alejandro Lagunas-Rangel
Summary: Cancer is a major global health concern, with high mortality rates. SIRT5, a protein involved in metabolic pathways, has a dual role in cancer, acting as a tumor suppressor or an oncogene depending on the cellular context. Its tumor suppressor role includes prevention of the Warburg effect, protection against ROS, and inhibition of cell proliferation and metastasis. However, as an oncogene, it promotes the opposite effects and increases resistance to chemotherapy and/or radiotherapy. This study aimed to identify the beneficial and deleterious effects of SIRT5 in different types of cancer based on their molecular characteristics, and assess its potential as a therapeutic target.
Review
Cell Biology
Francisco A. Lagunas-Rangel
Summary: The Fas/FasL system plays a significant role in apoptosis regulation and is implicated in the pathogenesis of neoplasms and immune system diseases. It is also involved in the development of age-related diseases. Exercise and diet can produce beneficial effects by regulating the Fas/FasL system.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Francisco Alejandro Lagunas-Rangel
Summary: Resveratrol, a natural compound, has diverse biological functions that provide health benefits in normal conditions and various diseases. This study used bioinformatics systems, RNA sequencing analysis, and protein-protein interaction networks to identify 16 potential target proteins of resveratrol. Further investigation focused on the interaction between resveratrol and the predicted target CDK5, revealing that resveratrol can bind to CDK5 in its ATP-binding pocket and inhibit its activity. These findings enhance our understanding of how resveratrol works and suggest the importance of CDK5 inhibition in its biological actions, particularly in neurodegenerative diseases.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Endocrinology & Metabolism
Alexander Rabinovitch, Daniil Koshelev, Francisco Alejandro Lagunas-Rangel, Liudmila Kosheleva, Tali Gavra, Helgi B. Schioth, Shmuel Levit
Summary: The purpose of this retrospective clinic chart review study was to determine the potential of a combination therapy consisting of gamma-aminobutyric acid (GABA), a dipeptidyl peptidase-4 inhibitor (DPP-4i), and a proton pump inhibitor (PPI) to improve glycemic control in patients with type 1 diabetes (T1D). The study found that the combination therapy significantly decreased fasting blood glucose, HbA1c, insulin dose, and insulin/weight ratio, while increasing fasting plasma C-peptide levels.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Parasitology
Francisco Alejandro Lagunas-Rangel
Summary: Giardia duodenalis is a common intestinal parasite causing infections primarily in low-income and developing countries, with treatment failures being a major concern. The nucleolus, as a vital structure within the eukaryotic nucleus, plays a crucial role in multiple essential cellular processes. Targeting the Giardia nucleolus presents a potential therapeutic avenue for anti-Giardia treatments. However, the understanding of the Giardia nucleolus is limited, and this study aims to provide a detailed molecular description of its structure, function, and potential as a therapeutic target.
PARASITOLOGY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Francisco Alejandro Lagunas-Rangel, Sifang Liao, Michael J. Williams, Vladimir Trukhan, Robert Fredriksson, Helgi B. Schioth
Summary: DPP4 inhibitors are effective in treating type 2 diabetes, but recent studies have shown adverse effects. Finding alternative methods is important, and Drosophila has emerged as a promising tool for screening new compounds.
Article
Cell Biology
Francisco Alejandro Lagunas-Rangel
Summary: SIRT7, a member of the sirtuin family, has emerged as a key player in various cellular processes and is involved in the development and progression of diseases, especially cancer. This review aims to provide an in-depth understanding of the role of SIRT7 in cancer carcinogenesis and progression by elucidating the underlying molecular mechanisms, and also discusses the feasibility and challenges associated with the development of drugs that can modulate SIRT7 activity.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
