Review
Medicine, General & Internal
Alessandro Mandurino-Mirizzi, Andrea Munafo, Gabriele Crimi
Summary: This review provides a summary of CA-AKI, including its epidemiology, risk stratification, diagnostic criteria, pathophysiology, clinical implications, and evidence for preventive strategies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Qingqing Li, Shengqi Pan
Summary: Contrast-induced acute kidney injury (CI-AKI) refers to a decrease in renal function after the intravascular administration of contrast medium. However, recent studies suggest that this decrease in renal function may be caused by factors other than contrast medium alone. The term contrast-associated acute kidney injury (CA-AKI) is increasingly used to indicate AKI after contrast medium administration, and its pathophysiological mechanism and effective preventive and therapeutic measures are still being debated.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Medicine, General & Internal
Kang Liu, Meiyuan Li, Li Li, Buyun Wu, Xueqiang Xu, Yifei Ge, Huijuan Mao, Changying Xing
Summary: The study found that undergoing cardiac surgery within 7 days after coronary angiography was not associated with increased incidence of postoperative acute kidney injury or worse prognosis. Age, cardiopulmonary bypass, and diabetes were identified as independent risk factors of postoperative acute kidney injury.
FRONTIERS IN MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Kavish R. Patidar, Mobasshir A. Naved, Ananth Grama, Mohammad Adibuzzaman, Arzina Aziz Ali, James E. Slaven, Archita P. Desai, Marwan S. Ghabril, Lauren Nephew, Naga Chalasani, Eric S. Orman
Summary: This study investigated hospitalized patients with cirrhosis and acute kidney injury in the US and found that acute kidney disease developed in 1 in 3 patients, which was associated with worse survival and chronic kidney disease.
JOURNAL OF HEPATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xihong Li, Qingqing Chen, Xinrui Yang, Duanbin Li, Changqing Du, Jun Zhang, Wenbin Zhang
Summary: This study found that female sex, perioperative anemia conditions, and lower erythrocyte parameters are risk factors for CA-AKI in patients undergoing CAG. The study also revealed that lower erythrocyte parameters in females have an indirect effect on sex differences in CA-AKI incidence.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yong Liu, Ning Tan, Yong Huo, Shi-Qun Chen, Jin Liu, Yan Wang, Lang Li, Jian-Hong Tao, Xi Su, Li Zhang, Qing-Xian Li, Jin-Ying Zhang, Yan-Song Guo, Zhi-Min Du, Yin-Pin Zhou, Zhen-Fei Fang, Guang-Ma Xu, Yan Liang, Ling Tao, Hui Chen, Zheng Ji, Bing Han, Ping-Yan Chen, Jun-Bo Ge, Ya-Ling Han, Ji-Yan Chen
Summary: This study found that in patients with chronic kidney disease, simplified rapid hydration is as effective as standard hydration in preventing contrast-associated acute kidney injury, with a shorter duration of hydration. This result is clinically significant for preventing contrast-associated acute kidney injury.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Nutrition & Dietetics
Ming Ying, Junqing Yang, Zhidong Huang, Yihang Ling, Bo Wang, Haozhang Huang, Qiang Li, Jin Liu, Yong Liu, Zhujun Chen
Summary: Malnutrition is an independent risk factor for contrast-associated acute kidney injury (CA-AKI) in congestive heart failure (CHF) patients following coronary angiography (CAG).
FRONTIERS IN NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Dianhua Zhou, Zhubin Lun, Bo Wang, Jin Liu, Liwei Liu, Guanzhong Chen, Ming Ying, Huanqiang Li, Shiqun Chen, Ning Tan, Jiyan Chen, Yong Liu, Jianfeng Ye
Summary: This study found a significant correlation between non-recovered contrast-associated acute kidney injury (CA-AKI) and long-term mortality. In patients with coronary artery disease (CAD), even recovered CA-AKI can increase the risk of all-cause mortality. Clinicians need to pay attention to CA-AKI patients whose kidney function has not recovered, and active prevention treatments should be taken by CAD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Solos Jaturapisanukul, Sathit Kurathong, Tanun Ngamvichchukorn, Thananda Trakarnvanich
Summary: This study suggests that prophylactic administration of curcuminoids, in addition to standard treatment, can reduce the incidence of PC-AKI in patients with chronic kidney disease undergoing elective coronary angiography, and have a protective effect on renal function.
Article
Immunology
Wenguang Lai, Xiaoli Zhao, Zhidong Huang, Yun Xie, Sijia Yu, Jiabin Tu, Dachuan Guo, Jiaming Xiu, Ziling Mai, Qiang Li, Haozhang Huang, Huanqiang Li, Jun-Yan Xu, Hongyu Lu, Guanzhong Chen, Shiqun Chen, Jin Liu, Yong Liu
Summary: This study analyzed the relationship between systemic immune inflammation index (SII) and contrast-associated acute kidney injury (CA-AKI) following coronary angiography (CAG). The results showed that elevated preprocedural SII levels were associated with an increased risk of CA-AKI.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Pablo Michel, Javier Amione-Guerra, Omar Sheikh, Lauren C. Jameson, Shweta Bansal, Anand Prasad
Summary: The analysis of published data showed that intravascular volume expansion is effective in preventing CA-AKI, with intensive IV volume expansion further decreasing the risk of CA-AKI.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Qingqing Chen, Duanbin Li, Hangpan Jiang, Tianli Hu, Yecheng Tao, Changqing Du, Wenbin Zhang
Summary: This retrospective study found an association between cardiac remodeling and contrast-associated acute kidney injury (CA-AKI). Specifically, left ventricular internal end-systolic diameter index (LVIDSI), left ventricular internal end-diastolic diameter index (LVIDDI), and left ventricular mass index (LVMI) were positively correlated with the risk of CA-AKI. These associations were consistent in different subgroups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ulf Nyman, Peter Leander, Per Liss, Gunnar Sterner, Torkel Brismar
Summary: Glomerular filtration rate (GFR) is the best index to evaluate kidney function and its use is recommended to assess the risk of iodine contrast medium-induced acute kidney injury (CI-AKI). GFR can be expressed in absolute terms (mL/min) or adjusted to body surface area (mL/min/1.73 m(2)). Absolute GFR represents the excretion capacity, while relative GFR is used to assess the degree of kidney damage and sensitivity for CI-AKI.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Duanbin Li, Hangpan Jiang, Xinrui Yang, Maoning Lin, Menghan Gao, Zhezhe Chen, Guosheng Fu, Dongwu Lai, Wenbin Zhang
Summary: An online pre-procedural nomogram for predicting contrast-associated acute kidney injury (CA-AKI) was established and validated in patients undergoing coronary angiography (CAG). The nomogram integrates seven pre-procedural predictors and shows good discrimination performance and clinical usefulness. It has been deployed online for public use.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Benedikt Frank, Jordi Kuehne Escola, Leoni Biermann-Ratjen, Anika Huesing, Yan Li, Philipp Dammann, Ulrich Sure, Christoph Kleinschnitz, Michael Forsting, Martin Koehrmann, Cornelius Deuschl
Summary: The additional administration of contrast medium for perfusion imaging in acute stroke did not significantly increase the risk of post-contrast acute kidney injury (PC-AKI). Patients with intracranial hemorrhage and/or a history of prior kidney disease are more likely to develop AKI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Transplantation
Daniel Lazzareschi, Ravindra L. Mehta, Laura M. Dember, Juliane Bernholz, Alparslan Turan, Amit Sharma, Sachin Kheterpal, Chirag R. Parikh, Omar Ali, Ivonne H. Schulman, Abigail Ryan, Jean Feng, Noah Simon, Romain Pirracchio, Patrick Rossignol, Matthieu Legrand
Summary: Acute kidney injury is a growing epidemic that is associated with increased risk of death, chronic kidney disease, and cardiovascular events. Clinical trials in this field are challenging due to the heterogeneity of the disease. Identifying subphenotypes of acute kidney injury can help elucidate its diverse etiologies and enhance prevention and treatment strategies.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Kalie L. Tommerdahl, Emily A. Hu, Elizabeth Selvin, Lyn M. Steffen, Josef Coresh, Morgan E. Grams, Petter Bjornstad, Casey M. Rebholz, Chirag R. Parikh
Summary: In the ARIC study, higher coffee intake was associated with a lower risk of incident AKI, indicating that coffee may have cardiorenal protective effects. Further evaluation of the physiological mechanisms underlying these effects is needed.
KIDNEY INTERNATIONAL REPORTS
(2022)
Review
Urology & Nephrology
Benjamin Talbot, Alan Cass, Robert Walker, Lai Hooi, Meg Jardine, Min Jun, Kris Rogers, Louisa Sukkar, Brendan Smyth, Martin Gallagher
Summary: This study examined whether there were differences in survival and causes of death among participants from Australia, Malaysia, and New Zealand in the extended follow-up of the SHARP study. It was found that participants from Malaysia and New Zealand had a higher risk of death compared to participants from Australia.
Article
Transplantation
Rakesh Malhotra, Ronit Katz, Paul L. Kimmel, Ramachandran S. Vasan, Jeffrey S. Schelling, Jason H. Greenberg, Chirag R. Parikh, Joseph Bonventre, Tala Al-Rousan, Mark J. Sarnak, Orlando M. Gutierrez, Michael G. Shlipak, Joachim H. Ix
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Min Jun, Anish Scaria, Jason Andrade, Sunil Badve, Peter Birks, Sarah E. Bota, Anna Campain, Ognjenka Djurdjev, Amit X. Garg, Jeffrey Ha, Ziv Harel, Brenda Hemmelgarn, Carinna Hockham, Matthew T. James, Meg J. Jardine, Adeera Levin, Eric McArthur, Pietro Ravani, Selena Shao, Manish M. Sood, Zhi Tan, Navdeep Tangri, Reid Whitlock, Martin Gallagher
Summary: This study found that the use of DOACs in atrial fibrillation patients was associated with a lower or similar risk of all-cause death, ischemic stroke, and major bleeding compared to the use of warfarin, regardless of kidney function levels.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Medicine, General & Internal
Ying Xie, Jin Lin, Martin Gallagher, Rinaldo Bellomo, Xia Wang, Meg Jardine, Meili Duan, Amanda Wang
Summary: This study aimed to investigate the associations between baseline blood glucose levels (BGL), glycemic variability, and clinical outcomes in severe acute kidney injury (AKI) patients receiving continuous renal replacement therapy (CRRT). The findings suggest that low baseline BGL within the normal physiological range and higher glycemic variability are significant modifiable risk factors for mortality in ICU patients with severe AKI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Pavan K. Bhatraju, David K. Prince, Sherry Mansour, T. Alp Ikizler, Edward D. Siew, Vernon M. Chinchilli, Amit X. Garg, Alan S. Go, James S. Kaufman, Paul L. Kimmel, Steve G. Coca, Chirag R. Parikh, Mark M. Wurfel, Jonathan Himmelfarb
Summary: This study identifies AKI subphenotypes that are molecularly distinct and have different risks of long-term outcomes, independent of the current criteria for risk stratifying AKI.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Urology & Nephrology
Steven Menez, Steven G. Coca, Dennis G. Moledina, Yumeng Wen, Lili Chan, Heather Thiessen-Philbrook, Wassim Obeid, Brian T. Garibaldi, Evren U. Azeloglu, Ugochukwu Ugwuowo, C. John Sperati, Lois J. Arend, Avi Z. Rosenberg, Madhurima Kaushal, Sanjay Jain, F. Perry Wilson, Chirag R. Parikh
Summary: The study found that sTNFR1 and sTNFR2 are independently associated with MAKE in patients hospitalized with COVID-19, and both can serve as predictors for adverse kidney outcomes.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Review
Urology & Nephrology
Benjamin Lazarus, Elisa Bongetti, Jonathan Ling, Martin Gallagher, Sradha Kotwal, Kevan R. Polkinghorne
Summary: Multifaceted quality improvement interventions may prevent hemodialysis catheter-related bloodstream infections outside of the ICU. However, the evidence supporting them is of low quality and further carefully conducted studies are warranted.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Urology & Nephrology
Lawrence Ledoux-Hutchinson, Ron Wald, Manu L. N. G. Malbrain, Francois Martin Carrier, Sean M. Bagshaw, Rinaldo Bellomo, Neill K. J. Adhikari, Martin Gallagher, Samuel A. Silver, Josee Bouchard, Michael J. J. Connor Jr, Edward G. Clark, Jean-Maxime Cote, Javier A. Neyra, Andre Denault, William Beaubien-Souligny
Summary: This international survey aimed to evaluate current practices and knowledge gaps related to fluid removal with KRT in critically ill patients. The survey revealed variations in fluid removal targets and differences between nephrologists and intensivists in fluid management methods and adjunct assessment methods. Most physicians agreed on the need for randomized controlled trials to address knowledge gaps in fluid management strategies.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Letter
Urology & Nephrology
Dipal M. Patel, Sumeska Thavarajah, Jack Bitzel, Thomas Grader-Beck, Derek M. Fine, Morgan E. Grams, Chirag R. Parikh, Deidra C. Crews
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Jeffrey T. Ha, Anish Scaria, Jason Andrade, Sunil V. Badve, Peter Birks, Sarah E. Bota, Anna Campain, Ognjenka Djurdjev, Amit X. Garg, Ziv Harel, Brenda Hemmelgarn, Carinna Hockham, Matthew T. James, Meg J. Jardine, Dickson Lam, Adeera Levin, Eric McArthur, Pietro Ravani, Selena Shao, Manish M. Sood, Zhi Tan, Navdeep Tangri, Reid Whitlock, Martin Gallagher, Min Jun
Summary: The benefit-risk profile of rivaroxaban versus warfarin for atrial fibrillation (AF) in patients with chronic kidney disease is uncertain. This study compared the effectiveness and bleeding risk of rivaroxaban and warfarin in adults with AF across different levels of kidney function. The results showed that rivaroxaban was associated with lower or similar risk of all-cause death, ischemic stroke, and transient ischemic attack, as well as similar risk of bleeding, compared to warfarin, regardless of kidney function.
Article
Urology & Nephrology
Kuan Jiang, Jason H. Greenberg, Alison Abraham, Yunwen Xu, Jeffrey R. Schelling, Harold I. Feldman, Sarah J. Schrauben, Sushrut S. Waikar, Michael G. Shlipak, Nicholas Wettersten, Steven G. Coca, Ramachandran S. Vasan, Orlando M. Gutierrez, Joachim H. Ix, Bradley A. Warady, Paul L. Kimmel, Joseph V. Bonventre, Chirag R. Parikh, Mark M. Mitsnefes, Michelle R. Denburg, Susan Furth
Summary: The prevalence of left ventricular hypertrophy (LVH) in children with chronic kidney disease (CKD) is associated with increased levels of kidney injury molecule-1 (KIM-1), monocyte chemoattractant protein-1 (MCP-1), and decreased levels of urine alpha-1 microglobulin (alpha-1m).
Article
Medicine, General & Internal
Hiddo J. L. Heerspink, Jai Radhakrishnan, Charles E. Alpers, Jonathan Barratt, Stewart Bieler, Ulysses Diva, Jula Inrig, Radko Komers, Alex Mercer, Irene L. Noronha, Michelle N. Rheault, William Rote, Brad Rovin, Howard Trachtman, Hernin Trimarchi, Muh Geot Wong, Vlado Perkovic
Summary: This study investigates the efficacy and safety of sparsentan, a novel medication, in adults with IgA nephropathy. The results demonstrate that sparsentan treatment significantly reduces proteinuria compared to irbesartan, with similar safety profiles. Further long-term studies are required to confirm the nephroprotective potential of sparsentan.
Article
Urology & Nephrology
Alison Craswell, Debbie Massey, Deepa Sriram, Marianne Wallis, Kevan Polkinghorne, Girish Talaulikar, Alan Cass, Martin Gallagher, Nicholas Gray, Sradha Kotwal
Summary: This study evaluates the implementation of a care bundle to standardize the practices of central venous catheters for hemodialysis. However, no reduction in catheter-related infections was observed. The process evaluation reveals that resistance to change in low-infection environments and the need for individualized patient education are barriers to the adoption of the care bundle.