Preliminary study on radiosensitivity to carbon ions in human breast cancer

High linear energy transfer carbon-ion irradiation increases the release of the immune mediator high mobility group box 1 from human cancer cells

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Melatonin restrains angiogenic factors in triple-negative breast cancer by targeting miR-152-3p: In vivo and in vitro studies

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Apoptosis induction in human breast cancer cell lines by synergic effect of raloxifene and resveratrol through increasing proapoptotic genes

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Apoptosis and injuries of heavy ion beam and x-ray radiation on malignant melanoma cell

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Carbon ion irradiation abrogates Lin28B-induced X-ray resistance in melanoma cells

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Estrogen Receptor Mediates the Radiosensitivity of Triple-Negative Breast Cancer Cells

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Radiosensitizing effect of diosmetin on radioresistant lung cancer cells via Akt signaling pathway

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Preclinical validation of a novel compound targeting p70S6 kinase in breast cancer

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Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions

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H2AX phosphorylation and DNA damage kinase activity are dispensable for herpes simplex virus replication

(2016) Carolyn Botting et al.   Virology Journal

Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells

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Targeting PI3K/Akt/mTOR signaling pathway in the treatment of prostate cancer radioresistance

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Targeting EGFR-PI3K-AKT-mTOR signaling enhances radiosensitivity in head and neck squamous cell carcinoma

(2015) Dominik Horn et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Role of the MAPK pathway in the observed bystander effect in lymphocytes co-cultured with macrophages irradiated with γ-rays or carbon ions

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Carbon ion beam combined with cisplatin effectively disrupts triple negative breast cancer stem-like cells in vitro

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Carbon ions induce autophagy effectively through stimulating the unfolded protein response and subsequent inhibiting Akt phosphorylation in tumor cells

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Downregulation of Cdk1 and CyclinB1 Expression Contributes to Oridonin-induced Cell Cycle Arrest at G2/M Phase and Growth Inhibition in SGC-7901 Gastric Cancer Cells

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Quantitative characteristics of clustered DNA damage in irradiated cells by heavy ion beams

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Increased effectiveness of carbon ions in the production of reactive oxygen species in normal human fibroblasts

(2014) Till Dettmering et al.   JOURNAL OF RADIATION RESEARCH

Targeting the epigenetic machinery of cancer cells

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Carbon Ion Radiation Inhibits Glioma and Endothelial Cell Migration Induced by Secreted VEGF

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Carbon-Ion Beam Irradiation Kills X-Ray-Resistant p53-Null Cancer Cells by Inducing Mitotic Catastrophe

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Bringing the heavy: carbon ion therapy in the radiobiological and clinical context

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PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways

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Simulated microgravity increases heavy ion radiation-induced apoptosis in human B lymphoblasts

(2013) Bingrong Dang et al.   LIFE SCIENCES

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Heavy Ion Radiation Exposure Triggered Higher Intestinal Tumor Frequency and Greater β-Catenin Activation than γ Radiation in APCMin/+ Mice

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Acquisition of epithelial–mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance

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(2013) Tatsuya Ohno   EPMA Journal

Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation

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mTOR Signaling in Growth Control and Disease

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Distinct distribution and prognostic significance of molecular subtypes of breast cancer in Chinese women: a population-based cohort study

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Carbon Ion Irradiation Suppresses Metastatic Potential of Human Non-small Cell Lung Cancer A549 Cells through the Phosphatidylinositol-3-Kinase/Akt Signaling Pathway

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mTOR Kinase Domain Phosphorylation Promotes mTORC1 Signaling, Cell Growth, and Cell Cycle Progression

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Heavy charged particle radiobiology: Using enhanced biological effectiveness and improved beam focusing to advance cancer therapy

(2011) Christopher Allen et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Unrepaired clustered DNA lesions induce chromosome breakage in human cells

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