Article
Biochemistry & Molecular Biology
Tingting Yin, Sheng Chen, Guohua Zeng, Wanwan Yuan, Yanli Lu, Yanan Zhang, Qianqian Huang, Xiaowei Xiong, Baohua Xu, Qiren Huang
Summary: The knockout of the ASP gene promotes the browning and angiogenesis of white adipose tissue in mice, leading to weight loss in obese mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yaoli Liu, Xiazhou Fu, Zhiyong Chen, Tingting Luo, Chunxia Zhu, Yaoting Ji, Zhuan Bian
Summary: Sulforaphane (SFN) shows potential as a nutritional factor in combating obesity by promoting the browning of white fat, which decreases fat mass, improves glucose metabolism, and enhances insulin sensitivity. This suggests that SFN could serve as a potential medicine in anti-obesity and related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Physiology
Mingchen Xiong, Weijie Hu, Yufang Tan, Honghao Yu, Qi Zhang, Chongru Zhao, Yi Yi, Yichen Wang, Yiping Wu, Min Wu
Summary: The study revealed that E2F1 knockout increased mitochondria and UCP-1 expression in mouse adipose tissue by suppressing autophagy, promoting WAT browning. In vitro experiments showed that adipocytes lacking E2F1 exhibited upregulated UCP-1 and downregulated autophagy-related gene expression.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Applied
Ahyoung Yoo, Min Jung Kim, Jiyun Ahn, Chang Hwa Jung, Hyo Deok Seo, Sun Yung Ly, Tae Youl Ha
Summary: Fuzhuan brick tea extract exerts anti-obesity effects by promoting browning of subcutaneous adipose tissue and enhancing energy expenditure.
Article
Endocrinology & Metabolism
Nuria Oliveras-Canellas, Jose Maria Moreno-Navarrete, Paula M. Lorenzo, Lourdes Garrido-Sanchez, Sara Becerril, Oriol Rangel, Jessica Latorre, Elena de la Calle Vargas, Maria Pardo, Victor Valenti, Juan L. Romero-Cabrera, Wilfredo Oliva-Olivera, Camilo Silva, Carlos Dieguez, Francesc Villarroya, Miguel Lopez, Ana B. Crujeiras, Luisa-Maria Seoane, Jose Lopez-Miranda, Gema Fruhbeck, Francisco Jose Tinahones, Jose-Manuel Fernandez-Real
Summary: This study investigated how outside temperature affects adipose tissue physiology and metabolic traits. The expression of genes associated with browning and adipogenesis in the subcutaneous adipose tissue were found to be negatively associated with temperature. These findings could have implications for the relationship between the obesity pandemic and global warming.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Bruna Caprioli, Rosangela A. S. Eichler, Renee N. O. Silva, Luiz Felipe Martucci, Patricia Reckziegel, Emer S. Ferro
Summary: This study demonstrates the importance of neurolysin oligopeptidase (Nln) in insulin signaling and glucose uptake, as well as its involvement in the physiological mechanisms related to diet-induced obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marcelo Paradiso Marinovic, Celso Pereira Batista Sousa-Filho, Fernanda Aparecida Heleno Batista, Thayna Mendonca Avelino, Bruno Cogliati, Ana Carolina Migliorini Figueira, Rosemari Otton, Alice Cristina Rodrigues
Summary: This study demonstrates that green tea can improve non-alcoholic fatty liver disease (NAFLD), and this improvement is dependent on the action of adiponectin in the liver. The researchers found that catechins in green tea can reduce hepatic steatosis in a PPAR alpha-dependent manner.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Food Science & Technology
Yang-Ju Son, Da Seul Jung, Ji Min Shin, Saruul Erdenebileg, Chu Won Nho
Summary: HD extract showed significant effects on weight reduction and improvement of serum lipid status in a high-fat diet-induced metabolic syndrome mouse model. Additionally, HD extract can alleviate oxidation, inflammation, and insulin resistance through various mechanisms, while also increasing energy expenditure.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Yuqin Zhu, Haoran Li, Mengchen Ma, Dandan Li, Ouyang Zhang, Suili Cai, Yajiao Wang, Dandan Chen, Shengnan Jin, Chunming Ding, Liang Xu
Summary: This study demonstrates the therapeutic effects of Swertiamarin (STM) on preventing obesity and its associated metabolic diseases. STM improves energy expenditure, promotes fat browning, and reduces fat deposition in mice with preexisting obesity. These findings suggest that STM may serve as a potential therapy for obesity.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Cell Biology
Lin Jia, Yinyan Ma, Jamie Haywood, Long Jiang, Bingzhong Xue, Hang Shi, Paul A. Dawson, Liqing Yu
Summary: NPC1L1 knockout mice fed a high-fat diet exhibit increased energy expenditure and bile acid pool size, with elevated expression of genes related to energy expenditure in brown adipose tissue, potentially contributing to protection against HFD-induced obesity.
Article
Nutrition & Dietetics
Joshua P. Nederveen, Katherine Manta, Adam L. Bujak, Alexander C. Simone, Matthew R. Fuda, Mats Nilsson, Bart P. Hettinga, Meghan C. Hughes, Christopher G. R. Perry, Mark A. Tarnopolsky
Summary: The study found that a novel multi-ingredient nutritional supplement induced significant fat loss in obese mice independent of physical activity while preserving muscle mass. Mechanistically, these supplements appear to act by inducing a browning program in white adipose tissue and decreasing pathophysiological impairments associated with obesity, including mitochondrial respiration alterations induced by a high-fat diet.
Article
Nutrition & Dietetics
Mi Jin Choi, Hana Yu, Jea Il Kim, Hee Seo, Ju Gyeong Kim, Seul-Ki Kim, Hak Sung Lee, Hyae Gyeong Cheon
Summary: This study demonstrates that Lactiplantibacillus plantarum SKO-001 has anti-obesity effects by reducing body weight gain and improving metabolic abnormalities in adipose and liver tissues. These findings suggest that SKO-001 could be a potential therapeutic or functional food for obesity treatment.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Prakash Raj Pandeya, Kyung-Hee Lee, Ramakanta Lamichhane, Gopal Lamichhane, Amrit Poudel, Hyun-Ju Jung
Summary: This study demonstrated the potential therapeutic role of herbal formulation F2 in treating obesity using the DIO mice model. F2 showed significant anti-obesity activity by reducing body weight gain, improving serum lipid profile, and decreasing white adipose tissue mass. The study also highlighted the quality control of F2 using the UPLC-DAD method and standardized it with five reference compounds.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Ji-Won Kim, Young-Mo Yang, Eun-Young Kwon, Ji-Young Choi
Summary: This study investigated the anti-obesity effect of Phlomis umbrosa Turcz. root ethanol extract (PUE) and found that PUE treatment can reduce diet-induced obesity and modulate associated metabolic disorders. The mechanisms involve suppressing hepatic lipogenesis and lipid absorption, increasing biliary sterol excretion and hepatic fatty acid oxidation, as well as activating the browning of white adipose tissue and brown adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Marlou Klein Hazebroek, Susanne Keipert
Summary: Metabolic diseases are a major health burden in modern society, but fibroblast growth factor 21 (FGF21) shows promise as a therapeutic target. However, obesity leads to increased resistance to FGF21, reducing its effectiveness. Interestingly, certain gene knockout mice show improved FGF21 sensitivity and resistance to obesity. These findings suggest that FGF21 sensitivity in adipose tissue is crucial for metabolic improvements.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ailma O. da Paixao, Anaysa Paola Bolin, Joao G. Silvestre, Alice Cristina Rodrigues
Summary: The saturated fatty acid palmitic acid negatively affects muscle tube diameter, fusion, and metabolism, which may be related to miR-206.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Meeting Abstract
Endocrinology & Metabolism
Bruna A. C. Santos, Lucas A. F. da Rocha, Emer S. Ferro, Alice C. Rodrigues
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Genetics & Heredity
Bruna Los, Jessica B. Borges, Victor F. Oliveira, Renata C. C. Freitas, Carolina Dagli-Hernandez, Raul H. Bortolin, Rodrigo M. Goncalves, Andre A. Faludi, Alice C. Rodrigues, Gisele M. Bastos, Cinthia E. Jannes, Alexandre C. Pereira, Rosario D. C. Hirata, Mario H. Hirata
Summary: In this study, functional analysis of PCSK9 3' UTR variants and mRNA-miRNA interactions were conducted in patients with familial hypercholesterolemia (FH). It was found that PCSK9 c.*345C>T may act as a loss-of-function variant and miR-4721 and miR-564 could downregulate PCSK9 expression, potentially improving the lipid profile in FH patients.
Article
Physiology
Fabio Rocha de Lima, Douglas Popp Marin, Leticia Torres Ferreira, Celso Pereira Batista Sousa Filho, Todd Anthony Astorino, Jonato Prestes, Marcelo Luis Marquezi, Rosemari Otton
Summary: The study found that partial BFR can increase muscular strength without increasing oxidative stress biomarkers in untrained men. Additionally, total BFR promoted similar responses of oxidative stress and markers of immune cell apoptosis compared to traditional RT.
FRONTIERS IN PHYSIOLOGY
(2021)
Correction
Medicine, Research & Experimental
Tamires Duarte Afonso Serdan, Laureane Nunes Mais, Joice Naiara Bertaglia Pereira, Luiz Eduardo Rodrigues, Amanda Lins Alecrim, Maria Vitoria Martins Scervino, Vinicius Leonardo Sousa Diniz, Alef Araga Carneiro dos Santos, Celso Pereira Batista Sousa Filho, Tatiana Carolina Alba-Loureiro, Gabriel Nasri Marzuca-Nassr, Roberto Barbosa Bazotte, Renata Gorja, Tania Cristina Pithon-Curi, Rui Curi, Sandro Massao Hirabara
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Marcelo Paradiso Marinovic, Celso Pereira Batista Sousa-Filho, Fernanda Aparecida Heleno Batista, Thayna Mendonca Avelino, Bruno Cogliati, Ana Carolina Migliorini Figueira, Rosemari Otton, Alice Cristina Rodrigues
Summary: This study demonstrates that green tea can improve non-alcoholic fatty liver disease (NAFLD), and this improvement is dependent on the action of adiponectin in the liver. The researchers found that catechins in green tea can reduce hepatic steatosis in a PPAR alpha-dependent manner.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Kaue Tognolli, Victoria Silva, Celso Pereira Batista Sousa-Filho, Claudia Andrea Lima Cardoso, Renata Gorjao, Rosemari Otton
Summary: This study aims to investigate the immune cell population in the subcutaneous and epididymal white adipose tissue (WAT) of obese mice, as well as the effects of green tea. The results suggest that a high-fat diet and thermoneutrality can induce chronic inflammation and insulin resistance. However, green tea can prevent weight gain, inflammation, and tissue fibrosis, while maintaining a similar immune cell profile to that of lean mice.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Review
Microbiology
Alef Aragao Carneiro dos Santos, Luiz Eduardo Rodrigues, Amanda Lins Alecrim-Zeza, Liliane de Araujo Ferreira, Caio dos Santos Trettel, Gabriela Mandu Gimenes, Adelson Fernandes da Silva, Celso Pereira Batista Sousa-Filho, Tamires Duarte Afonso Serdan, Adriana Cristina Levada-Pires, Elaine Hatanaka, Fernanda Teixeira Borges, Marcelo Paes de Barros, Maria Fernanda Cury-Boaventura, Gisele Lopes Bertolini, Priscila Cassolla, Gabriel Nasri Marzuca-Nassr, Kaio Fernando Vitzel, Tania Cristina Pithon-Curi, Laureane Nunes Masi, Rui Curi, Renata Gorjao, Sandro Massao Hirabara
Summary: COVID-19-induced tissue dysfunction is associated with cell damage in multiple organs and involves metabolic disturbances and mechanisms such as the production of proinflammatory cytokines, oxidative stress, and deregulation of the renin-angiotensin-aldosterone system.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Celso Pereira Batista Sousa-Filho, Victoria Silva, Anaysa Paola Bolin, Andrea Livia Silva Rocha, Rosemari Otton
Summary: This article presents studies on the modulation of miRNA expression by the main compounds of green tea in inflammation, adipose tissue, skeletal muscle, and liver. It emphasizes the need for further research on the role of miRNAs in the extensive beneficial health effects of green tea compounds already described, indicating miRNAs as potential mediators of polyphenols.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Victoria Silva, Hector Oreliana Fernandes Faria, Celso Pereira Batista Sousa-Filho, Jose Fernando Rinaldi de Alvarenga, Jarlei Fiamoncini, Rosemari Otton
Summary: Metabolic-associated fatty liver disease (MAFLD) is characterized by excessive accumulation of triglycerides in hepatocytes and is considered the leading cause of chronic liver disease. It is closely associated with obesity, type 2 diabetes, hyperlipidemia, and hypertension. This study investigates the effects of green tea (GT) on MAFLD and shows that GT has beneficial effects on the liver phenotype and gene expression involved in lipogenesis, regardless of housing temperature.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)