The role of pituitary adenylyl cyclase activating polypeptide in affective signs of nicotine withdrawal

The role of endogenous pituitary adenylyl cyclase activating polypeptide (PACAP) in nicotine self-administration, reward and aversion

(2019) Andy Tseng et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Effects of prenatal cigarette smoke exposure on BDNF, PACAP, microglia and gliosis expression in the young male mouse brainstem

(2019) Rita Machaalani et al.   NEUROTOXICOLOGY

Pharmacological modulation of the α7 nicotinic acetylcholine receptor in a mouse model of mecamylamine-precipitated nicotine withdrawal

(2018) Asti Jackson et al.   PSYCHOPHARMACOLOGY

Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background

(2017) József Farkas et al.   NEUROSCIENCE

PACAP Protects Against Ethanol and Nicotine Toxicity in SH-SY5Y Cells: Implications for Drinking-Smoking Co-morbidity

(2017) Sridharan Manavalan et al.   NEUROTOXICITY RESEARCH

Reversal of Nicotine Withdrawal Signs Through Positive Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors in Male Mice

(2017) Ayman K Hamouda et al.   NICOTINE & TOBACCO RESEARCH

Effects of Nicotine Metabolites on Nicotine Withdrawal Behaviors in Mice

(2017) Sagi Elhassan et al.   NICOTINE & TOBACCO RESEARCH

Pituitary adenylate cyclase activating polypeptide (PACAP), stress, and sex hormones

(2017) S. Bradley King et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

18-Methoxycoronaridine acts in the medial habenula to attenuate behavioral and neurochemical sensitization to nicotine

(2016) Branden L. Eggan et al.   BEHAVIOURAL BRAIN RESEARCH

Selective CRF2 receptor agonists ameliorate the anxiety- and depression-like state developed during chronic nicotine treatment and consequent acute withdrawal in mice

(2016) Zsolt Bagosi et al.   BRAIN RESEARCH

Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers

(2016) Viktória Kormos et al.   NEUROSCIENCE

Nicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms

(2016) Wanhong Zuo et al.   Scientific Reports

New mechanisms and perspectives in nicotine withdrawal

(2015) K.J. Jackson et al.   NEUROPHARMACOLOGY

The habenulo-interpeduncular pathway in nicotine aversion and withdrawal

(2015) Beatriz Antolin-Fontes et al.   NEUROPHARMACOLOGY

Repeated nicotine exposure in adolescent rats: Reduction of medial habenular activity and augmentation of nicotine preference

(2015) Hyunchan Lee et al.   PHYSIOLOGY & BEHAVIOR

Acute nicotine induces anxiety and disrupts temporal pattern organization of rat exploratory behavior in hole-board: a potential role for the lateral habenula

(2015) Maurizio Casarrubea et al.   Frontiers in Cellular Neuroscience

An essential role of acetylcholine-glutamate synergy at habenular synapses in nicotine dependence

(2015) Silke Frahm et al.   eLife

Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption

(2014) Marta A. Ślimak et al.   Frontiers in Human Neuroscience

VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation

(2014) Taryn E Grieder et al.   NATURE NEUROSCIENCE

Smoke, the Chief Killer — Strategies for Targeting Combustible Tobacco Use

(2014) Michael C. Fiore et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability

(2013) Christie D. Fowler et al.   NEUROPHARMACOLOGY

A mechanistic hypothesis of the factors that enhance vulnerability to nicotine use in females

(2013) Laura E. O'Dell et al.   NEUROPHARMACOLOGY

Reexposure to nicotine during withdrawal increases the pacemaking activity of cholinergic habenular neurons

(2013) A. Gorlich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide

(2012) Yukio Ago et al.   BEHAVIOURAL PHARMACOLOGY

PACAP is an Endogenous Protective Factor—Insights from PACAP-Deficient Mice

(2012) D. Reglodi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Nicotine modulates multiple regions in the limbic stress network regulating activation of hypophysiotrophic neurons in hypothalamic paraventricular nucleus

(2012) Guoliang Yu et al.   JOURNAL OF NEUROCHEMISTRY

PACAP-deficient mice show attenuated corticosterone secretion and fail to develop depressive behavior during chronic social defeat stress

(2012) Michael L. Lehmann et al.   PSYCHONEUROENDOCRINOLOGY

Illicit drug use in heavy smokers with and without schizophrenia

(2012) Kristen M. Mackowick et al.   SCHIZOPHRENIA RESEARCH

Treatment of Tobacco Dependence in People With Mental Health and Addictive Disorders

(2012) Kristen M. Mackowick et al.   Current Psychiatry Reports

Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice

(2012) Satoko Hattori et al.   Frontiers in Behavioral Neuroscience

Role of PACAP in Female Fertility and Reproduction at Gonadal Level – Recent Advances

(2012) Dora Reglodi et al.   Frontiers in Endocrinology

PACAP: a master regulator of neuroendocrine stress circuits and the cellular stress response

(2011) Nikolas Stroth et al.   Annals of the New York Academy of Sciences

Affect-Related Behaviors in Mice Selectively Bred for High and Low Voluntary Alcohol Consumption

(2011) Adem Can et al.   BEHAVIOR GENETICS

Antidepressant-like responses to lithium in genetically diverse mouse strains

(2011) A. Can et al.   GENES BRAIN AND BEHAVIOR

Pituitary Adenylate Cyclase-Activating Polypeptide Controls Stimulus-Transcription Coupling in the Hypothalamic-Pituitary-Adrenal Axis to Mediate Sustained Hormone Secretion During Stress

(2011) N. Stroth et al.   JOURNAL OF NEUROENDOCRINOLOGY

Aversion to Nicotine Is Regulated by the Balanced Activity of β4 and α5 Nicotinic Receptor Subunits in the Medial Habenula

(2011) Silke Frahm et al.   NEURON

Effects of pituitary adenylate cyclase activating polypeptide in the urinary system, with special emphasis on its protective effects in the kidney

(2011) Dora Reglodi et al.   NEUROPEPTIDES

The behavioral phenotype of pituitary adenylate-cyclase activating polypeptide-deficient mice in anxiety and depression tests is accompanied by blunted c-Fos expression in the bed nucleus of the stria terminalis, central projecting Edinger–Westphal nucleus, ventral lateral septum, and dorsal raphe nucleus

(2011) B. Gaszner et al.   NEUROSCIENCE

Roles for Pituitary Adenylate Cyclase-Activating Peptide (PACAP) Expression and Signaling in the Bed Nucleus of the Stria Terminalis (BNST) in Mediating the Behavioral Consequences of Chronic Stress

(2010) Sayamwong E. Hammack et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone

(2009) Hitoshi Hashimoto et al.   JOURNAL OF NEUROCHEMISTRY

The Role of  6-Containing Nicotinic Acetylcholine Receptors in Nicotine Reward and Withdrawal

(2009) K. J. Jackson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Stress hormone synthesis in mouse hypothalamus and adrenal gland triggered by restraint is dependent on pituitary adenylate cyclase-activating polypeptide signaling

(2009) N. Stroth et al.   NEUROSCIENCE

Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder

(2009) Ryota Hashimoto et al.   NEUROSCIENCE LETTERS

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

(2009) D. Vaudry et al.   PHARMACOLOGICAL REVIEWS