Clinical trials in REM sleep behavioural disorder: challenges and opportunities

Prolonged-release melatonin in patients with idiopathic REM sleep behavior disorder

(2019) Jin-Sun Jun et al.   Annals of Clinical and Translational Neurology

Physician and Patient Determinants of Prognostic Counseling in Idiopathic REM Sleep-Behavior Disorder

(2019) Max A. Feinstein et al.   SLEEP MEDICINE

Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study

(2019) Ronald B Postuma et al.   BRAIN

Yerba mate (Ilex paraguariensis) favors survival and growth of dopaminergic neurons in culture

(2019) Alejandra Bernardi et al.   MOVEMENT DISORDERS

Clonazepam for probable REM sleep behavior disorder in Parkinson's disease: A randomized placebo-controlled trial

(2019) Chaewon Shin et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Neuroprotection in idiopathic REM sleep behavior disorder: a role for exercise?

(2019) Stuart J McCarter et al.   SLEEP

Factors Hampering the Discovery of New Therapeutics for Rapid Eye Movement Sleep Behavior Disorder

(2019) Emmanuel H. During et al.   JAMA Neurology

Link Between Parkinson Disease and Rapid Eye Movement Sleep Behavior Disorder With Dream Enactment: Possible Implications for Early Rehabilitation

(2018) Brian P. Johnson et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Synchronizing effects of melatonin on diurnal and circadian rhythms

(2018) Martina Pfeffer et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Melatonin protects against behavioral deficits, dopamine loss and oxidative stress in homocysteine model of Parkinson's disease

(2018) Rajib Paul et al.   LIFE SCIENCES

Disease Modification in Parkinson's Disease: Current Approaches, Challenges, and Future Considerations

(2018) Anthony E. Lang et al.   MOVEMENT DISORDERS

Screening for idiopathic REM sleep behavior disorder: usefulness of actigraphy

(2018) Ambra Stefani et al.   SLEEP

Comparison of computerized methods for rapid eye movement sleep without atonia detection

(2018) Matteo Cesari et al.   SLEEP

Presynaptic dopaminergic neuroimaging in REM sleep behavior disorder: A systematic review and meta-analysis

(2018) Matteo Bauckneht et al.   SLEEP MEDICINE REVIEWS

Screening for idiopathic REM sleep behavior disorder: usefulness of actigraphy

(2018) Ambra Stefani et al.   SLEEP

Comparison of computerized methods for rapid eye movement sleep without atonia detection

(2018) Matteo Cesari et al.   SLEEP

Alcohol consumption and probable rapid eye movement sleep behavior disorder

(2018) Chaoran Ma et al.   Annals of Clinical and Translational Neurology

CSF Aβ1–42 level is associated with cognitive decline in early Parkinson’s disease with rapid eye movement sleep behavior disorder

(2018) Maowen Ba et al.   Translational Neurodegeneration

Validation of a new data-driven automated algorithm for muscular activity detection in REM sleep behavior disorder

(2018) Matteo Cesari et al.   JOURNAL OF NEUROSCIENCE METHODS

α-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies

(2018) Inger van Steenoven et al.   MOVEMENT DISORDERS

Therapeutic approaches to target alpha-synuclein pathology

(2017) Patrik Brundin et al.   EXPERIMENTAL NEUROLOGY

Repeated-Dose Oral N-Acetylcysteine in Parkinson's Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress

(2017) Lisa D. Coles et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Is there a common motor dysregulation in sleepwalking and REM sleep behaviour disorder?

(2017) Mehdi Haridi et al.   JOURNAL OF SLEEP RESEARCH

Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial

(2017) Dilan Athauda et al.   LANCET

Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial

(2017) Sandrine Andrieu et al.   LANCET NEUROLOGY

Idiopathic REM sleep behaviour disorder and neurodegeneration — an update

(2017) Birgit Högl et al.   Nature Reviews Neurology

Long-term effects of exercise and physical therapy in people with Parkinson disease

(2017) Margaret K. Mak et al.   Nature Reviews Neurology

Characterization of patients with longstanding idiopathic REM sleep behavior disorder

(2017) Alex Iranzo et al.   NEUROLOGY

Predictive markers for early conversion of iRBD to neurodegenerative synucleinopathy diseases

(2017) Yuanyuan Li et al.   NEUROLOGY

Skin nerve phosphorylated α-synuclein deposits in idiopathic REM sleep behavior disorder

(2017) Elena Antelmi et al.   NEUROLOGY

Twenty Years After: Another Case Report of Melatonin Effects on REM Sleep Behavior Disorder, Using Serial Dopamine Transporter Imaging

(2017) Dieter Kunz et al.   NEUROPSYCHOBIOLOGY

Seven tesla MRI of the substantia nigra in patients with rapid eye movement sleep behavior disorder

(2017) Daniela Frosini et al.   PARKINSONISM & RELATED DISORDERS

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

(2017) Michele Perni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease

(2017) Shuchi Mittal et al.   SCIENCE

Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder

(2017) Thomas R Barber et al.   SLEEP

Prevalence and determinants of rapid eye movement sleep behavior disorder in the general population

(2017) José Haba-Rubio et al.   SLEEP

Brain imaging findings in idiopathic REM sleep behavior disorder (RBD) – A systematic review on potential biomarkers for neurodegeneration

(2017) Julia Heller et al.   SLEEP MEDICINE REVIEWS

Idiopathic REM sleep behavior disorder and neurodegenerative risk: To tell or not to tell to the patient? How to minimize the risk?

(2017) Dario Arnaldi et al.   SLEEP MEDICINE REVIEWS

Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder

(2017) Thomas R Barber et al.   SLEEP

Prevalence and determinants of rapid eye movement sleep behavior disorder in the general population

(2017) José Haba-Rubio et al.   SLEEP

Elevated PEM (Phasic Electromyographic Metric) Rates Identify Rapid Eye Movement Behavior Disorder Patients on Nights Without Behavioral Abnormalities

(2017) Donald L. Bliwise et al.   SLEEP

123I-MIBG Cardiac Scintigraphy Provides Clues to the Underlying Neurodegenerative Disorder in Idiopathic REM Sleep Behavior Disorder

(2017) Tomoyuki Miyamoto et al.   SLEEP

An Open-Labeled Trial of Ramelteon in Idiopathic Rapid Eye Movement Sleep Behavior Disorder

(2016) Yuichi Esaki et al.   Journal of Clinical Sleep Medicine

Effects of Rotigotine on REM Sleep Behavior Disorder in Parkinson Disease

(2016) Yan Wang et al.   Journal of Clinical Sleep Medicine

Assessment of α-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study

(2016) Dolores Vilas et al.   LANCET NEUROLOGY

Subliminal gait initiation deficits in rapid eye movement sleep behavior disorder: A harbinger of freezing of gait?

(2016) Laila Alibiglou et al.   MOVEMENT DISORDERS

First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers

(2016) Dale B. Schenk et al.   MOVEMENT DISORDERS

Epigallocatechin Gallate (EGCG) Inhibits Alpha-Synuclein Aggregation: A Potential Agent for Parkinson’s Disease

(2016) Yan Xu et al.   NEUROCHEMICAL RESEARCH

The Clinical Phenotype of Idiopathic Rapid Eye Movement Sleep Behavior Disorder at Presentation: A Study in 203 Consecutive Patients

(2016) Ana Fernández-Arcos et al.   SLEEP

A prospective, naturalistic follow-up study of treatment outcomes with clonazepam in rapid eye movement sleep behavior disorder

(2016) Shirley Xin Li et al.   SLEEP MEDICINE

A Case of Rapid Eye Movement Sleep Behavior Disorder in Parkinson Disease Treated With Sodium Oxybate

(2016) Jennifer Liebenthal et al.   JAMA Neurology

Exploring the Association Between Rosacea and Parkinson Disease

(2016) Alexander Egeberg et al.   JAMA Neurology

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies

(2016) Graham Fairfoul et al.   Annals of Clinical and Translational Neurology

The Clinical Phenotype of Idiopathic Rapid Eye Movement Sleep Behavior Disorder at Presentation: A Study in 203 Consecutive Patients

(2016) Ana Fernández-Arcos et al.   SLEEP

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: A multicenter study

(2015) Ronald B. Postuma et al.   ANNALS OF NEUROLOGY

Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson’s disease

(2015) Aurelija Jucaite et al.   BRAIN

Parkinson’s Disease Genetic Loci in Rapid Eye Movement Sleep Behavior Disorder

(2015) Z. Gan-Or et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Inverse association between yerba mate consumption and idiopathic Parkinson's disease. A case–control study

(2015) Emilia Mabel Gatto et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

MDS research criteria for prodromal Parkinson's disease

(2015) Daniela Berg et al.   MOVEMENT DISORDERS

Parkinson risk in idiopathic REM sleep behavior disorder: Preparing for neuroprotective trials

(2015) R. B. Postuma et al.   NEUROLOGY

Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder

(2015) Fabienne S. Sprenger et al.   NEUROLOGY

Sleepiness in Idiopathic REM Sleep Behavior Disorder and Parkinson Disease

(2015) Isabelle Arnulf et al.   SLEEP

Melatonin therapy for REM sleep behavior disorder: a critical review of evidence

(2015) Ian R. McGrane et al.   SLEEP MEDICINE

Novel Methods and Technologies for 21st-Century Clinical Trials

(2015) E. Ray Dorsey et al.   JAMA Neurology

Sleepiness in Idiopathic REM Sleep Behavior Disorder and Parkinson Disease

(2015) Isabelle Arnulf et al.   SLEEP

Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

(2014) Min Shi et al.   ACTA NEUROPATHOLOGICA

Actigraphy as a diagnostic aid for REM sleep behavior disorder in Parkinson’s disease

(2014) Maartje Louter et al.   BMC Neurology

Consistent abnormalities in metabolic network activity in idiopathic rapid eye movement sleep behaviour disorder

(2014) Ping Wu et al.   BRAIN

Rivastigmine for Refractory REM Behavior Disorder in Mild Cognitive Impairment

(2014) Valerio Brunetti et al.   Current Alzheimer Research

Dairy foods intake and risk of Parkinson’s disease: a dose–response meta-analysis of prospective cohort studies

(2014) Wenjie Jiang et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Autonomic symptoms in idiopathic REM behavior disorder: a multicentre case–control study

(2014) Luigi Ferini-Strambi et al.   JOURNAL OF NEUROLOGY

Five-year follow-up of substantia nigra echogenicity in idiopathic REM sleep behavior disorder

(2014) Alex Iranzo et al.   MOVEMENT DISORDERS

Imaging prodromal Parkinson disease: The Parkinson Associated Risk Syndrome Study

(2014) D. Jennings et al.   NEUROLOGY

Abnormal metabolic network activity in REM sleep behavior disorder

(2014) F. Holtbernd et al.   NEUROLOGY

Neurodegenerative Disorder Risk in Idiopathic REM Sleep Behavior Disorder: Study in 174 Patients

(2014) Alex Iranzo et al.   PLoS One

Validation of an Integrated Software for the Detection of Rapid Eye Movement Sleep Behavior Disorder

(2014) Birgit Frauscher et al.   SLEEP

Diagnostic Thresholds for Quantitative REM Sleep Phasic Burst Duration, Phasic and Tonic Muscle Activity, and REM Atonia Index in REM Sleep Behavior Disorder with and without Comorbid Obstructive Sleep Apnea

(2014) Stuart J. McCarter et al.   SLEEP

Comparison between an automatic and a visual scoring method of the chin muscle tone during rapid eye movement sleep

(2014) Raffaele Ferri et al.   SLEEP MEDICINE

Circadian Melatonin Rhythm and Excessive Daytime Sleepiness in Parkinson Disease

(2014) Aleksandar Videnovic et al.   JAMA Neurology

Sleep and Circadian Rhythm Regulation in Early Parkinson Disease

(2014) David P. Breen et al.   JAMA Neurology

Nicotine from edibleSolanaceaeand risk of Parkinson disease

(2013) Susan Searles Nielsen et al.   ANNALS OF NEUROLOGY

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Validation of the Mayo Sleep Questionnaire to Screen for REM Sleep Behavior Disorder in a Community-Based Sample

(2013) Bradley F. Boeve et al.   Journal of Clinical Sleep Medicine

Increased REM sleep without atonia in Parkinson disease with freezing of gait

(2013) A. Videnovic et al.   NEUROLOGY

Longitudinal assessment of olfactory function in idiopathic REM sleep behavior disorder

(2013) Alex Iranzo et al.   PARKINSONISM & RELATED DISORDERS

Bee Venom and Its Component Apamin as Neuroprotective Agents in a Parkinson Disease Mouse Model

(2013) Daniel Alvarez-Fischer et al.   PLoS One

Cognitive Performances and Mild Cognitive Impairment in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: Results of a Longitudinal Follow-Up Study

(2013) Michele Terzaghi et al.   SLEEP

Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy—a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group

(2013) C.H. Schenck et al.   SLEEP MEDICINE

Treatment outcomes in REM sleep behavior disorder

(2013) Stuart J. McCarter et al.   SLEEP MEDICINE

Meta-analysis of early nonmotor features and risk factors for Parkinson disease

(2012) Alastair J. Noyce et al.   ANNALS OF NEUROLOGY

How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder

(2012) R. B. Postuma et al.   BRAIN

Rivastigmine as alternative treatment for refractory REM behavior disorder in Parkinson's disease

(2012) Raffaella Di Giacopo et al.   MOVEMENT DISORDERS

Validation of the Innsbruck REM sleep behavior disorder inventory

(2012) Birgit Frauscher et al.   MOVEMENT DISORDERS

Trial designs used to study neuroprotective therapy in Parkinson's disease

(2012) Anthony E. Lang et al.   MOVEMENT DISORDERS

A single-question screen for rapid eye movement sleep behavior disorder: A multicenter validation study

(2012) Ronald B. Postuma et al.   MOVEMENT DISORDERS

Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study

(2012) R. B. Postuma et al.   NEUROLOGY

Normative EMG Values during REM Sleep for the Diagnosis of REM Sleep Behavior Disorder

(2012) Birgit Frauscher et al.   SLEEP

An observational clinical and video-polysomnographic study of the effects of clonazepam in REM sleep behavior disorder

(2012) Raffaele Ferri et al.   SLEEP MEDICINE

Effectiveness of Pramipexole, a Dopamine Agonist, on Rapid Eye Movement Sleep Behavior Disorder

(2012) Taeko Sasai et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study

(2011) Alex Iranzo et al.   LANCET NEUROLOGY

Use of ibuprofen and risk of Parkinson disease

(2011) X. Gao et al.   NEUROLOGY

Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort

(2011) Bradley F. Boeve et al.   SLEEP MEDICINE

Utility of the REM sleep behavior disorder screening questionnaire (RBDSQ) in Parkinson’s disease patients

(2011) Takashi Nomura et al.   SLEEP MEDICINE

The effect of memantine on sleep behaviour in dementia with Lewy bodies and Parkinson's disease dementia

(2010) Victoria Larsson et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorder

(2010) DIETER KUNZ et al.   JOURNAL OF SLEEP RESEARCH

Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: Implications for early intervention on disease progression

(2010) Almas Siddiqui et al.   NEUROBIOLOGY OF DISEASE

Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease

(2010) R. B. Postuma et al.   NEUROLOGY

Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson's disease

(2009) Jean-François Gagnon et al.   ANNALS OF NEUROLOGY

Markers of neurodegeneration in idiopathic rapid eye movement sleep behaviour disorder and Parkinson's disease

(2009) R. B. Postuma et al.   BRAIN

Quantification of Tonic and Phasic Muscle Activity in REM Sleep Behavior Disorder

(2009) Geert Mayer et al.   JOURNAL OF CLINICAL NEUROPHYSIOLOGY

"Disease-modification" trials in Parkinson disease: Target populations, endpoints and study design

(2009) O. Rascol   NEUROLOGY

Validation of a new REM sleep behavior disorder questionnaire (RBDQ-HK)

(2009) S.X. Li et al.   SLEEP MEDICINE