Article
Oncology
Chao Zhang, Fan Zhang, Xiu Wang, Shuncang Zhang
Summary: This study reports a modified MVLESS procedure using self-made instruments to create a new vagina for MRKHS patients. The procedure is simple, safe, and minimally invasive, providing satisfactory anatomical and sexual function. However, fertility problems for patients with congenital absence of vagina remain a challenge.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Na Chen, Shuang Song, Xinmiao Bao, Lan Zhu
Summary: This review provides an update on the etiology, clinical manifestations, diagnosis, psychological impact, treatment, and reproductive options for Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. The underlying causes of MRKH syndrome remain unclear, with both genetic and non-genetic factors proposed. The syndrome has a significant psychological impact on patients, leading to low self-esteem, poor coping strategies, and symptoms of depression and anxiety. Psychological counseling and peer support are recommended for diagnosed patients. Vaginal dilation is the first-line therapy, with vaginal reconstruction as the second-line option for those who do not respond to dilation. Uterine transplantation and gestational surrogacy are potential options for women with MRKH syndrome to achieve biological motherhood.
FRONTIERS OF MEDICINE
(2022)
Editorial Material
Obstetrics & Gynecology
Mykhailo Medvediev, Dmytro Spesyvtsev, Dar'ya Pokrovenko
Summary: This study presented a novel approach to vaginoplasty in a patient with vaginal aplasia and a preserved cervix. The surgical procedure successfully restored normal vaginal anatomy and function, with the patient experiencing no postoperative complications and engaging in sexual activity during the follow-up period. The approach of cervicovulvar anastomosis was found to be more feasible in cases of preserved distended cervix, leading to better outcomes compared to traditional techniques.
FERTILITY AND STERILITY
(2021)
Article
Multidisciplinary Sciences
Valeria Stella Vanni, Alessandra Alteri, Lucia De Santis, Greta Chiara Cermisoni, Elisa Rabellotti, Diana Delprato, Marta Parma, Enrico Papaleo, Luigi Fedele, Massimo Candiani
Summary: In MRKHS patients, simultaneous laparoscopic oocyte retrieval and cryopreservation can be performed during laparoscopic vaginoplasty, reducing surgical invasiveness and anesthesiologic risks.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Medicine, General & Internal
Iori Kisu, Miho Iida, Kanako Nakamura, Kouji Banno, Tetsuro Shiraishi, Asahi Tokuoka, Keigo Yamaguchi, Kunio Tanaka, Moito Iijima, Hiroshi Senba, Kiyoko Matsuda, Nobumaru Hirao
Summary: The Kisu modification of laparoscopic vaginoplasty procedure is effective, feasible, and safe for creating neovagina in patients with MRKH syndrome. All surgeries were successful without complications, achieving both anatomical and functional success.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Christine M. Pennesi, Emily M. English, Sarah Bell, Amy C. Lossie, Elisabeth H. Quint, Carolyn W. Swenson
Summary: Mayer-Rokitansky-Kuster-Hauser syndrome, a rare condition, is associated with common urinary, prolapse, and bowel symptoms. Vaginal lengthening treatments do not significantly affect the prevalence of pelvic floor symptoms, except for recent urinary and anal incontinence. Further research is needed to understand the impact of different vaginal lengthening treatments on pelvic floor symptoms.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Xiwa Zhao, Yanan Zhang, Mengmeng Zhang, Haibo Zhang, Yunjie Tian, Shan Kang
Summary: The study compared two laparoscopic vaginoplasty techniques, Hebei I and Hebei II, for patients with MRKH syndrome. Both techniques achieved anatomical and functional success, but the Hebei II technique had a shorter operative time, less neovaginal secretions, and fewer granulomatous polyps postoperatively.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Article
Obstetrics & Gynecology
Nicole Fischer, Helen Xun, Amy Lossie, Darya Fadavi, Halley Darrach, Pooja Yesantharao, Franca Kraenzlin, Bhuchitra Singh, Justin M. Sacks, James H. Segars
Summary: The study found that most individuals with MRKH syndrome believe that uterine transplantation should be an option for all women with uterine factor infertility and should be covered by health insurance. Many participants perceived the benefits of the procedure to outweigh the risks and considered it to be an ethical procedure.
FERTILITY AND STERILITY
(2021)
Article
Medicine, General & Internal
Rebecca Buchert, Elisabeth Schenk, Thomas Hentrich, Nico Weber, Katharina Rall, Marc Sturm, Oliver Kohlbacher, Andre Koch, Olaf Riess, Sara Y. Brucker, Julia M. Schulze-Hentrich
Summary: By analyzing the genetic material of discordant monozygotic twins with MRKH, potential genetic causes were identified. The study revealed the involvement of estrogen in the pathology of MRKH, although no clear pathogenic differences were detected.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Zhi-yang Xu, Ling-xia Li, Xing-guo Wang, Meng-xin Wang, Gai-jing Cao, Bi-liang Chen, Shu-juan Liu
Summary: This study investigated the long-term outcomes for MRKH syndrome patients undergoing vaginoplasty using SIS grafts. The results showed that nearly half of the patients maintained good sexual function after the surgery. Both sexual function and psychological status improved as postoperative time increased. Additionally, reducing the diagnosis to surgery interval was associated with improved psychological function.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Qi Zhou, Xuyin Zhang, Yanyun Li, Keqin Hua, Jingxin Ding
Summary: This study compared the perioperative, anatomical, and functional outcomes of different techniques for vaginoplasty in patients with MRKHS. The results showed that Sheares vaginoplasty and vaginoplasty using SIS graft had similar functional outcomes to laparoscopic Davydov vaginoplasty, but with less trauma. However, patients in the Sheares and SIS graft groups required a longer duration of wearing a mould post-surgery.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Obstetrics & Gynecology
Xinyun Yang, Linling Zhu, Yan Jing Wang, Baoqin Tong, Shuangshuang Zhong, Chunbo Yang, Junxiao Liang, Hangmei Jin, Zhenwei Xie
Summary: This study compared the modified laparoscopic Vecchietti and Davydov techniques for vaginoplasty in patients with MRKH syndrome. Both techniques showed favorable anatomical and functional outcomes, with the modified Vecchietti technique being relatively simpler.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Review
Cell & Tissue Engineering
Jayson Sueters, Freek A. Groenman, Mark-Bram Bouman, Jan Paul W. Roovers, Ralph de Vries, Theo H. Smit, Judith A. F. Huirne
Summary: The potential of tissue engineering for vaginoplasty was studied and analyzed, showing a wide range of cell types, biomaterials, and signaling factors used. Autologous vaginal cells and extracellular matrix-based biomaterials showed promise, and stem cells were found to have potential. However, further research and clinical trials are needed to confirm the quality and effectiveness of cell-seeded acellular vaginal matrix and explore the use of signaling factors for vaginoplasty.
TISSUE ENGINEERING PART B-REVIEWS
(2023)
Article
Medicine, Research & Experimental
Wenli Wang, Fang Chen, Jiumei Cheng, Shuyan Peng, Hong Ye
Summary: Both intermittent and continuous use of postoperative vaginal moulds may be effective in maintaining vaginal length and width postoperatively for patients with MRKH syndrome after vaginoplasty.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Obstetrics & Gynecology
Iori Kisu, Masaaki Ito, Kanako Nakamura, Tetsuro Shiraishi, Tomoko Iijima, Hiroshi Senba, Kiyoko Matsuda, Nobumaru Hirao
Summary: The novel laparoscopic vaginoplasty procedure using an anteroposterior peritoneal pull-down technique showed to be successful in achieving anatomical and functional success in patients with MRKH syndrome, with high success rates in sexual intercourse.
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
(2021)