Article
Obstetrics & Gynecology
Nicole Fischer, Helen Xun, Amy Lossie, Darya Fadavi, Halley Darrach, Pooja Yesantharao, Franca Kraenzlin, Bhuchitra Singh, Justin M. Sacks, James H. Segars
Summary: The study found that most individuals with MRKH syndrome believe that uterine transplantation should be an option for all women with uterine factor infertility and should be covered by health insurance. Many participants perceived the benefits of the procedure to outweigh the risks and considered it to be an ethical procedure.
FERTILITY AND STERILITY
(2021)
Article
Medicine, General & Internal
Rebecca Buchert, Elisabeth Schenk, Thomas Hentrich, Nico Weber, Katharina Rall, Marc Sturm, Oliver Kohlbacher, Andre Koch, Olaf Riess, Sara Y. Brucker, Julia M. Schulze-Hentrich
Summary: By analyzing the genetic material of discordant monozygotic twins with MRKH, potential genetic causes were identified. The study revealed the involvement of estrogen in the pathology of MRKH, although no clear pathogenic differences were detected.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Yifei Dai, Chenglu Qin, Linling Zhu, Guangnan Luo
Summary: MRKH syndrome with genital inguinal hernia is rare and often underreported. This article presents 3 cases of this syndrome and highlights the importance of accurate diagnosis.
Article
Obstetrics & Gynecology
Shuyi Shao, Xiao Wang, Xiaohong Lei, Keqin Hua, Ying Zhang
Summary: MRKH patients have a high risk of depression and anxiety problems after artificial vaginoplasty, and early psychological intervention can alleviate these symptoms.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Review
Biology
Isaac Kyei-Barffour, Miranda Margetts, Alla Vash-Margita, Emanuele Pelosi
Summary: MRKH syndrome is a disorder caused by Mullerian ducts dysgenesis affecting women with a typical karyotype. The etiology is complex and largely unexplained, with possible genetic and epigenetic factors involved. Understanding the molecular mechanisms and improving clinical management remains a challenge due to limited research in functional validation and translational studies.
YALE JOURNAL OF BIOLOGY AND MEDICINE
(2021)
Review
Pediatrics
Varvara Ermioni Triantafyllidi, Despoina Mavrogianni, Andreas Kalampalikis, Michael Litos, Stella Roidi, Lina Michala
Summary: Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a congenital condition characterized by the absence of the uterus and part of the vagina in females. Numerous genetic defects have been associated with MRKH syndrome, and this study aimed to identify the most affected chromosomal areas and genes to aid in genetic counseling for patients.
Article
Cardiac & Cardiovascular Systems
Yifan Zeng, Yerong Hu, Bo Jiang, Ling Tan, Hao Tang
Summary: This is the first reported case in the world of early-onset recurrent aortic dissection combined with MRKH syndrome and 46,XX gonadal dysgenesis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Editorial Material
Obstetrics & Gynecology
Guiling Liang, Wei Xia, Yan Liang, Qian Zhu, Lujia Zou, Jian Zhang, Haowen Jiang
Summary: The article describes the treatment of a 28-year-old female patient with Mayer-Rokitansky-Ku ster-Hauser syndrome using laparoscopic surgery, as well as ureteral reimplantation for hydronephrosis. The surgical procedures included creating a neovaginal vault and removing a cyst laparoscopically, showing successful outcomes in terms of sexual function and reduction of hydronephrosis.
FERTILITY AND STERILITY
(2021)
Article
Genetics & Heredity
Kaizhen Su, Han Liu, Xiaoqun Ye, Hangmei Jin, Zhenwei Xie, Chunbo Yang, Daizhan Zhou, Hefeng Huang, Yanting Wu
Summary: This study identified 16p11.2 deletions in Chinese MRKH type I patients for the first time, supporting the association of 16p11.2 microdeletions with MRKH syndrome across populations. It suggests that 16p11.2 microdeletions should be considered in molecular diagnosis and genetic counseling of female reproductive tract disorders.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2023)
Article
Pediatrics
Wei Jin, Chunjian Gu, Zhenghua Fei, Jingying Fei, Gesheng Wen, Yanhua Min, Dongchan Chen, Wei Wu
Summary: This article reports a case of Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome combined with idiopathic central precocious puberty (ICPP). The patient, a 7-year-old girl, presented with bilateral breast development and relatively low body height. Treatment resulted in normal height and delayed bone age development. This case highlights the possibility of concurrent precocious puberty in MRKH syndrome patients and emphasizes the importance of careful monitoring and assessment of gonads and sexual organs in children with precocious puberty.
TRANSLATIONAL PEDIATRICS
(2023)
Article
Obstetrics & Gynecology
Atsuko Miyake, Yusuke Kobayashi, Keiyo Imaeda, Tomoko Yoshihama, Kanako Nakamura, Megumi Yokota, Shigenori Hayashi, Wataru Yamagami, Kouji Banno, Daisuke Aoki
Summary: This study reviewed the management of MRKH syndrome in our institution and found that Davydov's modified procedure is effective, preoperative vaginal dilation using the Frank method is important, attention is required to care for the plexus vein during the operation, and comprehensive psychological support and surgery planning according to patient's life stages are essential for successful treatment.
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Christine M. Pennesi, Emily M. English, Sarah Bell, Amy C. Lossie, Elisabeth H. Quint, Carolyn W. Swenson
Summary: Mayer-Rokitansky-Kuster-Hauser syndrome, a rare condition, is associated with common urinary, prolapse, and bowel symptoms. Vaginal lengthening treatments do not significantly affect the prevalence of pelvic floor symptoms, except for recent urinary and anal incontinence. Further research is needed to understand the impact of different vaginal lengthening treatments on pelvic floor symptoms.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Nursing
Anu Baby, Manju C. Pallam, Mark Hayter
Summary: The paper aims to present the evidence on the effectiveness of non-surgical interventions to improve health and well-being in women with MRKH syndrome. The review found that vaginal dilation is a viable treatment option and highlights the need for psychological intervention to enhance health and well-being.
JOURNAL OF ADVANCED NURSING
(2023)
Article
Medicine, General & Internal
Subha R. Samantray, Ipsita Mohapatra, Nikku Harshini
Summary: MRKH syndrome, also known as Mayer-Rokitansky-Kuster-Hauser syndrome, is a rare congenital condition characterized by the absence of vagina and uterus. Patients typically present with primary amenorrhea, normal external genitalia, and may require surgical intervention for vaginal reconstruction to improve their quality of life.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Obstetrics & Gynecology
Xiwa Zhao, Yanan Zhang, Mengmeng Zhang, Haibo Zhang, Yunjie Tian, Shan Kang
Summary: The study compared two laparoscopic vaginoplasty techniques, Hebei I and Hebei II, for patients with MRKH syndrome. Both techniques achieved anatomical and functional success, but the Hebei II technique had a shorter operative time, less neovaginal secretions, and fewer granulomatous polyps postoperatively.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)