Galectin-9 and VISTA Expression Define Terminally Exhausted T Cells in HIV-1 Infection

CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions

(2018) Masao Hashimoto et al.   Annual Review of Medicine

OUP accepted manuscript

(2018)   Journal of Crohns & Colitis

VISTA expressed in tumour cells regulates T cell function

(2018) Kumuluzi Mulati et al.   BRITISH JOURNAL OF CANCER

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells

(2018) Xiangbo Meng et al.   NATURE

CD71+VISTA+ erythroid cells promote the development and function of regulatory T cells through TGF-β

(2018) Shima Shahbaz et al.   PLOS BIOLOGY

Erythroid Suppressor Cells Compromise Neonatal Immune Response againstBordetella pertussis

(2017) Garett Dunsmore et al.   JOURNAL OF IMMUNOLOGY

The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia

(2017) Anna Bajnok et al.   MEDIATORS OF INFLAMMATION

Atorvastatin downregulates co-inhibitory receptor expression by targeting Ras-activated mTOR signalling

(2017) Isobel Okoye et al.   Oncotarget

CD71+ erythroid suppressor cells impair adaptive immunity against Bordetella pertussis

(2017) Afshin Namdar et al.   Scientific Reports

Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?

(2017) Nicole B. Crux et al.   Frontiers in Immunology

Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer

(2017) Isobel S. Okoye et al.   Frontiers in Immunology

Atorvastatin restricts HIV replication in CD4+ T cells by upregulation of p21

(2016) Shokrollah Elahi et al.   AIDS

CD4+ T cells with an activated and exhausted phenotype distinguish immunodeficiency during aviremic HIV-2 infection

(2016) Marcus Buggert et al.   AIDS

Dissecting How CD4 T Cells Are Lost During HIV Infection

(2016) Gilad Doitsh et al.   Cell Host & Microbe

CD14+ monocyte-derived galectin-9 induces natural killer cell cytotoxicity in chronic hepatitis C

(2016) Akira Nishio et al.   HEPATOLOGY

Correlation of transferrin receptor (CD71) with Ki67 expression on stimulated human and mouse T cells: The kinetics of expression of T cell activation markers

(2016) Melika Motamedi et al.   JOURNAL OF IMMUNOLOGICAL METHODS

IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection

(2016) Jean-Christophe Beltra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host

(2016) Anna Schurich et al.   Cell Reports

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation

(2016) Mohamed Abdel-Mohsen et al.   PLoS Pathogens

Elevated Spontaneous Interferon-Gamma Secretion in HIV-Infected Persons

(2015) Rachel Sparks et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Impact of Exogenous Galectin-9 on Human T Cells

(2015) Claire Lhuillier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKCs Sweeten Cell Metabolism by Phosphorylation of Glut1

(2015) Peter J. Siska et al.   MOLECULAR CELL

The bitter side of sweet: the role of Galectin-9 in immunopathogenesis of viral infections

(2015) Shahzma Merani et al.   REVIEWS IN MEDICAL VIROLOGY

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

(2015) Prakash K. Gupta et al.   PLoS Pathogens

The Role of PKC-θ in CD4+ T Cells and HIV Infection: To the Nucleus and Back Again

(2015) Chansavath Phetsouphanh et al.   Frontiers in Immunology

Galectin-9 Is Rapidly Released During Acute HIV-1 Infection and Remains Sustained at High Levels Despite Viral Suppression Even in Elite Controllers

(2014) Ravi Tandon et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

PD-1+ CD8+ T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients

(2014) X Wu et al.   BRITISH JOURNAL OF CANCER

VISTA Is an Immune Checkpoint Molecule for Human T Cells

(2014) J. L. Lines et al.   CANCER RESEARCH

IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter

(2014) R M Lowe et al.   GENES AND IMMUNITY

The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection

(2014) Matthew M. Staron et al.   IMMUNITY

Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection

(2014) Alison Crawford et al.   IMMUNITY

Galectin-9-CD44 Interaction Enhances Stability and Function of Adaptive Regulatory T Cells

(2014) Chuan Wu et al.   IMMUNITY

Galectin-9 controls the therapeutic activity of 4-1BB–targeting antibodies

(2014) Shravan Madireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular Basis of the Dual Functions of 2B4 (CD244)

(2014) L. K. Chlewicki et al.   JOURNAL OF IMMUNOLOGY

Too Much of a Good Thing? Tim-3 and TCR Signaling in T Cell Exhaustion

(2014) Robert L. Ferris et al.   JOURNAL OF IMMUNOLOGY

Characterization of Programmed Death-1 Homologue-1 (PD-1H) Expression and Function in Normal and HIV Infected Individuals

(2014) Preeti Bharaj et al.   PLoS One

VISTA Is a Novel Broad-Spectrum Negative Checkpoint Regulator for Cancer Immunotherapy

(2014) J. L. Lines et al.   Cancer Immunology Research

Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection

(2013) Clovis S. Palmer et al.   AIDS

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Tolerance and exhaustion: defining mechanisms of T cell dysfunction

(2013) Andrea Schietinger et al.   TRENDS IN IMMUNOLOGY

Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection

(2012) S. Elahi et al.   BLOOD

As Good As It Gets? The Problem of HIV Persistence despite Antiretroviral Drugs

(2012) Alex Sigal et al.   Cell Host & Microbe

Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory

(2012) Travis A. Doering et al.   IMMUNITY

Association of HLA-alleles with the immune regulation of chronic viral infections

(2012) Shokrollah Elahi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cell Surface Galectin-9 Expressing Th Cells Regulate Th17 and Foxp3+ Treg Development by Galectin-9 Secretion

(2012) Souichi Oomizu et al.   PLoS One

Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

(2012) M. A. Paley et al.   SCIENCE

Rapid Decrease of Plasma Galectin-9 Levels in Patients with Acute HIV Infection after Therapy

(2012) Hiroki Saitoh et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Identification of HIF2  as an important STAT5 target gene in human hematopoietic stem cells

(2011) S. Fatrai et al.   BLOOD

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

(2011) Q. Zhou et al.   BLOOD

Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection

(2011) T. Yamamoto et al.   BLOOD

CD154, a marker of antigen-specific stimulation of CD4 T cells, is associated with response to treatment in patients with chronic HCV infection

(2011) J. F. Möller et al.   JOURNAL OF VIRAL HEPATITIS

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

(2011) Wei Liao et al.   NATURE IMMUNOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Protective HIV-specific CD8+ T cells evade Treg cell suppression

(2011) Shokrollah Elahi et al.   NATURE MEDICINE

T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses

(2011) S. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry

(2011) S. Bi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-9 induces osteoblast differentiation through the CD44/Smad signaling pathway

(2010) Rena Tanikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo

(2010) Vandana Kalia et al.   IMMUNITY

T-cell exhaustion: characteristics, causes and conversion

(2010) John S. Yi et al.   IMMUNOLOGY

The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity

(2010) Yurong Li et al.   MOLECULAR IMMUNOLOGY

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

Stable form of galectin-9, a Tim-3 ligand, inhibits contact hypersensitivity and psoriatic reactions: A potent therapeutic tool for Th1- and/or Th17-mediated skin inflammation

(2009) Haruna Niwa et al.   CLINICAL IMMUNOLOGY

A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection

(2009) Haina Shin et al.   IMMUNITY

Galectin-3 regulates T-cell functions

(2009) Daniel K. Hsu et al.   IMMUNOLOGICAL REVIEWS

Galectin-9 Is a High Affinity IgE-binding Lectin with Anti-allergic Effect by Blocking IgE-Antigen Complex Formation

(2009) Toshiro Niki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Persistent Elevation of Plasma Osteopontin Levels in HIV Patients Despite Highly Active Antiretroviral Therapy

(2009) Haorile Chagan-Yasutan et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis

(2008) Masako Seki et al.   CLINICAL IMMUNOLOGY

Flow cytometric detection of perforin upregulation in human CD8 T cells

(2008) Adam R. Hersperger et al.   CYTOMETRY PART A

Tim-3-Galectin-9 pathway involves the suppression induced by CD4+CD25+ regulatory T cells

(2008) Feng Wang et al.   IMMUNOBIOLOGY

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

(2008) R. Brad Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Priming for T helper type 2 differentiation by interleukin 2–mediated induction of interleukin 4 receptor α-chain expression

(2008) Wei Liao et al.   NATURE IMMUNOLOGY