Blood–brain barrier dysfunction: the undervalued frontier of hypertension

Central Effects of Beta-Blockers May Be Due to Nitric Oxide and Hydrogen Peroxide Release Independently of Their Ability to Cross the Blood-Brain Barrier

(2019) Claire Laurens et al.   Frontiers in Neuroscience

Single Mild Traumatic Brain Injury Induces Persistent Disruption of the Blood-Brain Barrier, Neuroinflammation and Cognitive Decline in Hypertensive Rats

(2019) Nikolett Szarka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypertension-induced cognitive impairment: insights from prolonged angiotensin II infusion in mice

(2018) Sébastien Foulquier et al.   HYPERTENSION RESEARCH

Associations of Anti-Hypertensive Treatments with Alzheimer's Disease, Vascular Dementia, and Other Dementias

(2018) Neil M. Davies et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of Centrally Acting Angiotensin Converting Enzyme Inhibitors on Functional Decline in Patients with Alzheimer's Disease

(2018) Rónán O'Caoimh et al.   JOURNAL OF ALZHEIMERS DISEASE

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of the Immune System in Hypertension

(2017) Bernardo Rodriguez-Iturbe et al.   PHYSIOLOGICAL REVIEWS

Maintenance of Blood-Brain Barrier Integrity in Hypertension: A Novel Benefit of Exercise Training for Autonomic Control

(2017) Leila Buttler et al.   Frontiers in Physiology

Brain imaging of neurovascular dysfunction in Alzheimer’s disease

(2016) Axel Montagne et al.   ACTA NEUROPATHOLOGICA

Astrocytes Contribute to Angiotensin II Stimulation of Hypothalamic Neuronal Activity and Sympathetic OutflowNovelty and Significance

(2016) Javier E. Stern et al.   HYPERTENSION

Structural and functional brain alterations in a murine model of Angiotensin II-induced hypertension

(2016) Anja Meissner et al.   JOURNAL OF NEUROCHEMISTRY

An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer’s disease

(2016) Abdel G. Elkahloun et al.   Alzheimers Research & Therapy

Targeting transporters: Promoting blood–brain barrier repair in response to oxidative stress injury

(2015) Patrick T. Ronaldson et al.   BRAIN RESEARCH

Microglia Participate in Neurogenic Regulation of HypertensionNovelty and Significance

(2015) Xiao Z. Shen et al.   HYPERTENSION

Anatomy and physiology of the blood–brain barrier

(2015) Yonatan Serlin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A new strategy for treating hypertension by blocking the activity of the brain renin–angiotensin system with aminopeptidase A inhibitors

(2014) Ji Gao et al.   CLINICAL SCIENCE

Acute hypertension induces brain injury and blood–brain barrier disruption through reduction of claudins mRNA expression in rat

(2014) Mohammad Taghi Mohammadi et al.   PATHOLOGY RESEARCH AND PRACTICE

The effects of hypertension on the cerebral circulation

(2013) Paulo W. Pires et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hypertension

(2013) Giuseppe Faraco et al.   HYPERTENSION

Circulating Angiotensin II Gains Access to the Hypothalamus and Brain Stem During Hypertension via Breakdown of the Blood–Brain Barrier

(2013) Vinicia Campana Biancardi et al.   HYPERTENSION

Age-Related Autoregulatory Dysfunction and Cerebromicrovascular Injury in Mice with Angiotensin II-induced Hypertension

(2013) Peter Toth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Antihypertensive medication use and risk of cognitive impairment: The Honolulu-Asia Aging Study

(2013) R. P. Gelber et al.   NEUROLOGY

Intra-carotid angiotensin II activates tyrosine hydroxylase-expressing rostral ventrolateral medulla neurons following blood–brain barrier disruption in rats

(2013) S.T. Yao et al.   NEUROSCIENCE

Triggers and Effectors of Oxidative Stress at Blood-Brain Barrier Level: Relevance for Brain Ageing and Neurodegeneration

(2013) Ana-Maria Enciu et al.   Oxidative Medicine and Cellular Longevity

Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia

(2013) Yang Gao et al.   BMJ Open

High Blood Pressure Effects on the Blood to Cerebrospinal Fluid Barrier and Cerebrospinal Fluid Protein Composition: A Two-Dimensional Electrophoresis Study in Spontaneously Hypertensive Rats

(2013) Ibrahim González-Marrero et al.   International Journal of Hypertension

Hypertension Induces Brain β-Amyloid Accumulation, Cognitive Impairment, and Memory Deterioration Through Activation of Receptor for Advanced Glycation End Products in Brain Vasculature

(2012) Daniela Carnevale et al.   HYPERTENSION

IgG Leakage May Contribute to Neuronal Dysfunction in Drug-Refractory Epilepsies With Blood-Brain Barrier Disruption

(2012) Zuzanna Michalak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Low-density lipoprotein receptor-related protein 1: A physiological Aβ homeostatic mechanism with multiple therapeutic opportunities

(2012) Abhay P. Sagare et al.   PHARMACOLOGY & THERAPEUTICS

Contributions of vascular inflammation in the brainstem for neurogenic hypertension

(2011) Hidefumi Waki et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Blockade of AT1 Receptors Protects the Blood-Brain Barrier and Improves Cognition in Dahl Salt-Sensitive Hypertensive Rats

(2010) N. Pelisch et al.   AMERICAN JOURNAL OF HYPERTENSION

Circulating signals as critical regulators of autonomic state—central roles for the subfornical organ

(2010) Pauline M. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies

(2010) Craig Anderson et al.   LANCET NEUROLOGY

Mechanisms Underlying the Cerebral Microvascular Responses to Angiotensin II-Induced Hypertension

(2010) SHANTEL A. VITAL et al.   MICROCIRCULATION

Angiotensin II induced cerebral microvascular inflammation and increased blood–brain barrier permeability via oxidative stress

(2010) M. Zhang et al.   NEUROSCIENCE

Vascular basis for brain degeneration: faltering controls and risk factors for dementia

(2010) Raj N Kalaria   NUTRITION REVIEWS

Angiotensin-Converting Enzyme Inhibitors and Cognitive Decline in Older Adults With Hypertension

(2009) Kaycee M. Sink et al.   ARCHIVES OF INTERNAL MEDICINE

Brain cytokines as neuromodulators in cardiovascular control

(2009) Peng Shi et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling

(2009) Shuko Takeda et al.   HYPERTENSION

Angiotensin II Modulates BBB Permeability via Activation of the AT1 Receptor in Brain Endothelial Cells

(2009) Melissa A Fleegal-DeMotta et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Benefits of the RAS blockade: clinical evidence before the ONTARGET study

(2009) Christine Perret-Guillaume et al.   JOURNAL OF HYPERTENSION

Nicardipine use in cerebrovascular disease: A review of controlled clinical studies

(2009) Francesco Amenta et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal

(2008) Liana G. Apostolova et al.   NEUROBIOLOGY OF AGING