Article
Multidisciplinary Sciences
Xu-Dong Zhu, Yong-Fei Fan, Yi Zhao, Xue-Yu Song, Xiang-Sen Liu, Zhao-Jia Gao, Kai Yuan
Summary: This study investigates the impact of TK1-related ceRNA networks on the prognosis of NSCLC. The results suggest that TK1 may serve as a prognostic biomarker and therapeutic target for NSCLC.
Article
Reproductive Biology
Taojie Zhang, Lijuan Zhang, Guoliang Huang, Xiaomeng Hao, Zezheng Liu, Shengdong Huo
Summary: Melatonin regulates the expression of microRNAs in the ovaries, mainly through the STAT3 pathway. The LIN28/let-7b and STAT3/miR-21 axes are involved in cell differentiation, apoptosis, and proliferation.
Article
Plant Sciences
Jian-Hua Liu, Chen Li, Liang Cao, Chang-Hong Zhang, Zhi-Hua Zhang
Summary: The study found that Cucurbitacin B (CuB) can regulate the proliferation and apoptosis of lung cancer cells by inhibiting the XIST/miR-let-7c/IL-6/STAT3 axis.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xue Yang, Yunqing Yang, Xueke Qian, Xiaodong Xu, Pengwei Lv
Summary: LINC01559 is significantly upregulated in TNBC tissues and acts as a carcinogenic ceRNA by sponging miRNAs, resulting in the increased expression of oncogenes and promoting TNBC progression. Targeting LINC01559 may be a potential treatment for TNBC patients.
BIOMEDICAL JOURNAL
(2022)
Retraction
Biochemistry & Molecular Biology
Peng-Wei Lu, Lin Li, Fang Wang, Yuan-Ting Gu
Summary: The article on the effects of long non-coding RNA HOST2 on cell migration and invasion in breast cancer was retracted from Wiley Online Library due to image elements of the experimental data being published elsewhere. The conclusions of the article were considered invalid by the editors.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Leiming Wang, Xi Yang, Fei Zhou, Xuesi Sun, Shulin Li
Summary: circUBAP2 promotes cisplatin resistance in TNBC by upregulating ASF1B and activating PI3K/AKT/mTOR signaling.
Article
Biology
Vennila Ponnusamy, Richard T. H. Ip, Moumin A. E. K. Mohamed, Paul Clarke, Eva Wozniak, Charles Mein, Leslie Schwendimann, Akif Barlas, Philippa Chisholm, Ela Chakkarapani, Adina T. Michael-Titus, Pierre Gressens, Ping K. Yip, Divyen K. Shah
Summary: Ponnusamy et al identified let-7b-5p as an elevated microRNA in neonates with moderate to severe encephalopathy using next generation sequencing of dried blood spots. They demonstrated that let-7b-5p exerts its effects through the Hippo-YAP pathway in cell culture and murine models of perinatal brain injury, indicating the need for validation in larger neonate cohorts to confirm its role as a biomarker for neonatal encephalopathy.
COMMUNICATIONS BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wan-Jie Du, Huan Yang, Fang Tong, Shuai Liu, Chen Zhang, Yeying Chen, Yuze Yan, Yan-Wei Xiang, Ling-Yang Hua, Ye Gong, Zhi-Xiang Xu, Xiaoyan Liu, Xingyu Jiang, Mingfang Lu, Ji-Song Guan, Qingjian Han
Summary: This study reveals that primary sensory neurons modulate the cutaneous immune system by limiting the neuronal activity-dependent release of miR-let-7b, which can directly activate dermal dendritic cells via TLR7 and ultimately aggravate psoriatic lesions.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Yuanzhu Xie, Shuaiwen Zhu, Ling Chen, Hongdou Liu, Ting Peng, Zhengnan Ming, Zizheng Zou, Xiyuan Hu, Wensong Luo, Kunjian Peng, Yuan Nie, Tiao Luo, Dayou Ma, Suyou Liu, Zhiyong Luo
Summary: We designed and synthesized a series of novel naphthoquinone derivatives, and identified ZSW as a highly active and low toxic compound for inhibiting tumor cell growth. We demonstrated that ZSW suppresses triple-negative breast cancer (TNBC) cell activity by targeting STAT3, providing a new candidate structure for TNBC clinical drug development.
Article
Endocrinology & Metabolism
Lantian Wang, Xiawei Li, Jian Wu, Qiang Tang
Summary: Exosomal miRNA-let-7b-5p derived from pancreatic cancer cells promotes insulin resistance in C2C12 myotube cells by targeting RNF20 and activating the STAT3/FOXO1 axis.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Oncology
Jiankang Kang, Yanping Zhong, Wei Tian, Junying Li, Xinxiao Li, Lina Zhai, Huaxin Hou, Danrong Li
Summary: The study synthesized a novel anthraquinone-quinazoline hybrid 7B targeting EGFR and Rac1 in TNBC cells, demonstrating superior antiproliferative activity compared to Rhein and gefitinib. Functional assays indicated that hybrid 7B significantly reduced cell viability, induced apoptosis, and inhibited invasion and migration by regulating EMT markers and metastasis-related proteins in TNBC cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Neurosciences
Liyun Deng, Rui Gao, Hai Chen, Bo Jiao, Changteng Zhang, Liuxing Wei, Caiyi Yan, Shixin Ye-Lehmann, Tao Zhu, Chan Chen
Summary: Perioperative neurocognitive disorders (PNDs) are common and severe neurological complications in elderly patients after anesthesia and surgery. This study found that TLR7 activation and up-regulation, potentially triggered by increased let-7b, played a substantial role in the development of PNDs by initiating downstream inflammatory signaling pathways.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Xianglan Liu, Shufeng Li, Yi Yang, Yong Sun, Qingyuan Yang, Nan Gu, Jing Li, Tuo Huang, Ying Liu, Hui Dong, Song Sun, Guosheng Fu, Jian Wu, Bo Yu
Summary: The study investigated the expression of ANRIL in patients with coronary artery disease and its effect on endothelial dysfunction. The findings suggest that ANRIL is associated with markers of endothelial dysfunction and may regulate HUVEC dysfunction through the TGF-beta R1/Smad signaling pathway. This highlights a potential new therapeutic strategy for preventing endothelial dysfunction in cardiovascular disease.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yan Zhong, Lin Deng, Shuo Shi, Qiu-yao Huang, Shu-min Ou-Yang, Jian-shan Mo, Kai Zhu, Xin-ming Qu, Pei-qing Liu, Yuan-xiang Wang, Xiao-lei Zhang
Summary: The small molecule WZ-2-033 has shown promising results in inhibiting STAT3 activation and dimerization, as well as suppressing tumor growth, migration, and invasion in TNBC and gastric cancer cells with aberrant STAT3 activation.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Virology
Yung-Ju Yeh, Ching-Ping Tseng, Sheng-Da Hsu, His -Yuan Huang, Michael M. C. Lai, Hsien-Da Huang, Ju-Chien Cheng
Summary: MicroRNA let-7b is induced by HCV infection and directly targets the HCV genome to regulate HCV replication. Through targeting negative regulators of IFN signaling, let-7b enhances IFN expression and signaling to limit HCV replication in the early stage of infection. This study sheds new insight into the role of let-7b in combating HCV infection and understanding the initial defense mechanisms against RNA viruses.
JOURNAL OF VIROLOGY
(2021)
Article
Oncology
Tianqi Wu, Hongming Song, Dan Xie, Bingkun Zhao, Hui Xu, Chenyang Wu, Kaiyao Hua, Yijun Deng, Changle Ji, Jiashu Hu, Lin Fang
INTERNATIONAL JOURNAL OF ONCOLOGY
(2018)
Article
Oncology
Dan Xie, Hongming Song, Tianqi Wu, Dengfeng Li, Kaiyao Hua, Hui Xu, Bingkun Zhao, Chenyang Wu, Jiashu Hu, Changle Ji, Yijun Deng, Lin Fang
Article
Biochemistry & Molecular Biology
Hongming Song, Qifeng Luo, Xiaochong Deng, Changle Ji, Dengfeng Li, Amik Munankarmy, Wei Jian, Junyong Zhao, Lin Fang
EXPERIMENTAL AND MOLECULAR MEDICINE
(2019)
Article
Oncology
Jiashu Hu, Changle Ji, Kaiyao Hua, Xuehui Wang, Xiaochong Deng, Jiayi Li, Dinny Graham, Lin Fang
INTERNATIONAL JOURNAL OF ONCOLOGY
(2020)
Article
Pathology
Lei Chen, Xuehui Wang, Changle Ji, Jiashu Hu, Lin Fang
PATHOLOGY RESEARCH AND PRACTICE
(2020)
Article
Biochemistry & Molecular Biology
Hongming Song, Dengfeng Li, Tianqi Wu, Dan Xie, Kaiyao Hua, Jiashu Hu, Xiaochong Deng, Changle Ji, Yijun Deng, Lin Fang