Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Zhang, Hongwei Cheng, Hu Chen, Peiyao Xu, En Ren, Yonghe Jiang, Dengfeng Li, Xing Gao, Yating Zheng, Pan He, Huirong Lin, Biaoqi Chen, Gan Lin, Aizheng Chen, Chengchao Chu, Jingsong Mao, Gang Liu
Summary: SHIFT nanoICG technology integrates excellent anti-photobleaching capacity, great optical imaging property, and specific tumoral deposition, enabling enduring fluorescent-guided precise hepatectomy, especially in the resection of indiscoverable satellite lesions in rabbit models of VX2 orthotopic hepatocellular carcinoma.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Biotechnology & Applied Microbiology
Jing Zhu, Chengchao Chu, Dongsheng Li, Yang Zhang, Yi Cheng, Huirong Lin, Xiaoyong Wang, Junxian Liu, Xin Pang, Jingliang Cheng, Gang Liu
Summary: The novel nanoemulsion developed for optical surgical navigation in hepatocellular carcinoma (HCC) demonstrated superior fluorescence performance, allowing clear delineation of tumor tissues and precise resection, suggesting great translational potential in precise HCC imaging and intraoperative navigation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Toshihiro Tanaka, Hideki Iwamoto, Mitsuteru Fujihara, Hideyuki Nishiofuku, Tetsuya Masada, Hiroyuki Suzuki, Hironori Koga, Takuji Torimura, Kimihiko Kichikawa
Summary: The study compared the physiochemical characteristics and drug release properties of cisplatin powder and lipiodol mixtures formed by a glass membrane emulsification device and a 3-way stopcock. The results showed that emulsions formed by the device had a higher percentage of water-in-oil, more homogeneous droplet sizes, and slower cisplatin release compared to those formed by a 3-way stopcock.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xuqi Peng, Yating Zheng, Yi Xue, Xiaoliu Liang, Pan He, Hu Chen, Peng He, Yisheng Peng, Zhenwen Zhao, Yulun Chen, Xiran Gui, Lei Yang, Yongfu Xiong, Juan Lin, Yesi Shi, Chengchao Chu, Yang Zhang, Gang Liu
Summary: Transcatheter arterial ionic-embolization (TAIE) is a promising approach that disrupts intracellular ionic balance to inhibit tumor activity and invasion in treating hepatocellular carcinoma (HCC). The super-stable homogeneous embolic formulation lipiodol-sodium chloride (LSC) selectively deposits in HCC lesions and disrupts the cell's ionic balance, causing cell death without drug resistance. LSC treatment significantly hinders tumor cell migration and invasion by inducing cell swelling and remodeling the cytoskeleton.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Pan He, Yongfu Xiong, Bin Luo, Jianming Liu, Yang Zhang, Yu Xiong, Song Su, Cheng Fang, Yisheng Peng, Hongwei Cheng, Chengchao Chu, Jingsong Mao, Jingdong Li, Bo Li, Zhenyu Yin, Jie Tian, Gang Liu
Summary: This study presents a novel technology called super-stable homogeneous intermix formulating technology (SHIFT) to address the challenges of fluorescent surgical navigation after long-term embolization therapy. Through a retrospective study, it is found that SHIFT and indocyanine green (ICG) formulation have excellent tumor deposition effect and safety. During surgery, SHIFT and ICG can accurately identify tumor regions and boundaries, and improve variables associated with postoperative complications.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Stepan M. Esagian, Christos D. Kakos, Emmanouil Giorgakis, Lyle Burdine, J. Camilo Barreto, Michail N. Mavros
Summary: The role of postoperative TACE after liver resection for HCC is still unclear, with existing evidence suggesting potential benefits but limited to Eastern Asian populations. High-quality randomized clinical trials are needed to confirm the oncologic benefits and applicability of adjuvant TACE.
Review
Pharmacology & Pharmacy
Roshana Saghafian Larijani, Nazanin Shabani Ravari, Navid Goodarzi, Shahram Akhlaghpour, Samaneh Saghafian Larijani, Mohammad Reza Rouini, Rassoul Dinarvand
Summary: Primary liver cancer is the fourth most common cause of cancer-related mortality worldwide, with hepatocellular carcinoma being the most prevalent histological type. Among various therapeutic options, transarterial chemoembolization is an efficient option for patients with intermediate stage HCC. Different embolic materials used in the TACE procedure have their own pros and cons.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haochen Wang, Yanjing Han, Guang Chen, Long Jin
Summary: The study aimed to evaluate if the lipiodol deposition pattern on intraprocedural Angio-CT could predict tumor treatment response in HCC patients treated with c-TACE. Results showed that complete lipiodol deposition on Angio-CT was a predictive factor for therapeutic response to TACE. Additionally, hepatic vein development on Angio-CT in the arterial phase was strongly associated with poor efficacy of TACE.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Oncology
Jiang Bo, Han Peng, Zhu LianHua, Fei Xiang, Luo Yukun
Summary: This study demonstrates that intraprocedural IA-CEUS can be used to predict the tumour response in HCC patients after TACE, and identifies several risk factors associated with tumour response.
Article
Multidisciplinary Sciences
Chunjie Wang, Lei Zhang, Zhijuan Yang, Dongxu Zhao, Zheng Deng, Jialu Xu, Yumin Wu, Yu Hao, Ziliang Dong, Liangzhu Feng, Zhuang Liu
Summary: This study presents the development of a stable water-in-oil Lipiodol Pickering emulsion (LPE) for efficient encapsulation of lipoxygenase (LOX). The pH-responsive and self-fueling microreactor, LOX-loaded CaCO3&hemin-stabilized LPE (LHCa-LPE), showed greatly improved emulsion stability. By converting polyunsaturated fatty acids (PUFAs) to cytotoxic lipid radicals, this microreactor effectively induced ferroptosis of cancer cells and suppressed the progression of hepatocellular carcinoma (HCC) in rat models. This research provides a concise strategy for the preparation of pH-responsive and stable LPE-based self-fueling microreactors, which can serve as embolic and ferroptosis-inducing agents for transarterial ferro-embolization therapy of HCC.
NATIONAL SCIENCE REVIEW
(2023)
Article
Endocrinology & Metabolism
Miao-Ling Chen, Chun-Xue Wu, Jian-Bo Zhang, Hao Zhang, Yuan-Dong Sun, Shi-Lin Tian, Jian-Jun Han
Summary: The study found that HCC patients who received metformin treatment had better overall survival and progression-free survival. Metformin use, BCLC stage, and BMI were independent predictors of OS. PSM analysis showed that the metformin group had longer median OS and PFS compared to the non-metformin group.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Wei Zhang, Zhangkan Huang, Xu Che
Summary: This study compared the outcomes of emergency hepatectomy (EH) and delayed hepatectomy (DH) following transarterial embolization (TAE) in patients with spontaneously ruptured hepatocellular carcinoma (HCC). The results showed that DH patients had a lower in-hospital mortality rate compared to EH patients. There were no significant differences in postoperative complications, recurrence, peritoneal metastasis, and survival rates between the two treatment groups.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Xiang-Ke Niu, Xiao-Feng He
Summary: This study developed a nomogram based on lipiodol deposition to predict the long-term survival of BCLC B-stage HCC patients after sequential cTACE, showing better predictive ability compared to previous models.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Surgery
Hikaru Hayashi, Akira Shimizu, Hiroaki Motoyama, Koji Kubota, Tsuyoshi Notake, Shinsuke Sugenoya, Kiyotaka Hosoda, Koya Yasukawa, Ryoichiro Kobayashi, Yuji Soejima
Summary: Peritoneal recurrence of hepatocellular carcinoma (HCC) after hepatectomy is rare, with less than 1% of cases affected. Indocyanine green (ICG) fluorescence can assist in identifying and resecting peritoneal dissemination nodules, but difficulties in detecting deep lesions and false positives should be noted.
Article
Oncology
Lynn Jeanette Savic, Evan Chen, Nariman Nezami, Nikitha Murali, Charlie Alexander Hamm, Clinton Wang, MingDe Lin, Todd Schlachter, Kelvin Hong, Christos Georgiades, Julius Chapiro, Fabian M. Laage M. Gaupp
Summary: This study compared the efficacy and safety of conventional transarterial chemoembolization (cTACE) with drug-eluting beads (DEB)-TACE in patients with unresectable hepatocellular carcinoma (HCC). The overall survival was not significantly different between the two groups, but cTACE showed superior efficacy in patients with infiltrative disease, whereas DEB-TACE was more effective in nodular tumors. Based on these findings, tumor morphology and distribution can guide the selection of TACE for individual patients.
Article
Chemistry, Multidisciplinary
Huimin Zhu, Jingwen Yu, Jinfa Ye, Yiming Wu, Jintao Pan, Yingying Li, Chuan Chen, Li Zheng, Gang Liu, Chengchao Chu
Summary: Corneal neovascularization (CNV) is a major cause of vision impairment and blindness worldwide. Current treatment options, such as topical eyedrops and coagulation-based procedures, have limitations in terms of efficacy and side effects. Nanoparticle-based drug delivery systems show promise in improving treatment outcomes for CNV.
CHINESE CHEMICAL LETTERS
(2023)
Article
Engineering, Environmental
Fenglin Miao, Huirong Lin, Tianhong Yao, Ruyi Zhang, Xinfei Sun, Hongwei Cheng, Lingwei Gu, Xiaogang Xia, Ting Wu, Wengang Li, Gang Liu
Summary: A vesicle derived from gene-engineering cell membrane was developed to control intraoperative hemorrhage in patients with chemotherapy-induced thrombocytopenia. The vesicle exhibited a double clotting-triggering strategy that resulted in quick and stable clot formation, surpassing the effectiveness of commonly used thrombin and gelatin coagulants. This innovative approach has the potential to improve surgical outcomes for patients with myelosuppression.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Pan He, Yongfu Xiong, Bin Luo, Jianming Liu, Yang Zhang, Yu Xiong, Song Su, Cheng Fang, Yisheng Peng, Hongwei Cheng, Chengchao Chu, Jingsong Mao, Jingdong Li, Bo Li, Zhenyu Yin, Jie Tian, Gang Liu
Summary: This study presents a novel technology called super-stable homogeneous intermix formulating technology (SHIFT) to address the challenges of fluorescent surgical navigation after long-term embolization therapy. Through a retrospective study, it is found that SHIFT and indocyanine green (ICG) formulation have excellent tumor deposition effect and safety. During surgery, SHIFT and ICG can accurately identify tumor regions and boundaries, and improve variables associated with postoperative complications.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Yutian Xia, Jianzhong Zhang, Gang Liu
Summary: Apoptosis, as a fundamental process of cell death, has provided broad prospects for tumor treatment in nanomedicine. However, apoptosis resistance caused by various factors has led to therapeutic failure or tumor recurrence. Ferroptosis, a newly identified form of programmed cell death, offers a new approach to killing cancer cells beyond apoptosis. Combination therapy, which synergizes ferroptosis with apoptosis, has shown promising results in clinical applications. This review summarizes the latest research progress in combining ferroptosis with apoptosis for enhanced tumor therapeutic effects in nanomedicine and suggests a potential research focus for the future.
Article
Engineering, Chemical
Lei Li, Yun Zeng, Gang Liu
Summary: Cardiovascular diseases are a major global cause of disability and death. Traditional therapeutic strategies have limitations in stopping or reducing disease progression and may have side effects. Metal-based nanoparticles developed through nanotechnology have shown promising potential in the treatment of cardiovascular diseases.
Review
Chemistry, Multidisciplinary
Gan Lin, Jiajing Zhou, Hongwei Cheng, Gang Liu
Summary: The development of smart nanosystems has attracted significant attention in improving the efficacy of traditional nanomedicines. However, the diversity and scattered knowledge of these nanosystems pose challenges for their rational design. This review provides a summary of biological barriers and the strategies employed by smart nanosystems to overcome them, offering guidelines for the development of new-generation nanomedicines.
Review
Engineering, Biomedical
Dong Li, Shundong Cai, Peiyu Wang, Hongwei Cheng, Bingwei Cheng, Yang Zhang, Gang Liu
Summary: Due to their long absorption wavelengths, high molar absorptivity, and tunable photosensitivity, phthalocyanines have been widely used in photodynamic therapy. However, they still suffer from poor targeting, always-on photosensitizing properties, and unsatisfactory therapeutic efficiency, hindering their broad applications in biomedicine. Therefore, new design strategies such as modification of targeting molecules, formation of nanoparticles, and activation of photosensitizers have been developed to overcome these limitations. Recent studies have also demonstrated the diverse applications of novel phthalocyanines in fluorescence imaging, photoacoustic imaging, photothermal imaging, sonodynamic therapy, and photothermal therapy. This review focuses on the design strategies, biomedical applications, and clinical development of phthalocyanines, offering insights and references for their future translation into clinical practice.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xuan Liu, Lunzhi Yuan, Jijing Chen, Yali Zhang, Peiwen Chen, Ming Zhou, Jiaxuan Xie, Jian Ma, Jianzhong Zhang, Kun Wu, Qiyi Tang, Quan Yuan, Huachen Zhu, Tong Cheng, Yi Guan, Gang Liu, Ningshao Xia
Summary: Highly pathogenic coronavirus infection leads to defective innate immune response and excessive release of proinflammatory cytokines, resulting in acute respiratory distress syndrome (ARDS). A new antiviral nanobiologic, CoVR-MV, has been developed to interfere with viral infection and promote innate antiviral defenses. CoVR-MV absorbs viruses through its viral spike target interface, interacts with macrophages to clear the virus, and stimulates the production of endogenous type I interferon. These processes modulate the innate immune responses, activate antiviral defenses, and rescue Syrian hamsters from ARDS caused by SARS-CoV-2 and its variants.
Review
Engineering, Biomedical
Biao-Qi Chen, Yi Zhao, Yang Zhang, Yu-Jing Pan, Hong-Ying Xia, Ranjith Kumar Kankala, Shi-Bin Wang, Gang Liu, Ai-Zheng Chen
Summary: This article reviews the challenges in nano-immunotherapy related to immune elimination and immunosuppressive microenvironment in cancer treatment. To address these issues, immune-regulating camouflaged nanocomposites have emerged as prevailing strategies. The article discusses the composition, performances, and mechanisms of various immune-regulating nanoplatforms and their applications in cancer immunotherapy and other immunotherapeutic modalities.
BIOACTIVE MATERIALS
(2023)
Article
Immunology
Jianya Cai, Minjie Zhong, Jianhua Xu, Hongwei Cheng, Shuangta Xu
Summary: Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer with complex tumor heterogeneity. The unique immune tumor microenvironment of TNBC suggests the potential of immunotherapy. Triptolide, a regulator of immune-related signaling, has shown promise in treating TNBC. This study identified interferon-γ (IFN-γ) as a therapeutic target of triptolide, which plays an important role in antitumor immune activation. Triptolide reversed IFN-γ-inducible programmed death-ligand 1 (PD-L1) expression in TNBC and in combination with IFN-γ, it induced activation of cytotoxic CD8+ T lymphocytes, resulting in potent tumor inhibition.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Pan He, Haitian Tang, Yating Zheng, Yongfu Xiong, Hongwei Cheng, Jingdong Li, Yang Zhang, Gang Liu
Summary: Lymph nodes play a crucial role in tumor progression but have limited drug delivery efficiency. Nanomedicines have shown great advantages in targeting lymph nodes, enabling recognition and treatment of tumors. This review comprehensively discusses the factors affecting nanomedicine enrichment in lymph nodes and summarizes precise drug delivery systems, diagnostic drugs, and imaging techniques for lymph nodes. The review also addresses the challenges faced by lymphatic nanomedicines, proposing effective strategies. This review has implications for improving cancer treatment strategies.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shuangta Xu, Jianya Cai, Hongwei Cheng, Wei Wang
Summary: Gene therapy has shown remarkable effectiveness in managing diseases like cancer and inflammation, but there are still significant obstacles in discovering therapeutic drug targets, efficient gene delivery, and gene delivery vehicles. Supramolecular polymers have attracted significant interest due to their effective gene transport capabilities and low immunogenicity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
(2023)
Article
Chemistry, Physical
Zhen Wang, Chenteng Sun, Qian Xu, Xingli Zou, Hongwei Cheng, Xionggang Lu
Summary: This study thermodynamically evaluated the reaction between CO2 and Li2CaSiO4 and examined the CO2 adsorption performance of synthesized Li2CaSiO4 with and without alkali carbonates using thermal analyses. The results showed that alkali carbonates can improve the kinetics and facilitate the CO2 adsorption of Li2CaSiO4.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Review
Chemistry, Multidisciplinary
Jinyong Lin, Dong Li, Changhong Li, Ziqi Zhuang, Chengchao Chu, Kostya (Ken) Ostrikov, Erik W. W. Thompson, Gang Liu, Peiyu Wang
Summary: Cancer cells are more susceptible to oxidative stress and nanomaterials-based therapies that generate reactive oxygen species (ROS) have been effective in eliminating cancer cells. These therapies, including chemodynamic therapy, photodynamic therapy, sonodynamic therapy, as well as multi-modal therapies such as combination therapy, have shown significant inhibition of tumor growth. However, the limitations of multi-modal therapy in material preparation and operation protocols hinder its clinical application. Cold atmospheric plasma (CAP), as a reliable source of ROS, light, and electromagnetic fields, provides a simple alternative for implementing multi-modal treatments. Therefore, the emerging field of tumor precision medicine is expected to benefit from these promising multi-modal therapies based on ROS-generating nanomaterials and reactive media like CAPs.
Article
Materials Science, Biomaterials
Pengfei Zhang, Hu Chen, Chuan Chen, Xuan Liu, Hongwei Cheng, Yaming Wu, Xiaoyong Wang, Gang Liu, Yun Zeng
Summary: In this study, membrane-cloaked manganese dioxide nanoparticles displaying anti-PD-L1 antibodies were developed for targeted immuno-radio-therapy. The nanoparticles selectively delivered CpG-loaded MnO2 nanoparticles and induced systemic anti-tumor immunities, achieving favorable immuno/radio-therapeutic outcomes. This versatile nanoplatform opens a new avenue for personalized nanomedicine.
BIOMATERIALS SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)