Article
Biotechnology & Applied Microbiology
Jing Zhu, Chengchao Chu, Dongsheng Li, Yang Zhang, Yi Cheng, Huirong Lin, Xiaoyong Wang, Junxian Liu, Xin Pang, Jingliang Cheng, Gang Liu
Summary: The novel nanoemulsion developed for optical surgical navigation in hepatocellular carcinoma (HCC) demonstrated superior fluorescence performance, allowing clear delineation of tumor tissues and precise resection, suggesting great translational potential in precise HCC imaging and intraoperative navigation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Surgery
Hikaru Hayashi, Akira Shimizu, Hiroaki Motoyama, Koji Kubota, Tsuyoshi Notake, Shinsuke Sugenoya, Kiyotaka Hosoda, Koya Yasukawa, Ryoichiro Kobayashi, Yuji Soejima
Summary: Peritoneal recurrence of hepatocellular carcinoma (HCC) after hepatectomy is rare, with less than 1% of cases affected. Indocyanine green (ICG) fluorescence can assist in identifying and resecting peritoneal dissemination nodules, but difficulties in detecting deep lesions and false positives should be noted.
Article
Surgery
Daisuke Mito, Yu-Ming Wang, Shao-Chun Wu, Wei-Che Lin, Pei-Yu Tsai, Ching-Hua Hsieh, Johnson Chia-Shen Yang
Summary: This study found that maximizing MINIRF intensity can increase the number of deep lymphatic vessels found, and these deep lymphatic vessels are comparable to superficial lymphatic vessels in terms of number, size, and functionality, which is important for improving lymphedema.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Biochemical Research Methods
Zhidong Wang, Xiao Yang, Lin Mei, Tiantian Jiang, Tingkai Sun, HaiYan Chen, YouShen Wu, Yuanyuan Ji
Summary: Researchers have found various biomedical applications for indocyanine green (ICG) in drug delivery, medical imaging, and disease diagnosis. In this study, they explored the potential of ICG for intraoperative imaging guidance of the gall bladder using in vivo animal experiments. The results showed that ICG had specific uptake by gall bladder cells and tissues and exhibited dynamic biodistribution and clearance in mice. The fluorescence navigation using ICG provided good visualization and detection of gall bladder lesions in clinics.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Biotechnology & Applied Microbiology
Pattarapol Sittisart, Kitsakorn Locharoenrat
Summary: This study aimed to enhance the specific interactions between human hepatocellular carcinoma cell lines (HepG-2) by preparing and investigating the fluorescence emission properties of the Ag-Au-ICG complex. The complex was prepared via physical adsorption and evaluated for fluorescence spectra. The addition of an optimized dosage of Ag-Au-ICG to HepG-2 resulted in maximum fluorescence signal intensity and enhanced contrast fluorescence. The complex showed low cytotoxicity, making it a potential fluorescence enhancer for liver cancer imaging.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Oncology
Wang Jianxi, Zou Xiongfeng, Zheng Zehao, Zhao Zhen, Peng Tianyi, Lin Ye, Jin Haosheng, Jian Zhixiang, Wang Huiling
Summary: This study compared the short-term and survival outcomes of ICG-guided LH and CLH for HCC. The results showed differences between the two groups in operative time, but no significant differences in overall survival and recurrence-free survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Masahiko Kinoshita, Takahito Kawaguchi, Shogo Tanaka, Kenjiro Kimura, Hiroji Shinkawa, Go Ohira, Kohei Nishio, Ryota Tanaka, Shigeaki Kurihara, Shuhei Kushiyama, Takeaki Ishizawa
Summary: ICG fluorescence imaging facilitates the easy identification of hepatic tumors, even in robot-assisted hepatectomy, and can be useful for confirming appropriate surgical margins.
Article
Oncology
Xueyan Zhao, Ziyu Wang, Yulin Wu, Huiming Cai
Summary: The study utilized a fluorescence imaging navigation system to detect the diameter of mice tumors, demonstrating high accuracy and sensitivity in tumor detection.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Review
Medicine, Research & Experimental
Fan-Hua Kong, Qi-Fa Ye, Xiong-Ying Miao, Xi Liu, Si-Qi Huang, Li Xiong, Yu Wen, Zi-Jian Zhang
Summary: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and has high resistance to traditional chemotherapy. Sorafenib, an oral kinase inhibitor, has shown improved survival rates for advanced liver cancer patients, but its clinical application is limited by poor solubility and low bioavailability. Nanoparticles have been explored to enhance the therapeutic efficacy of sorafenib in treating HCC, offering new hope for liver cancer treatment.
Review
Chemistry, Multidisciplinary
Han Wu, Ming-Da Wang, Lei Liang, Hao Xing, Cheng-Wu Zhang, Feng Shen, Dong-Sheng Huang, Tian Yang
Summary: Nanotechnology has gained extensive attention in surveillance, imaging, and treatment of hepatocellular carcinoma. Nanomedicines focus on early diagnosis and precise treatment of HCC, offering promising potential applications in future clinical practice.
Article
Biochemistry & Molecular Biology
Jae Sun Park, Sohyun Park, Sang-Jae Park, Seok-Ki Kim
Summary: In this study, the combination of PDT and chemotherapy with ICG was used to treat HCC cells in vitro and in vivo, and synergistic therapeutic effects were observed. The synergistic effect of PDT and chemotherapy was confirmed in the HCC cell line and PDoX model, with no definite adverse effect.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Masaru Matsumura, Yoshikuni Kawaguchi, Yuta Kobayashi, Kosuke Kobayashi, Takeaki Ishizawa, Nobuhisa Akamatsu, Junichi Kaneko, Junichi Arita, Norihiro Kokudo, Kiyoshi Hasegawa
Summary: This study compared the fluorescence intensity and contrast of CBD and CBD-HDL between patients who received ICG on the day of LC and those who received it one day before. The results showed that administering ICG a day before surgery offers better CBD background contrast.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2021)
Article
Oncology
Takeaki Kusada, Akira Yogi, Hitoshi Hirakawa, Yuiko Yasutomi, Hajime Aoyama, Yuji Matsuo, Yuka Oota, Mayako Zaha, Takuro Ariga, Joichi Heianna, Sadayuki Murayama
Summary: Skin metastasis from primary squamous cell carcinoma of the head and neck is rare. Indocyanine green fluorescence angiography (ICG-FA) can be effective for detecting skin metastases, showing different fluorescence patterns of skin tumors. Further studies on various fluorescence patterns may enhance the efficiency of this technique.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Oncology
Xiaojun Zeng, Wen Zhu, Wenjun Lin, Jie Tian, Jian Yang, Chihua Fang
Summary: This article introduces the feasibility of laparoscopic extended right posterior sectionectomy and related methods, and demonstrates that virtual liver segment projection and ICG fluorescence imaging can improve the accuracy of the surgery.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Medicine, General & Internal
Zoe Garoufalia, Steven D. D. Wexner
Summary: ICG imaging is increasingly used in colorectal surgery for perfusion assessment, ureteral and urethral assessment, lymphatic mapping, and assessment of hepatic and peritoneal metastases. Although evidence level is low, promising results have been observed, especially in reducing anastomotic leaks. ICG imaging is a safe and relatively cheap imaging modality in colorectal surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Environmental
Fenglin Miao, Huirong Lin, Tianhong Yao, Ruyi Zhang, Xinfei Sun, Hongwei Cheng, Lingwei Gu, Xiaogang Xia, Ting Wu, Wengang Li, Gang Liu
Summary: A vesicle derived from gene-engineering cell membrane was developed to control intraoperative hemorrhage in patients with chemotherapy-induced thrombocytopenia. The vesicle exhibited a double clotting-triggering strategy that resulted in quick and stable clot formation, surpassing the effectiveness of commonly used thrombin and gelatin coagulants. This innovative approach has the potential to improve surgical outcomes for patients with myelosuppression.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Pan He, Yongfu Xiong, Bin Luo, Jianming Liu, Yang Zhang, Yu Xiong, Song Su, Cheng Fang, Yisheng Peng, Hongwei Cheng, Chengchao Chu, Jingsong Mao, Jingdong Li, Bo Li, Zhenyu Yin, Jie Tian, Gang Liu
Summary: This study presents a novel technology called super-stable homogeneous intermix formulating technology (SHIFT) to address the challenges of fluorescent surgical navigation after long-term embolization therapy. Through a retrospective study, it is found that SHIFT and indocyanine green (ICG) formulation have excellent tumor deposition effect and safety. During surgery, SHIFT and ICG can accurately identify tumor regions and boundaries, and improve variables associated with postoperative complications.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Environmental
Dong Li, Jie Pan, Shuyu Xu, Bingwei Cheng, Shuaiying Wu, Qixuan Dai, Mei-Rong Ke, Bi-Yuan Zheng, Chengchao Chu, Chao Liu, Yang Zhang, Xiao Xu, Jian-Dong Huang, Gang Liu
Summary: In this study, a novel nanoreactor FeS2@PcD, programmatically regulated by the bivariate factors of H+ and H2O2 in the tumor microenvironment (TME), was designed for specific fluorescence and MR dual-modality imaging-guided sono/chemodynamic therapies, representing a promising precision medicine approach.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Xiao Xu, Hu Chen, Pan He, Zhenwen Zhao, Xing Gao, Chao Liu, Hongwei Cheng, Lai Jiang, Peiyu Wang, Yang Zhang, Xiaofei Wen, Yesen Li, Jinxiong Huang, Yongfu Xiong, Jingsong Mao, Hongjuan Ma, Gang Liu
Summary: A novel injectable lutetium-177-labeled 3D hollow porous radio-granular hydrogels (Lu-177-3D-HPGH) are synthesized and shown to have excellent properties for brachytherapy of hepatocellular carcinoma. The hydrogels exhibit high radiolabeling efficiency, uniform size, controllable release of radiotherapy and excellent underwater adhesion. Animal models confirm the superior embolization performance, loading stability and anti-tumor effect of Lu-177-3D-HPGH.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Engineering, Biomedical
Dong Li, Shundong Cai, Peiyu Wang, Hongwei Cheng, Bingwei Cheng, Yang Zhang, Gang Liu
Summary: Due to their long absorption wavelengths, high molar absorptivity, and tunable photosensitivity, phthalocyanines have been widely used in photodynamic therapy. However, they still suffer from poor targeting, always-on photosensitizing properties, and unsatisfactory therapeutic efficiency, hindering their broad applications in biomedicine. Therefore, new design strategies such as modification of targeting molecules, formation of nanoparticles, and activation of photosensitizers have been developed to overcome these limitations. Recent studies have also demonstrated the diverse applications of novel phthalocyanines in fluorescence imaging, photoacoustic imaging, photothermal imaging, sonodynamic therapy, and photothermal therapy. This review focuses on the design strategies, biomedical applications, and clinical development of phthalocyanines, offering insights and references for their future translation into clinical practice.
ADVANCED HEALTHCARE MATERIALS
(2023)
Editorial Material
Oncology
Lei Cao, Yuanqin Chen, Shuangta Xu, Hongwei Cheng
FRONTIERS IN ONCOLOGY
(2023)
Review
Engineering, Biomedical
Biao-Qi Chen, Yi Zhao, Yang Zhang, Yu-Jing Pan, Hong-Ying Xia, Ranjith Kumar Kankala, Shi-Bin Wang, Gang Liu, Ai-Zheng Chen
Summary: This article reviews the challenges in nano-immunotherapy related to immune elimination and immunosuppressive microenvironment in cancer treatment. To address these issues, immune-regulating camouflaged nanocomposites have emerged as prevailing strategies. The article discusses the composition, performances, and mechanisms of various immune-regulating nanoplatforms and their applications in cancer immunotherapy and other immunotherapeutic modalities.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xiaoxiao Shi, Dazhuang Xu, Hongwei Cheng, Chengchao Chu, Gang Liu
Summary: Interventional fluorescence imaging is a promising strategy for disease diagnosis in clinic, facilitating targeted treatment. However, there are crucial issues such as fast probe clearance, light instability, and residual lesions. The development of SHIFT technology addresses these clinical problems and enables stable and long-lasting imaging, as well as precise visualization of microsatellite lesions.
ACCOUNTS OF MATERIALS RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Xiao Xu, Hu Chen, Zhenwen Zhao, Yangjie Wang, Pan He, Hongwei Cheng, Xing Gao, Yesi Shi, Yesen Li, Jinxiong Huang, Yisheng Peng, Chengchao Chu, Yang Zhang, Chao Liu, Bo Li, Jingsong Mao, Hongjuan Ma, Gang Liu
Summary: Introduces a new method for intravascular brachytherapy using modified lutetium-177 coordinated polymeric microspheres. This method enables precise and stable embolic radiotherapy with good anti-tumor effect and safety. This study provides a highly innovative approach for precision intra-arterial brachytherapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Fan Liang, Hongyan Xu, Hongwei Cheng, Yabo Zhao, Junhe Zhang
Summary: Esophageal cancer is a highly prevalent and deadly disease. The complexity of the tumor microenvironment and the genetic heterogeneity of tumors have made it difficult to treat. Patient-derived models, especially patient-derived xenograft models, offer advantages in predicting drug efficacy, identifying biomarkers, and improving patient prognosis.
CANCER GENE THERAPY
(2023)
Article
Engineering, Environmental
Peng He, Sha Yi, Jianzhong Zhang, Chengchao Chu, Xuqi Peng, Changhong Li, Xinfei Sun, Yang Zhang, Hongwei Cheng, Xia Xiong, Gang Liu
Summary: This study developed a novel formulation of 5-fluorouracil (5-Fu) called carrier-free pure 5-Fu nanoparticles (nano 5-Fu) for scar management. In vitro and in vivo tests showed that nano 5-Fu had superior efficacy in inactivating scar cells and longer retention time in soft tissues compared to free 5-Fu. Animal experiments and a first-in-human trial demonstrated that nano 5-Fu significantly reduced scar elevation, collagen fiber deposition, and microvessels, with excellent and stable efficacy and fewer side effects.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Chunyan Zhu, Lingjie Ke, Xiang Ao, Ying Chen, Hongwei Cheng, Huhu Xin, Xiang Xu, Xian-Jun Loh, Zibiao Li, Haiyan Lyu, Qi Wang, Dandan Zhang, Yuan Ping, Caisheng Wu, Yun-Long Wu
Summary: An injectable supramolecular hydrogel system is developed for in situ fabrication and effective accumulation of CAR-T cells at the tumor site in humanized mice models, resulting in significant promotion of secretion of inflammatory cytokines or tumor killer proteins. This innovative approach reverses the immunosuppressive microenvironment and enhances intra-tumor CAR-T cells and cytotoxic T cells infiltration, showing promise for solid tumor CAR-T immunotherapy.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Chuncheng Zhu, Xinbo Hu, Yu Lei, Qian Xu, Chenteng Sun, Xingli Zou, Hongwei Cheng, Xionggang Lu
Summary: This study investigated the effects of ultrasonic power, leaching time, reaction temperature, solution concentration, and particle size on the leaching process. The optimal leaching conditions were determined, and the results showed that ultrasonic-assisted leaching had higher efficiencies for nickel, copper, and cobalt compared to mechanical agitation leaching. Despite the changes in the sulfur layer's micro-morphology caused by cavitation, the removal effect of ultrasound on sulfur layer was limited.
Article
Materials Science, Biomaterials
Pengfei Zhang, Hu Chen, Chuan Chen, Xuan Liu, Hongwei Cheng, Yaming Wu, Xiaoyong Wang, Gang Liu, Yun Zeng
Summary: In this study, membrane-cloaked manganese dioxide nanoparticles displaying anti-PD-L1 antibodies were developed for targeted immuno-radio-therapy. The nanoparticles selectively delivered CpG-loaded MnO2 nanoparticles and induced systemic anti-tumor immunities, achieving favorable immuno/radio-therapeutic outcomes. This versatile nanoplatform opens a new avenue for personalized nanomedicine.
BIOMATERIALS SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jian Shu, Xiameng Ren, Hongwei Cheng, Shiyi Wang, Lixin Yue, Xia Li, Mengqi Yin, Xiangqin Chen, Tiantian Zhang, Ziye Hui, Xiaojuan Bao, Wanghua Song, Hanjie Yu, Liuyi Dang, Chen Zhang, Jun Wang, Qi Zhao, Zheng Li
Summary: This study reveals the impact of benign lesions on salivary glycopatterns and cancer screening, and demonstrates that adding benign diseases to the control group improves the performance of the classifier.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
