Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice

Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer

(2018) Sun-Hye Jeong et al.   JOURNAL OF CLINICAL INVESTIGATION

Origins of lifetime health around the time of conception: causes and consequences

(2018) Tom P Fleming et al.   LANCET

Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice

(2018) Kook Hwan Kim et al.   Scientific Reports

Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation

(2018) Manoj K. Gupta et al.   Molecular Metabolism

Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children

(2017) Kimberly P. Newton et al.   JOURNAL OF PEDIATRICS

Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease

(2017) Bo Kyung Koo et al.   LIVER INTERNATIONAL

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders

(2017) Stephen L. Pinkosky et al.   TRENDS IN MOLECULAR MEDICINE

TGF-β signalling and liver disease

(2016) Isabel Fabregat et al.   FEBS Journal

Additive effects of dexamethasone and palmitate on hepatic lipid accumulation and secretion

(2016) Ewa Harasim-Symbor et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity

(2016) Paula Walle et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Analyzing and interpreting genome data at the network level with ConsensusPathDB

(2016) Ralf Herwig et al.   Nature Protocols

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins

(2016) Ian B. Robertson et al.   Cold Spring Harbor Perspectives in Biology

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

(2016) Stephen L. Pinkosky et al.   Nature Communications

Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study

(2015) Rohit Loomba et al.   GASTROENTEROLOGY

Hepatic inflammation and fibrosis: Functional links and key pathways

(2015) Ekihiro Seki et al.   HEPATOLOGY

Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans

(2015) Ville T. Männistö et al.   LIVER INTERNATIONAL

P311 promotes renal fibrosis via TGFβ1/Smad signaling

(2015) Zhihui Yao et al.   Scientific Reports

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

(2015) Francine E. Garrett-Bakelman et al.   Jove-Journal of Visualized Experiments

Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes

(2015) Wasco Wruck et al.   Scientific Data

Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring

(2014) Sevim Kahraman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Early Life Exposure to Maternal Insulin Resistance Has Persistent Effects on Hepatic NAFLD in Juvenile Nonhuman Primates

(2014) S. R. Thorn et al.   DIABETES

In vitrotreatment of HepG2 cells with saturated fatty acids reproduces mitochondrial dysfunction found in nonalcoholic steatohepatitis

(2014) Inmaculada García-Ruiz et al.   Disease Models & Mechanisms

Epigenetic modifiers of islet function and mass

(2014) Dario F. De Jesus et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Epigenetic Mechanisms Underlying the Link between Non-Alcoholic Fatty Liver Diseases and Nutrition

(2014) Joo Lee et al.   Nutrients

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery

(2013) Markus Ahrens et al.   Cell Metabolism

Developmental Programming by Maternal Insulin Resistance: Hyperinsulinemia, Glucose Intolerance, and Dysregulated Lipid Metabolism in Male Offspring of Insulin-Resistant Mice

(2013) E. Isganaitis et al.   DIABETES

Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice

(2013) Ling Yang et al.   HEPATOLOGY

Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)

(2013) Laura J. Sharpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Developmental origins of nonalcoholic fatty liver disease

(2013) David E. Brumbaugh et al.   PEDIATRIC RESEARCH

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

(2012) Hae-Ki Min et al.   Cell Metabolism

Multigenerational epigenetic adaptation of the hepatic wound-healing response

(2012) Müjdat Zeybel et al.   NATURE MEDICINE

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gene Expression Profiling Unravels Cancer-Related Hepatic Molecular Signatures in Steatohepatitis but Not in Steatosis

(2012) Julia Starmann et al.   PLoS One

Parental Diabetes: The Akita Mouse as a Model of the Effects of Maternal and Paternal Hyperglycemia in Wildtype Offspring

(2012) Corinna Grasemann et al.   PLoS One

methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles

(2012) Altuna Akalin et al.   GENOME BIOLOGY

The Critical Role of AKT2 in Hepatic Steatosis Induced by PTEN Loss

(2010) Lina He et al.   AMERICAN JOURNAL OF PATHOLOGY

The Effects of Palmitate on Hepatic Insulin Resistance Are Mediated by NADPH Oxidase 3-derived Reactive Oxygen Species through JNK and p38MAPKPathways

(2010) Dan Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Akt–SREBP nexus: cell signaling meets lipid metabolism

(2010) James R. Krycer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Histopathology of nonalcoholic fatty liver disease

(2010) Elizabeth M Brunt   WORLD JOURNAL OF GASTROENTEROLOGY

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

Heritability of Nonalcoholic Fatty Liver Disease

(2009) Jeffrey B. Schwimmer et al.   GASTROENTEROLOGY

Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates

(2009) Carrie E. McCurdy et al.   JOURNAL OF CLINICAL INVESTIGATION

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

(2008) Sudha B. Biddinger et al.   Cell Metabolism

Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice

(2008) Qiong Wang et al.   HEPATOLOGY