Article
Veterinary Sciences
Hao Yu, Xinxing Gao, Juan J. Loor, Qianming Jiang, Zhiyuan Fang, Xue Hao, Zhen Shi, Minghe Fan, Meng Chen, Xinwei Li, Guowen Liu, Zhe Wang, Xiaobing Li, Xiliang Du
Summary: Excessive lipid mobilization caused by severe negative energy balance is the pathological basis for subclinical ketosis in dairy cows. This study found that enhanced transcriptional activity of the TFEB may contribute to lipolysis of adipose tissue in cows with subclinical ketosis. Regulation of TFEB activity could be an effective therapeutic strategy for controlling overt lipolysis in ketotic cows.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cell Biology
Xiaoyan Zheng, Wenjia Lin, Yimin Jiang, Kejia Lu, Wenjing Wei, Qingwei Huo, Shaoyang Cui, Xifei Yang, Min Li, Nenggui Xu, Chunzhi Tang, Ju-Xian Song
Summary: This study demonstrated the cognitive-enhancing effect of three-needle electroacupuncture in an animal model of Alzheimer's disease. The treatment reduced protein aggregation and inhibited glial cell activation by activating TFEB and promoting ALP in the brain. This suggests that three-needle electroacupuncture could be a promising therapy for Alzheimer's disease through a novel mechanism involving TFEB activation.
Review
Biochemistry & Molecular Biology
Anderson Tan, Renuka Prasad, Chaerin Lee, Eek-hoon Jho
Summary: This review summarizes the major advances in TFEB research over the past 30 years, discussing its roles in autophagy, metabolism, and human diseases, as well as the discovered regulatory mechanisms and unanswered questions. It provides important insights into the significance of TFEB in human health.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Pathology
Xiaojuan Chao, Shaogui Wang, Madeline Hlobik, Andrea Ballabio, Hong-Min Ni, Wen-Xing Ding
Summary: Alcohol is a known risk factor for hepatocellular carcinoma, and autophagy plays a dual role in liver cancer. Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and autophagy, and its impairment in alcohol-related liver disease is associated with hepatocellular carcinoma. Genetically deleting hepatic TFEB can attenuate chronic ethanol-induced liver tumor development.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Cell Biology
Martina La Spina, Michele Azzolini, Andrea Salmaso, Sofia Parrasia, Eva Galletta, Marco Schiavone, Martina Chrisam, Andrea Mattarei, Giulietta Di Benedetto, Andrea Ballabio, Natascia Tiso, Mario Zoratti, Lucia Biasutto
Summary: Pterostilbene, a plant phenol, activates transcription factor EB and promotes autophagy and organelle biogenesis. In vivo studies have shown significant functional improvements in disease models with Pterostilbene supplementation, highlighting its therapeutic potential.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Chien-Han Kao, Ting-Yu Su, Wei-Syun Huang, Xin-Ying Lu, Wann-Neng Jane, Chien-Yung Huang, Hung-Hsiang Huang, Won-Jing Wang
Summary: The combination of centrosome depletion and inhibition of the TFEB-TFE3 autophagy-lysosome pathway has strong anti-proliferative effects on cancer cells.
Article
Cell Biology
Zheng Wang, Chun Yang, Dongshi Guan, Jiaqi Li, Hong Zhang
Summary: The interfacial tension and functions of biological condensates can be regulated by cellular surfactant proteins in human cells. TFEB, a transcription factor, is regulated by interfacial tension and exhibits changes in transcriptional activity. Additionally, synergistic surfactant proteins such as MLX, MYC, and IPMK can decrease the interfacial tension and DNA affinity of TFEB condensates, suggesting their role in regulating cellular processes.
DEVELOPMENTAL CELL
(2023)
Article
Biochemistry & Molecular Biology
Xiaotong Chen, Yetong Guan, Yi Zhang, Yufeng Jia, Wen Li, Chun Guo, Yuan Li, Xiaoyan Wang, Yongyu Shi, Qun Wang, Faliang Zhu, Yan Li, Lining Zhang
Summary: TFEB is a crucial regulator of lysosomal biogenesis, whose translation is inhibited by PDCD4. PDCD4 reduces TFEB levels by suppressing its translation, without affecting its nucleocytoplasmic shuttling, leading to lysosomal function suppression.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Neurosciences
Clark W. Bird, Stefanie S. Mayfield, Katalina M. Lopez, Brooke R. Dunn, Angela Feng, Bryce T. Roberts, Roberto N. Almeida, Glenna J. Chavez, C. Fernando Valenzuela
Summary: Our study suggests that exposure to alcohol during the first week of life can induce apoptosis in brain regions and result in long-lasting alterations in neuronal function, contributing to learning and memory deficits.
Article
Food Science & Technology
Pengcheng Pang, Xing Zhang, Jingping Yuan, Hong Yan, Dandan Yan
Summary: Acrylamide (ACR), a neurotoxicant found in starchy foods, can inhibit autophagy and induce apoptosis. This study aimed to investigate the role of Transcription Factor EB (TFEB) in ACR-induced lysosomal dysfunction and cellular apoptosis in Neuro-2a cells. The results showed that ACR exposure inhibited autophagic flux and caused lysosomal dysfunction and increased apoptosis. TFEB overexpression alleviated lysosomal dysfunction, while TFEB knockdown exacerbated it. These findings provide new insights into the mechanism of ACR neurotoxicity and potential targets for prevention and treatment.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jara Tabitha Hees, Angelika Bettina Harbauer
Summary: Mitochondria play a critical role in neuronal function by providing ATP and buffering Ca2+. The regulation of mitochondrial biogenesis at the transcriptional and translational level is necessary for neurons to adapt to local differences in mitochondrial demand. Defects in the localization of mRNAs encoding mitochondrial proteins and contact site formation between mitochondria and endolysosomes can lead to mitochondrial dysfunction in various neurological disorders.
Article
Medicine, Research & Experimental
Hao-Yu Zou, Lin Guo, Bei Zhang, Si Chen, Xin-Rong Wu, Xian-Dong Liu, Xin-Yu Xu, Bin-Yin Li, Shengdi Chen, Nan-Jie Xu, Suya Sun
Summary: This study identifies the miR-339-5p/Nnat pathway as a crucial factor in the development of familial AD, highlighting its potential as a diagnostic and therapeutic target for early pathogenesis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Neurosciences
Pei-Pei Guan, Wei-Yan Ding, Pu Wang
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by neuronal loss and apoptosis. Abnormal expression of cell cycle-related genes and proteins is associated with β-amyloid protein, and treatment with acetylsalicylic acid can partially restore the abnormal expression and reduce neuronal apoptosis. Acetylsalicylic acid mediates the uptake of A beta by astrocytes and activates A beta-degrading mechanisms through multiple signaling pathways, thereby improving cognitive decline.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Toxicology
Wenmin Lu, Danni Li, Shengtao Wei, Jie Yang, Chuanqiao Tang, Xiaoli Ma, Yunfeng Zou
Summary: This study reveals the role of lncRNAs in Mn-induced neurotoxicity, identifying lncSh2d3c as a key regulatory factor that is involved in Mn-induced neuronal apoptosis through the mmu-miR-675-5p/Chmp4b/Bax pathway. This finding suggests a novel mechanism of Mn-induced neurotoxicity and highlights the potential of lncSh2d3c as a therapeutic target.
TOXICOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Yingying Tong, Dong Guo, Shu-Hai Lin, Jiazhen Liang, Dianqiang Yang, Chunmin Ma, Fei Shao, Min Li, Qiujing Yu, Yuhui Jiang, Lei Li, Jing Fang, Rilei Yu, Zhimin Lu
Summary: Glutaminase plays a critical role in promoting cancer cell proliferation, particularly in pancreatic ductal adenocarcinoma (PDAC). The study reveals a novel regulatory mechanism involving succinyl-coenzyme A synthetase and glutaminase catalytic activity, which contributes to survival and growth of tumor cells by counteracting oxidative stress. Moreover, the levels of SUCLA2 pS79 and GLS K311 succinylation are positively correlated with advanced stages of PDAC and poor prognosis for patients.
Article
Cell Biology
Yan Peng, Ren-Ping Xiong, Zhuo-Hang Zhang, Ya-Lei Ning, Yan Zhao, Si-Wei Tan, Yuan-Guo Zhou, Ping Li
Summary: This study demonstrated that Ski plays a crucial role in regulating fibroblast proliferation and apoptosis under high-glucose conditions through the FoxO1 pathway. Increasing Ski protein levels alleviated the inhibitory effects of high glucose on proliferation and promoted apoptosis, highlighting the potential therapeutic implications of targeting Ski in diabetic complications.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Ding-Juan Zhong, Yu Zhang, Shuya Zhang, Yuan-Yuan Ge, Mengyun Tong, Yijia Feng, Feng You, Xinyue Zhao, Ke Wang, Liping Zhang, Xiaoling Liu, Jiang-Fan Chen
Summary: Retinopathy of prematurity (ROP) is a major cause of blindness in children worldwide, and protecting against early hyperoxia-induced retinal vascular loss represents an effective therapeutic window. Research has shown that adenosine A(2A) receptor (A(2A)R) antagonists can reverse cellular proliferation inhibition, offering potential protection against hyperoxia-induced retinal vascular loss.
Article
Biochemistry & Molecular Biology
Yu Zhai, Shi-Yang Ye, Qiu-Shi Wang, Ren-Ping Xiong, Sheng-Yu Fu, Hao Du, Ya-Wei Xu, Yan Peng, Zhi-Zhong Huang, Nan Yang, Yan Zhao, Ya-Lei Ning, Ping Li, Yuan-Guo Zhou
Summary: This study found that ski overexpression after TBI can promote neurorestoration, facilitate neuronal regeneration, and reduce astrogliosis. These results suggest that ski may be an effective neurorestorative gene.
Article
Immunology
Wu Zheng, Yijia Feng, Zhenhai Zeng, Mengqian Ye, Mengru Wang, Xin Liu, Ping Tang, Huiping Shang, Xiaoting Sun, Xiangxiang Lin, Muran Wang, Zhengzheng Li, Yiyun Weng, Wei Guo, Sergii Vakal, Jiang-fan Chen
Summary: A(2A)R is upregulated in the choroid plexus (CP), enhancing its gateway activity in experimental autoimmune encephalomyelitis (EAE) mice. Treatment with the A(2A)R antagonist KW6002 reduces T cell trafficking across the CP and attenuates EAE pathology. Focal knock-down of CP-A(2A)R inhibits the infiltration of Th17(+) cells across the CP through the CCR6-CCL20 axis, leading to protection against EAE pathology. Activation of A(2A)R in the cultured CP epithelium increases CP permeability and facilitates lymphocyte migration.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Qiang Xiao, Xu Han, Gaoyu Liu, Dongmei Zhou, Lijuan Zhang, Juan He, Haixu Xu, Pan Zhou, Quan Yang, Jiangfan Chen, Jie Zhou, Guanmin Jiang, Zhi Yao
Summary: Adenosine signaling through A2A receptor negatively regulates ILC2s and allergic airway inflammation, providing protection against airway inflammation and representing a potential therapeutic target for controlling asthma.
MUCOSAL IMMUNOLOGY
(2022)
Correction
Immunology
Qiang Xiao, Xu Han, Gaoyu Liu, Dongmei Zhou, Lijuan Zhang, Juan He, Haixu Xu, Pan Zhou, Quan Yang, Jiangfan Chen, Jie Zhou, Guanmin Jiang, Zhi Yao
MUCOSAL IMMUNOLOGY
(2022)
Article
Neurosciences
Hao Du, Yan Tan, Chang-Hong Li, Yan Zhao, Ping Li, Ya-Lei Ning, Ruo-Bing Gao, Bo Wang, Yan Peng, Si-Wei Tan, Zhi-Zhong Huang, Xing Chen, Nan Yang, Fa-Bo Shan, Ren-Ping Xiong, Yuan-Guo Zhou
Summary: This study found that microglial adenosine 2A receptor (A(2A)R) has different regulatory effects on the activation of NLRP3 inflammasome at different glutamate concentrations. High glutamate concentrations reverse the inhibitory effect of A(2A)R on NLRP3 inflammasome activation.
NEUROSCIENCE LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Mengqian Ye, Mengru Wang, Yijia Feng, Huiping Shang, Yuwen Yang, Lanxin Hu, Muran Wang, Serhii Vakal, Xiangxiang Lin, Jiangfan Chen, Wu Zheng
Summary: The choroid plexus is a key gateway for peripheral immune cells to enter the CNS. The activity of this gateway is regulated by adenosine A(2A) receptor (A(2A)R) signaling. A(2A)R activity also influences CP permeability and immune homeostasis in the CNS.
PURINERGIC SIGNALLING
(2023)
Article
Neurosciences
Zhu Lin, Feng You, Ting Li, Yijia Feng, Xinyue Zhao, Jingjing Yang, Zhimo Yao, Ying Gao, Jiang-Fan Chen
Summary: Recent studies have shown that astrocytes in the hippocampus exhibit calcium dynamics regulated by sensory inputs and reward delivery, with synchronized but phase-differing dynamics compared to neurons. Additionally, robust synchronization of astrocytic calcium dynamics at the population level was observed among the hippocampus, medial prefrontal cortex, and striatum. The inter-locked, bidirectional communication between astrocytes and neurons may play a role in modulating information processing in working memory.
NEUROSCIENCE BULLETIN
(2022)
Article
Pharmacology & Pharmacy
Yawei Xu, Yalei Ning, Yan Zhao, Yan Peng, Fen Luo, Yuanguo Zhou, Ping Li
Summary: Caffeine as a nonspecific antagonist of the adenosine A(2A) receptor enhances learning and memory function while also correlating with feelings of anxiety. The differential effects of inhibiting A(2A)Rs in the dorsal and ventral hippocampus lead to enhanced memory and increased anxiety, respectively. Optogenetic activation of dorsal or ventral hippocampal A(2A)Rs can reverse these behavioral alterations caused by caffeine intake.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Akihisa Mori, Jiang-Fan Chen, Shinichi Uchida, Cecile Durlach, Shelby M. King, Peter Jenner
Summary: Adenosine A(2A) receptor antagonists are considered as pharmacological targets for treating Parkinson's disease and have the potential to address both motor and non-motor symptoms, as well as modify the disease itself.
Article
Neurosciences
Gengjing Fang, Yuling Zhou, Xiaopeng Zhou, Hui Zhou, Yuan-Yuan Ge, Shengtao Luo, Jiang-Fan Chen, Liping Zhang
Summary: The study revealed that A(2A)R antagonist KW6002 partially reversed CCCP-induced retinal injury by increasing mitochondrial content and reducing cell apoptosis. Transcriptome sequencing showed that A(2A)R blockade decreased the number of CCCP-induced microRNAs by 60% and increased circular RNAs by 50%. These findings provide insights into the neuroprotective mechanisms of A(2A)R antagonists against CCCP-induced retinal injury.
Article
Neurosciences
Hao Du, Chang-Hong Li, Ruo-Bing Gao, Xiao-Qing Cen, Ping Li
Summary: Pyroptosis and the role of GSDMD in neurological deficits and neuropathological alterations after TBI have been investigated. Inhibition of GSDMD exerts neuroprotective effects and is mainly driven by the NLRP3 inflammasome.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Hai-Ying Shen, Sadie B. Baer, Raey Gesese, John M. Cook, Landen Weltha, Shayla Q. Coffman, Jie Wu, Jiang-Fan Chen, Ming Gao, Teng Ji
Summary: This study aimed to evaluate the role of adenosine A(2A) receptor (A(2A)R) in the development of a SUDEP mouse model. The researchers found that the level of A(2A)R in the nucleus tractus solitarius (NTS) was increased in epileptic mice and that inhibiting A(2A)R could reduce SUDEP events. The findings suggest that A(2A)R may be a potential therapeutic target for preventing SUDEP.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Yan He, Linshan Huang, Ke Wang, Xinran Pan, Qionghui Cai, Feiyang Zhang, Jingjing Yang, Gengjing Fang, Xinyue Zhao, Feng You, Yijia Feng, Yan Li, Jiang-Fan Chen
Summary: This study investigates the behavioral mechanism of alpha-Syn in Parkinson's disease (PD) and suggests a novel therapeutic strategy to improve sequence-learning deficit by using adenosine A2A receptor antagonists.