Membrane mucins of the intestine at a glance

MUC1 is a receptor for the Salmonella SiiE adhesin that enables apical invasion into enterocytes

(2019) Xinyue Li et al.   PLoS Pathogens

Physical Principles of Membrane Shape Regulation by the Glycocalyx

(2019) Carolyn R. Shurer et al.   CELL

The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane

(2019) Hannah Schneider et al.   BIOCHEMICAL JOURNAL

Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease

(2018) Kelli L. VanDussen et al.   GASTROENTEROLOGY

Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers

(2018) Sergio Trillo-Muyo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Study of mucin turnover in the small intestine by in vivo labeling

(2018) Hannah Schneider et al.   Scientific Reports

A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns

(2018) April E. Price et al.   IMMUNITY

Regulation of actin-based apical structures on epithelial cells

(2018) Thaher Pelaseyed et al.   JOURNAL OF CELL SCIENCE

Intestinal Muc2 mucin O-glycosylation is affected by microbiota and regulated by differential expression of glycosyltranferases

(2017) Liisa Arike et al.   GLYCOBIOLOGY

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

Expansion of divergent SEA domains in cell surface proteins and nucleoporin 54

(2017) Jimin Pei et al.   PROTEIN SCIENCE

Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge mechanism

(2017) Thaher Pelaseyed et al.   eLife

Core 1– and 3–derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice

(2016) K Bergstrom et al.   Mucosal Immunology

N-Glycan-based ER Molecular Chaperone and Protein Quality Control System: The Calnexin Binding Cycle

(2016) Lydia Lamriben et al.   TRAFFIC

Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization

(2015) Malin E.V. Johansson et al.   Cell Host & Microbe

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch

(2015) Wendy R. Gordon et al.   DEVELOPMENTAL CELL

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Fucosylation and protein glycosylation create functional receptors for cholera toxin

(2015) Amberlyn M Wands et al.   eLife

Intestinal Brush Border Assembly Driven by Protocadherin-Based Intermicrovillar Adhesion

(2014) Scott W. Crawley et al.   CELL

Association of the interleukin-22 genetic polymorphisms with ulcerative colitis

(2014) Hong Gang Chi et al.   Diagnostic Pathology

Assembly of the Respiratory Mucin MUC5B

(2014) Caroline Ridley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes

(2013) Thaher Pelaseyed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution

(2013) Jessica M. Holmén Larsson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell-protective device

(2013) Thaher Pelaseyed et al.   FEBS Journal

Site-specificO-Glycosylation on the MUC2 Mucin Protein Inhibits Cleavage by thePorphyromonas gingivalisSecreted Cysteine Protease (RgpB)

(2013) Sjoerd van der Post et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells

(2012) Raghuvir Viswanatha et al.   JOURNAL OF CELL BIOLOGY

Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype

(2012) Jenny K. Gustafsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

(2012) D. Ambort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family

(2011) E. P. Bennett et al.   GLYCOBIOLOGY

Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation

(2011) Jessica M. Holmn Larsson et al.   INFLAMMATORY BOWEL DISEASES

Core-glycosylated Mucin-like Repeats from MUC1 Are an Apical Targeting Signal

(2011) Carol L. Kinlough et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CFTR anion channel modulates expression of human transmembrane mucin MUC3 through the PDZ protein GOPC

(2011) T. Pelaseyed et al.   JOURNAL OF CELL SCIENCE

Mucin 13: Structure, Function, and Potential Roles in Cancer Pathogenesis

(2011) D. M. Maher et al.   MOLECULAR CANCER RESEARCH

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Membrane-tethered mucins have multiple functions on the ocular surface

(2010) Bharathi Govindarajan et al.   EXPERIMENTAL EYE RESEARCH

DNA methylation and histone H3-K9 modifications contribute to MUC17 expression

(2010) Sho Kitamoto et al.   GLYCOBIOLOGY

Evasion of Endoplasmic Reticulum Surveillance Makes Wsc1p an Obligate Substrate of Golgi Quality Control

(2010) Songyu Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Ulcerative colitis–risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study

(2009) Mark S Silverberg et al.   NATURE GENETICS

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine

(2008) Emily K. Malmberg et al.   BIOCHEMICAL JOURNAL

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

(2008) W. R. Gordon et al.   BLOOD

Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases

(2008) Audrey Vincent et al.   FASEB JOURNAL

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

(2008) Ken Sugimoto et al.   JOURNAL OF CLINICAL INVESTIGATION

RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

(2008) Stephanie L Sanos et al.   NATURE IMMUNOLOGY

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

(2008) S. Vaishnava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA