Impact of circulating tumor DNA in hepatocellular and pancreatic carcinomas

Longitudinal monitoring of KRAS-mutated circulating tumor DNA enables the prediction of prognosis and therapeutic responses in patients with pancreatic cancer

(2020) Fumiaki Watanabe et al.   PLoS One

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Multiplex Enrichment and Detection of Rare KRAS Mutations in Liquid Biopsy Samples using Digital Droplet Pre-Amplification

(2019) Erica D. Pratt et al.   ANALYTICAL CHEMISTRY

The current state of molecular testing in the treatment of patients with solid tumors, 2019

(2019) Wafik S. El‐Deiry et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Circulating Tumor DNA as a Clinical Test in Resected Pancreatic Cancer

(2019) Vincent P Groot et al.   CLINICAL CANCER RESEARCH

Hepatocellular Carcinoma

(2019) Augusto Villanueva   NEW ENGLAND JOURNAL OF MEDICINE

Promoter methylation of ADAMTS1 and BNC1 as potential biomarkers for early detection of pancreatic cancer in blood

(2019) Maryam A. L. Eissa et al.   Clinical Epigenetics

Molecular profiling of hepatocellular carcinoma using circulating cell-free DNA

(2019) Ahmed O Kaseb et al.   CLINICAL CANCER RESEARCH

Detection of a novel panel of somatic mutations in plasma cell-free DNA and its diagnostic value in hepatocellular carcinoma

(2019) Yu Xiong et al.   Cancer Management and Research

Endoscopic Ultrasound for Early Diagnosis of Pancreatic Cancer

(2019) Takeichi Yoshida et al.   Diagnostics

Quantitative monitoring of circulating tumor DNA in patients with advanced pancreatic cancer undergoing chemotherapy

(2019) Makoto Sugimori et al.   CANCER SCIENCE

Clinical correlates of blood-derived circulating tumor DNA in pancreatic cancer

(2019) Hitendra Patel et al.   Journal of Hematology & Oncology

The diverse origins of circulating cell-free DNA in the human body: a critical re-evaluation of the literature

(2018) Janine Aucamp et al.   BIOLOGICAL REVIEWS

KRAS mutations in cell-free DNA from preoperative and postoperative sera as a pancreatic cancer marker: a retrospective study

(2018) Yutaka Nakano et al.   BRITISH JOURNAL OF CANCER

Circulating Tumor DNA as a Sensitive Marker in Patients Undergoing Irreversible Electroporation for Pancreatic Cancer

(2018) Mao Lin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Droplet digital PCR detects high rate of TP53 R249S mutants in cell-free DNA of middle African patients with hepatocellular carcinoma

(2018) Agnès Marchio et al.   CLINICAL AND EXPERIMENTAL MEDICINE

False positive plasma genotyping due to clonal hematopoiesis

(2018) Yuebi Hu et al.   CLINICAL CANCER RESEARCH

Prognostic Implications of Multiplex Detection ofKRASMutations in Cell-Free DNA from Patients with Pancreatic Ductal Adenocarcinoma

(2018) Min Kyeong Kim et al.   CLINICAL CHEMISTRY

Novel scores combining AFP with non-invasive markers for prediction of liver fibrosis in chronic hepatitis C patients

(2018) Mohamed Gamil et al.   JOURNAL OF MEDICAL VIROLOGY

Hepatocellular carcinoma

(2018) Alejandro Forner et al.   LANCET

Analysis of Tissue and Circulating Tumor DNA by Next-Generation Sequencing of Hepatocellular Carcinoma: Implications for Targeted Therapeutics

(2018) Sadakatsu Ikeda et al.   MOLECULAR CANCER THERAPEUTICS

MutantKRASCirculating Tumor DNA Is an Accurate Tool for Pancreatic Cancer Monitoring

(2018) Ruth Perets et al.   ONCOLOGIST

Next‐Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma

(2018) Sadakatsu Ikeda et al.   ONCOLOGIST

Plasma m SEPT9 : A Novel Circulating Cell-free DNA-Based Epigenetic Biomarker to Diagnose Hepatocellular Carcinoma

(2018) Abderrahim Oussalah et al.   EBioMedicine

OUP accepted manuscript

(2018)   ANNALS OF ONCOLOGY

Utility of targeted deep sequencing for detecting circulating tumor DNA in pancreatic cancer patients

(2018) Gahee Park et al.   Scientific Reports

Monitoring Tumor Burden in Response to FOLFIRINOX Chemotherapy Via Profiling Circulating Cell-Free DNA in Pancreatic Cancer

(2018) Tao Wei et al.   MOLECULAR CANCER THERAPEUTICS

Promoter hypermethylation in plasma-derived cell-free DNA as a prognostic marker for pancreatic adenocarcinoma staging

(2017) Stine Dam Henriksen et al.   INTERNATIONAL JOURNAL OF CANCER

Analysis of ctDNA to predict prognosis and monitor treatment responses in metastatic pancreatic cancer patients

(2017) He Cheng et al.   INTERNATIONAL JOURNAL OF CANCER

The Mutational Landscape of Gastrointestinal Malignancies as Reflected by Circulating Tumor DNA

(2017) Paul Riviere et al.   MOLECULAR CANCER THERAPEUTICS

Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA

(2017) Shicheng Guo et al.   NATURE GENETICS

Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma

(2017) Rui-hua Xu et al.   NATURE MATERIALS

Utility of serum DNA as a marker for KRAS mutations in pancreatic cancer tissue

(2017) Soichiro Ako et al.   PANCREATOLOGY

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers

(2017) Joshua D. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrasensitive plasma ctDNA KRAS assay for detection, prognosis, and assessment of therapeutic response in patients with unresectable pancreatic ductal adenocarcinoma

(2017) Inna Chen et al.   Oncotarget

Targeted deep sequencing of circulating tumor DNA in metastatic pancreatic cancer

(2017) Andreas W. Berger et al.   Oncotarget

Profiling tumour heterogeneity through circulating tumour DNA in patients with pancreatic cancer

(2017) Patricia Adamo et al.   Oncotarget

Cell-free DNA promoter hypermethylation in plasma as a predictive marker for survival of patients with pancreatic adenocarcinoma

(2017) Stine Dam Henriksen et al.   Oncotarget

Early changes in plasma DNA levels of mutant KRAS as a sensitive marker of response to chemotherapy in pancreatic cancer

(2017) Marzia Del Re et al.   Scientific Reports

Prognostic value of circulating tumour DNA in patients undergoing curative resection for pancreatic cancer

(2016) Naoto Hadano et al.   BRITISH JOURNAL OF CANCER

Plasma Circulating Tumor DNA in Pancreatic Cancer Patients Is a Prognostic Marker

(2016) Daniel Pietrasz et al.   CLINICAL CANCER RESEARCH

Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms

(2016) Jun Yu et al.   GUT

Understanding TERT Promoter Mutations: A Common Path to Immortality

(2016) R. J. A. Bell et al.   MOLECULAR CANCER RESEARCH

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Phase I/II Study of Refametinib (BAY 86-9766) in Combination with Gemcitabine in Advanced Pancreatic cancer

(2016) Jean-Luc Van Laethem et al.   Targeted Oncology

A pilot study evaluating concordance between blood-based and patient-matched tumor molecular testing within pancreatic cancer patients participating in the Know Your Tumor (KYT) initiative

(2016) Michael J. Pishvaian et al.   Oncotarget

Noninvasive detection of tumor-associated mutations from circulating cell-free DNA in hepatocellular carcinoma patients by targeted deep sequencing

(2016) Wenjun Liao et al.   Oncotarget

Cell-free DNA promoter hypermethylation in plasma as a diagnostic marker for pancreatic adenocarcinoma

(2016) Stine Dam Henriksen et al.   Clinical Epigenetics

Detecting Circulating Tumor DNA in Hepatocellular Carcinoma Patients Using Droplet Digital PCR Is Feasible and Reflects Intratumoral Heterogeneity

(2016) Ao Huang et al.   Journal of Cancer

Co-amplification at Lower Denaturation-temperature PCR Combined with Unlabled-probe High-resolution Melting to Detect KRAS Codon 12 and 13 Mutations in Plasma-circulating DNA of Pancreatic Adenocarcinoma Cases

(2015) Jiong Wu et al.   Asian Pacific Journal of Cancer Prevention

Circulating tumor cells (CTC) and KRAS mutant circulating free DNA (cfDNA) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancer

(2015) Julie Earl et al.   BMC CANCER

Detection ofK-rasgene mutation by liquid biopsy in patients with pancreatic cancer

(2015) Hideaki Kinugasa et al.   CANCER

Erratum: Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients

(2015) Lu Wen et al.   CELL RESEARCH

Intratumor Molecular and Phenotypic Diversity in Hepatocellular Carcinoma

(2015) J.-C. Nault et al.   CLINICAL CANCER RESEARCH

Clinical relevance of circulating KRAS mutated DNA in plasma from patients with advanced pancreatic cancer

(2015) Kjersti Tjensvoll et al.   Molecular Oncology

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

(2015) Richard A Moffitt et al.   NATURE GENETICS

Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments

(2015) Kun Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of droplet digital PCR and conventional quantitative PCR for measuring EGFR gene mutation

(2015) BO ZHANG et al.   Experimental and Therapeutic Medicine

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

(2015) Agnieszka K. Witkiewicz et al.   Nature Communications

Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

(2015) Mark Sausen et al.   Nature Communications

Cell-Free DNA Next-Generation Sequencing in Pancreatobiliary Carcinomas

(2015) O. A. Zill et al.   Cancer Discovery

Clinical utility of circulating tumor DNA for molecular assessment in pancreatic cancer

(2015) Erina Takai et al.   Scientific Reports

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Considerations for Digital PCR as an Accurate Molecular Diagnostic Tool

(2014) J. F. Huggett et al.   CLINICAL CHEMISTRY

Circulating Tumor DNA as a Liquid Biopsy for Cancer

(2014) E. Heitzer et al.   CLINICAL CHEMISTRY

Evaluation of INK4A promoter methylation using pyrosequencing and circulating cell-free DNA from patients with hepatocellular carcinoma

(2014) Gengming Huang et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Pharmacodynamic separation of gemcitabine and erlotinib in locally advanced or metastatic pancreatic cancer: therapeutic and biomarker results

(2014) Thomas Semrad et al.   International Journal of Clinical Oncology

Aberrant DNA Methylation of G-protein-coupled Bile Acid Receptor Gpbar1 (TGR5) is a Potential Biomarker for Hepatitis B Virus Associated Hepatocellular Carcinoma

(2014) Li-Yan Han et al.   International Journal of Medical Sciences

Liquid Biopsies: Genotyping Circulating Tumor DNA

(2014) Luis A. Diaz et al.   JOURNAL OF CLINICAL ONCOLOGY

Pancreatic Adenocarcinoma

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

(2014) C. Bettegowda et al.   Science Translational Medicine

MT1MandMT1Gpromoter methylation as biomarkers for hepatocellular carcinoma

(2014) Xiang-Fen Ji   WORLD JOURNAL OF GASTROENTEROLOGY

Circulating tumor DNA moves further into the spotlight

(2014) Mark Sausen et al.   Genome Medicine

Novel Methylation Biomarker Panel for the Early Detection of Pancreatic Cancer

(2013) J. M. Yi et al.   CLINICAL CANCER RESEARCH

High-Resolution Profiling of Fetal DNA Clearance from Maternal Plasma by Massively Parallel Sequencing

(2013) S. C. Y. Yu et al.   CLINICAL CHEMISTRY

Position paper of the Italian Association for the Study of the Liver (AISF): The multidisciplinary clinical approach to hepatocellular carcinoma

(2013) Luigi Bolondi et al.   DIGESTIVE AND LIVER DISEASE

Detection of Circulating Pancreas Epithelial Cells in Patients With Pancreatic Cystic Lesions

(2013) Andrew D. Rhim et al.   GASTROENTEROLOGY

Methylation profiling of serum DNA from hepatocellular carcinoma patients using an Infinium Human Methylation 450 BeadChip

(2013) Pengjun Zhang et al.   Hepatology International

Commonality and differences of methylation signatures in the plasma of patients with pancreatic cancer and colorectal cancer

(2013) Joshua Melson et al.   INTERNATIONAL JOURNAL OF CANCER

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

(2013) Muhammed Murtaza et al.   NATURE

Genetics and epigenetics of liver cancer

(2013) Cigdem Ozen et al.   New Biotechnology

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

(2013) Jean Charles Nault et al.   Nature Communications

Computational optimisation of targeted DNA sequencing for cancer detection

(2013) Pierre Martinez et al.   Scientific Reports

Screening for Pancreatic Cancer

(2012) Katherine E. Poruk et al.   ANNALS OF SURGERY

Pyrophosphorolysis-Activated Polymerization Detects Circulating Tumor DNA in Metastatic Uveal Melanoma

(2012) J. Madic et al.   CLINICAL CANCER RESEARCH

Genetically Defined Subsets of Human Pancreatic Cancer Show Unique In Vitro Chemosensitivity

(2012) Y. Cui et al.   CLINICAL CANCER RESEARCH

Mutant TP53 in Duodenal Samples of Pancreatic Juice From Patients With Pancreatic Cancer or High-Grade Dysplasia

(2012) Mitsuro Kanda et al.   Clinical Gastroenterology and Hepatology

Detection of TFPI2 Methylation in the Serum of Hepatocellular Carcinoma Patients

(2012) Feng-Kai Sun et al.   DIGESTIVE DISEASES AND SCIENCES

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

Is serum level of methylated RASSF1A valuable in diagnosing hepatocellular carcinoma in patients with chronic viral hepatitis C?

(2012) Nadia A. Mohamed et al.   Arab Journal of Gastroenterology

High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number

(2011) Benjamin J. Hindson et al.   ANALYTICAL CHEMISTRY

Quantitative analysis of multiple methylated genes in plasma for the diagnosis and prognosis of hepatocellular carcinoma

(2011) Zhao-Hui Huang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

A Locked Nucleic Acid Clamp-Mediated PCR Assay for Detection of a p53 Codon 249 Hotspot Mutation in Urine

(2011) Selena Y. Lin et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Role of Quantitative NPTX2 Hypermethylation as a Novel Serum Diagnostic Marker in Pancreatic Cancer

(2011) Joo Kyung Park et al.   PANCREAS

Universal noninvasive detection of solid organ transplant rejection

(2011) T. M. Snyder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential methylation of cell-free circulating DNA among patients with pancreatic cancer versus chronic pancreatitis

(2010) Thomas Liggett et al.   CANCER

The virtosome-a novel cytosolic informative entity and intercellular messenger

(2010) Peter B. Gahan et al.   CELL BIOCHEMISTRY AND FUNCTION

Efficient detection of hepatocellular carcinoma by a hybrid blood test of epigenetic and classical protein markers

(2010) Norio Iizuka et al.   CLINICA CHIMICA ACTA

K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer

(2010) H. Chen et al.   EJSO

Clinicopathological significance of RASSF1A reduced expression and hypermethylation in hepatocellular carcinoma

(2010) Lang Hu et al.   Hepatology International

Development of Personalized Tumor Biomarkers Using Massively Parallel Sequencing

(2010) R. J. Leary et al.   Science Translational Medicine

Concordance of DNA methylation pattern in plasma and tumor DNA of Egyptian hepatocellular carcinoma patients

(2009) Priyanka Iyer et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Follow-Up Study of K-ras Mutations in the Plasma of Patients With Pancreatic Cancer

(2009) Jan Däbritz et al.   PANCREAS

Quantitative Analysis of Circulating Methylated DNA as a Biomarker for Hepatocellular Carcinoma

(2008) K. C. A. Chan et al.   CLINICAL CHEMISTRY

Methylation profile of circulating plasma DNA in patients with pancreatic cancer

(2008) Anatoliy A. Melnikov et al.   JOURNAL OF SURGICAL ONCOLOGY

Circulating mutant DNA to assess tumor dynamics

(2008) Frank Diehl et al.   NATURE MEDICINE

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

K-rasMutations and Benefit from Cetuximab in Advanced Colorectal Cancer

(2008) Christos S. Karapetis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sensitive Detection of Colorectal Cancer in Peripheral Blood by Septin 9 DNA Methylation Assay

(2008) Robert Grützmann et al.   PLoS One

Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma

(2008) R. W. K. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE