Beyond the Fold: Emerging Biological Applications of DNA Origami

Evolution of DNA origami scaffolds

(2016) Arun Richard Chandrasekaran et al.   MATERIALS LETTERS

Programmable DNA scaffolds for spatially-ordered protein assembly

(2016) Arun Richard Chandrasekaran   Nanoscale

Nucleic Acid Nanostructures for Chemical and Biological Sensing

(2016) Arun Richard Chandrasekaran et al.   Small

Single-molecule observations of RNA–RNA kissing interactions in a DNA nanostructure

(2016) Yosuke Takeuchi et al.   Biomaterials Science

Electrochemical DNA Biosensor Based on a Tetrahedral Nanostructure Probe for the Detection of Avian Influenza A (H7N9) Virus

(2015) Shibiao Dong et al.   ACS Applied Materials & Interfaces

Covalent Linkage of One-Dimensional DNA Arrays Bonded by Paranemic Cohesion

(2015) Yoel P. Ohayon et al.   ACS Nano

Topological Linkage of DNA Tiles Bonded by Paranemic Cohesion

(2015) Yoel P. Ohayon et al.   ACS Nano

Purification of Functionalized DNA Origami Nanostructures

(2015) Alan Shaw et al.   ACS Nano

Electrochemical Quantification ofEscherichia coliwith DNA Nanostructure

(2015) Marcella Giovanni et al.   ADVANCED FUNCTIONAL MATERIALS

Post-Assembly Stabilization of Rationally Designed DNA Crystals

(2015) Jiemin Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reversible Reconfiguration of DNA Origami Nanochambers Monitored by Single-Molecule FRET

(2015) Barbara Saccà et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Growth and Origami Folding of DNA on Nanoparticles for High-Efficiency Molecular Transport in Cellular Imaging and Drug Delivery

(2015) Juan Yan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single-Molecule Visualization of the Activity of a Zn2+ -Dependent DNAzyme

(2015) Masayuki Endo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA nanotubes as intracellular delivery vehicles in vivo

(2015) Sabine Sellner et al.   BIOMATERIALS

A modular DNA origami-based enzyme cascade nanoreactor

(2015) Veikko Linko et al.   CHEMICAL COMMUNICATIONS

DNA origami and biotechnology applications: a perspective

(2015) Arun Richard Chandrasekaran   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

MicroRNA-triggered, cascaded and catalytic self-assembly of functional “DNAzyme ferris wheel” nanostructures for highly sensitive colorimetric detection of cancer cells

(2015) Wenjiao Zhou et al.   Nanoscale

Monitoring patterned enzymatic polymerization on DNA origami at single-molecule level

(2015) A. H. Okholm et al.   Nanoscale

DNA nanotechnology for nanophotonic applications

(2015) Anirban Samanta et al.   Nanoscale

Isothermal DNA origami folding: avoiding denaturing conditions for one-pot, hybrid-component annealing

(2015) Andreas Kopielski et al.   Nanoscale

Placing molecules with Bohr radius resolution using DNA origami

(2015) Jonas J. Funke et al.   Nature Nanotechnology

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Programmable motion of DNA origami mechanisms

(2015) Alexander E. Marras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic DNA devices and assemblies formed by shape-complementary, non-base pairing 3D components

(2015) T. Gerling et al.   SCIENCE

Construction of a Fuzzy and Boolean Logic Gates Based on DNA

(2015) Reza M. Zadegan et al.   Small

A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics

(2015) Qiao Jiang et al.   Small

Daunorubicin-Loaded DNA Origami Nanostructures Circumvent Drug-Resistance Mechanisms in a Leukemia Model

(2015) Patrick D. Halley et al.   Small

Programmable DNA Nanoswitches for Detection of Nucleic Acid Sequences

(2015) Arun Richard Chandrasekaran et al.   ACS Sensors

Engineering DNA Self-Assemblies as Templates for Functional Nanostructures

(2014) Zhen-Gang Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy

(2014) Qian Zhang et al.   ACS Nano

Addressing the Instability of DNA Nanostructures in Tissue Culture

(2014) Jaeseung Hahn et al.   ACS Nano

Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics

(2014) Dongfang Wang et al.   ANALYTICAL CHEMISTRY

Functionalizing Designer DNA Crystals with a Triple-Helical Veneer

(2014) David A. Rusling et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct and Single-Molecule Visualization of the Solution-State Structures of G-Hairpin and G-Triplex Intermediates

(2014) Arivazhagan Rajendran et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Facile and Scalable Preparation of Pure and Dense DNA Origami Solutions

(2014) Evi Stahl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single Molecule Visualization and Characterization of Sox2–Pax6 Complex Formation on a Regulatory DNA Element Using a DNA Origami Frame

(2014) Seigi Yamamoto et al.   NANO LETTERS

Toward Larger DNA Origami

(2014) Alexandria N. Marchi et al.   NANO LETTERS

Spatial control of membrane receptor function using ligand nanocalipers

(2014) Alan Shaw et al.   NATURE METHODS

Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT

(2014) Ralf Jungmann et al.   NATURE METHODS

DNA nanoswitches: a quantitative platform for gel-based biomolecular interaction analysis

(2014) Mounir A Koussa et al.   NATURE METHODS

Universal computing by DNA origami robots in a living animal

(2014) Yaniv Amir et al.   Nature Nanotechnology

Direct analysis of Holliday junction resolving enzyme in a DNA origami nanostructure

(2014) Y. Suzuki et al.   NUCLEIC ACIDS RESEARCH

A single-stranded architecture for cotranscriptional folding of RNA nanostructures

(2014) C. Geary et al.   SCIENCE

Nanomechanical DNA Origami pH Sensors

(2014) Akinori Kuzuya et al.   SENSORS

DNA Origami Structures Directly Assembled from Intact Bacteriophages

(2014) Philipp C. Nickels et al.   Small

Enzyme-Free Colorimetric Detection of DNA by Using Gold Nanoparticles and Hybridization Chain Reaction Amplification

(2013) Pei Liu et al.   ANALYTICAL CHEMISTRY

DNA Origami as a DNA Repair Nanosensor at the Single-Molecule Level

(2013) Maria Tintoré et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-Assembled DNA Crystals: The Impact on Resolution of 5′-Phosphates and the DNA Source

(2013) Ruojie Sha et al.   NANO LETTERS

Controlling the stoichiometry and strand polarity of a tetramolecular G-quadruplex structure by using a DNA origami frame

(2013) A. Rajendran et al.   NUCLEIC ACIDS RESEARCH

Functional DNA Nanostructures for Photonic and Biomedical Applications

(2013) Zhen-Gang Wang et al.   Small

A Facile Method for Preparation of Tailored Scaffolds for DNA-Origami

(2013) Michael Erkelenz et al.   Small

Rolling Circle Amplification-Based DNA Origami Nanostructrures for Intracellular Delivery of Immunostimulatory Drugs

(2013) Xiangyuan Ouyang et al.   Small

Isothermal Hybridization Kinetics of DNA Assembly of Two-Dimensional DNA Origami

(2013) Jie Song et al.   Small

Scaffolded biosensors with designed DNA nanostructures

(2013) Hao Pei et al.   NPG Asia Materials

G-quadruplex-binding ligand-induced DNA synapsis inside a DNA origami frame

(2013) Arivazhagan Rajendran et al.   RSC Advances

Design and Development of Nanosized DNA Assemblies in Polypod-like Structures as Efficient Vehicles for Immunostimulatory CpG Motifs to Immune Cells

(2012) Kohta Mohri et al.   ACS Nano

Direct Visualization of the Movement of a Single T7 RNA Polymerase and Transcription on a DNA Nanostructure

(2012) Masayuki Endo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Zinc-Finger Proteins for Site-Specific Protein Positioning on DNA-Origami Structures

(2012) Eiji Nakata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Folding super-sized DNA origami with scaffold strands from long-range PCR

(2012) Honglu Zhang et al.   CHEMICAL COMMUNICATIONS

Interenzyme Substrate Diffusion for an Enzyme Cascade Organized on Spatially Addressable DNA Nanostructures

(2012) Jinglin Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA Origami as a Carrier for Circumvention of Drug Resistance

(2012) Qiao Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-Step Rapid Assembly of DNA Origami Nanostructures for Addressable Nanoscale Bioreactors

(2012) Yanming Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

M1.3 – a small scaffold for DNA origami 

(2012) Hassan Said et al.   Nanoscale

Complex shapes self-assembled from single-stranded DNA tiles

(2012) Bryan Wei et al.   NATURE

Purification of DNA-origami nanostructures by rate-zonal centrifugation

(2012) Chenxiang Lin et al.   NUCLEIC ACIDS RESEARCH

Cryo-EM structure of a 3D DNA-origami object

(2012) X.-c. Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid Folding of DNA into Nanoscale Shapes at Constant Temperature

(2012) J.-P. J. Sobczak et al.   SCIENCE

Nanomaterials for Drug Delivery

(2012) J. A. Hubbell et al.   SCIENCE

Three-Dimensional Structures Self-Assembled from DNA Bricks

(2012) Y. Ke et al.   SCIENCE

A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

(2012) S. M. Douglas et al.   SCIENCE

Cellular Immunostimulation by CpG-Sequence-Coated DNA Origami Structures

(2011) Verena J. Schüller et al.   ACS Nano

DNA origami: a quantum leap for self-assembly of complex structures

(2011) Thomas Tørring et al.   CHEMICAL SOCIETY REVIEWS

Rolling Up Gold Nanoparticle-Dressed DNA Origami into Three-Dimensional Plasmonic Chiral Nanostructures

(2011) Xibo Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organizing DNA Origami Tiles into Larger Structures Using Preformed Scaffold Frames

(2011) Zhao Zhao et al.   NANO LETTERS

The Label-Free Unambiguous Detection and Symbolic Display of Single Nucleotide Polymorphisms on DNA Origami

(2011) Hari K. K. Subramanian et al.   NANO LETTERS

Stability of DNA Origami Nanoarrays in Cell Lysate

(2011) Qian Mei et al.   NANO LETTERS

Nanoengineering a single-molecule mechanical switch using DNA self-assembly

(2011) Ken Halvorsen et al.   NANOTECHNOLOGY

Organization of Intracellular Reactions with Rationally Designed RNA Assemblies

(2011) C. J. Delebecque et al.   SCIENCE

Scaling Up Digital Circuit Computation with DNA Strand Displacement Cascades

(2011) L. Qian et al.   SCIENCE

DNA Origami with Complex Curvatures in Three-Dimensional Space

(2011) D. Han et al.   SCIENCE

Asymmetric DNA Origami for Spatially Addressable and Index-Free Solution-Phase DNA Chips

(2010) Zhao Zhang et al.   ADVANCED MATERIALS

Orthogonal Protein Decoration of DNA Origami

(2010) Barbara Saccà et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Versatile DNA Nanochip for Direct Analysis of DNA Base-Excision Repair

(2010) Masayuki Endo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crystalline Two-Dimensional DNA-Origami Arrays

(2010) Wenyan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stepwise and reversible nanopatterning of proteins on a DNA origami scaffold

(2010) Kentaro Numajiri et al.   CHEMICAL COMMUNICATIONS

Regulation of DNA Methylation Using Different Tensions of Double Strands Constructed in a Defined DNA Nanostructure

(2010) Masayuki Endo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualization of Dynamic Conformational Switching of the G-Quadruplex in a DNA Nanostructure

(2010) Yuta Sannohe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-assembly of three-dimensional prestressed tensegrity structures from DNA

(2010) Tim Liedl et al.   Nature Nanotechnology

A DNA-Origami Chip Platform for Label-Free SNP Genotyping Using Toehold-Mediated Strand Displacement

(2010) Zhao Zhang et al.   Small

Organizing protein–DNA hybrids as nanostructures with programmed functionalities

(2010) Carsten Teller et al.   TRENDS IN BIOTECHNOLOGY

Precisely Programmed and Robust 2D Streptavidin Nanoarrays by Using Periodical Nanometer-Scale Wells Embedded in DNA Origami Assembly

(2009) Akinori Kuzuya et al.   CHEMBIOCHEM

Polymerase Chain Reaction Based Scaffold Preparation for the Production of Thin, Branched DNA Origami Nanostructures of Arbitrary Sizes

(2009) Elisabeth Pound et al.   NANO LETTERS

Self-assembly of DNA into nanoscale three-dimensional shapes

(2009) Shawn M. Douglas et al.   NATURE

From molecular to macroscopic via the rational design of a self-assembled 3D DNA crystal

(2009) Jianping Zheng et al.   NATURE

Self-assembly of a nanoscale DNA box with a controllable lid

(2009) Ebbe S. Andersen et al.   NATURE

Large-area spatially ordered arrays of gold nanoparticles directed by lithographically confined DNA origami

(2009) Albert M. Hung et al.   Nature Nanotechnology

A DNA nanomachine that maps spatial and temporal pH changes inside living cells

(2009) Souvik Modi et al.   Nature Nanotechnology

Enzyme cascades activated on topologically programmed DNA scaffolds

(2009) Ofer I. Wilner et al.   Nature Nanotechnology

Placement and orientation of individual DNA shapes on lithographically patterned surfaces

(2009) Ryan J. Kershner et al.   Nature Nanotechnology

Folding DNA into Twisted and Curved Nanoscale Shapes

(2009) H. Dietz et al.   SCIENCE

G-quadruplex structures: in vivo evidence and function

(2009) Hans J. Lipps et al.   TRENDS IN CELL BIOLOGY

New Redesigned Zinc-Finger Proteins: Design Strategy and Its Application

(2008) Shigeru Negi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Isothermal Assembly of DNA Origami Structures Using Denaturing Agents

(2008) Ralf Jungmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-assembled DNA nanostructures for distance-dependent multivalent ligand–protein binding

(2008) Sherri Rinker et al.   Nature Nanotechnology

Self-Assembled Water-Soluble Nucleic Acid Probe Tiles for Label-Free RNA Hybridization Assays

(2008) Y. Ke et al.   SCIENCE