Review
Pharmacology & Pharmacy
Youri G. Bolsius, Matias D. Zurbriggen, Jae Kyoung Kim, Martien J. Kas, Peter Meerlo, Sara J. Aton, Robbert Havekes
Summary: Circadian clock genes serve as the molecular basis for animals' internal timekeeping, integrating temporal information into various physiological processes. In addition to their canonical cellular timekeeping functions, clock proteins interact with proteins involved in processes unrelated to timekeeping. Recent data suggests that clock genes outside the SCN play a role in fundamental brain processes and may function independently of their circadian timekeeping function under certain circumstances.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Plant Sciences
Chuan Liu, Na Li, Zeping Lu, Qianxi Sun, Xinhan Pang, Xudong Xiang, Changhao Deng, Zhengshuojian Xiong, Kunxian Shu, Fang Yang, Zhongli Hu
Summary: This study revealed the regulatory role of DNA methylation in the transcriptional control of OsPRR37-output genes, and showed that hypomethylation of OsHXK1 leads to decreased starch content and reduced plant growth in rice. The findings suggest that CG and CHG methylation contribute to the transcriptional regulation of OsPRR37-output genes.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Clinical Neurology
Long Niu, Feng Zhang, Xiaojiao Xu, Yuting Yang, Song Li, Hui Liu, Weidong Le
Summary: Chronic sleep deprivation impaired learning and memory, exacerbating disease progression in Alzheimer's disease (AD) mice. Abnormal expression of clock genes in the circadian rhythm-related nuclei, especially in AD mice, was found after chronic sleep deprivation. Moreover, abnormal tau phosphorylation was accompanied by alterations in BMAL1 protein levels in the retrosplenial cortex.
Review
Biochemistry & Molecular Biology
Agata Gabryelska, Szymon Turkiewicz, Filip Franciszek Karuga, Marcin Sochal, Dominik Strzelecki, Piotr Bialasiewicz
Summary: Obstructive sleep apnea (OSA) is a chronic condition characterized by recurrent pauses in breathing, leading to intermittent hypoxia and arousals during the night. It is associated with comorbidities in various systems, including cardiovascular, metabolic, psychiatric, and neurological complications. The disruption of the circadian clock may play a significant role in the development and progression of OSA-related complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Yanhao Chu, Yaqi Wu, Shilin Jia, Ke Xu, Jinyue Liu, Lijia Mai, Wenguo Fan, Fang Huang
Summary: In this study, the distribution and expression of core clock genes, pain-related genes, melatonin-related genes, and opioid-related genes in different cell types and neuron subtypes within the mouse and human trigeminal ganglion were analyzed. Species differences were investigated by comparing these genes between human and mouse trigeminal ganglion. The results of this study provide a valuable resource for exploring the molecular mechanisms underlying oral facial pain and pain rhythms.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Environmental Sciences
Chung-Yao Hsu, Yao-Chung Chuang, Fang-Chia Chang, Hung-Yi Chuang, Terry Ting-Yu Chiou, Chien-Te Lee
Summary: Chronic lead exposure disrupts the sleep-wake cycle in rats, particularly disrupting sleep homeostasis. This disturbance is associated with toxic effects on clock gene expression in the hypothalamus.
Article
Clinical Neurology
Evelina Pajediene, Erlandas Paulekas, Violeta Salteniene, Jurgita Skieceviciene, Justina Arstikyte, Kestutis Petrikonis, Juozas Kupcinskas, Claudio L. Bassetti, Rastenyte Daiva
Summary: This study is the first to investigate clock genes expression profiles in ischemic stroke patients, revealing specific circadian desynchrony features in different loops of the molecular circadian clock system.
Article
Genetics & Heredity
Julie M. Cridland, Alex C. Majane, Li Zhao, David J. Begun
Summary: Research on de novo gene discovery in Drosophila has revealed significant differences in gene abundance and expression between different tissues, particularly in the testis and accessory gland. While other properties such as transcript length and chromosomal distribution are more similar, regulatory mechanisms may vary and interact with selection to produce differences in de novo genes expressed in male reproductive tissues.
Article
Medical Laboratory Technology
Afaf Elsaid, Rasha M. S. Shoaib, Sara S. Badr, Yahya Wahba, Seif-Eldin N. Ayyad
Summary: The study found that IL4 VNTR and IL4R (A1902G) gene polymorphisms are associated with the risk of bronchial asthma among Egyptian children, with certain genotypes of IL4 VNTR and IL4R (A1902G) showing significantly higher frequencies in asthmatic patients.
CLINICAL BIOCHEMISTRY
(2021)
Review
Oncology
Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak
Summary: IL-1 receptor accessory protein (IL-1RAP) plays a crucial role in inflammatory conditions and tumorigenesis in the tumor microenvironment. It is involved in the progression, metastasis, and angiogenesis of solid tumors and hematological malignancies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Article
Multidisciplinary Sciences
Xudan Lou, Haidong Wang, Yanyuan Tu, Wen Tan, Cuiping Jiang, Jiao Sun, Zhijun Bao
Summary: The study investigated the alterations of sleep quality and circadian rhythm genes in elderly thyroid nodule patients, revealing that poor sleep quality and daytime dysfunction were independent risk factors for thyroid malignancies. The expression levels of CLOCK, BMAL1, and PER2 were higher in malignant nodules while CRY2 levels were decreased. High expression of CLOCK and BMAL1, and low expression of CRY2 may play a role in the occurrence of elderly thyroid malignancy.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Jie Ma, Ian Kar Yin Lam, Chak-Sing Lau, Vera Sau Fong Chan
Summary: The study found that IL18RAP expression is elevated in neutrophils of SLE patients, especially those with a history of nephritis, and is associated with disease activity and immunological manifestations. Neutrophils from SLE patients exhibit higher IL-18-mediated reactive oxygen species generation, which may be attributed to the upregulation of IL18RAP expression.
Article
Biochemistry & Molecular Biology
Weitian Li, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
Summary: Lack of sleep time is a threat to modern people, leading to chronic diseases and mental illnesses. This study in mice found that sleep restriction disrupted the circadian rhythm of clock genes and advanced the output signals in the plasma.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Erica C. Jansen, Dana Dolinoy, Karen E. Peterson, Louise M. O'Brien, Ronald D. Chervin, Alejandra Cantoral, Martha Maria Tellez-Rojo, Maritsa Solano-Gonzalez, Jaclyn Goodrich
Summary: The study found that later sleep timing was significantly associated with higher DNA methylation of several circadian genes, and different dietary patterns were also related to circadian gene DNA methylation, with the "breakfast" pattern having the clearest inverse associations. These findings suggest that timing-related sleep and eating behaviors among adolescents could result in epigenetic modification of clock genes.
Article
Cell Biology
Emanuel Barth, Akash Srivastava, Diane Wengerodt, Milan Stojiljkovic, Hubertus Axer, Otto W. Witte, Alexandra Kretz, Manja Marz
Summary: Research indicates that the circadian clock system is influenced by aging-related gene alterations across different species and tissues, showing consistent aging-related expression patterns. These findings help to elucidate how the circadian system and aging interact with each other and why this interaction is crucial during a long lifespan.
Article
Environmental Sciences
Elena Skornyakov, Shobhan Gaddameedhi, Gemma M. Paech, Amy R. Sparrow, Brieann C. Satterfield, Nita L. Shattuck, Matthew E. Layton, Ilia Karatsoreos, Hans P. A. Van Dongen
Article
Endocrinology & Metabolism
Scott A. Kinlein, Derrick J. Phillips, Chandler R. Keller, Ilia N. Karatsoreos
PSYCHONEUROENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Rebecca E. Hay, Alex Edwards, Marianne Klein, Lindsay Hyland, David MacDonald, Ilia Karatsoreos, Matthew N. Hill, Alfonso Abizaid
Review
Endocrinology & Metabolism
Scott A. Kinlein, Ilia N. Karatsoreos
FRONTIERS IN NEUROENDOCRINOLOGY
(2020)
Article
Immunology
Gregory L. Pearson, Marina Savenkova, John J. Barnwell, Ilia N. Karatsoreos
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Biographical-Item
Neurosciences
Matthew N. Hill, Ilia N. Karatsoreos, E. Ron de Kloet, Sonia Lupien, Catherine S. Woolley
NATURE NEUROSCIENCE
(2020)
Article
Neurosciences
Naomi K. Wallace, Felicity Pollard, Marina Savenkova, Ilia N. Karatsoreos
Article
Cell Biology
Forrest J. Ragozzino, Rachel A. Arnold, Cody W. Kowalski, Marina I. Savenkova, Ilia N. Karatsoreos, James H. Peters
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Article
Biology
Brieann C. Satterfield, Marina Savenkova, Ilia N. Karatsoreos, Melinda L. Jackson, Gregory Belenky, Hans P. A. Van Dongen
CHRONOBIOLOGY INTERNATIONAL
(2020)
Editorial Material
Neurosciences
Ilia N. Karatsoreos
BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Scott A. Kinlein, Naomi K. Wallace, Marina Savenkova, Ilia N. Karatsoreos
Summary: It is well-known that stress has significant impacts on both the brain and body, affecting various aspects of health. The hypothalamic-pituitary-adrenal (HPA) axis plays a crucial role in the body's response to stress. Glutamate signaling, on the other hand, plays a major role in transmitting stress-related information in the brain. However, the connection between HPA dysfunction and glutamate signaling is not fully understood. This study found that chronic HPA axis dysfunction alters the expression of genes related to glutamate signaling in the medial prefrontal cortex, hippocampus, and amygdala, providing more evidence of the link between HPA dysfunction and vulnerability to stress.
NEUROBIOLOGY OF STRESS
(2022)
Article
Chemistry, Organic
Chathuri J. Kombala, Neha Agrawal, Agne Sveistyte, Ilia N. Karatsoreos, Hans P. A. Van Dongen, Kristoffer R. Brandvold
Summary: The diurnal rhythmicity of cellular function is crucial for survival for most organisms. This study focuses on microbial bile salt biotransformation and develops a novel assay to detect bile salt hydrolase (BSH) activity in small quantities of stool samples. The study demonstrates the diurnal fluctuations of BSH activity in the large intestine of mice and its correlation with feeding patterns.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Meeting Abstract
Clinical Neurology
B. C. Satterfield, M. Savenkova, I. N. Karatsoreos, H. Van Dongen
Article
Neurosciences
G. Balsevich, A. Abizaid, A. Chen, I. N. Karatsoreos, M. Schmidt
NEUROBIOLOGY OF STRESS
(2019)