Functional Characterization of PyrG, an Unusual Nonribosomal Peptide Synthetase Module from the Pyridomycin Biosynthetic Pathway

Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA

(2013) Ruben C Hartkoorn et al.   Nature Chemical Biology

Towards a new tuberculosis drug: pyridomycin - nature's isoniazid

(2012) Ruben C. Hartkoorn et al.   EMBO Molecular Medicine

Structural Basis of the Interaction of MbtH-like Proteins, Putative Regulators of Nonribosomal Peptide Biosynthesis, with Adenylating Enzymes

(2012) Dominik A. Herbst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyridomycin: Evaluating its antimycobacterial potential through the synthesis and testing of new analogues

(2012) K Laqua et al.   PLANTA MEDICA

Synthesis and Antimycobacterial Activity of 2,1′-Dihydropyridomycins

(2012) Oliver P. Horlacher et al.   ACS Medicinal Chemistry Letters

Identification and Characterization of the Pyridomycin Biosynthetic Gene Cluster ofStreptomyces pyridomyceticusNRRL B-2517

(2011) Tingting Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemoenzymatic Synthesis of Cryptophycin Anticancer Agents by an Ester Bond-Forming Non-ribosomal Peptide Synthetase Module

(2011) Yousong Ding et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity

(2011) Marc Röttig et al.   NUCLEIC ACIDS RESEARCH

Activation of the Pacidamycin PacL Adenylation Domain by MbtH-like Proteins

(2010) Wenjun Zhang et al.   BIOCHEMISTRY

MbtH-Like Proteins as Integral Components of Bacterial Nonribosomal Peptide Synthetases

(2010) Elizabeth A. Felnagle et al.   BIOCHEMISTRY

Natural Products Version 2.0: Connecting Genes to Molecules

(2010) Christopher T. Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conformational Dynamics in the Acyl-CoA Synthetases, Adenylation Domains of Non-ribosomal Peptide Synthetases, and Firefly Luciferase

(2009) Andrew M. Gulick   ACS Chemical Biology

A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis

(2009) S. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA