Article
Agriculture, Multidisciplinary
Zhenbiao Li, Yingying Wei, Zidan Cao, Shu Jiang, Yi Chen, Xingfeng Shao
Summary: Terpinen-4-ol, the main component of tea tree oil, enhances disease resistance in postharvest strawberry fruit by inducing gene expression, particularly through activation of the jasmonic acid pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agronomy
Zhenbiao Li, Yingying Wei, Yangyang Xu, Peipei Han, Shu Jiang, Feng Xu, Hongfei Wang, Nengguo Tao, Xingfeng Shao
Summary: Terpinen-4-ol was found to maintain the quality of strawberry fruit by regulating sucrose metabolism and anthocyanin biosynthesis. Treatments led to higher levels of sucrose and fructose in the fruit, accompanied by decreased levels of α-D-glucose, β-D-glucose, and citric acid.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Yanhong Yong, Biao Fang, Yingxin Huang, Junyu Li, Tianyue Yu, Lianyun Wu, Canying Hu, Xiaoxi Liu, Zhichao Yu, Xingbin Ma, Ravi Gooneratne, Sidong Li, A. M. Abd El-Aty, Xianghong Ju
Summary: The primary constituent of tea tree oil, terpinen-4-ol, protects intestinal epithelial cell barrier function and attenuates colitis by promoting the expression of tight junction proteins.
FRONTIERS IN NUTRITION
(2022)
Article
Microbiology
Francesca Mondello, Stefano Fontana, Maria Scaturro, Antonietta Girolamo, Marisa Colone, Annarita Stringaro, Maura Di Vito, Maria Luisa Ricci
Summary: This study evaluated the in vitro activity of Terpinen-4-ol as a potential agent for Legionella pneumophila (Lp) control and compared it with tea tree oil. The results showed that Terpinen-4-ol exhibited strong antimicrobial activity against Lp, with enhanced bactericidal effects at higher temperatures.
Article
Biochemistry & Molecular Biology
Bianca Johansen, Raphael E. Duval, Jean-Christophe Sergere
Summary: This study investigates the potential antibacterial synergy between a combination of terpinen-4-ol and alpha-terpineol and standard tea tree oil, and suggests that it could be a valuable weapon against ESKAPE pathogens.
Article
Biochemistry & Molecular Biology
Wenpeng Cao, Yumei Li, Zhirui Zeng, Shan Lei
Summary: According to previous research, turmeric seeds with an abundance of terpinen-4-ol (T4O) have anti-inflammatory, anti-malignancy, and anti-aging properties. However, the specific effects of T4O on glioma cells are still unclear. In this study, various assays were used to determine the viability and effects of T4O on glioma cell lines. Through comprehensive analyses, key signaling pathways and targets of T4O were identified. The data suggests that T4O has potential as a prospective compound for glioma treatment by inducing ferroptosis and inhibiting cell proliferation.
Article
Microbiology
Feng Cheng, Yanan Mo, Keyuan Chen, Xiaofei Shang, Zhen Yang, Baocheng Hao, Ruofeng Shang, Jianping Liang, Yu Liu
Summary: The study found that terpinen-4-ol has good antibacterial activity and significantly inhibits the formation of MRSA biofilm by inhibiting purine and pyrimidine metabolism.
Article
Pharmacology & Pharmacy
Yanyan Zhang, Li He, Mengxin Tu, Mei Huang, Yan Chen, Di Pan, Jianqing Peng, Xiangchun Shen
Summary: Research suggests that terpinen-4-ol can alleviate vascular calcification by inhibiting calcium deposition, phenotypic switching, and endoplasmic reticulum stress in vascular smooth muscle cells through the upregulation of SIRT1 expression. This study sheds light on the molecular mechanism of terpinen-4-ol and supports its potential as a therapeutic agent for chronic kidney disease-related vascular calcification.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Entomology
Hailong Wu, Shuaili Yue, Yong Huang, Xinping Zhao, Haiqun Cao, Min Liao
Summary: Long noncoding RNAs (lncRNAs) play important regulatory roles in various biological processes. In this study, the researchers identified differentially transcribed lncRNAs associated with terpinen-4-ol resistance in the red flour beetle. They also found that these lncRNAs regulate the metabolism of terpinen-4-ol. This study provides valuable information for understanding resistance to terpinen-4-ol and other compounds, as well as other biological processes in the red flour beetle.
Article
Biotechnology & Applied Microbiology
Wenpeng Cao, Ruhua Tian, Runsang Pan, Baofei Sun, Chaolun Xiao, Yunhua Chen, Zhirui Zeng, Shan Lei
Summary: This study demonstrates that terpinen-4-ol (T4O) can suppress the malignant behavior of pancreatic cancer cells by reducing the expression of Rho-associated coiled-coil containing protein kinase 2 (ROCK2), thus contributing to pancreatic cancer therapy.
Article
Biochemistry & Molecular Biology
Shanshan Gao, Kui Liu, Hui Liu, Se Yin, Xinlong Guo, Yonglei Zhang, Kunpeng Zhang, Ruimin Li
Summary: In this study, a P450 gene (CYP9Z6) was identified from Tribolium castaneum and its role in detoxifying terpinen-4-ol was investigated. The results showed that TcCYP9Z6 plays a significant role in the detoxification of terpinen-4-ol, which suggests its potential as a target for RNAi-mediated prevention and control of T. castaneum.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Immunology
Sania Aslam, Waqas Younis, Muhammad Nasir Hayat Malik, Shah Jahan, Alamgeer, Ambreen Malik Uttra, Muhammad Usman Munir, Muhammad Roman
Summary: This study investigated the effect of terpinen-4-ol on arthritis using in vitro and in vivo models. It was found that terpinen-4-ol has a significant anti-inflammatory and antioxidant effect, inhibits joint swelling, and improves related parameters.
INFLAMMOPHARMACOLOGY
(2022)
Article
Chemistry, Physical
Francisco Garnes-Portoles, Carlos Lopez-Cruz, Jorge Sanchez-Quesada, Estela Espinos-Ferri, Antonio Leyva-Perez
Summary: This study demonstrates an isomers-free synthesis of terpinen-4-ol, using solid catalysts for selective epoxidation, isomerization, and hydrogenation reactions. The method achieves high yields and can be performed in batch or flow mode for the isomerization reaction.
MOLECULAR CATALYSIS
(2022)
Review
Biochemistry & Molecular Biology
Md Atiar Rahman, Abida Sultana, Mohammad Forhad Khan, Rachasak Boonhok, Sharmin Afroz
Summary: Complementary and alternative treatments, including tea tree oil, have gained popularity worldwide. This systematic review examines the anti-inflammatory effects and immunomodulatory potential of tea tree oil, focusing on its neuroprotective mechanisms. The study analyzes data from scientific databases and discusses the prospects of tea tree oil as a neuroprotective agent.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Article
Plant Sciences
Jing Chen, Yujian Guo, Xinwen Hu, Kaibing Zhou
Summary: This study compared chloroplast genome sequences of 13 different oil-tea camellia samples to identify an undetermined species from Hainan Province. The findings indicate that chloroplast genome sequences can be used for species identification and phylogenetic analysis of oil-tea camellia.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Horticulture
Keqin Xie, Chenghao Wu, Zongyu Chi, Jing Wang, Hongfei Wang, Yingying Wei, Xingfeng Shao, Feng Xu
Summary: Mannose treatment significantly enhances the content of GABA in germinated broccoli sprouts and promotes the synthesis of other beneficial health-promoting metabolites, such as anthocyanins and total glucosinolates.
SCIENTIA HORTICULTURAE
(2021)
Article
Agriculture, Multidisciplinary
Zhenbiao Li, Yingying Wei, Zidan Cao, Shu Jiang, Yi Chen, Xingfeng Shao
Summary: Terpinen-4-ol, the main component of tea tree oil, enhances disease resistance in postharvest strawberry fruit by inducing gene expression, particularly through activation of the jasmonic acid pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Agriculture, Multidisciplinary
Ke Zhao, Mei Yao, Xin Zhang, Feng Xu, Xingfeng Shao, Yingying Wei, Hongfei Wang
Summary: Flavonoids have beneficial biological activities for human health, mainly exerted in the intestine due to low bioavailability. They can modulate the structure of intestinal microorganisms to improve health, and the changes in gut microbes are associated with the development of depression, which can be significantly improved through the gut-brain axis. Therefore, the interaction between flavonoids and intestinal microbes in alleviating depression is discussed.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Agronomy
Xiurong Zou, Yingying Wei, Shu Jiang, Zidan Cao, Feng Xu, Hongfei Wang, Pingping Zhan, Xingfeng Shao
Summary: The study investigated the effectiveness of Candida pseudolambica W16 as a biocontrol agent against Botrytis cinerea in peach fruit. Results showed that C. pseudolambica W16 significantly reduced the disease incidence of gray mold and repressed natural decay without negative effects on postharvest quality. The primary modes of action include rapid growth and antifungal volatile organic compounds production.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Kun Dai, Yingying Wei, Shu Jiang, Feng Xu, Hongfei Wang, Xin Zhang, Xingfeng Shao
Summary: Thinned peach polyphenols (TPPs) were extracted and purified, and they exhibited high antioxidant, hypoglycemic, and hypolipidemic capacities. TPPs inhibited the activities of alpha-amylase and alpha-glucosidase, and showed a higher binding capacity for bile acids.
Article
Agriculture, Multidisciplinary
Peipei Han, Yingying Wei, Shu Jiang, Yi Chen, Feng Xu, Hongfei Wang, Xingfeng Shao
Summary: In this study, the role of hexokinase (HXK) on disease resistance in peach fruit was investigated. The results showed that the inhibition of HXK activity using N-acetyl-D-glucosamine (NAG) significantly reduced the resistance of peach fruit to Monilinia fructicola infection. Transcriptome and metabolomic analysis revealed the differential expression of genes and metabolites related to the mitogen-activated protein kinase signaling pathway, plant-pathogen interaction, plant hormone signal transduction, and the phenylpropanoid biosynthesis pathway. Furthermore, the inhibition of HXK activity also affected sugar metabolism and the phenylpropanoid pathway, leading to decreased disease resistance in peach fruit.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Agriculture, Multidisciplinary
Mei Yao, Xingfeng Shao, Yingying Wei, Xin Zhang, Hongfei Wang, Feng Xu
Summary: Dietary fiber plays a significant role in alleviating lead-induced neuroinflammation by regulating gut microbiota and the immune system, providing a potential dietary protective strategy.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Agriculture, Multidisciplinary
Xiurong Zou, Yingying Wei, Shu Jiang, Feng Xu, Hongfei Wang, Pingping Zhan, Xingfeng Shao
Summary: 2-Phenylethanol exhibits antifungal activity against Botrytis cinerea by inducing ROS stress and disrupting cell membrane.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Applied
Yu Song, Leyi Zhou, Decai Zhang, Yingying Wei, Shu Jiang, Yi Chen, Jianfen Ye, Xingfeng Shao
Summary: In this study, Pickering high internal phase emulsions (HIPEs) were used to protect peach polyphenols in vitro and in vivo. The stability of HIPEs was analyzed by adjusting the pH and gum Arabic (GA) concentration. Peach polyphenols were encapsulated in HIPEs and showed improved stability during UV irradiation, storage, and heating. The bioaccessibility of peach polyphenols during gastrointestinal digestion was enhanced and the content of polyphenols in different parts of the body also increased. These results suggest that HIPEs can be an excellent protective and effective delivery method for peach polyphenols during digestion.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Decai Zhang, Jianfen Ye, Yu Song, Yingying Wei, Shu Jiang, Yi Chen, Xingfeng Shao
Summary: This study analyzed the conditions of isomerization, cytotoxic activity, and stabilization of amygdalin from peach kernels. It was found that temperatures above 40 degrees C and pH levels higher than 9.0 accelerated the increase of isomer ratio. Isomerization was inhibited at acidic pH levels, even at high temperatures. Ethanol also inhibited isomerization, with a decrease in isomer rate as ethanol concentration increased. The encapsulation of amygdalin in hydrogel beads improved its thermal stability and showed a slow-release effect in in vitro digestion.
Article
Agronomy
Kefeng Cao, Shiyun Zhang, Yi Chen, Jianfen Ye, Yingying Wei, Shu Jiang, Xingfeng Shao
Summary: In this study, we found that the ethylene-responsive transcription factor PpRAP2.12 directly binds to the PpVIN2 promoter and enhances its activity, leading to increased invertase activity and decreased sucrose levels in peach fruit. Overexpression of PpRAP2.12 in tobacco reduces cold tolerance and increases VIN expression and activity, as well as reactive oxygen species production. Therefore, PpRAP2.12 acts as a negative regulator of cold resistance in plants and could be a potential target for mitigating chilling injury in peach fruit.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Xiurong Zou, Yingying Wei, Jianhua Zhu, Jincai Sun, Xingfeng Shao
Summary: This study evaluates the antifungal effects of volatile organic compounds (VOCs) produced by Scheffersomyces spartinae W9, a marine biocontrol yeast. The results show that these VOCs inhibit the growth and spore germination of Botrytis cinerea, a gray mold fungi. Micrograph analysis reveals that the VOCs cause damage to the morphology and ultrastructure of the fungus. Among the VOCs identified, 2-phenylethanol exhibits the strongest antifungal activity.
Article
Agriculture, Multidisciplinary
Zichang Zhao, Yingying Wei, Xiurong Zou, Shu Jiang, Yi Chen, Jianfen Ye, Feng Xu, Hongfei Wang, Xingfeng Shao
Summary: This study found that tryptophol, a quorum-sensing molecule, can enhance the biocontrol efficacy of marine yeast Scheffersomyces spartinae against Botrytis cinerea. Tryptophol promotes population density, biofilm formation, and cell aggregation of S. spartinae, which improves its biocontrol efficacy. Transcriptome analysis reveals that tryptophol upregulates genes associated with cell adhesion and biofilm formation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Jianfen Ye, Xiao Hua, Xingfeng Shao, Ruijin Yang
Summary: The acidification of peanut polysaccharide at pH 3.0 led to the formation of a stable gel structure for preparing oil-in-water emulsions, which exhibited resistance to digestion and maintained a strong structure. This emulsion showed promising potential as a cholesterol-free and low-fat salad dressing substitute.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)