Mutational landscape of receptor guanylyl cyclase C: Functional analysis and disease‐related mutations

The pseudokinase domains of guanylyl cyclase–A and –B allosterically increase the affinity of their catalytic domains for substrate

(2019) Aaron B. Edmund et al.   Science Signaling

Non-Cystic Fibrosis−Related Meconium Ileus: GUCY2C-Associated Disease Discovered through Rapid Neonatal Whole-Exome Sequencing

(2019) Jeremy D. Woods et al.   JOURNAL OF PEDIATRICS

Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin

(2019) D. J. Merlino et al.   Brain Structure & Function

Structural insights into the mechanism of human soluble guanylate cyclase

(2019) Yunlu Kang et al.   NATURE

Adenylate cyclases: Receivers, transducers, and generators of signals

(2018) Jens Bassler et al.   CELLULAR SIGNALLING

Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders

(2018) Scott A Waldman et al.   GUT

Pilot Study Measuring the Novel Satiety Hormone, Pro-Uroguanylin, in Adolescents With and Without Obesity

(2018) Matthew D. Di Guglielmo et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty

(2018) Cintia Folgueira et al.   Scientific Reports

The regulatory role of the kinase-homology domain in receptor guanylyl cyclases: nothing ‘pseudo’ about it!

(2018) Vishwas Mishra et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Uroguanylin: a new actor in the energy balance movie

(2017) C Folgueira et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Uroguanylin Action in the Brain Reduces Weight Gain in Obese Mice via Different Efferent Autonomic Pathways

(2015) Cintia Folgueira et al.   DIABETES

Congenital secretory diarrhoea caused by activating germline mutations inGUCY2C

(2015) Thomas Müller et al.   GUT

Effect of Guanylate Cyclase-C Activity on Energy and Glucose Homeostasis

(2014) Denovan P. Begg et al.   DIABETES

Meconium ileus in a Lebanese family secondary to mutations in the GUCY2C gene

(2014) Amanda Smith et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Cyclic GMP Kinase II (cGKII) Inhibits NHE3 by Altering Its Trafficking and Phosphorylating NHE3 at Three Required Sites

(2014) Tiane Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intestinal Cell Proliferation and Senescence Are Regulated by Receptor Guanylyl Cyclase C and p21

(2013) Nirmalya Basu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase G linked to dopamine D3 receptors in the dorsal striatum controls dopamine release, ΔFosB expression and locomotor activity after repeated cocaine administration

(2013) Dong Kun Lee et al.   NEUROSCIENCE LETTERS

Meconium Ileus Caused by Mutations in GUCY2C, Encoding the CFTR-Activating Guanylate Cyclase 2C

(2012) Hila Romi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The multiple and enigmatic roles of guanylyl cyclase C in intestinal homeostasis

(2012) Najla Arshad et al.   FEBS LETTERS

Site-specificN-Linked Glycosylation of Receptor Guanylyl Cyclase C Regulates Ligand Binding, Ligand-mediated Activation and Interaction with Vesicular Integral Membrane Protein 36, VIP36

(2012) Najla Arshad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to a high-fat diet

(2012) Sayaka Akieda-Asai et al.   JOURNAL OF LIPID RESEARCH

Familial Diarrhea Syndrome Caused by an ActivatingGUCY2CMutation

(2012) Torunn Fiskerstrand et al.   NEW ENGLAND JOURNAL OF MEDICINE

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase

(2012) Jonathan A Winger et al.   BMC STRUCTURAL BIOLOGY

Reduced Vascular Nitric Oxide–cGMP Signaling Contributes to Adipose Tissue Inflammation During High-Fat Feeding

(2011) Priya Handa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Guanylyl cyclase structure, function and regulation

(2011) Lincoln R. Potter   CELLULAR SIGNALLING

A uroguanylin-GUCY2C endocrine axis regulates feeding in mice

(2011) Michael A. Valentino et al.   JOURNAL OF CLINICAL INVESTIGATION

Role for the Membrane Receptor Guanylyl Cyclase-C in Attention Deficiency and Hyperactive Behavior

(2011) R. Gong et al.   SCIENCE

The Linker Region in Receptor Guanylyl Cyclases Is a Key Regulatory Module

(2009) Sayanti Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Evolution of Guanylyl Cyclases as Multidomain Proteins: Conserved Features of Kinase-Cyclase Domain Fusions

(2009) Kabir Hassan Biswas et al.   JOURNAL OF MOLECULAR EVOLUTION

Enterotoxin preconditioning restores calcium-sensing receptor-mediated cytostasis in colon cancer cells

(2008) Giovanni M. Pitari et al.   CARCINOGENESIS

Relaxing the actin cytoskeleton for adhesion and movement with Ena/VASP

(2008) Léa Trichet et al.   JOURNAL OF CELL BIOLOGY

Crystal structure of the guanylyl cyclase Cya2

(2008) A. Rauch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA