Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin

Cell-type specific expression of constitutively-active Rheb promotes regeneration of bulbospinal respiratory axons following cervical SCI

(2018) Mark W. Urban et al.   EXPERIMENTAL NEUROLOGY

Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders

(2018) Scott A Waldman et al.   GUT

Pilot Study Measuring the Novel Satiety Hormone, Pro-Uroguanylin, in Adolescents With and Without Obesity

(2018) Matthew D. Di Guglielmo et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases

(2018) Michael S. Magee et al.   Cancer Immunology Research

Blaming the Brain for Obesity: Integration of Hedonic and Homeostatic Mechanisms

(2017) Hans-Rudolf Berthoud et al.   GASTROENTEROLOGY

Uroguanylin: a new actor in the energy balance movie

(2017) C Folgueira et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Immunohistochemical Staining for Uroguanylin, a Satiety Hormone, is Decreased in Intestinal Tissue Specimens From Female Adolescents With Obesity

(2017) Matthew D Di Guglielmo et al.   PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice

(2017) Peng Li et al.   Toxins

Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat: Historical perspective

(2016) Dianne P. Figlewicz   BRAIN RESEARCH

Guanylin and uroguanylin stimulate lipolysis in human visceral adipocytes

(2016) A Rodríguez et al.   INTERNATIONAL JOURNAL OF OBESITY

Molecular Physiology of Membrane Guanylyl Cyclase Receptors

(2016) Michaela Kuhn   PHYSIOLOGICAL REVIEWS

Obesity Impairs the Action of the Neuroendocrine Ghrelin System

(2016) Jeffrey M. Zigman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Calorie-induced ER stress suppresses uroguanylin satiety signaling in diet-induced obesity

(2016) G W Kim et al.   Nutrition & Diabetes

Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping

(2015) Kevin T. Beier et al.   CELL

Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding

(2015) Michael J. Waterson et al.   Cell Metabolism

Uroguanylin Action in the Brain Reduces Weight Gain in Obese Mice via Different Efferent Autonomic Pathways

(2015) Cintia Folgueira et al.   DIABETES

Uroguanylin levels in intestine and plasma are regulated by nutritional status in a leptin-dependent manner

(2015) C. Folgueira et al.   EUROPEAN JOURNAL OF NUTRITION

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer

(2015) Glen P. Marszalowicz et al.   Oncotarget

Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

(2014) Kevin W. Williams et al.   Cell Metabolism

Effect of Guanylate Cyclase-C Activity on Energy and Glucose Homeostasis

(2014) Denovan P. Begg et al.   DIABETES

Hypothalamic Gliosis Associated With High-Fat Diet Feeding Is Reversible in Mice: A Combined Immunohistochemical and Magnetic Resonance Imaging Study

(2014) Kathryn E. Berkseth et al.   ENDOCRINOLOGY

20 YEARS OF LEPTIN: Role of leptin in energy homeostasis in humans

(2014) Michael Rosenbaum et al.   JOURNAL OF ENDOCRINOLOGY

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

A mesoscale connectome of the mouse brain

(2014) Seung Wook Oh et al.   NATURE

Presynaptic Leptin Action Suppresses Excitatory Synaptic Transmission onto Ventral Tegmental Area Dopamine Neurons

(2013) Jennifer L. Thompson et al.   BIOLOGICAL PSYCHIATRY

Parallel, Redundant Circuit Organization for Homeostatic Control of Feeding Behavior

(2013) J. Nicholas Betley et al.   CELL

Metformin enhances glucagon-like peptide 1 via cooperation between insulin and Wnt signaling

(2013) Mi-Hyun Kim et al.   JOURNAL OF ENDOCRINOLOGY

Lesions of the ventral premammillary nucleus disrupt the dynamic changes in Kiss1 and GnRH expression characteristic of the proestrus–estrus transition

(2013) J. Donato et al.   NEUROSCIENCE

Protein kinase G linked to dopamine D3 receptors in the dorsal striatum controls dopamine release, ΔFosB expression and locomotor activity after repeated cocaine administration

(2013) Dong Kun Lee et al.   NEUROSCIENCE LETTERS

Neuronal circuits that regulate feeding behavior and metabolism

(2013) Jong-Woo Sohn et al.   TRENDS IN NEUROSCIENCES

IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes

(2012) Juxue Li et al.   NATURE CELL BIOLOGY

Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells

(2011) Christa M. Patterson et al.   BRAIN RESEARCH

The interhemispheric connections of the striatum: Implications for Parkinson's disease and drug-induced dyskinesias

(2011) Christopher A. Lieu et al.   BRAIN RESEARCH BULLETIN

Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice

(2011) Michael M. Scott et al.   JOURNAL OF CLINICAL INVESTIGATION

A uroguanylin-GUCY2C endocrine axis regulates feeding in mice

(2011) Michael A. Valentino et al.   JOURNAL OF CLINICAL INVESTIGATION

Uroguanylin: how the gut got another satiety hormone

(2011) Randy J. Seeley et al.   JOURNAL OF CLINICAL INVESTIGATION

Health and economic burden of the projected obesity trends in the USA and the UK

(2011) Y Claire Wang et al.   LANCET

Reward Mechanisms in Obesity: New Insights and Future Directions

(2011) Paul J. Kenny   NEURON

Quantitative Expression Profile of Distinct Functional Regions in the Adult Mouse Brain

(2011) Takeya Kasukawa et al.   PLoS One

Role for the Membrane Receptor Guanylyl Cyclase-C in Attention Deficiency and Hyperactive Behavior

(2011) R. Gong et al.   SCIENCE

Leptin’s effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons

(2010) Jose Donato et al.   JOURNAL OF CLINICAL INVESTIGATION

Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats

(2010) Maura L. Perry et al.   JOURNAL OF NEUROCHEMISTRY

Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding

(2009) Gina M. Leinninger et al.   Cell Metabolism

The Hormone Receptor GUCY2C Suppresses Intestinal Tumor Formation by Inhibiting AKT Signaling

(2009) Jieru Egeria Lin et al.   GASTROENTEROLOGY

Leptin targets in the mouse brain

(2009) Michael M. Scott et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The Ventral Premammillary Nucleus Links Fasting-Induced Changes in Leptin Levels and Coordinated Luteinizing Hormone Secretion

(2009) J. Donato et al.   JOURNAL OF NEUROSCIENCE

Homeostatic and Hedonic Signals Interact in the Regulation of Food Intake

(2009) Michael Lutter et al.   JOURNAL OF NUTRITION

Insulin, cGMP, and TGF-β Signals Regulate Food Intake and Quiescence in C. elegans: A Model for Satiety

(2008) Young-jai You et al.   Cell Metabolism