Can melatonin reduce the severity of COVID-19 pandemic?

Chloroquine and hydroxychloroquine as available weapons to fight COVID-19

(2020) Philippe Colson et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Arguments in favor of remdesivir for treating SARS-CoV-2 infections

(2020) Wen-Chien Ko et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Anti-HCV, nucleotide inhibitors, repurposing against COVID-19

(2020) Abdo A. Elfiky   LIFE SCIENCES

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Effectiveness of glucocorticoid therapy in patients with severe coronavirus disease 2019

(2020) Yuan-Yuan Qin et al.   CHINESE MEDICAL JOURNAL

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

(2020) Xueting Yao et al.   CLINICAL INFECTIOUS DISEASES

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

(2020) Philippe Gautret et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bat Coronaviruses in China

(2019) Yi Fan et al.   Viruses-Basel

Global Epidemiology of Bat Coronaviruses

(2019) Antonio Wong et al.   Viruses-Basel

Efficacy and safety of melatonin for sleep onset insomnia in children and adolescents: a meta-analysis of randomized controlled trials

(2019) Sha Wei et al.   SLEEP MEDICINE

Hemin-induced platelet activation and ferroptosis is mediated through ROS-driven proteasomal activity and inflammasome activation: Protection by Melatonin

(2019) Somanathapura K. NaveenKumar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sleep deprivation alters neutrophil functions and levels of Th1-related chemokines and CD4+ T cells in the blood

(2019) Elias A. Said et al.   Sleep and Breathing

Melatonin possesses an anti-influenza potential through its immune modulatory effect

(2019) Shing-Hwa Huang et al.   Journal of Functional Foods

Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

(2019) Burak I. Arioz et al.   Frontiers in Immunology

The Association Between Supra-Physiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients: A Multi-Centre Observational Cohort Study

(2019) Edward Palmer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis

(2019) Xuebin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacological Inhibitors of the NLRP3 Inflammasome

(2019) Ayesha Zahid et al.   Frontiers in Immunology

Ebola Virus Produces Discrete Small Noncoding RNAs Independently of the Host MicroRNA Pathway Which Lack RNA Interference Activity in Bat and Human Cells

(2019) Abhishek N. Prasad et al.   JOURNAL OF VIROLOGY

Effect of melatonin on antioxidant capacity, ınflammation and apoptotic cell death in lung tissue of diabetic rats

(2018) Didem Onk et al.   Acta Cirurgica Brasileira

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

(2018) Nava Zisapel   BRITISH JOURNAL OF PHARMACOLOGY

Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway

(2018) Xiaoguang Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Renalase contributes to protection against renal fibrosis via inhibiting oxidative stress in rats

(2018) Yiru Wu et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition

(2018) Sai Ma et al.   Oxidative Medicine and Cellular Longevity

Redox Biology of Respiratory Viral Infections

(2018) Olga Khomich et al.   Viruses-Basel

Going to Bat(s) for Studies of Disease Tolerance

(2018) Judith N. Mandl et al.   Frontiers in Immunology

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR-223/NLRP3 axis

(2017) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue

(2017) Zhenjiang Liu et al.   JOURNAL OF PINEAL RESEARCH

Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection

(2017) Thiagarajan Venkataraman et al.   JOURNAL OF VIROLOGY

Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption

(2017) Yvan Touitou et al.   LIFE SCIENCES

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus

(2017) Ben Hu et al.   PLoS Pathogens

Melatonin and Respiratory Diseases: A Review

(2016) Solomon Habtemariam et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome

(2016) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Physiological melatonin levels in healthy older people: A systematic review

(2016) Rikie M. Scholtens et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

Critical role of phospholipase A2group IID in age-related susceptibility to severe acute respiratory syndrome–CoV infection

(2015) Rahul Vijay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Bidirectional Relationship between Sleep and Immunity against Infections

(2015) Elizabeth G. Ibarra-Coronado et al.   Journal of Immunology Research

Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus

(2012) P. C. Y. Woo et al.   JOURNAL OF VIROLOGY

Retinal Toxicity Associated With Hydroxychloroquine and Chloroquine

(2011) Michel Michaelides   ARCHIVES OF OPHTHALMOLOGY

Mechanical stress induces lung fibrosis by epithelial–mesenchymal transition*

(2011) Nuria E. Cabrera-Benítez et al.   CRITICAL CARE MEDICINE

Effects of sleep and circadian rhythm on the human immune system

(2010) Tanja Lange et al.   Annals of the New York Academy of Sciences

Mental inertia in the biological sciences

(2010) Alexander M. Shneider   TRENDS IN BIOCHEMICAL SCIENCES

The Effects of Red and Blue Lights on Circadian Variations in Cortisol, Alpha Amylase, and Melatonin

(2010) Mariana G. Figueiro et al.   International Journal of Endocrinology

Malaria: therapeutic implications of melatonin

(2009) Venkataramanujan Srinivasan et al.   JOURNAL OF PINEAL RESEARCH

Enhancing versus Suppressive Effects of Stress on Immune Function: Implications for Immunoprotection and Immunopathology

(2009) Firdaus S. Dhabhar   NEUROIMMUNOMODULATION

Vaccination in the elderly: an immunological perspective

(2009) Wilbur H. Chen et al.   TRENDS IN IMMUNOLOGY

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Cross-Species Virus Transmission and the Emergence of New Epidemic Diseases

(2008) C. R. Parrish et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS