Animal Models to Translate Phage Therapy to Human Medicine

Phage therapy efficacy: a review of the last 10 years of preclinical studies

(2020) Luís D. R. Melo et al.   CRITICAL REVIEWS IN MICROBIOLOGY

RLP, a bacteriophage of the family Podoviridae, rescues mice from bacteremia caused by multi-drug-resistant Pseudomonas aeruginosa

(2020) Iqbal Ahmad Alvi et al.   ARCHIVES OF VIROLOGY

The Ability of Lytic Staphylococcal Podovirus vB_SauP_phiAGO1.3 to Coexist in Equilibrium With Its Host Facilitates the Selection of Host Mutants of Attenuated Virulence but Does Not Preclude the Phage Antistaphylococcal Activity in a Nematode Infection Model

(2019) Aleksandra Głowacka-Rutkowska et al.   Frontiers in Microbiology

Phage therapy against Pseudomonas aeruginosa infections in a cystic fibrosis zebrafish model

(2019) Marco Cafora et al.   Scientific Reports

Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review

(2019) Krystyna Dąbrowska   MEDICINAL RESEARCH REVIEWS

Successful Bacteriophage Therapy for Treatment of Multidrug-Resistant Pseudomonas aeruginosa Infection in a Cystic Fibrosis Patient

(2019) N. Law et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

(2019) Rebekah M. Dedrick et al.   NATURE MEDICINE

Phage Therapy Regulation: From Night to Dawn

(2019) Alan Fauconnier   Viruses-Basel

Efficacy of Newly Isolated and Highly Potent Bacteriophages in a Mouse Model of XDRAB Bacteremia

(2019) Lika Leshkasheli et al.   Journal of Global Antimicrobial Resistance

Eradication of a multi-drug resistant, carbapenemase-producing Klebsiella pneumoniae isolate following oral and intra-rectal therapy with a custom-made, lytic bacteriophage preparation

(2019) Mario Corbellino et al.   CLINICAL INFECTIOUS DISEASES

Identification of novel bacteriophages with therapeutic potential targeting Enterococcus faecalis

(2019) M Al-Zubidi et al.   INFECTION AND IMMUNITY

Pharmacologically Aware Phage Therapy: Pharmacodynamic and Pharmacokinetic Obstacles to Phage Antibacterial Action in Animal and Human Bodies

(2019) Krystyna Dąbrowska et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Improved lyophilization conditions for long-term storage of bacteriophages

(2019) Prasanth Manohar et al.   Scientific Reports

Phage Therapy for treatment of virulent Klebsiella pneumoniae infection in mouse model

(2019) Taruna Anand et al.   Journal of Global Antimicrobial Resistance

Use of phage therapy to treat long-standing, persistent, or chronic bacterial infections

(2018) Stephen T. Abedon   ADVANCED DRUG DELIVERY REVIEWS

Design of a Broad-Range Bacteriophage Cocktail That Reduces Pseudomonas aeruginosa Biofilms and Treats Acute Infections in Two Animal Models

(2018) Francesca Forti et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phage therapy against Achromobacter xylosoxidan s lung infection in a patient with cystic fibrosis: a case report

(2018) N. Hoyle et al.   RESEARCH IN MICROBIOLOGY

Development of Phage Lysins as Novel Therapeutics: A Historical Perspective

(2018) Vincent Fischetti   Viruses-Basel

Bacteriophage for Gastrointestinal Health (PHAGE) Study: Evaluating the Safety and Tolerability of Supplemental Bacteriophage Consumption

(2018) Melinda Gindin et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Applications of Bacteriophages in the Treatment of Localized Infections in Humans

(2018) Vera V. Morozova et al.   Frontiers in Microbiology

Bacteriophage Therapy Increases Complement-Mediated Lysis of Bacteria and Enhances Bacterial Clearance After Acute Lung Infection With Multidrug-Resistant Pseudomonas aeruginosa

(2018) Abeer M Abd El-Aziz et al.   JOURNAL OF INFECTIOUS DISEASES

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial

(2018) Patrick Jault et al.   LANCET INFECTIOUS DISEASES

Antibiotic Therapy Using Phage Depolymerases: Robustness Across a Range of Conditions

(2018) Han Lin et al.   Viruses-Basel

Antiphage activity of sera during phage therapy in relation to its outcome

(2017) Marzanna Łusiak-Szelachowska et al.   Future Microbiology

Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa

(2017) Elaine M Waters et al.   THORAX

Bacteriophage therapy to combat bacterial infections in poultry

(2017) Andrzej Wernicki et al.   Virology Journal

A cocktail of three virulent bacteriophages prevents Vibrio cholerae infection in animal models

(2017) Minmin Yen et al.   Nature Communications

Therapeutic Application of Phage Capsule Depolymerases against K1, K5, and K30 Capsulated E. coli in Mice

(2017) Han Lin et al.   Frontiers in Microbiology

Refractory Pseudomonas Bacteremia in a 2-Year-Old Sterilized by Bacteriophage Therapy

(2017) C. Duplessis et al.   Journal of the Pediatric Infectious Diseases Society

Synergy and Order Effects of Antibiotics and Phages in Killing Pseudomonas aeruginosa Biofilms

(2017) Waqas Nasir Chaudhry et al.   PLoS One

Microencapsulation with alginate/CaCO3: A strategy for improved phage therapy

(2017) Joan Colom et al.   Scientific Reports

Phage therapy of staphylococcal chronic osteomyelitis in experimental animal model

(2016) Gopal Nath et al.   INDIAN JOURNAL OF MEDICAL RESEARCH

In vivo efficacy of single phage versus phage cocktail in resolving burn wound infection in BALB/c mice

(2016) Parul Chadha et al.   MICROBIAL PATHOGENESIS

Antibody Production in Response to Staphylococcal MS-1 Phage Cocktail in Patients Undergoing Phage Therapy

(2016) Maciej Żaczek et al.   Frontiers in Microbiology

Commentary: Phage Therapy of Staphylococcal Chronic Osteomyelitis in Experimental Animal Model

(2016) Stephen T. Abedon   Frontiers in Microbiology

Prophylactic Bacteriophage Administration More Effective than Post-infection Administration in Reducing Salmonella enterica serovar Enteritidis Shedding in Quail

(2016) Mosab Ahmadi et al.   Frontiers in Microbiology

‘Get in Early’; Biofilm and Wax Moth (Galleria mellonella) Models Reveal New Insights into the Therapeutic Potential of Clostridium difficile Bacteriophages

(2016) Janet Y. Nale et al.   Frontiers in Microbiology

Bacteriophage Combinations Significantly Reduce Clostridium difficile GrowthIn Vitroand ProliferationIn Vivo

(2015) Janet Y. Nale et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antipseudomonal Bacteriophage Reduces Infective Burden and Inflammatory Response in Murine Lung

(2015) Rishi Pabary et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Liposome-Encapsulated Bacteriophages for Enhanced Oral Phage Therapy against Salmonella spp.

(2015) Joan Colom et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Microbial pathogenesis and host defense in the nematode C. elegans

(2015) Lianne B Cohen et al.   CURRENT OPINION IN MICROBIOLOGY

Oral Application of T4 Phage Induces Weak Antibody Production in the Gut and in the Blood

(2015) Joanna Majewska et al.   Viruses-Basel

Bacteriophages and their Enzymes in Biofilm Control

(2014) Benjamin Chan et al.   CURRENT PHARMACEUTICAL DESIGN

Application of ΦSP-1 and ΦSP-3 as a therapeutic strategy againstSalmonellaEnteritidis infection usingCaenorhabditis elegansas model organism

(2014) Jeena Augustine et al.   FEMS MICROBIOLOGY LETTERS

Immunogenicity Studies of Proteins Forming the T4 Phage Head Surface

(2014) K. D browska et al.   JOURNAL OF VIROLOGY

Phage Neutralization by Sera of Patients Receiving Phage Therapy

(2014) Marzanna Łusiak-Szelachowska et al.   VIRAL IMMUNOLOGY

Vesicular system: Versatile carrier for transdermal delivery of bioactives

(2014) Deependra Singh et al.   Artificial Cells Nanomedicine and Biotechnology

Learning from Bacteriophages - Advantages and Limitations of Phage and Phage-Encoded Protein Applications

(2013) Zuzanna Drulis-Kawa et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Phage cocktails and the future of phage therapy

(2013) Benjamin K Chan et al.   Future Microbiology

Evaluation of Galleria mellonella larvae for measuring the efficacy and pharmacokinetics of antibiotic therapies against Pseudomonas aeruginosa infection

(2013) Lucy Hill et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Safety analysis of a Russian phage cocktail: From MetaGenomic analysis to oral application in healthy human subjects

(2013) Shawna McCallin et al.   VIROLOGY

Phage Therapy Is Effective against Infection by Mycobacterium ulcerans in a Murine Footpad Model

(2013) Gabriela Trigo et al.   PLoS Neglected Tropical Diseases

Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium

(2012) Read Pukkila-Worley et al.   CURRENT OPINION IN IMMUNOLOGY

Oral T4-like phage cocktail application to healthy adult volunteers from Bangladesh

(2012) Shafiqul Alam Sarker et al.   VIROLOGY

The Insect Galleria mellonella as a Powerful Infection Model to Investigate Bacterial Pathogenesis

(2012) Nalini Ramarao et al.   Jove-Journal of Visualized Experiments

C. elegans: model host and tool for antimicrobial drug discovery

(2011) J. J. Ewbank et al.   Disease Models & Mechanisms

Evidence to Support the Therapeutic Potential of Bacteriophage Kpn5 in Burn Wound Infection Caused by Klebsiella pneumoniae in BALB/c Mice

(2011) Seema Kumari   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Phage Choice, Isolation, and Preparation for Phage Therapy

(2010) Jason Gill et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Phage Therapy in Clinical Practice: Treatment of Human Infections

(2010) Elizabeth Kutter et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Bacteriophages Can Treat and PreventPseudomonas aeruginosaLung Infections

(2010) Laurent Debarbieux et al.   JOURNAL OF INFECTIOUS DISEASES

Orally Administered P22 Phage Tailspike Protein Reduces Salmonella Colonization in Chickens: Prospects of a Novel Therapy against Bacterial Infections

(2010) Shakeeba Waseh et al.   PLoS One

Experimental Bacteriophage Therapy Increases Survival of Galleria mellonella Larvae Infected with Clinically Relevant Strains of the Burkholderia cepacia Complex

(2009) K. D. Seed et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibacterial Efficacy of Phages against Pseudomonas aeruginosa Infections in Mice and Drosophila melanogaster

(2009) Y.-J. Heo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phage therapy experience at the Eliava Institute

(2008) M. Kutateladze et al.   MEDECINE ET MALADIES INFECTIEUSES

Evaluation of bacteriophages for prevention and treatment of diarrhea due to experimental enterotoxigenic Escherichia coli O149 infection of pigs

(2008) Nidham Jamalludeen et al.   VETERINARY MICROBIOLOGY

PEGylation of bacteriophages increases blood circulation time and reduces T-helper type 1 immune response

(2008) Kwang-Pyo Kim et al.   Microbial Biotechnology