Role of the Hyaluronan Receptor, Stabilin-2/HARE, in Health and Disease

Stab2-Mediated Clearance of Supramolecular Polymer Nanoparticles in Zebrafish Embryos

(2020) Victorio Saez Talens et al.   BIOMACROMOLECULES

Mechanisms regulating myoblast fusion: A multilevel interplay

(2020) Lilya Lehka et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The endothelial lectin clearance receptor CLEC4M binds and internalizes factor VIII in a VWF-dependent and independent manner

(2019) Laura L. Swystun et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Elimination Pathways of Nanoparticles

(2019) Wilson Poon et al.   ACS Nano

Ligand Binding and Signaling of HARE/Stabilin-2

(2019) Edward N. Harris et al.   Biomolecules

Stabilin Receptors: Role as Phosphatidylserine Receptors

(2019) Seung-Yoon Park et al.   Biomolecules

Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake

(2018) Frederick Campbell et al.   ACS Nano

Structural Determinants for the Interactions of Chemically Modified Nucleic Acids with the Stabilin-2 Clearance Receptor

(2018) Hans Gaus et al.   BIOCHEMISTRY

Single-Molecule Unbinding Forces between the Polysaccharide Hyaluronan and Its Binding Proteins

(2018) Fouzia Bano et al.   BIOPHYSICAL JOURNAL

Anti-tumor efficacy of hyaluronan-based nanoparticles for the co-delivery of drugs in lung cancer

(2018) Victor Jeannot et al.   JOURNAL OF CONTROLLED RELEASE

The biology and role of CD44 in cancer progression: therapeutic implications

(2018) Chen Chen et al.   Journal of Hematology & Oncology

3- O sulfation of heparin leads to hepatotropism and longer circulatory half-life

(2018) Colton M. Miller et al.   THROMBOSIS RESEARCH

Crystal structure of the FAS1 domain of the hyaluronic acid receptor stabilin-2

(2018) Aleksandra Twarda-Clapa et al.   Acta Crystallographica Section D-Structural Biology

The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity

(2018) Laura L. Swystun et al.   JOURNAL OF CLINICAL INVESTIGATION

Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion

(2018) Noumeira Hamoud et al.   Nature Communications

What is special about 200 kDa hyaluronan that activates hyaluronan receptor signaling?

(2017) Paul H Weigel et al.   GLYCOBIOLOGY

Homotypic Interaction of Stabilin-2 Plays a Critical Role in Lymph Node Metastasis of Tongue Cancer

(2016) MYUNG WOUL HAN et al.   ANTICANCER RESEARCH

Targeted Delivery of MicroRNA125a-5p by Engineered Lipid Nanoparticles for the Treatment of HER2 Positive Metastatic Breast Cancer

(2016) Stephen L. Hayward et al.   Journal of Biomedical Nanotechnology

Targeting CD44 receptor-positive lung tumors using polysaccharide-based nanocarriers: Influence of nanoparticle size and administration route

(2016) Victor Jeannot et al.   Nanomedicine-Nanotechnology Biology and Medicine

Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver

(2016) Colton M. Miller et al.   NUCLEIC ACIDS RESEARCH

Stabilin-2 modulates the efficiency of myoblast fusion during myogenic differentiation and muscle regeneration

(2016) Seung-Yoon Park et al.   Nature Communications

Deconvoluting hepatic processing of carbon nanotubes

(2016) Simone Alidori et al.   Nature Communications

Endotoxin free hyaluronan and hyaluronan fragments do not stimulate TNF-α, interleukin-12 or upregulate co-stimulatory molecules in dendritic cells or macrophages

(2016) Yifei Dong et al.   Scientific Reports

Tissue-specific splice variants of HARE/Stabilin-2 are expressed in bone marrow, lymph node, and spleen

(2015) Amanda K. Hare et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Recent developments in hyaluronic acid-based nanomedicine for targeted cancer treatment

(2015) N. Vijayakameswara Rao et al.   Expert Opinion on Drug Delivery

Tissue invasion and metastasis: Molecular, biological and clinical perspectives

(2015) W.G. Jiang et al.   SEMINARS IN CANCER BIOLOGY

Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic Target

(2015) Yongmin Yan et al.   Stem Cells Translational Medicine

A Hyaluronan Receptor for Endocytosis (HARE) Link DomainN-Glycan Is Required for Extracellular Signal-regulated Kinase (ERK) and Nuclear Factor-κB (NF-κB) Signaling in Response to the Uptake of Hyaluronan but Not Heparin, Dermatan Sulfate, or Acetylated Low Density Lipoprotein (LDL)

(2014) Madhu S. Pandey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronic Acid Receptor Stabilin-2 Regulates Erk Phosphorylation and Arterial - Venous Differentiation in Zebrafish

(2014) Megan S. Rost et al.   PLoS One

The Hyaluronan Receptor for Endocytosis (HARE) Activates NF-κB-mediated Gene Expression in Response to 40–400-kDa, but Not Smaller or Larger, Hyaluronans

(2013) Madhu S. Pandey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronic Acid Receptor for Endocytosis (HARE)-mediated Endocytosis of Hyaluronan, Heparin, Dermatan Sulfate, and Acetylated Low Density Lipoprotein (AcLDL), but Not Chondroitin Sulfate Types A, C, D, or E, Activates NF-κB-regulated Gene Expression

(2013) Madhu S. Pandey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin-2 expression in peri-tumourous liver correlates with increased survival

(2013) Cyrill Géraud et al.   LIVER INTERNATIONAL

Sticky Signaling--Adhesion Class G Protein-Coupled Receptors Take the Stage

(2013) T. Langenhan et al.   Science Signaling

Systemic blockade of the hyaluronan receptor for endocytosis prevents lymph node metastasis of prostate cancer

(2012) Melanie A. Simpson et al.   INTERNATIONAL JOURNAL OF CANCER

Cross Talk between Engulfment Receptors Stabilin-2 and Integrin  v 5 Orchestrates Engulfment of Phosphatidylserine-Exposed Erythrocytes

(2012) S. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis

(2012) Y. Hirose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism for phosphatidylserine-dependent erythrophagocytosis in mouse liver

(2011) S.-J. Lee et al.   BLOOD

Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors

(2011) Kai Schledzewski et al.   JOURNAL OF CLINICAL INVESTIGATION

Nanostructured hyaluronic acid-based materials for active delivery to cancer

(2010) Dmitri A Ossipov   Expert Opinion on Drug Delivery

N-Glycans on the link domain of human HARE/Stabilin-2 are needed for hyaluronan binding to purified ecto-domain, but not for cellular endocytosis of hyaluronan

(2010) E. N. Harris et al.   GLYCOBIOLOGY

The conserved histidine in epidermal growth factor-like domains of stabilin-2 modulates pH-dependent recognition of phosphatidylserine in apoptotic cells

(2010) Soyoun Kim et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Role of glycosylation of Notch in development

(2010) Hideyuki Takeuchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Stabilins are expressed in bone marrow sinusoidal endothelial cells and mediate scavenging and cell adhesive functions

(2009) Hong Qian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stabilin-2 mediates homophilic cell-cell interactions via its FAS1 domains

(2009) Seung-Yoon Park et al.   FEBS LETTERS

Stabilin-1 mediates phosphatidylserine-dependent clearance of cell corpses in alternatively activated macrophages

(2009) S.-Y. Park et al.   JOURNAL OF CELL SCIENCE

Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives

(2009) Eun Ju Oh et al.   JOURNAL OF CONTROLLED RELEASE

Splenic marginal zone antigen-presenting cells are critical for the primary allo-immune response to therapeutic factor VIII in hemophilia A

(2009) A. NAVARRETE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Endocytosis of Advanced Glycation End-Products in Bovine Choriocapillaris Endothelial Cells

(2009) Ruomei Li et al.   MICROCIRCULATION

Thymosin β4 is involved in stabilin-2-mediated apoptotic cell engulfment

(2008) Sung-Jin Lee et al.   FEBS LETTERS

The ligand-binding profile of HARE: hyaluronan and chondroitin sulfates A, C, and D bind to overlapping sites distinct from the sites for heparin, acetylated low-density lipoprotein, dermatan sulfate, and CS-E

(2008) E. N. Harris et al.   GLYCOBIOLOGY

The Human Hyaluronan Receptor for Endocytosis (HARE/Stabilin-2) Is a Systemic Clearance Receptor for Heparin

(2008) Edward N. Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hyaluronan Receptor for Endocytosis Mediates Hyaluronan-dependent Signal Transduction via Extracellular Signal-regulated Kinases

(2008) Svetlana V. Kyosseva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Requirement of Adaptor Protein GULP during Stabilin-2-mediated Cell Corpse Engulfment

(2008) Seung-Yoon Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cytoplasmic Domain of the Hyaluronan Receptor for Endocytosis (HARE) Contains Multiple Endocytic Motifs Targeting Coated Pit-mediated Internalization

(2008) Madhu S. Pandey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal Growth Factor-Like Domain Repeat of Stabilin-2 Recognizes Phosphatidylserine during Cell Corpse Clearance

(2008) S.-Y. Park et al.   MOLECULAR AND CELLULAR BIOLOGY