When the balance is broken: X‐linked gene dosage from two X chromosomes and female‐biased autoimmunity

Diversity of Epigenetic Features of the Inactive X-Chromosome in NK Cells, Dendritic Cells, and Macrophages

(2019) Camille M. Syrett et al.   Frontiers in Immunology

CD40LG duplication-associated autoimmune disease is silenced by nonrandom X-chromosome inactivation

(2018) Carole Le Coz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Our Environment Shapes Us: The Importance of Environment and Sex Differences in Regulation of Autoantibody Production

(2018) Michael Edwards et al.   Frontiers in Immunology

The Implication of Early Chromatin Changes in X Chromosome Inactivation

(2018) Jan Jakub Żylicz et al.   CELL

When the Lyon(ized chromosome) roars: ongoing expression from an inactive X chromosome

(2017) Laura Carrel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective

(2017) Vaishali R. Moulton et al.   TRENDS IN MOLECULAR MEDICINE

O-GlcNAcylation is required for B cell homeostasis and antibody responses

(2017) Jung-Lin Wu et al.   Nature Communications

Brief Report: Rare X Chromosome Abnormalities in Systemic Lupus Erythematosus and Sjögren's Syndrome

(2017) Rohan Sharma et al.   Arthritis & Rheumatology

Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome

(2016) Valerie M. Harris et al.   CLINICAL IMMUNOLOGY

Gender-specific incidence of autoimmune diseases from national registers

(2016) Jianguang Ji et al.   JOURNAL OF AUTOIMMUNITY

Enhanced Expression of Bruton’s Tyrosine Kinase in B Cells Drives Systemic Autoimmunity by Disrupting T Cell Homeostasis

(2016) Odilia B. J. Corneth et al.   JOURNAL OF IMMUNOLOGY

New insights into the immunopathogenesis of systemic lupus erythematosus

(2016) George C. Tsokos et al.   Nature Reviews Rheumatology

Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X

(2016) Jianle Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton’s Tyrosine Kinase

(2016) Samantha A. Chalmers et al.   Scientific Reports

Systematic Discovery of Xist RNA Binding Proteins

(2015) Ci Chu et al.   CELL

X-chromosome inactivation and escape

(2015) CHRISTINE M. DISTECHE et al.   JOURNAL OF GENETICS

Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-  Production in Women

(2015) M. Griesbeck et al.   JOURNAL OF IMMUNOLOGY

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

(2015) Colleen A. McHugh et al.   NATURE

Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis

(2015) Chandra Mohan et al.   Nature Reviews Nephrology

A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation

(2015) A. Minajigi et al.   SCIENCE

Escape from X Inactivation Varies in Mouse Tissues

(2015) Joel B. Berletch et al.   PLoS Genetics

Derivation of consensus inactivation status for X-linked genes from genome-wide studies

(2015) Bradley P. Balaton et al.   Biology of Sex Differences

The Expansion of CD25highIL-10highFoxP3highB Regulatory Cells Is in Association with SLE Disease Activity

(2015) Zahava Vadasz et al.   Journal of Immunology Research

Female Bias in Systemic Lupus Erythematosus is Associated with the Differential Expression of X-Linked Toll-Like Receptor 8

(2015) Gabrielle McDonald et al.   Frontiers in Immunology

Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus

(2014) Yan Zhang et al.   HUMAN MOLECULAR GENETICS

New regulatory CD19+CD25+ B-cell subset in clinically isolated syndrome and multiple sclerosis relapse. Changes after glucocorticoids

(2014) Clara de Andrés et al.   JOURNAL OF NEUROIMMUNOLOGY

Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice

(2013) Eda Yildirim et al.   CELL

Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse

(2013) Kristi A. Koelsch et al.   JOURNAL OF AUTOIMMUNITY

Overexpression of X-Linked genes in T cells from women with lupus

(2013) Anura Hewagama et al.   JOURNAL OF AUTOIMMUNITY

Selective Inhibition of BTK Prevents Murine Lupus and Antibody-Mediated Glomerulonephritis

(2013) A. L. Rankin et al.   JOURNAL OF IMMUNOLOGY

High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation

(2013) Matthew D. Simon et al.   NATURE

Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination

(2013) D. Furman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome

(2013) J. M. Engreitz et al.   SCIENCE

Female polysomy-X and systemic lupus erythematosus

(2013) Mordechai Slae et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

SeXX matters in immunity

(2013) J.G. Markle et al.   TRENDS IN IMMUNOLOGY

Fine mapping of Xq28: bothMECP2 and IRAK1contribute to risk for systemic lupus erythematosus in multiple ancestral groups

(2012) Kenneth M Kaufman et al.   ANNALS OF THE RHEUMATIC DISEASES

Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice

(2012) L. P. Kil et al.   BLOOD

Molecular Signatures of Human Induced Pluripotent Stem Cells Highlight Sex Differences and Cancer Genes

(2012) Montserrat C. Anguera et al.   Cell Stem Cell

TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice

(2012) Anatoly V. Rubtsov et al.   IMMUNOLOGIC RESEARCH

B Cell TLR7 Expression Drives Anti-RNA Autoantibody Production and Exacerbates Disease in Systemic Lupus Erythematosus-Prone Mice

(2012) S.-H. Hwang et al.   JOURNAL OF IMMUNOLOGY

Sex Differences in the Response to Viral Infections: TLR8 and TLR9 Ligand Stimulation Induce Higher IL10 Production in Males

(2012) Maria Gabriella Torcia et al.   PLoS One

Overexpression of Methyl-CpG Binding Protein 2 Impairs TH1 Responses

(2012) T. Yang et al.   Science Translational Medicine

Escape from X inactivation in mice and humans

(2012) Joel B Berletch et al.   GENOME BIOLOGY

Gender effect on in vitro lymphocyte subset levels of healthy individuals

(2011) Maha Abdullah et al.   CELLULAR IMMUNOLOGY

Genes that escape from X inactivation

(2011) Joel B. Berletch et al.   HUMAN GENETICS

The X chromosome and immune associated genes

(2011) Ilaria Bianchi et al.   JOURNAL OF AUTOIMMUNITY

Murine Models of Systemic Lupus Erythematosus

(2011) Daniel Perry et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation

(2011) Anton Wutz   NATURE REVIEWS GENETICS

Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population

(2010) H. Garcia-Ortiz et al.   ANNALS OF THE RHEUMATIC DISEASES

Global survey of escape from X inactivation by RNA-sequencing in mouse

(2010) F. Yang et al.   GENOME RESEARCH

The Xs and Y of immune responses to viral vaccines

(2010) Sabra L Klein et al.   LANCET INFECTIOUS DISEASES

Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus

(2010) N. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCR3, Inflammation, and Autoimmune Diseases

(2009) Stéphanie Lacotte et al.   Annals of the New York Academy of Sciences

CXCR3+CD4+ T cells are enriched in inflamed kidneys and urine and provide a new biomarker for acute nephritis flares in systemic lupus erythematosus patients

(2009) P. Enghard et al.   ARTHRITIS AND RHEUMATISM

Variants withinMECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus

(2009) Ryan Webb et al.   ARTHRITIS AND RHEUMATISM

46,X,del(X)(q13) Turner's syndrome women with systemic lupus erythematosus in a pedigree multiplex for SLE

(2009) C M Cooney et al.   GENES AND IMMUNITY

Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis

(2009) A Hewagama et al.   GENES AND IMMUNITY

Autoimmunity and Klinefelter's syndrome: When men have two X chromosomes

(2009) Amr H. Sawalha et al.   JOURNAL OF AUTOIMMUNITY

CXCR3 Mediates Renal Th1 and Th17 Immune Response in Murine Lupus Nephritis

(2009) O. M. Steinmetz et al.   JOURNAL OF IMMUNOLOGY

Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus

(2009) C. O. Jacob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of autoimmunity by pristane and other naturally occurring hydrocarbons

(2009) Westley H. Reeves et al.   TRENDS IN IMMUNOLOGY

Sexual Inequality in Tuberculosis

(2009) Olivier Neyrolles et al.   PLOS MEDICINE

X Chromosome Dosage Compensation: How Mammals Keep the Balance

(2008) Bernhard Payer et al.   Annual Review of Genetics

Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: Support for the notion of a gene-dose effect from the X chromosome

(2008) R. Hal Scofield et al.   ARTHRITIS AND RHEUMATISM

Yaaautoimmune phenotypes are conferred by overexpression of TLR7

(2008) Anna‐Marie Fairhurst et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A role for sex chromosome complement in the female bias in autoimmune disease

(2008) Deborah L. Smith-Bouvier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses

(2008) Denis Gaucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypothesis: Increased male mortality caused by infection is due to a decrease in heterozygous loci as a result of a single X chromosome

(2008) James A. Morris et al.   MEDICAL HYPOTHESES

Common Variants within MECP2 Confer Risk of Systemic Lupus Erythematosus

(2008) Amr H. Sawalha et al.   PLoS One

X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells

(2008) S. S. Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations

(2008) Y. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sexual dimorphism of humoral immunity with human vaccines

(2008) Ian Francis Cook   VACCINE