Simulations of NPC1(NTD):NPC2 Protein Complex Reveal Cholesterol Transfer Pathways
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Title
Simulations of NPC1(NTD):NPC2 Protein Complex Reveal Cholesterol Transfer Pathways
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 9, Pages 2623
Publisher
MDPI AG
Online
2018-09-05
DOI
10.3390/ijms19092623
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Note: Only part of the references are listed.- 3.3 Å structure of Niemann–Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport
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- Computational Analysis of Sterol Ligand Specificity of the Niemann Pick C2 Protein
- (2016) Vasanthanathan Poongavanam et al. BIOCHEMISTRY
- Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
- (2016) Xin Gong et al. CELL
- Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2
- (2016) Xiaochun Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Niemann–Pick Type C Disease: A QM/MM Study of Conformational Changes in Cholesterol in the NPC1(NTD) and NPC2 Binding Pockets
- (2014) Nadia Elghobashi-Meinhardt BIOCHEMISTRY
- Computational Studies of the Cholesterol Transport between NPC2 and the N-Terminal Domain of NPC1 (NPC1(NTD))
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- Update of the Cholesterol Force Field Parameters in CHARMM
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- Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection
- (2011) Marceline Côté et al. NATURE
- Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
- (2011) Jan E. Carette et al. NATURE
- Niemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding
- (2011) M. S. Deffieu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of Surface Residues on Niemann-Pick C2 Essential for Hydrophobic Handoff of Cholesterol to NPC1 in Lysosomes
- (2010) Michael L. Wang et al. Cell Metabolism
- Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types
- (2010) Jeffery B. Klauda et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol
- (2009) Hyock Joo Kwon et al. CELL
- NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes
- (2008) R. E. Infante et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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