Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 151, Issue -, Pages 421-427Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.02.114
Keywords
Lignin-based drug-loaded material; Nano-formulation; Anti-photolysis; Controlled-release; Adhesion
Funding
- National Natural Science Foundation of China [21436004, 21706038, 21690083]
- Natural Science Foundation of Guangdong Province [2017A030308012, 2019B151502038, 2017B090903003]
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In this work, the anionic and cationic lignin-based drug-loaded materials (SL/CTAB) with strong hydrophobicity were prepared by using Sodium Lignosulfonate (SL) via self-assembly. The obtained SL/CTAB was used as drug-loaded material and emulsifier to prepare avermectin nano-formulation, which can be automatically dispersed into nano drug-loaded nanospheres in water. The cold and hot storage experiments show that the physical and chemical stability of the nano-formulation is good. The nano-formulation exhibits controlled-release performance, and the cumulative release amounts range from 5627% to 87.33% in 62 h. Meanwhile, the release rates slow down with increasing SL/CTAB dosage. After UV irradiation for 50 h, the retention rates of avermectin in the nano-formulation range from 46.67% to 63.41%, which is 2.18-2.96 times higher than commercial avermectin Emulsifiable Concentrate (EC).The experiment of simulated rainwater scour-resistance shows that the affinity of lignin-based nano-formulation to the Epipremnum aureum leaves is higher than EC formulation. (C) 2020 Elsevier B.V. All rights reserved.
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