Article
Immunology
Mohammad Reza Javan, Azam Rahimpour, Seyed Mohammad Moazzeni
Summary: Simultaneous overexpression of A20 and BTLA genes in DCs resulted in the development of tolerogenic DCs with enhanced potential in inducing Treg cells. These DCs showed remarkable stability after inflammatory stimulation, offering a promising potential in treating autoimmune and inflammatory disorders.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xianmei Liu, Peng Yu, Yujun Xu, Yun Wang, Jin Chen, Fuzhou Tang, Zuquan Hu, Jing Zhou, Lina Liu, Wei Qiu, Yuannong Ye, Yi Jia, Weijuan Yao, Jinhua Long, Zhu Zeng
Summary: Dendritic cells (DCs) can mediate immune responses or immune tolerance depending on their immunophenotype and functional status. Metformin can induce tolerance in DCs by reprogramming their metabolic patterns, thereby exerting anti-inflammatory effects.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Immunology
Caiyun Liu, Jie Zhu, Yan Mi, Tao Jin
Summary: Dendritic cells (DCs) play a crucial role in autoimmune diseases such as multiple sclerosis (MS) and can be significantly affected by current disease-modifying therapies (DMT). The induction of tolerogenic DCs (tolDCs) has shown therapeutic potential in laboratory models and early clinical trials. Targeting specific cell-surface receptors to induce tolDCs in vivo has greater promise and advantages compared to in vitro induction.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Morgan Vandermeulen, Pauline Erpicum, Noella Bletard, Laurence Poma, Francois Jouret, Olivier Detry
Summary: This study evaluated the effects of MSCs in combination with everolimus on Treg expansion and liver graft tolerance in a rat model of liver transplantation. The results showed that the combination of MSCs with everolimus did not have a synergistic effect in preventing acute rejection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jinwen Lin, Hongyi Wang, Chenxi Liu, Ao Cheng, Qingwei Deng, Huijuan Zhu, Jianghua Chen
Summary: Dendritic cells play a crucial role in inducing and regulating adaptive immunity in the kidney, with different phenotypes having varying effects such as promoting rejection or suppressing inflammation and damage. These cells interact with effector T cells and regulatory T cells, but the classification and effects of different subsets are still controversial.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Nick Giannoukakis
Summary: Tolerogenic dendritic cells (tDC) have the potential to prevent the progression of autoimmune-driven dysglycemia into insulin-requiring type 1 diabetes (T1D) and preserve β cells. tDC act via multiple layers of immune regulation to suppress effector lymphocytes targeting β cells. It is now appropriate to conduct phase II clinical trials for T1D using well-characterized tDC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Farhan Ullah Khan, Puregmaa Khongorzul, Ahmed Aziz Raki, Ashwini Rajasekaran, Denis Gris, Abdelaziz Amrani
Summary: Type 1 diabetes is caused by the destruction of pancreatic beta cells mediated by T cells. Dendritic cells play a crucial role in the initiation and development of this disease by presenting antigens to activate and regulate the immune response. Recent advancements in understanding dendritic cell function and regulation have led to the development of potential therapeutic strategies for treating type 1 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Vivien Li, Michele D. Binder, Trevor J. Kilpatrick
Summary: Dendritic cells can induce anti-inflammatory/tolerogenic properties and promote immune tolerance. Dexamethasone can generate tolerogenic dendritic cells and upregulate MERTK expression. The study suggests that dexamethasone's tolerogenic effects are mediated via MERTK and may be exerted by increasing Rab17 expression to prevent the presentation of efferocytosed material on the cell surface.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Hanna Abberger, Romy Barthel, Jasmin Bahr, Jacqueline Thiel, Sina Luppus, Jan Buer, Astrid M. Westendorf, Wiebke Hansen
Summary: The study found that in activated CD4(+) non-Tregs, Nrp-1 expression has an activating role, while in CD4(+) non-Tregs from naive mice, Nrp-1 expression leads to dysfunction.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Sara Ness, Shiming Lin, John R. Gordon
Summary: Dendritic cells are antigen-presenting cells that interact with T cells to regulate adaptive immune responses. Under certain conditions, dendritic cells can develop into anti-inflammatory cells, inducing immunologic tolerance. Studies have shown that regulatory dendritic cells induce T cell tolerance by suppressing effector T cells and inducing regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Hilal Bashir, Sanpreet Singh, Raghwendra Pratap Singh, Javed N. Agrewala, Rashmi Kumar
Summary: Age-related loss of immune tolerance leads to autoimmune and inflammatory diseases. Aging and gut dysbiosis disrupt the tolerance of dendritic cells, which are responsible for maintaining immune tolerance. Our study reveals that gut dysbiosis in both aged and young mice leads to the loss of dendritic cell tolerance, highlighting the importance of gut microbiota in immune responses.
Article
Immunology
H. Hackstein, A. Kalina, B. Dorn, I. S. Keil, N. Baal, G. Michel, C. Brendel, A. Neubauer, T. Jakob, G. Bein
Summary: Extracorporeal photopheresis (ECP) acts through antigen-presenting dendritic cells (DC) and is influenced by CD11c(+) DC, demonstrating antigen specificity and showing the critical importance of CD11c(+) DC for ECP activity.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Aurelie Moreau, Delphine Kervella, Laurence Bouchet-Delbos, Cecile Braudeau, Soraya Saiagh, Pierrick Guerif, Sophie Limou, Anne Moreau, Sylvain Bercegeay, Mathias Streitz, Birgit Sawitzki, Ben James, Paul N. Harden, David Game, Qizhi Tang, James F. Markmann, Ian S. D. Roberts, Edward K. Geissler, Brigitte Dreno, Regis Josien, Maria-Cristina Cuturi, Gilles Blancho
Summary: Survival rates of kidney transplant patients are affected by chronic rejection and side effects of immunosuppressive drugs. Cell-based immunotherapy using tolerogenic dendritic cells has shown promise in reducing general immunosuppression. A phase I clinical trial using human autologous tolerogenic dendritic cells in kidney transplantation has demonstrated the safety and effectiveness of this approach in improving graft survival.
KIDNEY INTERNATIONAL
(2023)
Review
Cell Biology
Xiaodong Du, Mingqian Li, Chen Huan, Guoyue Lv
Summary: This review discusses the origin, maturation, migration, and pathological effects of dendritic cell subsets in liver transplantation, as well as their roles in transplant rejection and tolerance. The latest progress in dendritic cell-based treatment regimens is also outlined.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Jiawei Li, Juntao Chen, Mingnan Zhang, Chao Zhang, Renyan Wu, Tianying Yang, Yue Qiu, Jingjing Liu, Tongyu Zhu, Yi Zhang, Ruiming Rong
Summary: The study found that mTOR deficiency enhances the immunosuppressive function of monocytic MDSCs and prolongs the survival time of mouse cardiac transplantation, mainly manifested as promoting MDSC differentiation, increasing intracellular autophagy levels, and inhibiting T cell activation and inducing regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)