Review
Nutrition & Dietetics
Brigitte M. Gonzalez Olmo, Michael J. Butler, Ruth M. Barrientos
Summary: The transition from consuming preagricultural wild foods to postindustrial semi-processed and ultra-processed foods in the Western diet within a short period of time has disrupted the evolution of the gut microbiota, leading to negative impacts on digestive, immune, and nervous systems. Dysbiosis of the gut microbiota caused by the Western diet can result in digestive issues, immune system abnormalities, and exaggerated neuroinflammation, ultimately contributing to the development of diseases and disorders such as memory impairments, neurodegenerative disorders, and depression.
Review
Biochemistry & Molecular Biology
Youssef Bouferraa, Andrea Chedid, Ghid Amhaz, Ahmed El Lakkiss, Deborah Mukherji, Sally Temraz, Ali Shamseddine
Summary: The gut microbiota plays a significant role in modulating tumor treatment, particularly in response to and resistance of immune checkpoint inhibitors. Modulating the microbial environment may offer a potential pathway to overcoming treatment resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Pernille Kihl, Lukasz Krych, Ling Deng, Lars H. Hansen, Karsten Buschard, Soren Skov, Dennis S. Nielsen, Axel Kornerup Hansen
Summary: The purpose of this study was to compare the effect of a gluten-free diet and/or antibiotics on tetanus vaccine induced immunoglobulin G titers and immune cell levels in BALB/c mice. The results showed that the gluten-free diet reduced the specific antibody response and significantly increased the abundance of anti-inflammatory Bifidobacterium in some mice. Antibiotics also led to changes in gut microbiota and lower vaccine titers. These results suggest that diet and gut microbiota play a role in the vaccine response of mice.
Review
Biochemistry & Molecular Biology
Ludovico Abenavoli, Giuseppe Guido Maria Scarlata, Maria Rosaria Paravati, Luigi Boccuto, Francesco Luzza, Emidio Scarpellini
Summary: Liver transplantation is the preferred treatment for patients with certain liver conditions, but rejection after transplantation is a significant issue. The gut microbiota is involved in the gut-liver axis and can affect the immune response, potentially leading to graft rejection. Evaluating changes in the gut microbiota composition is essential for monitoring the success of liver transplantation and implementing appropriate preventive measures.
Article
Cardiac & Cardiovascular Systems
Pedram Honarpisheh, Robert M. Bryan, Louise D. McCullough
Summary: The microbiota-gut-brain-axis (MGBA) is a communication network between gut microbes and the host, and dysbiosis disrupts this network, affecting the host's immune, metabolic, and nervous systems. Dysbiosis is linked to aging and stroke, and is associated with stroke risk factors such as obesity and diabetes. The article summarizes the role of MGBA signaling in the development of stroke risk factors and discusses current understanding of microbiota-based therapies for stroke.
CIRCULATION RESEARCH
(2022)
Article
Nutrition & Dietetics
Ravichandra Vemuri, Christopher J. Martoni, Kylie Kavanagh, Rajaraman Eri
Summary: Age-related changes in gut microbiome are associated with co-occurrence patterns, with reduced nodes and associations in elderly mice. DDS-1 strain can modulate microbial co-occurrence networks, with differential effects on fecal, mucosal, and cecal samples. Beneficial bacteria act as connectors in aging networks in response to DDS-1 supplementation.
Review
Biochemistry & Molecular Biology
Javier Calleja-Conde, Victor Echeverry-Alzate, Kora-Mareen Buhler, Pedro Duran-Gonzalez, Jose Angel Morales-Garcia, Lucia Segovia-Rodriguez, Fernando Rodriguez de Fonseca, Elena Gine, Jose Antonio Lopez-Moreno
Summary: The human gut houses a diverse population of microorganisms called microbiota which play a key role in maintaining immune and metabolic homeostasis. Factors like diet and alcohol can influence the composition of gut bacteria, with alcohol consumption disrupting the intestinal barrier integrity and leading to a compromised mucosal immunity. This disruption allows bacteria to enter the blood tissue and affect organs like the liver and brain, contributing to the link between alcohol consumption, gut microbiota, and the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Xiaodong Du, Mingqian Li, Chen Huan, Guoyue Lv
Summary: This review discusses the origin, maturation, migration, and pathological effects of dendritic cell subsets in liver transplantation, as well as their roles in transplant rejection and tolerance. The latest progress in dendritic cell-based treatment regimens is also outlined.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Endocrinology & Metabolism
Sonali Dagar, Jagdeep Singh, Aastha Saini, Yashwant Kumar, Seema Chhabra, Ranjana Walker Minz, Lekha Rani
Summary: Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes joint damage and various symptoms. The imbalance between different immune cells and changes in gut microbiota may contribute to the development of RA. Further research on gut bacteria, fungi, and viruses could provide new insights into the etiology and potential therapeutic targets for RA.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Kaijin Yao, Yina Xie, Jiali Wang, Yongda Lin, Xiutian Chen, Tianbiao Zhou
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that primarily affects women of childbearing age and causes damage to multiple organs. The pathogenesis of SLE involves genetic and environmental factors, and there is currently no effective cure for SLE. Recent evidence suggests that gut microbiota, as an environmental factor, can trigger autoimmunity and contribute to the development of SLE. Modulating gut microbiota through dietary intervention, drug therapy, probiotics, and fecal microbiome transplantation may be a potential treatment for SLE. This review summarizes the dysbiosis of gut microbiota in SLE, potential mechanisms linking gut microbiota and SLE, and immune dysregulation associated with gut microbiota in SLE.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mario Caldarelli, Laura Franza, Pierluigi Rio, Antonio Gasbarrini, Giovanni Gambassi, Rossella Cianci
Summary: The microbiota has a significant impact on health and disease, including inflammation and immune disorders, as well as complex conditions such as neurological, psychiatric, gastrointestinal, and cardiovascular diseases. The gut microbiota may serve as an intermediary in the close interaction between the kidneys and the cardiovascular system, known as the gut-kidney-heart axis.
Article
Biochemistry & Molecular Biology
So Yoon Ahn, Dong Kyung Sung, Yun Sil Chang, Won Soon Park
Summary: This study aimed to investigate whether intratracheal transplantation of mesenchymal stem cells (MSCs) could attenuate hyperoxia-induced lung injuries and microbial dysbiosis in the lungs, brain, and gut of newborn rats. The results showed that microbial dysbiosis in the lungs, brain, and gut was caused by hyperoxic lung inflammation and injuries, and transplantation of MSCs attenuated dysbiosis primarily through their anti-oxidative and anti-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Min'an Zhao, Jiayi Chu, Shiyao Feng, Chuanhao Guo, Baigong Xue, Kan He, Lisha Li
Summary: The gut microbiota plays a crucial role in maintaining host health by enhancing digestion, protecting the intestinal barrier, and interacting with the immune system. Dysbiosis of the gut microbiota, caused by various factors, is a major contributor to inflammatory diseases. The mechanisms underlying these diseases resulting from gut microbiota dysbiosis are not well categorized.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Mohammad S. Alam, Jayanthi Gangiredla, Nur A. Hasan, Tammy Barnaba, Carmen Tartera
Summary: Aging and L. monocytogenes infection impact the gut microbiota of mice differently, with infected old mice showing increased colonization of Listeria and inflammatory bacterial species, while beneficial commensals diminish. This study suggests that aging may alter gut microbiota composition and increase susceptibility to invasive L. monocytogenes infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jun Miyoshi, Sawako Miyoshi, Tom O. Delmont, Candace Cham, Sonny T. M. Lee, Aki Sakatani, Karen Yang, Yue Shan, Megan Kennedy, Evan Kiefl, Mahmoud Yousef, Sean Crosson, Mitchell Sogin, Dionysios A. Antonopoulos, A. Murat Eren, Vanessa Leone, Eugene B. Chang
Summary: Early engraftment of a specific Bacteroides strain can help restore gut microbiome development, promote immune tolerance, and reduce the risk of colitis in genetically susceptible hosts.
Article
Biochemical Research Methods
Deepyan Chatterjee, Pragya Priyadarshini, Deepjyoti K. Das, Khurram Mushtaq, Balvinder Singh, Javed N. Agrewala
JOURNAL OF PROTEOME RESEARCH
(2020)
Article
Chemistry, Medicinal
Mohammad Aqdas, Sudeep Kumar Maurya, Susanta Pahari, Sanpreet Singh, Nargis Khan, Kanupriya Sethi, Gurpreet Kaur, Javed Naim Agrewala
Summary: The study found that enhancing host immunity through NOD-2 and TLR-4 signaling can reduce the dose and duration of drugs for tuberculosis treatment, as well as improve resistance to Mycobacterium tuberculosis.
ACS INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Sanpreet Singh, Sudeep K. Maurya, Mohammad Aqdas, Hilal Bashir, Ashish Arora, Vijayender Bhalla, Javed N. Agrewala
Summary: The MPT64 protein released by Mycobacterium tuberculosis can transform dendritic cells into myeloid-derived suppressor cells, enabling the pathogen to evade the immune system. This transformation is accompanied by high expression of immunosuppressive molecules and the generation of immunosuppressive cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Microbiology
Raghwendra Pratap Singh, Naina Kumari, Sameer Gupta, Riddhi Jaiswal, Divya Mehrotra, Sudhir Singh, Souvik Mukherjee, Rashmi Kumar
Summary: This study explores the influence of the microbiome on the tumor immune system by analyzing the microbial composition at different stages of oral cancer. It identifies the immunomodulatory role of microbes in the tumor microenvironment.
MICROBIOLOGY SPECTRUM
(2023)