Endothelin-1 Mediates the Systemic and Renal Hemodynamic Effects of GPR81 Activation

Afferent arteriole responsiveness to endothelin receptor activation: does sex matter?

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Activation of GPR81 by lactate inhibits oscillatory shear stress‐induced endothelial inflammation by activating the expression of KLF2

(2019) Zirui Sun et al.   IUBMB LIFE

Pericytes in the renal vasculature: roles in health and disease

(2018) Isaac Shaw et al.   Nature Reviews Nephrology

Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types

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Impaired pressure natriuresis and non‐dipping blood pressure in Rats with early type 1 diabetes mellitus

(2018) Geoffrey J. Culshaw et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

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Pharmacological characterization of the mechanisms underlying the vascular effects of succinate

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G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion

(2016) Yu Jin Lee et al.   Oncotarget

Endothelin‐1 Drives Epithelial‐Mesenchymal Transition in Hypertensive Nephroangiosclerosis

(2016) Teresa M. Seccia et al.   Journal of the American Heart Association

Synthesis and Pharmacological Properties of Silicon-Containing GPR81 and GPR109A Agonists

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Renal Hemodynamics in AKI: In Search of New Treatment Targets

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Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival

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Inhibition of G Protein-Coupled Receptor 81 (GPR81) Protects Against Ischemic Brain Injury

(2014) Zhe Shen et al.   CNS Neuroscience & Therapeutics

Identification of a novel GPR81-selective agonist that suppresses lipolysis in mice without cutaneous flushing

(2014) Taku Sakurai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor– and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

(2014) Rafaz Hoque et al.   GASTROENTEROLOGY

Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism

(2013) K. H. Lauritzen et al.   CEREBRAL CORTEX

Progressive endothelin-1 gene activation initiates chronic/end-stage renal disease following experimental ischemic/reperfusion injury

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Taming the “sleeping giant”: the role of endothelin-1 in the regulation of skeletal muscle blood flow and arterial blood pressure during exercise

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ET-1 actions in the kidney: evidence for sex differences

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Cilostazol Prevents Endothelin-Induced Smooth Muscle Constriction and Proliferation

(2012) Yoshifumi Kawanabe et al.   PLoS One

Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects

(2012) Curt A. Dvorak et al.   ACS Medicinal Chemistry Letters

Inflammation inhibits GPR81 expression in adipose tissue

(2011) Kenneth R. Feingold et al.   INFLAMMATION RESEARCH

Cellular pathophysiology of ischemic acute kidney injury

(2011) Joseph V. Bonventre et al.   JOURNAL OF CLINICAL INVESTIGATION

GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors

(2009) Kashan Ahmed et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells

(2008) Shobha H. Ganji et al.   ATHEROSCLEROSIS

Role of GPR81 in lactate-mediated reduction of adipose lipolysis

(2008) Tian-Quan Cai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81

(2008) Changlu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY