Comprehensive characterisation of pancreatic ductal adenocarcinoma with microsatellite instability: histology, molecular pathology and clinical implications

Real-time Targeted Genome Profile Analysis of Pancreatic Ductal Adenocarcinomas Identifies Genetic Alterations that Might be Targeted with Existing Drugs or Used as Biomarkers

(2019) Aatur D. Singhi et al.   GASTROENTEROLOGY

Tumor mutational burden is predictive of response to immune checkpoint inhibitors in MSI-high metastatic colorectal cancer

(2019) A B Schrock et al.   ANNALS OF ONCOLOGY

ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach

(2019) C Luchini et al.   ANNALS OF ONCOLOGY

Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants

(2019) Danielle Hutchings et al.   MODERN PATHOLOGY

Tumour response to TRK inhibition in a patient with pancreatic adenocarcinoma harbouring an NTRK gene fusion

(2019) E M O’Reilly et al.   ANNALS OF ONCOLOGY

Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair–Deficient Cancer: Results From the Phase II KEYNOTE-158 Study

(2019) Aurelien Marabelle et al.   JOURNAL OF CLINICAL ONCOLOGY

Precision medicine in pancreatic cancer: treating every patient as an exception

(2019) Brian Herbst et al.   Lancet Gastroenterology & Hepatology

Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations

(2018) Zishuo I. Hu et al.   CLINICAL CANCER RESEARCH

Integrated genomic and immunophenotypic classification of pancreatic cancer reveals three distinct subtypes with prognostic/predictive significance

(2018) Martin Wartenberg et al.   CLINICAL CANCER RESEARCH

Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas

(2018) Renato M. Lupinacci et al.   GASTROENTEROLOGY

Landscape of Tumor Mutation Load, Mismatch Repair Deficiency, and PD-L1 Expression in a Large Patient Cohort of Gastrointestinal Cancers

(2018) Mohamed E. Salem et al.   MOLECULAR CANCER RESEARCH

Multicenter experience with large panel next-generation sequencing in patients with advanced solid cancers in Japan

(2018) Shingo Kato et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer

(2018) Alicia Latham et al.   JOURNAL OF CLINICAL ONCOLOGY

Prevalence of elevated microsatellite alterations at selected tetranucleotide repeats in pancreatic ductal adenocarcinoma

(2018) Taiki Mori et al.   PLoS One

Pancreatic ductal adenocarcinoma harboring microsatellite instability / DNA mismatch repair deficiency. Towards personalized medicine

(2018) Renato M. Lupinacci et al.   SURGICAL ONCOLOGY-OXFORD

Hypermutation In Pancreatic Cancer

(2017) Jeremy L. Humphris et al.   GASTROENTEROLOGY

Chromatin remodelling and DNA repair genes are frequently mutated in endometrioid endometrial carcinoma

(2017) Pablo García-Sanz et al.   INTERNATIONAL JOURNAL OF CANCER

Pancreatic cancer incidence trends: evidence from the Surveillance, Epidemiology and End Results (SEER) population-based data

(2017) Vanessa L Gordon-Dseagu et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

First FDA Approval Agnostic of Cancer Site — When a Biomarker Defines the Indication

(2017) Steven Lemery et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma

(2017) Ashton A. Connor et al.   JAMA Oncology

Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion

(2017) Lee A. Albacker et al.   PLoS One

Pancreatic cancer

(2016) Terumi Kamisawa et al.   LANCET

Prevalence of Germline Mutations in Cancer Predisposition Genes in Patients With Pancreatic Cancer

(2015) Robert C. Grant et al.   GASTROENTEROLOGY

Mismatch repair status may predict response to adjuvant chemotherapy in resectable pancreatic ductal adenocarcinoma

(2015) Maziar Riazy et al.   MODERN PATHOLOGY

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

A histomorphologic comparison of familial and sporadic pancreatic cancers

(2015) Aatur D. Singhi et al.   PANCREATOLOGY

Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis

(2015) Kei Mitsuhashi et al.   Oncotarget

Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas

(2014) Eliana Amato et al.   JOURNAL OF PATHOLOGY

Ampullary Region Carcinomas

(2012) Volkan Adsay et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Irrelevance of Microsatellite Instability in the Epidemiology of Sporadic Pancreatic Ductal Adenocarcinoma

(2012) Luigi Laghi et al.   PLoS One

Multivariate analysis of immunohistochemical evaluation of protein expression in pancreatic ductal adenocarcinoma reveals prognostic significance for persistent Smad4 expression only

(2012) Niki A. Ottenhof et al.   CELLULAR ONCOLOGY

Simulation-based analyses reveal stable microsatellite sequences in human pancreatic cancer

(2009) Kei Fujii et al.   CANCER GENETICS AND CYTOGENETICS